scholarly journals Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingjing Wang ◽  
Luyao Sun ◽  
Jie Liu ◽  
Bing Sun ◽  
Li Li ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Layered Double Hydroxide ◽  
Immune Clearance ◽  
Targeting Delivery ◽  
Tumor Accumulation ◽  
Therapeutic Doses ◽  
Double Hydroxide

Abstract Background Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges. Hypothetically, cancer cell membrane (CCM) can homologously target the tumor whereas multi-modal therapy can complement the disadvantages of singular therapies. Meanwhile, moderate hyperthermia induced by photothermal therapy can boost the cellular uptake of therapeutic agents by cancer cells. Results CCM-cloaked indocyanine green (ICG)-incorporated and abraxane (PTX-BSA)-loaded layered double hydroxide (LDH) nanosheets (LIPC NSs) were fabricated for target efficient photo-chemotherapy of colorectal carcinoma (CRC). The CCM-cloaked LDH delivery system showed efficient homologous targeting and cytotoxicity, which was further enhanced under laser irradiation to synergize CRC apoptosis. On the other hand, CCM-cloaking remarkably reduced the uptake of LDH NSs by HEK 293T cells and macrophages, implying mitigation of the side effects and the immune clearance, respectively. In vivo data further exhibited that LIPC NSs enhanced the drug accumulation in tumor tissues and significantly retarded tumor progression under laser irradiation at very low therapeutic doses (1.2 and 0.6 mg/kg of ICG and PTX-BSA), without observed side effects on other organs. Conclusions This research has demonstrated that targeting delivery efficiency and immune-escaping ability of LIPC NSs are tremendously enhanced by CCM cloaking for efficient tumor accumulation and in situ generated hyperthermia boosts the uptake of LIPC NSs by cancer cells, a potential effective way to improve the multi-modal cancer therapy. Graphical Abstract

Brain Targeting Delivery Facilitated by Ligand-Functionalized Layered Double Hydroxide Nanoparticles

2018 ◽  
Vol 10 (24) ◽  
pp. 20326-20333 ◽  
Author(s):  
Weiyu Chen ◽  
Huali Zuo ◽  
Enqi Zhang ◽  
Li Li ◽  
Petra Henrich-Noack ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
Brain Targeting ◽  
Targeting Delivery ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

scholarly journals Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1210
Author(s):  
Sang-Yong Jung ◽  
Hyoung-Mi Kim ◽  
Soonjae Hwang ◽  
Do-Gak Jeung ◽  
Ki-Jong Rhee ◽  
...  
Keyword(s):  
Particle Size ◽  
Layered Double Hydroxide ◽  
Anticancer Drug ◽  
Delivery System ◽  
Blood Cells ◽  
Hydrodynamic Radius ◽  
Hydrothermal Reaction ◽  
Membrane Damage ◽  
Double Hydroxide

A layered double hydroxide (LDH)-based anticancer delivery system was investigated in terms of crystalline phase, particle size, hydrodynamic radius, zeta potential, etc. through in vitro and in vivo study. Size controlled LDH with anticancer drug methotrexate (MTX) incorporation was successfully prepared through step-by-step hydrothermal reaction and ion-exchange reaction. The MTX-LDH was determined to have a neutral surface charge and strong agglomeration in the neutral aqueous condition due to the surface adsorbed MTX; however, the existence of proteins in the media dramatically reduced agglomeration, resulting in the hydrodynamic radius of MTX-LDH being similar to the primary particle size. The protein fluorescence quenching assay exhibited that MTX readily reduced the fluorescence of proteins, suggesting that the interaction between MTX and proteins was strong. On the other hand, MTX-LDH showed much less binding constant to proteins compared with MTX, implying that the protein interaction of MTX was effectively blocked by the LDH carrier. The in vivo hemolysis assay after intravenous injection of MTX-LDH showed neither significant reduction in red blood cell number nor membrane damage. Furthermore, the morphology of red blood cells in a mouse model did not change upon MTX-LDH injection. Scanning electron microscopy showed that the MTX-LDH particles were attached on the blood cells without serious denaturation of cellular morphology, taking advantage of the cell hitchhiking property.

Synthesis and Characterization of Dual Radiolabeled Layered Double Hydroxide Nanoparticles for Use in In Vitro and In Vivo Nanotoxicology Studies

2009 ◽  
Vol 114 (2) ◽  
pp. 734-740 ◽  
Author(s):  
Anthony W. Musumeci ◽  
Tara L. Schiller ◽  
Zhi Ping Xu ◽  
Rodney F. Minchin ◽  
Darren J. Martin ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
Synthesis And Characterization ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

scholarly journals Host−guest complexation-mediated codelivery of anticancer drug and photosensitizer for cancer photochemotherapy

2019 ◽  
Vol 116 (14) ◽  
pp. 6618-6623 ◽  
Author(s):  
Guocan Yu ◽  
Benyue Zhu ◽  
Li Shao ◽  
Jiong Zhou ◽  
Manik Lal Saha ◽  
...  
Keyword(s):  
Side Effects ◽  
Click Reaction ◽  
Tumor Model ◽  
Therapeutic Outcome ◽  
In Vivo Studies ◽  
Drug Resistant ◽  
Hydrophobic Core ◽  
Anticancer Efficacy ◽  
Tumor Accumulation

