scholarly journals Imaging features of primary sites and metastatic patterns of angiosarcoma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Basrull N. Bhaludin ◽  
Khin Thway ◽  
Margaret Adejolu ◽  
Alexandra Renn ◽  
Christian Kelly-Morland ◽  
...  
Keyword(s):  
Metastatic Disease ◽  
Wide Spectrum ◽  
Imaging Techniques ◽  
Soft Tissue Sarcomas ◽  
Final Diagnosis ◽  
The Body ◽  
Imaging Features ◽  
Imaging Findings ◽  
Wide Range ◽  
Metastatic Patterns

AbstractAngiosarcomas are rare, aggressive soft tissue sarcomas originating from endothelial cells of lymphatic or vascular origin and associated with a poor prognosis. The clinical and imaging features of angiosarcomas are heterogeneous with a wide spectrum of findings involving any site of the body, but these most commonly present as cutaneous disease in the head and neck of elderly men. MRI and CT are complementary imaging techniques in assessing the extent of disease, focality and involvement of adjacent anatomical structures at the primary site of disease. CT plays an important role in the evaluation of metastatic disease. Given the wide range of imaging findings, correlation with clinical findings, specific risk factors and patterns of metastatic disease can help narrow the differential diagnosis. The final diagnosis should be confirmed with histopathology and immunohistochemistry in combination with clinical and imaging findings in a multidisciplinary setting with specialist sarcoma expertise. The purpose of this review is to describe the clinical and imaging features of primary sites and metastatic patterns of angiosarcomas utilising CT and MRI.

A Review on Meropenem

2021 ◽  
pp. 5034-5038
Author(s):  
Mohsina Abed ◽  
Sara Yousuf
Keyword(s):  
Intravenous Administration ◽  
Wide Spectrum ◽  
Gastrointestinal Haemorrhage ◽  
The Body ◽  
Antibacterial Drug ◽  
Bacterial Strains ◽  
Enhanced Absorption ◽  
Bacterial Cell Death ◽  
Wide Range ◽  
Synthetic Derivative

Meropenem is a new Carbapenem antibacterial agent with wide spectrum of activity for intravenous administration. It is synthetic derivative of Thienamycin. Three analogues of Meropenem are evaluated and active against 18 bacterial strains. Meropenem causes rapid bacterial cell death by covalently binding to penicillin binding proteins (PBS). Structural modification at C-2 position, produced double promoiety prodrug of Meropenem and increases bioavailability of oral administration. Other forms of drug such as liposome and nanoparticles are also available with enhanced absorption. 14C labelled Meropenem prepared from 14C Dimethylamine hydrochloride is used for the analysis of M. tuberculosis transpeptidase. ICI213,689 is the only metabolite of Meropenem and it is inactive. Meropenem penetrates well into the body fluids and tissues including cerebrospinal fluid. Its bioavailability is 100% on intravenous administration. Hence it is used in the treatment of meningitis, febrile neutropenia, anthrax and various other skin and skin structure infections. Dosage reduction is required in patient with reduced renal function but not in hepatic impairment. Seizures, gastrointestinal haemorrhage are observed in patients. Vabmoere is the combination of Meropenem and Vaborbactam which is active against the Carbapenem resistant Enterobacteriacea. Meropenem is an effective broad-spectrum antibacterial drug for the treatment of wide range of infection including polymicrobial infection in both children and adult.

scholarly journals Cystic and alveolar echinococcosis of the hepatobiliary tract – the role of new imaging techniques for improved diagnosis

2020 ◽  
Vol 1 (1) ◽  
pp. 75 ◽  
Author(s):  
Christoph F Dietrich ◽  
Wiem Douira-Khomsi ◽  
Hassen Gharbi ◽  
Malay Sharma ◽  
Xin Wu Cui ◽  
...  
Keyword(s):  
Alveolar Echinococcosis ◽  
Wide Spectrum ◽  
Imaging Techniques ◽  
Imaging Features ◽  
Hydatid Cysts ◽  
Fatal Disease ◽  
Symptomatic Infection ◽  
Hepatobiliary Tract

Cystic echinococcosis (CE) or hydatidosis (hydatid cysts) is an infection with a wide spectrum of manifestations, from symptomatic infection to fatal disease. Ultrasound (US) allows screening, diagnosis, differential diagnosis, treatment guidance and follow-up of CE under many circumstances. Hydatid cysts are predominantly observed in the liver. Herewith we present a review to demonstrate established and innovative imaging features of CE of the hepatobiliary tract.

scholarly journals Sinonasal Hemangiopericytomas: Clinicopathologic and Imaging Findings

