scholarly journals Primary mediastinal seminoma with florid follicular lymphoid hyperplasia: a case report and review of the literature

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Charlotte Holmes ◽  
Peh Sun Loo ◽  
Sion Barnard
Keyword(s):  
Germ Cell Tumors ◽  
Median Sternotomy ◽  
Surgical Excision ◽  
Lymphoid Hyperplasia ◽  
Radiological Imaging ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Oncological Treatment ◽  
Mediastinal Tumours ◽  
Mediastinal Seminoma

Abstract Background First described in 1955 Primary mediastinal seminomas are rare. Only 1–4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 years. Very few cases are reported in the literature. Florid follicular lymphoid hyperplasia can obscure the malignant cells and is a rarer finding still. We present a rare case of a 48 year old man with a primary mediastinal seminoma with florid follicular lymphoid hyperplasia; found following excision of a clinically presumed thymoma. Case presentation A 48 year old man was referred for excision of a thymic mass. The presumed diagnosis was a thymoma; following preoperative investigations. The mass was incidentally found on a radiological imaging. However, the patient did report mid-sternal discomfort on lying flat and breathlessness. The patient underwent a thymectomy via a partial median sternotomy with good recovery. Histological assessment was that the mass was in fact a primary mediastinal seminoma with florid follicular lymphoid hyperplasia. A primary testicular malignancy was excluded and the patient required no further oncological treatment. Conclusions Only 11 cases have previously been reported of primary mediastinal seminoma with florid follicular lymphoid hyperplasia. Although rare, a primary mediastinal seminoma should be considered as a differential diagnosis for presentations with a thymic mass. Tumour markers can be helpful, however are only positive in third of cases. Ultrasound imaging of the gonads is essential to exclude a primary gonadal lesion. Pure seminomas are radiotherapy and chemotherapy sensitive however the mainstay treatment of primary mediastinal seminomas remains surgical excision. Radiotherapy is reserved postoperatively for incomplete surgical margins.

scholarly journals Neonatal oral teratoma: A case report

2021 ◽  
Vol 10 ◽  
pp. 24
Author(s):  
Helle Moustapha ◽  
Oumarou Habou ◽  
Kadre Alio Kadre Ousmane ◽  
Mahamoud Omid Ali Ada ◽  
Inoussa Daouda Bako ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Germ Cells ◽  
Primordial Germ Cells ◽  
Germ Cell Tumors ◽  
Surgical Excision ◽  
Good Prognosis ◽  
Upper Lip ◽  
Complete Excision ◽  
Case Presentation ◽  
Irregular Mass

Background: Teratomas of the oral cavity are rare and can pose danger to a patient's life in terms of obstruction to the aerodigestive tract. These are the germ cell tumors that arise from all three layers of primordial germ cells. Case Presentation: A 2-day-old female neonate presented with a mass protruding from the oral cavity since birth with no significant antenatal history. Examination revealed a large (8 cm), firm, and irregular mass protruding from the oral cavity extending up to the inner surface of the upper lip and onto the gums, associated with cleft palate. Complete excision of the mass was done and histopathology confirmed the diagnosis. There were no postoperative complications. Conclusion: Oral cavity teratoma is a rare tumor with a good prognosis especially in its mature form. Surgical excision with multidisciplinary collaboration is needed in order to avoid any complications.

scholarly journals Synovial sarcoma of the hand-wrist: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Serenella Serinelli ◽  
Lorenzo Gitto ◽  
Daniel J. Zaccarini
Keyword(s):  
Literature Review ◽  
Synovial Sarcoma ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Caucasian Woman ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Synovial Sarcomas ◽  
Uncommon Case

Abstract Background Synovial sarcomas are infrequent malignant tumors occurring mostly in adolescents and young adults. The occurrence of synovial sarcoma in the hand-wrist area is rare (4 to 8.5% of all synovial sarcomas in different studies). Case presentation This report documents an uncommon case of synovial sarcoma occurring in the hand-wrist of a 69-year-old Caucasian woman. She was subsequently treated with surgical excision and radiotherapy without recurrence after follow up. Conclusions This paper aims to characterize the demographic, pathologic, and clinical features with a literature review. The present literature review confirms that hand-wrist synovial sarcomas are more frequent among males and subjects 10 to 40 years old. Most cases in this location are usually not larger than 5 cm in size. The five-year survival rate is higher than that reported in a previous review on hand synovial sarcomas, and this suggests an improved survival in recent decades.

scholarly journals Recurrent Masses after Testicular Cancer: Growing Teratoma Syndrome. A Case Report and Review of the Literature

