scholarly journals Adult onset egg allergy: a case report

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Elisa Maria Cremonte ◽  
Eugenia Galdi ◽  
Chiara Roncallo ◽  
Elisa Boni ◽  
Luigi Giovanni Cremonte
Keyword(s):  
Gastrointestinal Symptoms ◽  
Rare Condition ◽  
Specific Ige ◽  
Food Allergies ◽  
Adult Onset ◽  
Egg Allergy ◽  
Case Presentation ◽  
Prick Test ◽  
Active Smoker ◽  
Ige Mediated

Abstract Background Egg allergy is one of the most frequent food allergies in childhood while adult onset of egg allergy is a rare condition. Case presentation We report the case of a 30 years old man sent to our center in order to investigate gastrointestinal symptoms occurring since 2 years after egg and derivatives intake. He did not suffer from egg or other food allergies in childhood. He is an active smoker with a contact dermatitis related to nickel and mild allergic rhinoconjunctivitis to grass pollen. Skin prick test and serum specific IgE to egg were performed and revealed sensitization to egg proteins. Conclusions Even though IgE-mediated egg allergy affects children, this report witnesses a rare case of adult onset.

scholarly journals Adult Onset Egg Allergy: A Case Report

2021 ◽  
Author(s):  
Elisa Maria Cremonte ◽  
Eugenia Galdi ◽  
Chiara Roncallo ◽  
Elisa Boni ◽  
Luigi Cremonte
Keyword(s):  
Gastrointestinal Symptoms ◽  
Rare Condition ◽  
Specific Ige ◽  
Food Allergies ◽  
Adult Onset ◽  
Egg Allergy ◽  
Case Presentation ◽  
Prick Test ◽  
Active Smoker ◽  
Ige Mediated

Abstract Background: Egg allergy is one of the most frequent food allergies in childhood while adult onset of egg allergy is a rare condition.Case presentation: We report the case of a 30 years old man sent to our center in order to investigate gastrointestinal symptoms occurring since two years after egg and derivatives intake. He did not suffer from egg or other food allergies in childhood. He is an active smoker with a contact dermatitis related to nickel and mild allergic rhinoconjunctivitis to grass pollen. Skin prick test and serum specific IgE to egg were performed and revealed sensitization to egg proteins. Conclusions: Even though IgE-mediated egg allergy affects children, this report witnesses a rare case of adult onset.

scholarly journals Eliciting dose is associated with tolerance development in peanut and cow’s milk allergic children

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
C. Nitsche ◽  
C. D. Westerlaken-van Ginkel ◽  
B. J. Kollen ◽  
A. B. Sprikkelman ◽  
G. H. Koppelman ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Food Challenge ◽  
Specific Ige ◽  
Food Allergies ◽  
Milk Allergy ◽  
Egg Allergy ◽  
Tolerance Development ◽  
Double Blind ◽  
Gold Standard Method

Abstract Background Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the reported prevalence rates. Little is known about the association of the eliciting dose (ED) obtained during the initial DBPCFC with later tolerance development. Methods This was a retrospective, tertiary care study of children who had a positive DBPCFC to either peanut, milk or egg, and at least one follow-up food challenge (open or DBPCFC) with the same food. The association between ED and negative (tolerant) follow-up food challenge outcome was analyzed by logistic regression, with adjustment for confounders. Suspected confounders were initial DBPCFC test characteristics, atopic comorbidities and serum specific IgE (sIgE) levels. Results In 47 peanut allergic children, tolerance developed in 27.7% (median follow-up duration of 43 months). In 80 milk (follow-up 23 months) and 55 egg (follow-up 37 months) allergic children, tolerance developed in 55.0% and 65.5%. The ED obtained during the initial DBPCFC was significantly associated with tolerance development in peanut and milk allergy, but not in egg allergy. Conclusion Approximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC.

scholarly journals Egg Baked in Product Open Oral Food Challenges are Safe in Selected Egg-Allergic Patients

