scholarly journals Neglected intrauterine fetal demise for more than two decades leading to the development of a lithopedion: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Fitsum Fikru Gebresenbet ◽  
Abdu Mengesha Mulat ◽  
Namus Muhajir Nur ◽  
Ferehiwot Bekele Getaneh
Keyword(s):  
Vesicovaginal Fistula ◽  
Rare Complication ◽  
Clinical Manifestations ◽  
Clinical History ◽  
The Body ◽  
Obstructed Labor ◽  
Fetal Demise ◽  
Case Presentation ◽  
Intrauterine Fetal Demise ◽  
Long Time

Abstract Background Lithopedion is a word derived from the Greek words lithos, meaning stone, and paidion, meaning child, to describe a fetus that has become stony or petrified. Lithopedion is a rare complication of pregnancy which occurs when a fetus dies and becomes too large to be reabsorbed by the body. This entity in rare circumstances can be challenging for physicians to diagnose since it has a range of clinical manifestations. Case presentation We present a case of a 55-year-old, gravida IV para III, Ethiopian woman from Ethiopia with a retained fetus and vesicovaginal fistula after an obstructed labor and a neglected intrauterine fetal demise of approximately 22 years. The diagnosis was confirmed by suggestive clinical history, physical examination findings, and an abdominopelvic computed tomography scan. Laparotomy and removal of the lithopedion was done and our patient was sent to a fistula hospital for vesicovaginal fistula repair. Conclusion This case is a rare phenomenon in which the dead fetus remained in the uterus for a long time after a neglected obstructed labor and uterine rupture.

scholarly journals Excited delirium syndrome from psychostimulant abuse can mimic a violent scene of death

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shatishraj Jothee ◽  
Mohamed Swarhib Shafie ◽  
Faridah Mohd Nor
Keyword(s):  
Clinical Manifestations ◽  
The Body ◽  
Law Enforcement Agencies ◽  
Manner Of Death ◽  
Case Presentation ◽  
Excited Delirium ◽  
The Common ◽  
Violent Scene ◽  
Naked Body ◽  
Psychostimulant Abuse

Abstract Background Previous reported cases on excited delirium syndrome studied on the common clinical manifestations of the syndrome. The usual forensics implication for the syndrome is that death commonly is associated with restraint procedures by law enforcement agencies; however, not many cases reported highlights the difficulties in attributing a violent scene of death to the syndrome. Case presentation We present a case of a partially naked body found in an apartment unit under suspicious circumstances with multiple injuries. The scene of death was violent, and the body was found with blood wiped all over the floor and walls. Investigators believed a violent crime had occurred, and a suspect was reprimanded. However, upon autopsy, it was found that all injuries were superficially inflicted and were unlikely to have been part of an act of commission or caused his death. Internal examination found no remarkable pathology. Toxicology revealed a presence of psychostimulants, that is, methamphetamine, MDMA, and ethyl alcohol. Reconstruction of events by the witness, who was initially suspected of the ‘murder’, revealed that the injuries and his death could likely be explained by an episode of excited delirium. Conclusion The case highlights the challenges faced when attributing excited delirium syndrome as a cause of death. The syndrome can present with injuries from aggressive or bizarre behaviour, coupled with the destruction of property, which may confuse investigators on the possible manner of death.

CHRONIC ATYPICAL NEUTROPHILIC DERMATOSIS WITH LIPODYSTROPHY AND FEVER (CANDLE SYNDROME) IN PEDIATRIC PRACTICE

2021 ◽  
Vol 100 (2) ◽  
pp. 254-261
Author(s):  
O.G. Sukhovjova ◽  
◽  
I.A. Ivanova ◽  
N.A. Kalugina ◽  
E.S. Zholobova ◽  
...  
Keyword(s):  
Clinical Observation ◽  
Clinical Manifestations ◽  
Maculopapular Rash ◽  
The Body ◽  
Neutrophilic Dermatosis ◽  
Inherited Disease ◽  
Laboratory Activity ◽  
Ubiquitinated Proteins ◽  
Systemic Inflammatory Reaction ◽  
Long Time

The purpose of this publication is to describe the CANDLE syndrome (its etiology, pathogenesis, clinical manifestations) and present a clinical observation. CANDLE syndrome is a rare genetically inherited disease caused by impaired assembly by of the protease, which leads to the accumulation of abnormal (ubiquitinated) proteins in B-lymphocytes, fibroblasts, macrophages and some other cells of the body. As a result, an excessive activation of interferon synthesis occurs and a systemic inflammatory reaction develops with symptoms such as febrile fever, skin syndrome, represented by nodules and maculopapular rash, hepatosplenomegaly, lipodystrophy, amyotrophy, delayed physical development, as well as high laboratory activity. The article describes a clinical observation of a female patient with typical symptoms of CANDLE syndrome. However, due to the rarity of the disease and lack of publications describing it, it has not been possible to diagnose the child for a long time.

scholarly journals A Solitary Giant Neurofibroma of Inguinal Region—A Case Report