2017 ◽  
Vol 10 (3) ◽  
pp. 910-915 ◽  
Author(s):  
Fanny Priod ◽  
Francis Lorge ◽  
Marcelo Di Gregorio ◽  
Michaël V. Dupont ◽  
Marie-Cécile Nollevaux ◽  
...  
Keyword(s):  
Case Report ◽  
Tumor Markers ◽  
Germ Cell Tumors ◽  
Curative Treatment ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Growing Teratoma Syndrome ◽  
Tumor Onset ◽  
Nonseminomatous Germ Cell Tumors

Background: Growing teratoma syndrome is a rare syndrome that affects patients with nonseminomatous germ-cell tumors (NSGCTs). It is characterized by recurrent growing masses that appear during or after chemotherapy in the presence of normal levels of tumor markers. Histological examination is the only way to confirm the diagnosis. Case Presentation: We present the case of a 36-year-old man who developed recurrent masses after curative treatment for NSGCT of the testicle. His tumor markers were normal. The patient was cured after multiple surgical procedures. Conclusions: Close follow-up after treatment for NSGCT is very important for early detection of this syndrome, which can occur even many years after tumor onset. Normal blood makers can be misleading, and surgery remains the only curative treatment.

scholarly journals Primary Testicular Mantle Cell Lymphoma in a 23-Year-Old Man: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Yanan Gao ◽  
Runfen Cheng ◽  
Yi Pan ◽  
Qiongli Zhai
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Surgical Excision ◽  
Pathological Examination ◽  
Review Of The Literature ◽  
Elderly Men ◽  
Aberrant Expression ◽  
Case Presentation ◽  
First Case ◽  
Mantle Cell

Abstract Background: Primary testicular mantle cell lymphoma (PTMCL) is a very rare disease, mostly occurred in elderly men, usually diagnosed at an advanced stage. Mantle cell lymphoma (MCL) has a distinctive immunophenotype, positive for CD5 and cyclin D1, but negative for CD10 and CD23. The genetic hallmark of MCL is t(11;14)(q13;q32). Case presentation: Here we reported a case of 23-year-old man who presented with a tumor in the testis. Surgical excision and pathological examination revealed the lesion was a primary testicular mantle cell lymphoma with aberrant expression of CD10 and loss of CD5. Conclusion: This study reports the first case of PTMCL in a 23-year-old man with aberrant expression of CD10 and loss of CD5, summarizes PTMCL reported in PUBMED and found that CD5 might be an independent factor that influences not only the diagnosis but also the prognosis of MCL.

scholarly journals Giant vascular eccrine spiradenoma: the first case in the scrotum and review of the literature author

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zan Li ◽  
Gang Li ◽  
Xin Jiang ◽  
Xiaoming Fu
Keyword(s):  
Rare Variant ◽  
Malignant Tumor ◽  
Surgical Excision ◽  
Pathological Examination ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Small Nodule ◽  
First Case ◽  
Over Time

Abstract Background Giant vascular eccrine spiradenoma is a rare variant of eccrine spiradenoma. It is different from the eccrine spiradenoma in its larger size and greater degree of vascularity. It is often clinically confusedwith a vascular or malignant tumor. Case presentation Here, we report a case of a 67-year-old man who presented with a tumor in the scrotum scrotal region for 6 years. The tumor had begun as a small nodule and had grown slowly with over time. Surgical excision and pathological examination revealed that the lesion was the a giant vascular eccrine spiradenoma. Conclusion This study reports the first case of giant vascular eccrine spiradenoma in the scrotum.

scholarly journals Peripheral Solitary Osteoma of the Zygomatic Arch: A Case Report and Literature Review

2017 ◽  
Vol 11 (1) ◽  
pp. 120-125 ◽  
Author(s):  
Thomas Starch-Jensen
Keyword(s):  
Surgical Excision ◽  
Zygomatic Arch ◽  
Surgical Removal ◽  
Radiological Imaging ◽  
Review Of The Literature ◽  
Craniofacial Skeleton ◽  
Jaw Bones ◽  
Peripheral Osteoma ◽  
Dense Mass ◽  
Slow Growing