2014 ◽  
Vol 5 (2) ◽  
pp. ar.2014.5.0092 ◽  
Author(s):  
Becky J. Buelow ◽  
Carrie Lee ◽  
Heidi T. Zafra ◽  
Mahua Dasgupta ◽  
Ray G. Hoffmann ◽  
...  
Keyword(s):  
Skin Prick Test ◽  
Clinical Characteristics ◽  
Food Allergies ◽  
Prior History ◽  
Egg Allergy ◽  
Clinical Tool ◽  
Laboratory Findings ◽  
Prick Test ◽  
Increased Risk ◽  
Wheal Size

Egg allergy is one of the most common food allergies in children. Most egg-allergic children are able to tolerate egg baked in product (EBP) and will likely outgrow his/her egg allergy. By introducing EBP in the diet of an egg-allergic child, diet can be expanded and family stress can be reduced. Recent evidence suggests that children who tolerate EBP and continue to consume it will have quicker resolution of egg allergy than those who strictly avoid EBP; therefore, we aimed to evaluate the egg-allergic children who underwent EBP oral food challenge (OFC) in our allergy clinic to help define any specific predictors to be used in predicting the outcome of such challenges. We performed a retrospective chart review and 43 egg-allergic patients underwent EBP OFC in our outpatient allergy office from January 2011 to December 2012 were excluded. Nine patients who did not have a prior history of symptomatic egg ingestion. Clinical characteristics and laboratory findings of the remaining 34 patients were all recorded and analyzed. Of the remaining 34 patients, 22 (64.7%) were boys. Average age of first reaction to egg was 12.90 months, with average age at EBP OFC of 71.32 months. The average of the most recent skin-prick test wheal size was 10.10 mm and serum-specific IgE to egg white was 3.21 kU/L. Twenty-eight of the 34 patients (82.4%) passed the EBP OFC. Of the six patients who failed, none required epinephrine. After analysis of all of the clinical characteristics and laboratory findings, no risk factors, such as skin-prick test wheal size, were identified to be associated with an increased risk of failing EBP OFC. EBP OFC is a valuable tool to assess tolerance. As seen in our group of patients, the majority of egg-allergic patients pass EBP OFC. Thus, OFC should be considered as a clinical tool to expand a patient's diet and to improve quality of life as early as possible. Because we were unable to determine any clinical or laboratory predictors helpful to select egg-allergic patients who are likely to pass EBP OFC, additional prospective studies are necessary to determine the ideal egg-allergic patient who is likely to pass EBP OFC.

Birch pollen associated soy allergy – possibilities in diagnostic and clinical relevance1)

2012 ◽  
Vol 36 (3) ◽  
Author(s):  
Susanne Beyer ◽  
Ulrich Sack ◽  
Regina Treudler
Keyword(s):  
Birch Pollen ◽  
Basophil Activation Test ◽  
Specific Ige ◽  
Oral Allergy Syndrome ◽  
Food Allergies ◽  
Food Allergens ◽  
Prick Test ◽  
The Past ◽  
Immunological Cross Reaction

AbstractBirch pollen allergic individuals frequently suffer from food allergies in the form of an oral allergy syndrome after eating pome and stone fruits. These complaints are based on an immunological cross-reaction between pollen and food allergens. In the past, it has been shown that many birch pollen allergic patients are additionally not able to tolerate high protein soy products. Some severe immediate type reactions to soy have been observed. The cause for these immediate type reactions to soy is a Bet v 1 cross-reactive soy allergen called Gly m 4.Using a collective of 73 birch pollen allergic patients with associated food allergy in Leipzig as an example, the results of a standardized questioning, prick-to-prick test with a soy drink, determination of specific IgE against rGly m 4, and basophil activation test with Gly m 4 are presented.We showed that commercially available prick test extracts and determination of specific IgE against soy bean mix/f14 are not appropriate to diagnose birch pollen associated soy allergy. Generally, soy sensitization could be proven when a prick-to-prick-test with a soy drink and determination of specific IgE against rGly m 4 were done. A positive prick-to-prick test with a soy drink was found in 79% (55/70) of the birch pollen allergic patients with 89% (65/73) showing specific IgE for rGly m 4 (CAP>1). Although not every sensitization was clinically relevant, every third patient with a proven soy sensitization was diagnosed with a clinically relevant allergy to soy.