2005 ◽  
Vol 84 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Enrique Palacios ◽  
Santiago Restrepo ◽  
Luciano Mastrogiovanni ◽  
Giovanni D. Lorusso ◽  
Rafael Rojas
Keyword(s):  
Soft Tissue ◽  
Retrospective Review ◽  
Soft Tissue Sarcomas ◽  
The Body ◽  
Vascular Tumors ◽  
Imaging Findings ◽  
Mesenchymal Tumors ◽  
Imaging Characteristics ◽  
Neoplastic Lesions ◽  
Pathologic Findings

Hemangiopericytomas are rare soft-tissue neoplastic lesions that can arise in any part of the body. They are mesenchymal tumors that account for 3 to 5% of all soft-tissue sarcomas and 1% of all vascular tumors. They originate in extravascular cells (pericytes). Some 15 to 30% of all hemangiopericytomas occur in the head and neck; of these, approximately 5% occur in the sinonasal area. We describe our brief retrospective review of 7 histologically proven cases of sinonasal hemangiopericytoma, and we discuss the imaging characteristics and clinical and pathologic findings in these patients.

Solitary fibrous tumor: A Brazilian cohort analysis.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 11068-11068
Author(s):  
Marcelle Goldner Cesca ◽  
Celso Lopes Mello ◽  
Tiago Felismino ◽  
Maria Nirvana Formiga ◽  
Ulisses Ribaldo Nicolau ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Systemic Treatment ◽  
Cohort Analysis ◽  
Locally Advanced ◽  
Soft Tissue Sarcomas ◽  
Primary Objective ◽  
The Body ◽  
Cancer Center ◽  
Wide Range ◽  
Fibrous Tumor

11068 Background: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that account for less than 2% of all soft tissue sarcomas. SFT has been identified in multiple anatomic locations and can arise anywhere in the body. Surgical management is the mainstay of treatment for localized disease. However, about 20% will develop locoregional recurrences or distant metastasis with a role for systemic treatment. Methods: A retrospective analysis was carried out in a large cancer center in Brazil. Our primary objective was to evaluate clinical and treatment aspects of metastatic/ locally advanced (Mtx/LA) SFT cohort and secondary to describe clinical characteristics of entire population diagnosed with SFT. Descriptive statistics was used for main results. Survival curves were estimated using Kaplan-Meier. Data were retrieved from electronic patient medical records. Results: From April, 1971 to October, 2017, 82 patients with SFT were treated. Median follow-up was 45.5 months. 67 (81.7%) were alive on the cut-off date. Median age at diagnosis was 51 (14-78). 40.2% men. Most common primary sites (PS) were pleura (19.8%), central nervous system (CNS - 11%) and pelvis (11%). 18 (21.9%) underwent chemotherapy for Mtx/LA disease. In this subgroup, 61.1% were men; PS retroperitoneal (22.2%), extremities (16.7%), CNS (16.7%). 66.7% had pulmonary, 44.4% hepatic, 27.8% bone metastasis and one (5.5%) local recurrence. All patients had at least one adverse prognostic factor (tumor size ≥ 10cm, positive margins, necrosis, ≥ 4/10 mitosis). One (5,5%) had Doege-Potter syndrome. 7 (38.9%) did one, 5 (27.8%) two and 6 (33.3%) ≥ 3 lines of treatment. First line was temozolomide/bevacizumab (TMZ/Bev) in 55.6%, followed by chemotherapy (Ch) in 27.8% and tyrosine kinase inhibitors (TKI) in 16.7%. Median progression-free survival was 3.5 months (95% IC: 0.0-7.4) and overall survival 27.3 months (95% IC: 18.7-36.0). Response rate using RECIST criteria was 12.5% for TMZ/Bev and 62.5% had stable disease. TKI and Ch had no response. Conclusions: SFT is rare and with heterogeneous clinical presentation. In our analysis, patients received a wide range of therapy, reflecting the lack of well-established systemic treatment option. TMZ/Bev showed consistent activity in Mtx/LA scenario.

scholarly journals A sarcoma synoviale kezelési lehetőségei

2015 ◽  
Vol 156 (22) ◽  
pp. 875-880
Author(s):  
Dániel Deme ◽  
András Telekes
Keyword(s):  
Metastatic Disease ◽  
Tumour Size ◽  
Locally Advanced ◽  
Soft Tissue Sarcomas ◽  
Disease Recurrence ◽  
The Body ◽  
Malignant Neoplasms ◽  
Biological Behaviour ◽  
Synovial Sarcomas

Synovial sarcomas account for approximately 5 to 10% of soft tissue sarcomas and 0.05 to 0.1% of all malignant neoplasms. They predominantly affect the extremities but can occur in any part of the body. More than 50% of the patients are expected to develop metastatic disease within 3–5 years. In some patients disease recurrence may develop after 20 years. The 5-year overall survival rate is 10% for patients with metastatic disease and 76% for patients with localized one. Age, tumour size, histological subtype, and adjuvant radiotherapy influence prognosis. The role of adjuvant chemotherapy has not been proven yet. There are several ongoing clinical trials to determine the efficacy of active agents used for therapy of locally advanced, relapsed/refractory or metastatic disease. Better understanding of the biological behaviour of synovial sarcomas would provide the future way for the targeted therapy in combination with conventional treatments. Orv. Hetil., 2015, 156(22), 875–880.