Osteoma is a benign slow-growing osteogenic neoplasm commonly occurring in the craniofacial skeleton, characterized by the proliferation of compact and/or cancellous bone. Osteomas may be peripheral, central, or extraskeletal. Peripheral osteomas arise from the periosteum and are quite uncommon in the jaw bones. The exact aetiology and pathogenesis of peripheral osteoma are unknown. Clinically, peripheral osteomas are usually asymptomatic, but depending on the location and size of the lesion, it may cause swelling, pain, esthetic disfigurement and functional impairment. On radiological imaging, a peripheral osteoma appears often as well-circumscribed, round to oval, pedunculated radiopaque mass attached to the cortex by a broad base or a pedicle. Asymptomatic osteomas are treated conservatively, while surgical excision is indicated when the lesion is symptomatic, actively growing, or for cosmetic reasons. Histologically, osteomas are composed of a normal-appearing, dense mass of lamellar bone. Recurrence of peripheral osteoma after surgical removal is extremely rare and there are no reports of malignant transformation. A review of the literature disclosed only 7 well-documented cases of peripheral osteoma located at the zygomatic bone. The purpose of this article is to present the clinical, radiographic, surgical and histological features of a solitary peripheral osteoma of the left zygomatic arch in a 55-year-old woman and to review the literature about this uncommon pathologic entity.

scholarly journals Angiomatoid Fibrous Histiocytoma: Case Presentation with Review of Literature

Osteology ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 112-117
Author(s):  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Antonietta Cimmino ◽  
Mariella Silecchia ◽  
Teresa Lettini ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Surgical Excision ◽  
Malignant Potential ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Genetic Characteristics ◽  
Case Presentation ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Spindle Cells ◽  
The Right

Angiomatoid fibrous histiocytoma is a rare neoplasm with an intermediate malignant potential, that mostly occurs in the subcutis and features varying proportions of epithelioid, ovoid and spindle cells in a nodular and syncytial growth pattern, with hemorrhagic pseudovascular spaces. Here, we report the clinical case of a 68-year-old man who presented with AFH on the right arm; the disease relapsed a few years after surgical excision. We also conduct a brief review of the literature, focusing on the biological and genetic characteristics and the differential diagnosis from other more or less similar entities.

scholarly journals Treatment of intramuscular lipoma of tongue with enveloped mucosal flap design: a case report and review of the literature

2020 ◽  
Vol 42 (1) ◽  
Author(s):  
Sung-Hwi Hur ◽  
Jae-Seok Lim ◽  
Sun-Gyu Choi ◽  
Ji-Yeon Kang ◽  
Ji-Hye Jung ◽  
...  
Keyword(s):  
Relevant Literature ◽  
Surgical Excision ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Mucosal Flap ◽  
Presenting Symptoms ◽  
Intramuscular Lipoma ◽  
Surgical Methods ◽  
Flap Design

Abstract Background Lipomas are benign soft tissue neoplasms of mature adipose tissue commonly occurring in the trunk or extremities. But, intraoral lipomas are rare entities which may be only noticed during routine dental examinations. Especially intramuscular lipomas on the tongue have been reported very rarely. In this study, we report a case of intramuscular lipoma on tongue, with a review of the literature from 1978 to 2019, providing data on age, gender, location, presenting symptoms, size, surgical methods, and recurrence. Case presentation A case of intramuscular lipoma occurring in tongue region in a 65-year-old male is reported. Surgical excision is the mainstay of treatment for the lesion. In order to decrease the deformity and discomfort after the excision, we tried to modify surgical technique using enveloped mucosal flap. This technique provided more comfortable healing procedure on the operative site without recurrence. Conclusion This is a rare case of large intramuscular lipoma on tongue. Surgical excision with enveloped mucosal flap design was performed to diminish postoperative raw surface and discomfort and a 24-month follow-up showed excellent healing without any recurrence. A case of intramuscular lipoma on tongue and relevant literature reviews are presented in this study.

scholarly journals Clinical report of a neonate carrying a large deletion in the 10p15.3p13 region and review of the literature

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Qiao-Yan Shao ◽  
Pei-Lin Wu ◽  
Bi-Yun Lin ◽  
Sen-Jing Chen ◽  
Jian Liu ◽  
...  
Keyword(s):  
Digeorge Syndrome ◽  
Clinical Manifestations ◽  
Large Deletion ◽  
Terminal Deletion ◽  
Facial Features ◽  
Clinical Report ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Contiguous Gene ◽  
Renal Abnormalities

Abstract Background Terminal deletion of chromosome 10p is a rare chromosomal abnormality. We report a neonatal case with a large deletion of 10p15.3p13 diagnosed early because of severe clinical manifestations. Case presentation Our patient presented with specific facial features, hypoparathyroidism, sen sorineural deafness, renal abnormalities, and developmental retardation, and carried a 12.6 Mb deletion in the 10p15.3 p13 region. The terminal 10p deletion involved in our patient is the second largest reported terminal deletion reported to date, and includes the ZMYND11 and GATA3 genes and a partial critical region of the DiGeorge syndrome 2 gene (DGS2). Conclusion On the basis of a literature review, this terminal 10p deletion in the present case is responsible for a specific contiguous gene syndrome. This rare case may help the understanding of the genotype–phenotype spectrum of terminal deletion of chromosome 10p.

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