Neonatal oral teratoma: A case report

Journal of Neonatal Surgery ◽

10.47338/jns.v10.963 ◽

2021 ◽

Vol 10 ◽

pp. 24

Author(s):

Helle Moustapha ◽

Oumarou Habou ◽

Kadre Alio Kadre Ousmane ◽

Mahamoud Omid Ali Ada ◽

Inoussa Daouda Bako ◽

...

Keyword(s):

Oral Cavity ◽

Germ Cells ◽

Primordial Germ Cells ◽

Germ Cell Tumors ◽

Surgical Excision ◽

Good Prognosis ◽

Upper Lip ◽

Complete Excision ◽

Case Presentation ◽

Irregular Mass

Background: Teratomas of the oral cavity are rare and can pose danger to a patient's life in terms of obstruction to the aerodigestive tract. These are the germ cell tumors that arise from all three layers of primordial germ cells. Case Presentation: A 2-day-old female neonate presented with a mass protruding from the oral cavity since birth with no significant antenatal history. Examination revealed a large (8 cm), firm, and irregular mass protruding from the oral cavity extending up to the inner surface of the upper lip and onto the gums, associated with cleft palate. Complete excision of the mass was done and histopathology confirmed the diagnosis. There were no postoperative complications. Conclusion: Oral cavity teratoma is a rare tumor with a good prognosis especially in its mature form. Surgical excision with multidisciplinary collaboration is needed in order to avoid any complications.

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Primary mediastinal seminoma with florid follicular lymphoid hyperplasia: a case report and review of the literature

Diagnostic Pathology ◽

10.1186/s13000-021-01137-9 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Charlotte Holmes ◽

Peh Sun Loo ◽

Sion Barnard

Keyword(s):

Germ Cell Tumors ◽

Median Sternotomy ◽

Surgical Excision ◽

Lymphoid Hyperplasia ◽

Radiological Imaging ◽

Review Of The Literature ◽

Case Presentation ◽

Oncological Treatment ◽

Mediastinal Tumours ◽

Mediastinal Seminoma

Abstract Background First described in 1955 Primary mediastinal seminomas are rare. Only 1–4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 years. Very few cases are reported in the literature. Florid follicular lymphoid hyperplasia can obscure the malignant cells and is a rarer finding still. We present a rare case of a 48 year old man with a primary mediastinal seminoma with florid follicular lymphoid hyperplasia; found following excision of a clinically presumed thymoma. Case presentation A 48 year old man was referred for excision of a thymic mass. The presumed diagnosis was a thymoma; following preoperative investigations. The mass was incidentally found on a radiological imaging. However, the patient did report mid-sternal discomfort on lying flat and breathlessness. The patient underwent a thymectomy via a partial median sternotomy with good recovery. Histological assessment was that the mass was in fact a primary mediastinal seminoma with florid follicular lymphoid hyperplasia. A primary testicular malignancy was excluded and the patient required no further oncological treatment. Conclusions Only 11 cases have previously been reported of primary mediastinal seminoma with florid follicular lymphoid hyperplasia. Although rare, a primary mediastinal seminoma should be considered as a differential diagnosis for presentations with a thymic mass. Tumour markers can be helpful, however are only positive in third of cases. Ultrasound imaging of the gonads is essential to exclude a primary gonadal lesion. Pure seminomas are radiotherapy and chemotherapy sensitive however the mainstay treatment of primary mediastinal seminomas remains surgical excision. Radiotherapy is reserved postoperatively for incomplete surgical margins.

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A Huge Dermoid Cyst in Postmenopausal Women with Third Degree Uterine Prolapse

The Journal of South Asian Federation of Menopause Societies ◽

10.5005/jp-journals-10032-1010 ◽

2013 ◽

Vol 1 (1) ◽

pp. 43-44 ◽

Cited By ~ 1

Author(s):

Deepti Shrivastava ◽

Anuradha Kakani ◽

Indradeep Bannerjee

Keyword(s):

Germ Cell ◽

Postmenopausal Women ◽

Dermoid Cyst ◽

South Asian ◽

Germ Cells ◽

Ovarian Tumor ◽

Rare Case ◽

Uterine Prolapse ◽

Primordial Germ Cells ◽

Germ Cell Tumors

ABSTRACT Germ cell tumors are derived from primordial germ cells of the ovary. Approximately 25 to 30% of all ovarian tumors are of germ cell origin and of these, 95% are benign and only 3 to 4% are malignant. They are seen mostly in women in their second and third decades of life and very rarely in postmenopausal women. There are many reported cases of ovarian tumor in postmenopausal women but a huge dermoid cyst in postmenopausal women causing prolapse uterus is very rare. Here, we are presenting a rare case of large dermoid cyst in a 58-year-old postmenopausal multiparous woman with third degree uterine prolapse. How to cite this article Kakani A, Bannerjee I, Shrivastava D. A Huge Dermoid Cyst in Postmenopausal Women with Third Degree Uterine Prolapse. J South Asian Feder Menopause Soc 2013;1(1):43-44.