scholarly journals Prevalence of aspergillus skin hypersensitivity in allergic rhinitis

2021 ◽  
Author(s):  
Monika Bansal ◽  
Komaldeep Kaur ◽  
Aditi Gupta ◽  
Deepak Goyal ◽  
Nidhi Girdhar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Aspergillus Fumigatus ◽  
Specific Ige ◽  
Chi Square ◽  
Prick Test ◽  
Skin Hypersensitivity ◽  
Chi Square Test ◽  
Ige Mediated

Allergic rhinitis (AR) is a chronic allergen specific, IgE-mediated hypersensitivity disorder which significantly impairs the quality of life in affected patients. Many aeroallergens and molds are responsible for AR. This study was  conducted to find prevalence of Aspergillus fumigatus skin hypersensitivity in patients of AR by skin prick test (SPT).  150 clinically diagnosed AR patients visiting our OPD were enrolled. Skin hypersensitivity for Aspergillus f. was done by SPT in all the enrolled patients. Chi square test and Student’s t-test were applied for statistical analysis. Out of 150 patients, 60 (40%) were positive for Aspergillus fumigatus SPT. Majority of the positive patients had persistent AR and among those 39/60 (65%) had moderate to severe persistent AR and 12/60 (20%) had mild persistent AR.  Our study concluded that there is high (40%) prevalence of Aspergillus f. skin hypersensitivity among AR patients. The hypersensitivity to Aspergillus f. was found more in severe AR patients and it was statistically significant.

scholarly journals Oral Allergy Syndrome Caused by Japanese Radish: A Case Report

2021 ◽  
Author(s):  
Atsushi Uesugi ◽  
Fumihiko Tsushima ◽  
Youji Miyamoto ◽  
Hiroyuki Harada
Keyword(s):  
Oral Cavity ◽  
Epigastric Pain ◽  
Oral Allergy Syndrome ◽  
Food Allergies ◽  
Case Presentation ◽  
Prick Test ◽  
Japanese Radish ◽  
History Of ◽  
Herpetic Gingivostomatitis ◽  
Possible Cause

Abstract Background:Oral allergy syndrome (OAS) is a type of food allergy that manifests as hypersensitivity symptoms of the oropharyngeal mucosa on ingestion of specific foods with oral findings resembling herpetic gingivostomatitis. Symptoms can also appear in parts other than the oral cavity. There are a few reports of OAS caused by consuming radishes in the literature.Case presentation:A 31-year-old male presented to our department with stomatitis and pharyngeal pain. The patient did not have a history of allergy, and herpetic gingivostomatitis was suspected. He was admitted to the emergency room of our hospital after complaining of oral and epigastric pain a few days later. On admission, symptoms noted were similar to those when he first visited our department. After detailed history taking, he reported consuming raw Japanese radish frequently, which gave rise to his symptoms. Radish was strongly suspected as the causative allergen. The skin prick test result was positive, confirming the diagnosis of OAS.Conclusions:OAS can be diagnosed easily once the food causing symptoms is identified. However, guiding the diagnosis can be challenging if the patient is unaware of food allergies. Upon encountering widespread erosion in the oral cavity, it is essential to consider OAS as the possible cause.

scholarly journals Oral Allergy Syndrome Caused By Japanese Radish: A Case Report

