scholarly journals A wearable ring-shaped inertial system to identify action planning impairments during reach-to-grasp sequences: a pilot study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Erika Rovini ◽  
Guenda Galperti ◽  
Valeria Manera ◽  
Gianmaria Mancioppi ◽  
Laura Fiorini ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neuropsychological Tests ◽  
Reaction Times ◽  
Action Planning ◽  
Ease Of Use ◽  
Kinematic Parameters ◽  
Reach To Grasp ◽  
Motor Test ◽  
Reach And Grasp ◽  
Larger Sample

Abstract Background The progressive ageing of the population is leading to an increasing number of people affected by cognitive decline, including disorders in executive functions (EFs), such as action planning. Current procedures to evaluate cognitive decline are based on neuropsychological tests, but novel methods and approaches start to be investigated. Reach-to-grasp (RG) protocols have shown that intentions can influence the EFs of action planning. In this work, we proposed a novel ring-shaped wearable inertial device, SensRing, to measure kinematic parameters during RG and after-grasp (AG) tasks with different end-goals. The aim is to evaluate whether SensRing can characterize the motor performances of people affected by Mild Neurocognitive Disorder (MND) with impairment in EFs. Methods Eight Individuals with dysexecutive MND, named d-MND, were compared to ten older healthy subjects (HC). They were asked to reach and grasp a can with three different intentions: to drink (DRINK), to place it on a target (PLACE), or to pass it to a partner (PASS). Twenty-one kinematic parameters were extracted from SensRing inertial data. Results Seven parameters resulted able to differentiate between HC and d-MND in the RG phase, and 8 features resulted significant in the AG phase. d-MND, indeed, had longer reaction times (in RG PLACE), slower peak velocities (in RG PLACE and PASS, in AG DRINK and PLACE), longer deceleration phases (in all RG and AG DRINK), and higher variability (in RG PLACE, in AG DRINK and PASS). Furthermore, d-MND showed no significant differences among conditions, suggesting that impairments in EFs influence their capabilities in modulating the action planning based on the end-goal. Conclusions Based on this explorative study, the system might have the potential for objectifying the clinical assessment of people affected by d-MND by administering an easy motor test. Although these preliminary results have to be investigated in-depth in a larger sample, the portability, wearability, accuracy, and ease-of use of the system make the SensRing potentially appliable for remote applications at home, including analysis of protocols for neuromotor rehabilitation in patients affected by MND.

scholarly journals "A Wearable Ring-shaped Inertial System to Identify Action Planning Impairments During Reach-to-grasp Sequences: A Pilot Study"

2020 ◽  
Author(s):  
Erika Rovini ◽  
Guenda Galperti ◽  
Valeria Manera ◽  
Gianmaria Mancioppi ◽  
Laura Fiorini ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neuropsychological Tests ◽  
Reaction Times ◽  
Action Planning ◽  
Ease Of Use ◽  
Neurocognitive Disorder ◽  
Kinematic Parameters ◽  
Reach To Grasp ◽  
Motor Test ◽  
Reach And Grasp

Abstract Background. The progressive ageing of the population is leading to an increasing of people affected by cognitive decline, included disorders in executive functions (EFs), such as action planning. Current procedures to evaluate cognitive decline are based on neuropsychological tests, but novel methods and approaches start to be investigated. Reach-to-grasp (RG) protocols have shown that intentions can influence the EFs of action planning.Methods. In this work, we proposed a novel ring-shaped wearable inertial device, SensRing, to measure kinematic parameters during RG and after-grasp tasks with different end-goals. The aim is to evaluate whether SensRing can characterize the motor performances of people affected by Mild Neurocognitive Disorder (MND) with impairment in EFs, named dysexecutive MND (d-MND), compared to older healthy subjects (HC). Ten HC and eight d-MND were asked to reach and grasp a can with three different intentions: to drink (DRINK), to place it on a target (PLACE), or to pass it to a partner (PASS). Twenty-one kinematic parameters have been extracted from SensRing inertial data.Results. Several parameters resulted able to differentiate between HC and d-MND, showing that patients generally have longer reaction times, slower peak velocities and longer deceleration phases. Furthermore, d-MND showed fewer differences among conditions, suggesting that impairments in EFs influence their capabilities into modulating the action planning based on the end-goal.Conclusions. Therefore, the system can be proposed for objectifying the clinical assessment of people affected by d-MND by administering an easy quick motor test. Furthermore, the portability, wearability, accuracy, and ease-of use of the system make the SensRing sytem suitable for remote applications at home, including analysis of protocols for neuromotor rehabilitation in patients affected by MND.

