Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women

Abstract Background Although anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent. Methods We investigated the association between NSAID use and BC incidence in the French E3N prospective cohort, which includes 98,995 women born between 1925 and 1950 and insured by a health insurance plan that covers mostly teachers. Self-reported information on lifestyle and medical history has been collected biennially by questionnaires and matched with data from a drug reimbursement database covering the period 2004–2014. Women who self-reported current NSAID use in the 2000 or 2002 questionnaires or with at least two reimbursements in any previous 3-month period were defined as exposed to NSAIDs. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for the association of NSAID use with BC risk. Results In the current analysis, 62,512 postmenopausal women were followed between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 2864 incident BC). In multivariable models, there was no statistically significant association between NSAID use and BC risk [HR = 1.00 (0.92–1.08), compared with non-exposed women]. The NSAID-BC associations did not differ by NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and dose of use. However, a statistically significant interaction was observed by proton pump inhibitor (PPI) drug use (Pinteraction = 0.01) whereby a decreased risk of BC with NSAID use was only observed among women who also used PPI before. Conclusion Only women who used NSAIDs after having used PPI had a lower risk of BC. This result is novel and requires replication in other studies.

Download Full-text

Use of Aspirin, Other Nonsteroidal Anti-Inflammatory Drugs, and Acetaminophen and Postmenopausal Breast Cancer Incidence

Journal of Clinical Oncology ◽

10.1200/jco.2012.42.2006 ◽

2012 ◽

Vol 30 (28) ◽

pp. 3468-3477 ◽

Cited By ~ 40

Author(s):

Xuehong Zhang ◽

Stephanie A. Smith-Warner ◽

Laura C. Collins ◽

Bernard Rosner ◽

Walter C. Willett ◽

...

Keyword(s):

Breast Cancer ◽

Postmenopausal Women ◽

Cancer Incidence ◽

Molecular Subtype ◽

Breast Cancer Incidence ◽

Postmenopausal Breast Cancer ◽

Luminal A ◽

Inflammatory Drugs ◽

Cox 2 ◽

Anti Inflammatory

Purpose The associations between use of aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen and breast cancer incidence in postmenopausal women are uncertain. We examined these associations with breast cancer, both overall and by molecular subtype. Patients and Methods We observed 84,602 postmenopausal women, free of cancer in 1980, until June 2008 and prospectively collected data on analgesic use, reproductive history, and other lifestyle factors using biennial questionnaires. Proportional hazards models were used to estimate multivariable relative risks (RRs) and 95% CIs. Results We documented 4,734 cases of incident invasive breast cancer. Compared with nonuse of aspirin, multivariable RRs of regular aspirin use (≥ two tablets per week) for more than 20 years were 0.91 for overall breast cancer (95% CI, 0.81 to 1.01; Ptrend = 0.16), 0.90 for estrogen receptor (ER) –positive progesterone receptor (PR) –positive breast cancer (95% CI, 0.77 to 1.06; Ptrend = 0.17), and 0.91 for ER-negative PR-negative breast cancer (95% CI, 0.68 to 1.22; Ptrend = 0.97). Results did not vary appreciably by past or current use, days per week of use, or dosage of use. Use of other NSAIDs and acetaminophen was largely not significantly associated with breast cancer risk. Additionally, use of higher doses of each analgesic (≥ six tablets per week) for more than 10 years was generally not significantly associated with risk of breast cancer, either overall or by subtype. Furthermore, largely no substantial associations were noted for breast cancer molecular subtypes, including luminal A, luminal B, triple negative, basal-like, human epidermal growth factor receptor 2 positive, cyclooxygenase-2 (COX-2) negative, and COX-2 positive. Conclusion Our study suggests that use of aspirin, other NSAIDs, and acetaminophen is not importantly associated with risk of postmenopausal breast cancer, either overall or by specific subtype.