scholarly journals The many faces of primary and secondary hepatic lymphoma: imaging manifestations and diagnostic approach

2019 ◽  
Vol 52 (5) ◽  
pp. 325-330 ◽  
Author(s):  
Aldo Maurici Araújo Alves ◽  
Ulysses Santos Torres ◽  
Fernanda Garozzo Velloni ◽  
Bruno Jucá Ribeiro ◽  
Dario Ariel Tiferes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Bone Marrow ◽  
Wide Spectrum ◽  
Imaging Features ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Primary Hepatic Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
The Many

Abstract Hepatic lymphoma can be divided into its primary and secondary forms. To be classified as primary hepatic lymphoma, the disease should be limited to the liver and hilar lymph nodes, with no distant involvement (to the bone marrow or other sites). Primary hepatic lymphoma is quite rare, accounting for less than 1% of all cases of non-Hodgkin lymphoma, whereas secondary hepatic lymphoma affects nearly half of such cases. Familiarity with the imaging features of hepatic lymphoma is important for its early diagnosis and appropriate management. In this essay, we aim to review the roles of computed tomography and magnetic resonance imaging in identifying and monitoring hepatic lymphomas, using sample cases to describe and illustrate the wide spectrum of imaging findings in the primary and secondary forms of this disorder.

scholarly journals The “Epulis” Dilemma. Considerations from Provisional to Final Diagnosis. A Systematic Review

Oral ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 224-235
Author(s):  
Paola Costa ◽  
Matteo Peditto ◽  
Antonia Marcianò ◽  
Antonio Barresi ◽  
Giacomo Oteri
Keyword(s):  
Systematic Review ◽  
Microscopic Examination ◽  
Wide Spectrum ◽  
Data Extraction ◽  
Final Diagnosis ◽  
Electronic Search ◽  
Wide Range ◽  
Gingival Enlargement ◽  
Neoplastic Lesions ◽  
Slow Growing

“Epulis” is a widely used term to describe a localized gingival enlargement. However, a wide range of neoformations might present as localized, slow-growing, asymptomatic gingival masses. A systematic review was conducted to outline the pathological entities that were provisionally dignosed as “epulis” and whose final diagnosis was made after microscopic examination. An electronic search of PubMed, Google Scholar and Scopus databases from January 2000 to February 2021 was performed. An initial search of the databases identified a total of 864 documents, and after a careful process of screening and selection, 14 studies were included in this systematic review and processed for data extraction. The results show that histological examination, sometimes combined with immunohistochemistry, might reveal a wide spectrum of lesions, including hamartomatous lesions, non-neoplastic lesions, benign and malign neoplasms and metastases from distant cancers.

An extremely rare epithelioid sarcoma arising from the infratemporal fossa: a case report and literature review

2021 ◽  
Vol 16 ◽  
Author(s):  
Weiming Ran ◽  
Wei Tang ◽  
Junyan Duan ◽  
Jiao Qing ◽  
Zhaohua Zhai
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Head And Neck ◽  
Imaging Techniques ◽  
Infratemporal Fossa ◽  
Epithelioid Sarcoma ◽  
The Body ◽  
Imaging Features ◽  
Anatomic Structure ◽  
Medical College

Introduction: Epithelioid sarcoma (ES) is a rare histopathological type of soft tissue sarcoma. They are subcutaneous soft tissue masses that tend to arise in extremity sites (the classic type, formerly referred to as distal type) or proximal midline region of the body (the proximal type), such as the perineum, genital tract, and pelvis. The head and neck regions are rarely affected by ES, but the infratemporal fossa (ITF) is extremely rare. ES involving the ITF has not been reported before in literature. In this paper, the imaging features of ES were reviewed in detail, and the anatomical structure and epidemiology of ITF were briefly introduced. Sources: We performed a systematic search from 3 databases, CNKI(China National Knowledge Internet), FMRS(Foreign Medical Literature Retrieval Service, Shenzhen METSTR Technology CO., Led. China), and PubMed, to obtain literature from January 1970 to July 2020. Epithelioid sarcoma, head and neck regions, infratemporal fossa, diagnostic imaging, anatomy, MRI, and CT were used as keywords for advanced retrieval. A study had to be found eligible for inclusion to be closely related to ES and/or ITF. A total of 129 related pieces of literature were retrieved successfully, of which 37 were closely related to this study. The case report in this article is from the Affiliated Hospital of North Sichuan Medical College. The present study was approved by the institutional review board of the Affiliated Hospital of North Sichuan Medical College and a written informed consent for the publication of the case was obtained from the patient. Case Presentation: A 33-year-old man accidentally found a slowly growing, painless mass in the left cheek more than a month ago. On plain computed tomography (CT) scan of the outpatient department, an oval slightly low-density mass with well-defined and uniform boundary in the infratemporal fossa was revealed, and on the contrast-enhanced scan, it was homogeneous and moderately enhanced. Initially, the CT appearance favored benign lesions. However, the possibility of a malignant tumor can not be excluded completely. Finally, the patient was referred to the inpatient department a tumor arose from IF and underwent a selective operation. The tumor was completely removed. Histologic findings were compatible with epithelioid sarcoma. Post-operatively, the patient received 2 cycles of radiotherapy, and there was no evidence of recurrence after 6 months follow-up. Conclusion: The imaging manifestations of ES are various. The anatomic structure of ITF is complex and the pathological types are various. It should be very careful in the qualitative diagnosis of tumors from the ITF, and advanced imaging techniques will be useful in imaging diagnosis.