scholarly journals Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort

2021 ◽  
pp. 1-12
Author(s):  
Rachael A. Lawson ◽  
Caroline H. Williams-Gray ◽  
Marta Camacho ◽  
Gordon W. Duncan ◽  
Tien K. Khoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Verbal Fluency ◽  
Neuropsychological Tests ◽  
Visual Memory ◽  
Attention And Memory ◽  
Memory And Attention ◽  
Global Cognition

Background: Cognitive impairment is common in Parkinson’s disease (PD), with 80% cumulatively developing dementia (PDD). Objective: We sought to identify tests that are sensitive to change over time above normal ageing so as to refine the neuropsychological tests predictive of PDD. Methods: Participants with newly diagnosed PD (n = 211) and age-matched controls (n = 99) completed a range of clinical and neuropsychological tests as part of the ICICLE-PD study at 18-month intervals over 72 months. Impairments on tests were determined using control means (<1-2SD) and median scores. Mild cognitive impairment (PD-MCI) was classified using 1-2SD below normative values. Linear mixed effects modelling assessed cognitive decline, while Cox regression identified baseline predictors of PDD. Results: At 72 months, 46 (cumulative probability 33.9%) participants had developed PDD; these participants declined at a faster rate in tests of global cognition, verbal fluency, memory and attention (p <  0.05) compared to those who remained dementia-free. Impaired baseline global cognition, visual memory and attention using median cut-offs were the best predictors of early PDD (area under the curve [AUC] = 0.88, p <  0.001) compared to control-generated cut-offs (AUC = 0.76–0.84, p <  0.001) and PD-MCI (AUC] = 0.64–0.81, p <  0.001). Impaired global cognition and semantic fluency were the most useful brief tests employable in a clinical setting (AUC = 0.79, p <  0.001). Conclusion: Verbal fluency, attention and memory were sensitive to change in early PDD and may be suitable tests to measure therapeutic response in future interventions. Impaired global cognition, attention and visual memory were the most accurate predictors for developing a PDD. Future studies could consider adopting these tests for patient clinical trial stratification.

scholarly journals Cognitive trajectories of patients with focal ß-amyloid deposition

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Si Eun Kim ◽  
Byungju Lee ◽  
Hyemin Jang ◽  
Juhee Chin ◽  
Ching Soong Khoo ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neuropsychological Tests ◽  
Mixed Effects ◽  
Amnestic Mild Cognitive Impairment ◽  
Emission Tomography ◽  
Amyloid Pet ◽  
Cognitive Level ◽  
Visual Rating ◽  
Positron Emission ◽  
The Brain