2020 ◽  
Author(s):  
Haiying Zhou ◽  
Hui Lu
Keyword(s):  
Tumor Resection ◽  
Clinical Manifestations ◽  
Inguinal Region ◽  
Case Presentation ◽  
Neurogenic Tumors ◽  
Long Time ◽  
Giant Neurofibroma ◽  
History Of ◽  
Recurrence Tendency

Abstract Background:Neurofibroma is a rare nerve sheath tumorofneuroectodermal origin, especially the huge and isolated neurofibroma located in the inguinal region. To our knowledge, no such case has previously been reported.Case presentation:We report a case of 34-year-old male patient with a 4-year history of progressive enlargement of the medial root mass in his left thigh with sitting and standing disorders along with pain. The tumor was completely removed by operation, and pathological diagnosisshowed neurofibroma. There was no obvious neurologic defect after surgery, and no recurrence tendency was found in the follow-up of 2years.Conclusions:For a large solitary mass with slow growth and no malignant clinical manifestations for a long time, clinicians can not rule out the hypothetical diagnosis of neurofibroma, even though its growth site is very rare, such as this case of a huge tumor located in the groin. For neurogenic tumors, early operation should be performed, and the prognosis of patients after tumor resection isexcellent.

scholarly journals Correction of micronutrient deficiencies is one of the priority directions in the practical work of a pediatrician

2019 ◽  
pp. 24-35
Author(s):  
I. N. Zakharova ◽  
Т. M. Tvorogova
Keyword(s):  
Clinical Manifestations ◽  
Physiological Role ◽  
Total Content ◽  
Functional Condition ◽  
Negative Influence ◽  
The Body ◽  
Water Soluble ◽  
Micronutrient Deficiencies ◽  
Long Time ◽  
Group B

Micronutrients (vitamins, minerals, micronutrients) are essential for the normal functioning of the body. The problem of vitamin deficiency leads to the risk of alimentary-dependent diseases. The reasons of inadequate provision with vitamins and minerals are given: unbalanced irrational nutrition, the quality of the products themselves, the nutritional value of which is significantly reduced with the use of modern production technologies. It is noted that the biological availability, i.e. the degree of absorption of vitamins from different products, varies widely from 5 to 80% of their total content in the product. In order to concretize the diverse physiological role of micronutrients as an important component of various enzyme systems and metabolic catalysts, the authors summarize the literature reflecting the importance of vitamins of group B, ascorbic acid, retinol, vitamin D and their functional correlations, as well as the need for a balanced and harmonious approach to their dosing. The problem of negative influence of deficiency of microelements on the structural and functional condition of various organs and systems, on morbidity, linear growth, development of various skills and psycho-emotional sphere of the child is covered. Attention is paid to the danger of micronutrient deficiency, which often remains unrecognized for a long time, because its clinical manifestations are not specific and can be observed in various diseases. However, the excess of individual micronutrients also disrupts the physiological and biochemical processes in the body. The vitamin requirements of healthy infants correspond to the amount of vitamins consumed daily with the mother’s milk: From 4-6 months of age, the provision of vitamins to the child is significantly affected by the introduction of complementary foods, for children from 1.5 to 3 years of age, the daily dose of vitamins and minerals in the VMC should not exceed 50% of the daily physiological needs, and for children over 3 years of age should not exceed 100% of the daily physiological needs for vitamins A, D and micronutrients (selenium, zinc, iodine, copper, iron), and 200% for water-soluble vitamins. An example of balanced and complete composition of vitamin complexes Multi-Tabs is given.

scholarly journals Pituitary apoplexy accompanying temporal lobe epilepsy as a complication: case report

2019 ◽  
Author(s):  
Katsunori Shijo ◽  
Sodai Yoshimura ◽  
Fumi Mori ◽  
Shun Yamamuro ◽  
Koichiro Sumi ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pituitary Apoplexy ◽  
Rare Complication ◽  
Cranial Nerves ◽  
Clinical Manifestations ◽  
Clinical Syndrome ◽  
Healthy Male ◽  
Case Presentation

Abstract Background : Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However, temporal lobe epileptic seizure has not been viewed as a symptom of pituitary apoplexy in the literature. Case presentation : To elucidate further such a rare complication of temporal lobe epilepsy-like seizure, we describe here the rare clinical manifestations of a 55-year-old previously healthy male with pituitary apoplexy harboring headache, combined palsies involving cranial nerves III to VI, endocrinologic disturbances, and temporal lobe epilepsy-like seizure. In addition, we discuss the temporal lobe epilepsy associated with pituitary adenoma based on the literature. Conclusion : Although further accumulation of clinical data is needed, we would like to emphasize the importance of recognition of temporal lobe epilepsy-like seizure due to pituitary apoplexy, and to suggest that early surgery should be considered as an option in patients displaying such a rare complication.

scholarly journals Dermoid cyst of ovary misdiagnosed as intrauterine fetal demise: a case report

2012 ◽  
Vol 1 (2) ◽  
pp. 82-83
Author(s):  
Shanti Subedi Varsha ◽  
Anju Deo ◽  
Anjana Sharma ◽  
Sita Ghimire
Keyword(s):  
Case Report ◽  
Dermoid Cyst ◽  
Uterine Rupture ◽  
Rare Complication ◽  
Fetal Demise ◽  
Medical College ◽  
Intrauterine Fetal Demise ◽  
Chemical Peritonitis ◽  
Period Of Gestation