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The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors

The International Journal of Developmental Biology ◽

10.1387/ijdb.072486cr ◽

2008 ◽

Vol 52 (4) ◽

pp. 333-344 ◽

Cited By ~ 38

Author(s):

Christopher Runyan ◽

Ying Gu ◽

Amanda Shoemaker ◽

Leendert Looijenga ◽

Christopher Wylie

Keyword(s):

Germ Cell ◽

Germ Cells ◽

Primordial Germ Cells ◽

Germ Cell Tumors ◽

Mutant Mice ◽

And Behavior

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Sialolithiasis of minor salivary glands

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-863720150001000092592 ◽

2015 ◽

Vol 63 (1) ◽

pp. 63-68 ◽

Cited By ~ 1

Author(s):

Isabela Fernandes SOUZA ◽

Michele Montini KAWATAKE ◽

Andresa Borges SOARES ◽

Paulo de Camargo MORAES ◽

Vera Cavalcanti de ARAÚJO ◽

...

Keyword(s):

Oral Cavity ◽

Salivary Glands ◽

Surgical Excision ◽

Minor Salivary Glands ◽

Upper Lip ◽

Lower Lip ◽

Favorable Prognosis ◽

Appropriate Treatment ◽

Treatment Plans ◽

Microscopic Findings

Sialolithiasis, or salivary calculus, is a disease of the salivary glands, characterized by the formation of mineralized structures within the excretory salivary ducts or the glandular parenchyma. Approximately 80% occur in the submandibular gland, followed by the parotid and sublingual glands. Although rare, sialolithiasis can also occur in the minor salivary glands. Although the oral cavity and upper lip are the most common sites, they can develop in any region of the oral cavity that contains minor salivary glands. Treatment is based on surgical excision of the lesion, with a favorable prognosis. This study presents three cases of sialolithiasis of minor salivary glands of the upper and lower lip, addresses their clinical characteristics and correlation with microscopic findings, diagnosis and treatment plans. Etiology and factors that should be considered during diagnosis, appropriate treatment and improved prognosis are discussed in this study.

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Surgical Excision of Thoracic Osteoblastoma with Secondary Aneurysmal Bone Cyst from a 12-Year-Old Child

Pediatric Neurosurgery ◽

10.1159/000510015 ◽

2020 ◽

Vol 55 (5) ◽

pp. 280-288

Author(s):

David Shaoen Sim ◽

Jayanthi Karunanithi ◽

Sathiyamoorthy Selvarajan ◽

Reuben Chee Cheong Soh

Keyword(s):

Aneurysmal Bone Cyst ◽

Posterior Instrumentation ◽

Bone Cyst ◽

Rare Condition ◽

Surgical Excision ◽

Neurological Deficits ◽

Complete Excision ◽

Case Presentation ◽

Surgical Debulking ◽

Secondary Aneurysmal Bone Cyst

Introduction: Osteoblastoma is a primary benign tumour which commonly presents in the younger population during the second decade of life. However, more aggressive osteoblastomas may present with features of aneurysmal bone cyst, and these can occur at uncommon locations. Case Presentation: We report the case of a 12-year-old child having an osteoblastoma on the left side of T11 with secondary aneurysmal bone cyst presenting with neurological deficits and myelopathic symptoms. Surgical debulking of the lesion with decompression laminectomy and posterior instrumentation of the spine was performed. The child is currently recovering well with improvement of neurological deficits. Discussion/Conclusion: Osteoblastoma with aneurysmal bone cyst of the thoracic spine is a rare condition with few reports in the literature, and surgical intervention with complete excision has been demonstrated here with recovery of neurological function.

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Effectiveness of carboplatin, etoposide, and bleomycin combination chemotherapy in good-prognosis metastatic testicular nonseminomatous germ cell tumors.

Journal of Clinical Oncology ◽

10.1200/jco.1991.9.1.62 ◽

1991 ◽

Vol 9 (1) ◽

pp. 62-69 ◽

Cited By ~ 75

Author(s):

A Horwich ◽

D P Dearnaley ◽

J Nicholls ◽

G Jay ◽

M Mason ◽

...

Keyword(s):