scholarly journals Autologous Fat Grafting to the Breast: An Educational Review

2021 ◽  
Author(s):  
Nicole S Winkler ◽  
Alexander Tran ◽  
Alvin C Kwok ◽  
Phoebe E Freer ◽  
Laurie L Fajardo
Keyword(s):  
Fat Grafting ◽  
The Body ◽  
Breast Cancer Surgery ◽  
Safe Procedure ◽  
Imaging Features ◽  
Imaging Findings ◽  
Fat Necrosis ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Over Time

Abstract Autologous fat grafting (AFG) is a technique that is increasingly utilized in breast cosmetic and reconstructive surgery. In this procedure, fat is aspirated by liposuction from one area of the body and injected into the breast. The procedure and process of AFG has evolved over the last few decades, leading to more widespread use, though there is no standard method. Autologous fat grafting is generally considered a safe procedure but may result in higher utilization of diagnostic imaging due to development of palpable lumps related to fat necrosis. Imaging findings depend on surgical technique but typically include bilateral, symmetric, retromammary oil cysts and scattered dystrophic and/or coarse calcifications when AFG is used for primary breast augmentation. More focal findings occur when AFG is used to improve specific areas of cosmetic deformity, scarring, or pain following breast cancer surgery. As with any cause of fat necrosis, imaging features tend to appear more benign over time, with development of rim calcifications associated with oil cysts and a shift in echogenicity of oil cyst contents on ultrasound towards anechoic in some cases. This article reviews the AFG procedure, uses, complications, and imaging findings.

Diagnostic yield and safety of percutaneous CT-guided biopsy of retroperitoneal lesions and analysis of imaging features

2021 ◽  
pp. 028418512199028
Author(s):  
Anil Kumar Singh ◽  
Zafar Neyaz ◽  
Ritu Verma ◽  
Anshul Gupta ◽  
Richa Mishra ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Final Diagnosis ◽  
Microbiological Analysis ◽  
Imaging Features ◽  
Imaging Findings ◽  
Chi Square ◽  
Tissue Samples ◽  
Ct Guided ◽  
Guided Biopsy ◽  
Ct Guided Biopsy

Background Computed tomography (CT)-guided biopsy is emerging as a preferred method for obtaining tissue samples from retroperitoneal lesions due to clear visualization of needle and vessels. Purpose To assess diagnostic yield and safety of CT-guided biopsy of retroperitoneal lesions and compare CT findings in different disease categories. Material and Methods This retrospective analytical study included 86 patients with retroperitoneal lesions who underwent CT-guided biopsy from December 2010 to March 2020. All procedures were performed with co-axial technique and multiple cores were obtained and subjected to histopathology. Additional tests like immunohistochemistry or microbiological analysis were done depending on clinical suspicion. Diagnostic yield calculation and comparison of imaging findings was done by one-way ANOVA, chi-square, and Fisher’s exact tests. Results CT-guided biopsy was technically successful in all cases with a diagnostic yield of 91.9%. Minor complications in the form of small hematomas were seen in two patients. Major disease categories on final diagnosis were lymphoma, tuberculosis, and metastases. A variety of malignant and benign soft-tissue neoplasms were also noted less commonly. With help of immunohistochemistry, lymphoma subtype was established in 88.8% of cases. Addition of microbiological tests like the GeneXpert assay helped in the diagnosis of tuberculosis in some cases. A mass-like appearance and vascular encasement was common in metastatic group and lymphoma. Conclusion Percutaneous CT-guided biopsy is a safe method for the sampling of retroperitoneal lesions with high diagnostic yield. Imaging findings are mostly overlapping; however, some features are more common in a particular disease condition.

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