Abstract Background The presence of ß-amyloid (Aß) in the brain can be identified using amyloid PET. In clinical practice, the amyloid PET is interpreted based on dichotomous visual rating, which renders focal Aß accumulation be read as positive for Aß. However, the prognosis of patients with focal Aß deposition is not well established. Thus, we investigated cognitive trajectories of patients with focal Aß deposition. Methods We followed up 240 participants (112 cognitively unimpaired [CU], 78 amnestic mild cognitive impairment [aMCI], and 50 Alzheimer’s disease (AD) dementia [ADD]) for 2 years from 9 referral centers in South Korea. Participants were assessed with neuropsychological tests and 18F-flutemetamol (FMM) positron emission tomography (PET). Ten regions (frontal, precuneus/posterior cingulate (PPC), lateral temporal, parietal, and striatum of each hemisphere) were visually examined in the FMM scan, and participants were divided into three groups: No-FMM, Focal-FMM (FMM uptake in 1–9 regions), and Diffuse-FMM. We used mixed-effects model to investigate the speed of cognitive decline in the Focal-FMM group according to the cognitive level, extent, and location of Aß involvement, in comparison with the No- or Diffuse-FMM group. Results Forty-five of 240 (18.8%) individuals were categorized as Focal-FMM. The rate of cognitive decline in the Focal-FMM group was faster than the No-FMM group (especially in the CU and aMCI stage) and slower than the Diffuse-FMM group (in particular in the CU stage). Within the Focal-FMM group, participants with FMM uptake to a larger extent (7–9 regions) showed faster cognitive decline compared to those with uptake to a smaller extent (1–3 or 4–6 regions). The Focal-FMM group was found to have faster cognitive decline in comparison with the No-FMM when there was uptake in the PPC, striatum, and frontal cortex. Conclusions When predicting cognitive decline of patients with focal Aß deposition, the patients’ cognitive level, extent, and location of the focal involvement are important.

Ultra-fast selection of grasping points

2013 ◽  
Vol 110 (7) ◽  
pp. 1484-1489 ◽  
Author(s):  
D. Voudouris ◽  
J. B. J. Smeets ◽  
E. Brenner
Keyword(s):  
Reaction Times ◽  
Preferred Orientation ◽  
Reach To Grasp ◽  
Contact Points ◽  
Selection Of

To grasp an object one needs to determine suitable positions on its surface for placing the digits and to move the digits to those positions. If the object is displaced during a reach-to-grasp movement, the digit movements are quickly adjusted. Do these fast adjustments only guide the digits to previously chosen positions on the surface of the object, or is the choice of contact points also constantly reconsidered? Subjects grasped a ball or a cube that sometimes rotated briefly when the digits started moving. The digits followed the rotation within 115 ms. When the object was a ball, subjects quickly counteracted the initial following response by reconsidering their choice of grasping points so that the digits ended at different positions on the rotated surface of the ball, and the ball was grasped with the preferred orientation of the hand. When the object was a cube, subjects sometimes counteracted the initial following response to grasp the cube by a different pair of sides. This altered choice of grasping points was evident within ∼160 ms of rotation onset, which is shorter than regular reaction times.

scholarly journals Grasping Social Apathy: The Role of Reach-To-Grasp Action Kinematics for the Assessment of Social Apathy in Mild Neurocognitive Disorders

2021 ◽  
pp. 1-14
Author(s):  
Valeria Manera ◽  
Guenda Galperti ◽  
Erika Rovini ◽  
Radia Zeghari ◽  
Gianmaria Mancioppi ◽  
...  
Keyword(s):  
Neurocognitive Disorders ◽  
Reach To Grasp ◽  
Future Studies ◽  
Clinical Scales ◽  
Non Invasive ◽  
Reach And Grasp ◽  
The Social ◽  
Self Reports ◽  
Individual Condition

Background: Social apathy, a reduction in initiative in proposing or engaging in social activities or interactions, is common in mild neurocognitive disorders (MND). Current apathy assessment relies on self-reports or clinical scales, but growing attention is devoted to defining more objective, measurable and non-invasive apathy proxies. Objective: In the present study we investigated the interest of recording action kinematics in a social reach-to-grasp task for the assessment of social apathy. Methods: Thirty participants took part in the study: 11 healthy controls (HC; 6 females, mean age = 68.3±10.5 years) and 19 subjects with MND (13 females, mean age = 75.7±6.3 years). Based on the Diagnostic Criteria for Apathy, MND subjects were classified as socially apathetic (A-MND, N = 9) versus non-apathetic (NA-MND, N = 10). SensRing, a ring-shaped wearable sensor, was placed on their index finger, and subjects were asked to reach and grasp a can to place it into a cup (individual condition) and pass it to a partner (social condition). Results: In the reach-to-grasp phase of the action, HC and NA-MND showed different acceleration and velocity profiles in the social versus individual condition. No differences were found for A-MND. Conclusion: Previous studies showed the interest of recording patients’ level of weekly motor activity for apathy assessment. Here we showed that a 10-min reach-to-grasp task may provide information to differentiate socially apathetic and non-apathetic subjects with MND, thus providing a tool easily usable in the clinical practice. Future studies with a bigger sample are needed to better characterize these findings.