Germ Cell ◽

Combination Chemotherapy ◽

Germ Cell Tumors ◽

Surgical Excision ◽

Good Prognosis ◽

Neutropenic Sepsis ◽

Reduced Toxicity ◽

Wbc Count ◽

Nonseminomatous Germ Cell Tumors

The combination of carboplatin, etoposide, and bleomycin (CEB) was evaluated as initial chemotherapy in 76 patients with good-prognosis metastatic nonseminomatous germ cell tumors (NSGCT) between 1984 and 1988. The classification of eligible patients included Royal Marsden Hospital (RMH) stages IM, IIA, IIB, IIC, IIIA, IIIB, IV0ABCL1, and IV0ABL2. Four courses of combination chemotherapy were administered in a 21-day cycle, and surgical excision of residual mass was performed in 27 cases (23 laparotomies and four thoracotomies). At the time of analysis, median follow-up was 24 months from start of chemotherapy (range, 6 to 54 months). The 2-year cause-specific survival probability was 98.5%, the single cause-related mortality being caused by bleomycin pneumonitis. Five patients failed CEB chemotherapy, but all have been successfully salvaged with a combination of surgery and intensive chemotherapy, follow-up from completion of all treatment being 35 to 44 months. The toxicity of CEB included bone marrow suppression and alopecia in all patients but no significant neurotoxicity or ototoxicity, and minimal renal toxicity. Only four (5%) patients had a decrease in the glomerular filtration rate greater than 15%. In 51% of patients, the hemoglobin fell below 10 g/dL. The WBC count nadir was less than 1,500/microL in 11% of treatment cycles and in 16% the platelet nadir fell below 50,000/microL. Decreases in the WBC and platelet counts were of very brief duration. Only one of 310 CEB cycles was complicated by neutropenic sepsis, and there were no episodes of thrombocytopenic purpura or bleeding. We conclude that the CEB combination represents an effective alternative to cisplatin-based chemotherapy in good-prognosis NSGCT and that the replacement of cisplatin by carboplatin leads to reduced toxicity.

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Nuclear Reprogramming in Mouse Primordial Germ Cells: Epigenetic Contribution

Stem Cells International ◽

10.4061/2011/425863 ◽

2011 ◽

Vol 2011 ◽

pp. 1-15 ◽

Cited By ~ 23

Author(s):

Massimo De Felici

Keyword(s):

Germ Cells ◽

Germ Line ◽

Primordial Germ Cells ◽

Germ Cell Tumors ◽

Cell Lineage ◽

Epigenetic Modifications ◽

Epigenetic Reprogramming ◽

Nuclear Reprogramming

The unique capability of germ cells to give rise to a new organism, allowing the transmission of primary genetic information from generation to generation, depends on their epigenetic reprogramming ability and underlying genomic totipotency. Recent studies have shown that genome-wide epigenetic modifications, referred to as “epigenetic reprogramming”, occur during the development of the gamete precursors termed primordial germ cells (PGCs) in the embryo. This reprogramming is likely to be critical for the germ line development itself and necessary to erase the parental imprinting and setting the base for totipotency intrinsic to this cell lineage. The status of genome acquired during reprogramming and the associated expression of key pluripotency genes render PGCs susceptible to transform into pluripotent stem cells. This may occurin vivounder still undefined condition, and it is likely at the origin of the formation of germ cell tumors. The phenomenon appears to be reproduced under partly definedin vitroculture conditions, when PGCs are transformed into embryonic germ (EG) cells. In the present paper, I will try to summarize the contribution that epigenetic modifications give to nuclear reprogramming in mouse PGCs.

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Germ cell determination and the developmental origin of germ cell tumors

Development ◽

10.1242/dev.198150 ◽

2021 ◽

Vol 148 (8) ◽

Author(s):

Peter K. Nicholls ◽

David C. Page

Keyword(s):

Germ Cell ◽

Germ Cells ◽

Primordial Germ Cells ◽

Germ Cell Tumors ◽

Cell Types ◽

The Body ◽

Developmental Potential ◽

Animal Development ◽

Cell Determination ◽

Diverse Species

ABSTRACT In each generation, the germline is tasked with producing somatic lineages that form the body, and segregating a population of cells for gametogenesis. During animal development, when do cells of the germline irreversibly commit to producing gametes? Integrating findings from diverse species, we conclude that the final commitment of the germline to gametogenesis – the process of germ cell determination – occurs after primordial germ cells (PGCs) colonize the gonads. Combining this understanding with medical findings, we present a model whereby germ cell tumors arise from cells that failed to undertake germ cell determination, regardless of their having colonized the gonads. We propose that the diversity of cell types present in these tumors reflects the broad developmental potential of migratory PGCs.

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CT features of mature teratoma in the mediastinum of two young adults—a report of two cases

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-020-00360-6 ◽

2020 ◽

Vol 51 (1) ◽

Author(s):

Naqibullah Foladi ◽

Farhad Farzam ◽

Najibullah Rahil ◽

Mer Mahmood Shah Hoshang

Keyword(s):

Germ Cell ◽

Mature Teratoma ◽

Germ Cell Tumors ◽

Anterior Mediastinum ◽

Good Prognosis ◽

Chest Ct ◽

Case Presentation ◽

Superior Mediastinum ◽

Chest Ct Scan ◽

Ct Features

Abstract Background Germ cell tumors prefer gonadal regions, but they can be expected in extragonadal sites such as the anterior mediastinum, which is the commonly involved region after gonads. Amongst germ cell tumors, teratomas are the rarer subtypes which develop in the anterior mediastinum. Case presentation The authors present two adult patients, a male and a female, both complaining of chronic chest pain and cough. Chest CT scans were performed revealing characteristic CT features of mature teratomas in the anterior mediastinum which were extending to the superior mediastinum in both patients. Conclusion Germ cell tumors are involving the mediastinum; however, amongst all germ cell tumors, teratoma is the least common type arising in the mediastinum, and a chest CT scan considered the imaging investigation of choice. Surgery is the best option and patients may have a very good prognosis.

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