A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women

microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.

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Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2using five methods: results from a population-based study of young breast cancer patients

Breast Cancer Research ◽

10.1186/bcr1865 ◽

2008 ◽

Vol 10 (1) ◽

Cited By ~ 15

Author(s):

Eunjung Lee ◽

Roberta McKean-Cowdin ◽

Huiyan Ma ◽

Zhengjia Chen ◽

David Van Den Berg ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Cancer Susceptibility ◽

Breast Cancer Susceptibility ◽

Population Based ◽

Breast Cancer Patients ◽

Population Based Study ◽

Cancer Susceptibility Genes ◽

Breast Cancer Susceptibility Genes ◽

Young Breast Cancer

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The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility

PLoS ONE ◽

10.1371/journal.pone.0070656 ◽

2013 ◽

Vol 8 (9) ◽

pp. e70656 ◽

Cited By ~ 20

Author(s):

Ping-Yu Wang ◽

Zong-Hua Gao ◽

Zhong-Hua Jiang ◽

Xin-Xin Li ◽

Bao-Fa Jiang ◽

...

Keyword(s):

Breast Cancer ◽

Single Nucleotide Polymorphisms ◽

Cancer Susceptibility ◽

Breast Cancer Susceptibility ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

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Evidence for further breast cancer susceptibility genes in addition toBRCA1 andBRCA2 in a population-based study

Genetic Epidemiology ◽

10.1002/gepi.1014 ◽

2001 ◽

Vol 21 (1) ◽

pp. 1-18 ◽

Cited By ~ 183

Author(s):

Antonis C. Antoniou ◽

Paul D.P. Pharoah ◽

Greg McMullan ◽

Nickolas E. Day ◽

Bruce A.J. Ponder ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Susceptibility ◽

Breast Cancer Susceptibility ◽

Population Based ◽

Susceptibility Genes ◽

Population Based Study ◽

Cancer Susceptibility Genes ◽

Breast Cancer Susceptibility Genes

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Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer

BioMed Research International ◽

10.1155/2017/2352874 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Jiaping Chen ◽

Yue Jiang ◽

Jing Zhou ◽

Sijun Liu ◽

Yayun Gu ◽

...

Keyword(s):

Breast Cancer ◽

Single Nucleotide Polymorphisms ◽

In Silico ◽

Promoter Region ◽

Cancer Susceptibility ◽

Chinese Women ◽

Close Association ◽

Breast Cancer Susceptibility ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear. This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women. Seven potentially functional SNPs were investigated using genotyping assays. The potential biological functions of the identified positive SNPs were further evaluated using in silico databases. We found that rs4078756, which was located at the promoter region of miR-10b, was significantly associated with breast cancer risk (rs4078756 AG/GG versus AA, adjusted odds ratio: 1.17, 95% confidence interval: 1.02–1.35). The other six single nucleotide polymorphisms exhibited negative associations. Based on the in silico prediction, rs4078756 potentially regulated miR-10b expression through promoter activation or repression. These findings indicate that a potentially functional SNP (rs4078756) in the promoter region of miR-10b may contribute to breast cancer susceptibility among Chinese women.

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Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

Oncotarget ◽

10.18632/oncotarget.10754 ◽

2016 ◽

Vol 7 (34) ◽

pp. 54771-54781 ◽

Cited By ~ 5

Author(s):

Ming Liu ◽

Bin Li ◽

Wen Guo ◽

Xiyang Zhang ◽

Zhengshuai Chen ◽

...

Keyword(s):

Breast Cancer ◽

Single Nucleotide Polymorphisms ◽

Chinese Population ◽

Cancer Susceptibility ◽

Breast Cancer Susceptibility ◽

Han Chinese ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Han Chinese Population

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LRRC3B polymorphisms contributed to breast cancer susceptibility in Chinese Han Population

10.21203/rs.3.rs-61551/v1 ◽

2020 ◽

Author(s):

Tianbo Jin ◽

Linna Peng ◽

Shishi Xing ◽

Dandan Li ◽

Chunjuan He ◽

...

Keyword(s):

Breast Cancer ◽

Poor Prognosis ◽

Cancer Susceptibility ◽

Breast Cancer Susceptibility ◽

Suppressor Gene ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Single Nucleotide ◽

Increased Risk ◽

The Status

Abstract Purpose LRRC3B gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of LRRC3B polymorphisms on BC has rarely been reported. In the study, we aims to evaluate the relation between LRRC3B variants and BC risk. Methods Among 563 BC patients and 552 healthy controls, ten single-nucleotide polymorphisms (SNPs) in LRRC3B were genotyped by Agena MassARRAY. Odds ratios (OR) and 95% confidence interval (CI) was calculate using logistic regression model. Results Our study demonstrated that rs1907168 polymorphism (OR = 0.71, p = 0.017) reduced the risk of BC in the overall. In stratified analyses by age, rs1907168 decreased (OR = 0.53, p = 0.002) while rs78205284 (OR = 2.83, p = 0.034) increased BC susceptibility among the population at age ≤ 51 years. Clinical parameters such as tumor size, the status of PR and Ki67 were associated with LRRC3B variants. Furthermore, we found that the association of ‘GATT’ haplotype with an increased risk for BC. In addition, LRRC3B gene was down-regulated in BC tumor and had a poor prognosis in BC in silico analysis. Conclusion Our study firstly found LRRC3B SNPs contributed to the risk of BC, suggesting LRRC3B variants might help to predict BC progression.

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