scholarly journals The Cognitive Change Index as a Measure of Self and Informant Perception of Cognitive Decline: Relation to Neuropsychological Tests

2016 ◽  
Vol 51 (4) ◽  
pp. 1145-1155 ◽  
Author(s):  
Chatchawan Rattanabannakit ◽  
Shannon L. Risacher ◽  
Sujuan Gao ◽  
Kathleen A. Lane ◽  
Steven A. Brown ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neuropsychological Tests ◽  
Cognitive Change

Abstract WP338: Development of a Veteran Specific Stroke Educational Guide

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Karen Stonecypher ◽  
Pamela Willson
Keyword(s):  
Multidisciplinary Team ◽  
Inpatient Care ◽  
Role Model ◽  
Action Planning ◽  
Ease Of Use ◽  
Self Management ◽  
Health Administration ◽  
Management Skills ◽  
Dietary Compliance ◽  
Specific Patient

Background and Purpose: Nearly 6,000 veterans are hospitalized annually for an ischemic stroke. The Veteran’s Health Administration (VHA) estimates care cost at $111 million for acute inpatient care, $75 million post-acute inpatient care, and $88 million for the first six months post stroke follow-up care. Presently, few national publications are uniquely designed for the veteran population. The primary focus of this initiative was to lead a multidisciplinary team of experts in the development of a veteran specific stroke risk prevention and reduction educational guide. Methods: A nurse lead multidisciplinary team of experts were assembled to develop a disease and population specific patient educational guide. The VHA educational guidelines, chronic disease self-management, and the Joint Commission Stroke educational core measures were used as the developmental framework. Mort Walker, creator of Beetle Bailey, provided illustrations throughout the guide for key concepts that were veteran specific and culturally-appropriate. The Sergeant Snorkel character emulates an ideal role model for veterans on how to prevent and reduce stroke risks. Results: A 28 page guide was developed for electronic distribution to healthcare providers across the VHA system. The printed version was designed to be the pivotal organizing resource for veteran and caregiver education during the hospital stay. The incorporation of self-management skills makes this guide uniquely different from other educational manuals. Documentation of self management implementation includes goal setting, action planning, and problem solving. The didactic components addressed are medication management, dietary compliance, smoking cessation, weight loss, increasing physical activity, improving functional status, and self-management skills. Development facilitators will be discussed. Conclusions: A nurse led multidisciplinary team of experts was assembled to develop a disease and population specific patient education guide for military veterans who have experienced a stroke. Veteran specific artwork seems to lend credibility to the health information for this population. The guide’s unique self-management documentation aides ease of use.

scholarly journals The influence of schooling on cognitive screening test in the elderly

2007 ◽  
Vol 1 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Gustavo Christofoletti ◽  
Merlyn Mércia Oliani ◽  
Florindo Stella ◽  
Sebastião Gobbi ◽  
Lílian Teresa Bucken Gobbi
Keyword(s):  
Cognitive Decline ◽  
Educational Level ◽  
Screening Test ◽  
Neuropsychological Tests ◽  
Formal Education ◽  
The Elderly ◽  
Cognitive Status ◽  
Cognitive Screening ◽  
Screening Battery ◽  
Cognitive Screening Test

