scholarly journals Ultrasound evaluation of the fetal fat tissue, heart, liver and umbilical cord measurements in pregnancies complicated by gestational and type 1 diabetes mellitus: potential application in the fetal birth-weight estimation and prediction of the fetal macrosomia

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Paweł Jan Stanirowski ◽  
Agata Majewska ◽  
Michał Lipa ◽  
Dorota Bomba-Opoń ◽  
Mirosław Wielgoś
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Birth Weight ◽  
Soft Tissue ◽  
Type 1 Diabetes Mellitus ◽  
Umbilical Cord ◽  
Predictive Value ◽  
Fetal Macrosomia ◽  
Fetal Birth Weight

Abstract Background The aim of the study was to evaluate the ultrasound-derived measurements of the fetal soft-tissue, heart, liver and umbilical cord in pregnancies complicated by gestational (GDM) and type 1 diabetes mellitus (T1DM), and further to assess their applicability in the estimation of the fetal birth-weight and prediction of fetal macrosomia. Methods Measurements were obtained from diet-controlled GDM (GDMG1) (n = 40), insulin-controlled GDM (GDMG2) (n = 40), T1DM (n = 24) and healthy control (n = 40) patients. The following parameters were selected for analysis: fetal sub-scapular fat mass (SSFM), abdominal fat mass (AFM), mid-thigh fat/lean mass (MTFM/MTLM) and inter-ventricular septum (IVS) thicknesses, heart and thorax circumference and area (HeC/HeA; ThC/ThA), liver length (LL), umbilical cord/vein/arteries circumference and area (UmC/UmA; UvC/UvA; UaC/UaA) together with total umbilical vessels (UveA) and Wharton's jelly area (WjA). Regression models were created in order to assess the contribution of selected parameters to fetal birth-weight (FBW) and risk of fetal macrosomia. Results Measurements of the fetal SSFM, AFM, MTFM, MTFM/MTLM ratio, HeC, HeA, IVS, LL, UmC, UmA, UaC, UaA, UveA and WjA were significantly increased among patients with GDMG2/T1DM as compared to GDMG1 and/or control groups (p < .05). The regression analysis revealed that maternal height as well as fetal biparietal diameter, abdominal circumference (AC), AFM and LL measurements were independent predictors of the FBW (p < .05). In addition, increase in the fetal AFM, AC and femur length (FL) was associated with a significant risk of fetal macrosomia occurrence (p < .05). The equation developed for the FBW estimation [FBW(g) = − 2254,942 + 17,204 * FL (mm) + 105,531 * AC (cm) + 131,347 * AFM (mm)] provided significantly lower mean absolute percent error than standard formula in the sub-group of women with T1DM (5.7% vs 9.4%, p < .05). Moreover, new equation including AC, FL and AFM parameters yielded sensitivity of 93.8%, specificity 77.7%, positive predictive value 54.5% and negative predictive value of 97.8% in the prediction of fetal macrosomia. Conclusions Ultrasound measurements of the fetal soft tissue, heart, liver and umbilical cord are significantly increased among women with GDM treated with insulin and T1DM. In addition to standard biometric measurements, parameters, such as AFM, may find application in the management of diabetes-complicated pregnancies.

scholarly journals Sensitivity, Specificity and Predictive Value of Heart Rate Variability Indices in Type 1 Diabetes Mellitus

2017 ◽  
Author(s):  
Anne Kastelianne França da Silva ◽  
Diego Giuliano Destro Christofaro ◽  
Aline Fernanda Barbosa Bernardo ◽  
Franciele Marques Vanderlei ◽  
Luiz Carlos Marques Vanderlei
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Predictive Value ◽  
Sensitivity Specificity

No association between birth weight and Type 1 diabetes mellitus - a twin-control study

2000 ◽  
Vol 17 (2) ◽  
pp. 158-162 ◽  
Author(s):  
K. O. Kyvik ◽  
I. Bache ◽  
A. Green ◽  
H. Beck-Nielsen ◽  
K. Buschard
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Birth Weight ◽  
Type 1 Diabetes Mellitus ◽  
Control Study

scholarly journals Xenotransplantation of human umbilical cord derived stem cells for treatment of type 1 diabetes mellitus in mice

2016 ◽  
Vol 3 (12) ◽  
pp. 1018
Author(s):  
Loan Thi-Tung Dang ◽  
Anh Nguyen-Tu Bui ◽  
Cong Le-Thanh Nguyen ◽  
Nhat Chau Truong ◽  
Anh Thi-Van Bui ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Umbilical Cord ◽  
Human Umbilical Cord

scholarly journals IMMUNOGENETICS OF TYPE 1 DIABETES MELLITUS — FROM FUNDAMENTAL IDEAS TO MEDICAL PRACTICE

2012 ◽  
Vol 67 (1) ◽  
pp. 75-80 ◽  
Author(s):  
L. P. Alekseev ◽  
I. I. Dedov ◽  
R. M. Khaitov ◽  
M. N. Boldyreva ◽  
D. Yu. Trofimov ◽  
...  
Keyword(s):  
Public Health ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Health Outcomes ◽  
Type 1 Diabetes Mellitus ◽  
Medical Practice ◽  
Genetic Predisposition ◽  
Predictive Value ◽  
Ctla4 Gene

The review of studies of Russian researchers on theoretical and practical aspects of genetic predisposition to type 1 diabetes associated with immunity: HLA and not HLA genes. Most important for practical public health outcomes are evidence that HLA-genetic predisposition to type 1 diabetes is associated with the DRB1-genotype, consisting entirely of variants DRB1-genes associated with the development of T1D. It was also established that CTLA4 gene has an independent predictive value for T1D.

Urinary bisphenol-A levels in children with type 1 diabetes mellitus

2018 ◽  
Vol 31 (8) ◽  
pp. 829-836 ◽  
Author(s):  
Tolga İnce ◽  
Aylin Balcı ◽  
Siddika Songül Yalçın ◽  
Gizem Özkemahlı ◽  
Pinar Erkekoglu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Birth Weight ◽  
Bisphenol A ◽  
Type 1 Diabetes Mellitus ◽  
Inverse Relationship ◽  
Control Group ◽  
Healthy Children ◽  
Exposure Routes

Abstract Background: Bisphenol-A (BPA) is one of the most abundantly produced chemicals globally. Concerns have been raised about BPA’s possible role in the pathogenesis of type 1 diabetes mellitus (T1DM). The main aim of the current study was to evaluate the possible association between BPA exposure and T1DM. The second aim was to investigate children’s possible BPA exposure routes in Turkey. Methods: A total of 100 children aged between 5 and 18 years including 50 children with T1DM and 50 healthy children were included. Urinary BPA levels of all children were measured using high-performance liquid chromatography. Mothers of children enrolled in the study were also requested to complete a survey that included questions on the sociodemographic characteristics, medical history and possible BPA exposure routes of their children. Results: In the T1DM group, urinary BPA levels were slightly higher compared to the control group, but this difference was not significant (p=0.510). However, there was an inverse relationship between current urinary BPA levels and birth weight. It was found that the use of plastic kettles and the consumption of dairy products in plastic boxes significantly increased the urinary BPA concentrations in all subjects. Conclusions: Although there was no significant association between urinary BPA levels and T1DM, we found an inverse relationship between current urinary BPA levels and birth weight. This finding might be important for prenatal exposure, and further prospective research must be conducted. Also, the use of plastic kettles, which has not been mentioned much in the literature before, was found to be an important exposure route for BPA.

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