Download Full-text

Nonsteroidal anti-inflammatory drugs and the risk of developing breast cancer in a population-based prospective cohort study in Washington County, MD

International Journal of Cancer ◽

10.1002/ijc.22656 ◽

2007 ◽

Vol 121 (1) ◽

pp. 211-215 ◽

Cited By ~ 31

Author(s):

Lisa Gallicchio ◽

Kala Visvanathan ◽

Alyce Burke ◽

Sandra C. Hoffman ◽

Kathy J. Helzlsouer

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Population Based ◽

Washington County ◽

Inflammatory Drugs ◽

Anti Inflammatory

Download Full-text

Breast Cancer Stem Cell Potency of Nickel(II)‐Polypyridyl Complexes Containing Non‐steroidal Anti‐inflammatory Drugs

Chemistry - A European Journal ◽

10.1002/chem.202001578 ◽

2020 ◽

Vol 26 (61) ◽

pp. 14011-14017

Author(s):

Catherine J. Feld ◽

Alice Johnson ◽

Zhiyin Xiao ◽

Kogularamanan Suntharalingam

Keyword(s):

Breast Cancer ◽

Stem Cell ◽

Cancer Stem Cell ◽

Breast Cancer Stem Cell ◽

Polypyridyl Complexes ◽

Inflammatory Drugs ◽

Anti Inflammatory

Download Full-text

Use of Aspirin, Other Nonsteroidal Anti-inflammatory Drugs, and Acetaminophen and Risk of Breast Cancer Among Premenopausal Women in the Nurses' Health Study II—Invited Commentary

Archives of Internal Medicine ◽

10.1001/archinternmed.2008.515 ◽

2009 ◽

Vol 169 (2) ◽

pp. 121

Author(s):

Madhuri Kakarala ◽

Dean E. Brenner

Keyword(s):

Breast Cancer ◽

Premenopausal Women ◽

Health Study ◽

Inflammatory Drugs ◽

Anti Inflammatory

Download Full-text

Abstract P382: Fried Food Consumption is Associated with a Higher Risk of Heart Failure among US Male Physicians

Circulation ◽

10.1161/circ.131.suppl_1.p382 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Luc Djousse ◽

Andrew Petrone ◽

John M Gaziano

Keyword(s):

Heart Failure ◽

Food Intake ◽

Food Consumption ◽

Prospective Cohort ◽

Cox Regression ◽

Health Study ◽

Median Frequency ◽

Fried Food ◽

Hazard Ratios

Background: While previous studies have reported a positive relation of fried food consumption with type 2 diabetes, hypertension, and obesity, no previous study has examined the relation of total fried food intake with risk of heart failure (HF) in a prospective cohort. Objective: To test the hypothesis that fried food consumption is positively associated with risk of HF in male physicians. Methods: A prospective cohort of 19,968 participants from the Physicians’ Health Study. Frequency of fried food consumption was assessed between 1999 and 2002 using a food frequency questionnaire and HF was ascertained through annual follow-up questionnaires with validation in a subsample. We used Cox regression to estimate multivariable adjusted hazard ratios of HF. Results: During a median follow-up of 10.6 years, 862 cases of HF occurred. The mean age at baseline was 66.4 ± 9.2 years. Median frequency of fried food consumption was <1 time per week. Multivariable adjusted hazard ratios (95% CI) were: 1.0 (ref), 1.18 (1.01-1.37), 1.25 (1.02-1.54), and 1.68 (1.19-2.36) for fried food consumption of <1/week, 1-3/week, 4-6/week, and 7+/week, respectively (p for linear trend: 0.0004), after adjustment for age, alcohol use, smoking, exercise, and history of myocardial infarction, coronary artery bypass graph or angioplasty (Fig). Additional adjustment of total trans fats did not alter the findings. In a secondary analysis, body mass index did not modify the relation of fried foods with HF risk. Conclusions: Our data show a positive association between fried food intake and risk of HF in US male physicians.

Download Full-text