Abstract Introduction: Tests for screening cognitive functions are gaining importance with the increasing incidence and prevalence of demential syndromes. For our elderly population, the challenge is to develop neuropsychological tests independent from the influence of educational level. Objective: To compare the influence of education on the elderly with or without cognitive decline, on the Brief Cognitive Screening Battery (BCSB). Methods: We studied 176 elderly people: 60 with cognitive decline (aged 73.6±9.3 years and with 5.7±0.7 years of education) and 116 without cognitive impairments (aged 73.4±0.6 years and with 5.6±0.5 years of education). The BCSB was applied in all subjects. The data were submitted to descriptive statistics and analyzed by Independent Student test with 95% confidence intervals. Results: The data showed that the BCSB is an appropriate battery for identifying cognitive status in normal elderly individuals, as well as cognitive decline in our elderly sample. The BCSB items were not significantly influenced by schooling years, making this test favorable for different groups characterized by illiterate individuals, as well as by those with low or high levels of formal education. Conclusion: The BCSB proved to be a useful cognitive screening test for old people with or without cognitive decline independent of their educational level.

scholarly journals Neural coordination during reach-to-grasp

2015 ◽  
Vol 114 (3) ◽  
pp. 1827-1836 ◽  
Author(s):  
Mukta Vaidya ◽  
Konrad Kording ◽  
Maryam Saleh ◽  
Kazutaka Takahashi ◽  
Nicholas G. Hatsopoulos
Keyword(s):  
Cortical Neurons ◽  
Coordination Dynamics ◽  
Reach To Grasp ◽  
Neuronal Ensembles ◽  
Reach And Grasp ◽  
Dimensional State Space ◽  
Catch Up ◽  
Low Dimensional ◽  
Bidirectional Interactions ◽  
New Framework

When reaching to grasp, we coordinate how we preshape the hand with how we move it. To ask how motor cortical neurons participate in this coordination, we examined the interactions between reach- and grasp-related neuronal ensembles while monkeys reached to grasp a variety of different objects in different locations. By describing the dynamics of these two ensembles as trajectories in a low-dimensional state space, we examined their coupling in time. We found evidence for temporal compensation across many different reach-to-grasp conditions such that if one neural trajectory led in time the other tended to catch up, reducing the asynchrony between the trajectories. Granger causality revealed bidirectional interactions between reach and grasp neural trajectories beyond that which could be attributed to the joint kinematics that were consistently stronger in the grasp-to-reach direction. Characterizing cortical coordination dynamics provides a new framework for understanding the functional interactions between neural populations.

Kernels for Longitudinal Data with Variable Sequence Length and Sampling Intervals

2011 ◽  
Vol 23 (9) ◽  
pp. 2390-2420 ◽  
Author(s):  
Zhengdong Lu ◽  
Todd K. Leen ◽  
Jeffrey Kaye
Keyword(s):  
Longitudinal Data ◽  
Cognitive Decline ◽  
Likelihood Ratio ◽  
Neuropsychological Tests ◽  
Motor Behavior ◽  
Generative Models ◽  
Mixed Effects ◽  
Mixed Effects Models ◽  
Sequence Length ◽  
Better Than

We develop several kernel methods for classification of longitudinal data and apply them to detect cognitive decline in the elderly. We first develop mixed-effects models, a type of hierarchical empirical Bayes generative models, for the time series. After demonstrating their utility in likelihood ratio classifiers (and the improvement over standard regression models for such classifiers), we develop novel Fisher kernels based on mixture of mixed-effects models and use them in support vector machine classifiers. The hierarchical generative model allows us to handle variations in sequence length and sampling interval gracefully. We also give nonparametric kernels not based on generative models, but rather on the reproducing kernel Hilbert space. We apply the methods to detecting cognitive decline from longitudinal clinical data on motor and neuropsychological tests. The likelihood ratio classifiers based on the neuropsychological tests perform better than than classifiers based on the motor behavior. Discriminant classifiers performed better than likelihood ratio classifiers for the motor behavior tests.

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