2021 ◽  
Author(s):  
Atsushi Uesugi ◽  
Fumihiko Tsushima ◽  
Youji Miyamoto ◽  
Hiroyuki Harada
Keyword(s):  
Oral Cavity ◽  
Epigastric Pain ◽  
Oral Allergy Syndrome ◽  
Food Allergies ◽  
Case Presentation ◽  
Prick Test ◽  
Japanese Radish ◽  
History Of ◽  
Herpetic Gingivostomatitis ◽  
Possible Cause

Abstract Background: Oral allergy syndrome (OAS) is a type of food allergy that manifests as hypersensitivity symptoms of the oropharyngeal mucosa on ingestion of specific foods with oral findings resembling herpetic gingivostomatitis. Symptoms can also appear in parts other than the oral cavity. There are a few reports of OAS caused by consuming radishes in the literature.Case presentation: A 31-year-old male presented to our department with stomatitis and pharyngeal pain. The patient did not have a history of allergy, and herpetic gingivostomatitis was suspected. He was admitted to the emergency room of our hospital after complaining of oral and epigastric pain a few days later. On admission, symptoms noted were similar to those when he first visited our department. After detailed history taking, he reported consuming raw Japanese radish frequently, which gave rise to his symptoms. Radish was strongly suspected as the causative allergen. The skin prick test result was positive, confirming the diagnosis of OAS.Conclusions: OAS can be diagnosed easily once the food causing symptoms is identified. However, guiding the diagnosis can be challenging if the patient is unaware of food allergies. Upon encountering widespread erosion in the oral cavity, it is essential to consider OAS as the possible cause.

scholarly journals Successful sublingual immunotherapy for severe egg allergy in children: a case report

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Nagatoshi Sagara ◽  
Satoshi Fujita ◽  
Ryohei Suzuki ◽  
Akiko Aota ◽  
Kenichi Akashi ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Specific Ige ◽  
Oral Immunotherapy ◽  
Food Allergies ◽  
Egg Allergy ◽  
Efficacy And Safety ◽  
Safety Issues ◽  
Epinephrine Injection ◽  
Promising Treatment ◽  
Whole Egg

Abstract Background Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy. However, safety issues remain concerning severe adverse events requiring epinephrine injection. Hence, establishing a safer method to treat egg allergy would be beneficial. We report here two children with egg allergy who were safely treated with sublingual immunotherapy (SLIT) before transitioning to OIT. Case presentation Patient 1 was a 7-year-old girl and Patient 2 was a 5-year-old girl. Although OIT for egg had been attempted in both patients, severe anaphylactic symptoms were induced by ingesting only 0.1 g of heated whole egg. Therefore, SLIT was conducted with aqueous suspensions consisting of water and heated whole egg powder. Suspensions were administered sublingually, kept in the mouth for 2 min, and spat out immediately thereafter. SLIT was continued for 7 months for Patient 1 and 8 months for Patient 2 due to the exploratory character of the study. Afterwards, the patients successfully transferred to low-dose OIT with 1 g of heated whole egg (≒170 mg of egg protein) daily, and are continuing the therapy as of June 2020. As for adverse reactions, Patient 1 expressed oral cavity itchiness once at the beginning of SLIT. Patient 2 had no adverse reaction. The levels of antigen-specific IgE decreased in both patients after SLIT, and further decreased after switching to OIT. Conclusions Few clinical studies have evaluated the efficacy and safety of SLIT for egg allergy. Although the treatment was conducted in only two patients, our results have shown that SLIT is a promising treatment procedure for egg allergy. Further clinical trials will be needed to additionally assess the efficacy and safety of SLIT in children with food allergy.

scholarly journals Oral Food Challenge

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 651
Author(s):  
Calvani ◽  
Bianchi ◽  
Reginelli ◽  
Peresso ◽  
Testa
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Clinical History ◽  
Specific Ige ◽  
Oral Food Challenge ◽  
Food Allergies ◽  
Pediatric Allergy ◽  
Expert Review ◽  
Ige Mediated ◽  
Food Specific Ige

: Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP)

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