Although platinum-based anticancer drugs prevail in cancer treatment, their clinical applications are limited by the severe side effects as well as their ineffectiveness against drug resistant cancers. A precise combination of photodynamic therapy (PDT) and chemotherapy can synergistically improve the therapeutic outcome and thereby may overcome drug resistance through a multipronged assault. Herein, we employ the well-defined cavity of a discrete organoplatinum(II) metallacage (M) to encapsulate octaethylporphine (OEP), a photosensitizer, forming a dual-functionalized system M⊃OEP that is wrapped into the hydrophobic core of the nanoparticles (MNPs) self-assembled from an amphiphilic diblock copolymer. Using a copper-free click reaction, a targeting ligand is conjugated on the surface of the MNPs, aiming to specifically deliver a chemotherapeutic drug and a photosensitizer to cancer cells. Benefiting from the enhanced permeability and retention effect and active targeting capability, high tumor accumulation of MNPs is achieved, leading to an improved therapeutic outcome and reduced side effects. In vivo studies demonstrate that the combination of chemotherapy and PDT exhibits a superior antitumor performance against a drug-resistant tumor model attributed to their synergistic anticancer efficacy.

scholarly journals Low dose amiodarone reduces tumor growth and angiogenesis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eliana Steinberg ◽  
Arnon Fluksman ◽  
Chalom Zemmour ◽  
Katerina Tischenko ◽  
Adi Karsch-Bluman ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Cells ◽  
Low Dose ◽  
Tumor Model ◽  
In Vitro Assays ◽  
Potential Candidate ◽  
Key Factor ◽  
Angiogenic Effect

Abstract Amiodarone is an anti-arrhythmic drug that was approved by the US Food and Drug Administration (FDA) in 1985. Pre-clinical studies suggest that Amiodarone induces cytotoxicity in several types of cancer cells, thus making it a potential candidate for use as an anti-cancer treatment. However, it is also known to cause a variety of severe side effects. We hypothesized that in addition to the cytotoxic effects observed in cancer cells Amiodarone also has an indirect effect on angiogensis, a key factor in the tumor microenvironment. In this study, we examined Amiodarone's effects on a murine tumor model comprised of U-87 MG glioblastoma multiforme (GBM) cells, known to form highly vascularized tumors. We performed several in vitro assays using tumor and endothelial cells, along with in vivo assays utilizing three murine models. Low dose Amiodarone markedly reduced the size of GBM xenograft tumors and displayed a strong anti-angiogenic effect, suggesting dual cancer fighting properties. Our findings lay the ground for further research of Amiodarone as a possible clinical agent that, used in safe doses, maintains its dual properties while averting the drug’s harmful side effects.

Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 48415-48419 ◽  
Author(s):  
Tae-Hyun Kim ◽  
Jun Young Lee ◽  
Min-Kyu Kim ◽  
Jeong Hoon Park ◽  
Jae-Min Oh
Keyword(s):  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Cancer Imaging ◽  
Imaging Agent ◽  
Isomorphous Substitution ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Radioisotope Co-57 substituted LDH were successfully prepared by isomorphous substitution and showed high in vitro cellular uptake and tumor targeting in vivo biodistribution.

Selenium doped Ni–Ti layered double hydroxide (Ni–Ti LDH) films with selective inhibition effect to cancer cells and bacteria

RSC Advances ◽  
2015 ◽  
Vol 5 (129) ◽  
pp. 106848-106859 ◽  
Author(s):  
Donghui Wang ◽  
Naijian Ge ◽  
Shi Qian ◽  
Jinhua Li ◽  
Yuqin Qiao ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Layered Double Hydroxide ◽  
Hydroxyl Radicals ◽  
Selective Inhibition ◽  
Normal Cells ◽  
Inhibition Effect ◽  
Double Hydroxide

Selenium doped LDH films effectively inhibit the growth of cancer cells and bacteria with little adverse effect on normal cells. The selectivity stems from the synergistic effect of the doped selenium and hydroxyl radicals produced by the LDH films.

scholarly journals Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Xi Zhang ◽  
Guoqing Hou ◽  
Andong Liu ◽  
Hui Xu ◽  
Yang Guan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Side Effects ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Chemotherapy Resistance ◽  
Treatment Strategies ◽  
Ovarian Cancer Cells

Abstract Ovarian cancer remains the most lethal gynecologic malignancy with late detection and acquired chemoresistance. Advanced understanding of the pathophysiology and novel treatment strategies are urgently required. A growing body of proteomic investigations suggest that phosphorylation has a pivotal role in the regulation of ovarian cancer associated signaling pathways. Matrine has been extensively studied for its potent anti-tumor activities. However, its effect on ovarian cancer cells and underlying molecular mechanisms remain unclear. Herein we showed that matrine treatment inhibited the development and progression of ovarian cancer cells by regulating proliferation, apoptosis, autophagy, invasion and angiogenesis. Matrine treatment retarded the cancer associated signaling transduction by decreasing the phosphorylation levels of ERK1/2, MEK1/2, PI3K, Akt, mTOR, FAK, RhoA, VEGFR2, and Tie2 in vitro and in vivo. Moreover, matrine showed excellent antitumor effect on chemoresistant ovarian cancer cells. No obvious toxic side effects were observed in matrine-administrated mice. As the natural agent, matrine has the potential to be the targeting drug against ovarian cancer cells with the advantages of overcoming the chemotherapy resistance and decreasing the toxic side effects.

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