Thirty two years multipara with amenorrhoea of five months presented with bleeding per vagina for ten days. Clinically and radiologically she was diagnosed with intrauterine fetal demise at 20 weeks period of gestation. She was induced with prostaglandins continuously for seven days. On eighth day of admission features of uterine rupture was present. On laparotomy ruptured huge dermoid cyst with chemical peritonitis was discovered. There was no evidence of pregnancy. We are reporting this case for a rare complication of ruptured dermoid cyst and also to illustrate the importance of clinical assessment.DOI: http://dx.doi.org/10.3126/jonmc.v1i2.7305 Journal of Nobel Medical College (2012), Vol.1 No.2 p.82-83

scholarly journals A case of needle embolism in a drug abuser, a diagnostic and therapeutic challenge

2020 ◽  
Vol 28 (1) ◽  
Author(s):  
Valentina Scheggi ◽  
Tiziano Mariani ◽  
Carlotta Mazzoni ◽  
Pier Luigi Stefàno
Keyword(s):  
Rare Complication ◽  
Clinical Manifestations ◽  
Shortness Of Breath ◽  
Recurrent Pericarditis ◽  
Peripheral Vessel ◽  
Ct Guided ◽  
Case Presentation ◽  
Cardiac Perforation ◽  
Surgical Extraction ◽  
Mini Thoracotomy

Abstract Background Needle embolism is a rare complication of intravenous habit. Clinical manifestations include recurrent pericarditis, tamponade, cardiac perforation, and infective endocarditis. We describe the case of needle embolization in a young intravenous opiate abuser. Case presentation We describe a rare complication of intravenous misuse in a 23-year-old patient. He presented at the emergency department with chest pain and shortness of breath. He complained of remittent fever ensued 6 months before. Echocardiographic and radiologic images revealed pericardial effusion and a needle fragment inside the pericardium. The needle was removed through left-anterior mini-thoracotomy, after CT-guided carbon tracking. Conclusions The presence of a foreign body within the heart resulted from the migration of a needle fragment from a peripheral vessel. It caused fever and recurrent pericarditis. In similar cases, surgical extraction is the therapy of choice.

scholarly journals Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case?

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2545
Author(s):  
Pavel Babal ◽  
Lucia Krivosikova ◽  
Lucia Sarvaicova ◽  
Ivan Deckov ◽  
Tomas Szemes ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Rare Complication ◽  
Placental Tissue ◽  
Receptor Protein ◽  
Fetal Demise ◽  
Intrauterine Fetal Demise ◽  
Virus Rna ◽  
Cd147 Expression ◽  
Fetal Movements

Background: SARS-CoV-2 infection in pregnant women can lead to placental damage and transplacental infection transfer, and intrauterine fetal demise is an unpredictable event. Case study: A 32-year-old patient in her 38th week of pregnancy reported loss of fetal movements. She overcame mild COVID-19 with positive PCR test 22 days before. A histology of the placenta showed deposition of intervillous fibrinoid, lympho-histiocytic infiltration, scant neutrophils, clumping of villi, and extant infarctions. Immunohistochemistry identified focal SARS-CoV-2 nucleocapsid and spike protein in the syncytiotrophoblast and isolated in situ hybridization of the virus’ RNA. Low ACE2 and TMPRSS2 contrasted with strong basigin/CD147 and PDL-1 positivity in the trophoblast. An autopsy of the fetus showed no morphological abnormalities except for lung interstitial infiltrate, with prevalent CD8-positive T-lymphocytes and B-lymphocytes. Immunohistochemistry and in situ hybridization proved the presence of countless dispersed SARS-CoV-2-infected epithelial and endothelial cells in the lung tissue. The potential virus-receptor protein ACE2, TMPRSS2, and CD147 expression was too low to be detected. Conclusion: Over three weeks’ persistence of trophoblast viral infection lead to extensive intervillous fibrinoid depositions and placental infarctions. High CD147 expression might serve as the dominant receptor for the virus, and PDL-1 could limit maternal immunity in placental tissue virus clearance. The presented case indicates that the SARS-CoV-2 infection-induced changes in the placenta lead to ischemia and consecutive demise of the fetus. The infection of the fetus was without significant impact on its death. This rare complication of pregnancy can appear independently to the severity of COVID-19’s clinical course in the pregnant mother.

Pituitary apoplexy accompanying temporal lobe epilepsy as a complication: case report

2019 ◽  
Author(s):  
Katsunori Shijo ◽  
Sodai Yoshimura ◽  
Fumi Mori ◽  
Shun Yamamuro ◽  
Koichiro Sumi ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pituitary Apoplexy ◽  
Rare Complication ◽  
Cranial Nerves ◽  
Clinical Manifestations ◽  
Clinical Syndrome ◽  
Healthy Male ◽  
Case Presentation

Abstract Abstract Background: Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However, temporal lobe epileptic seizure has not been viewed as a symptom of pituitary apoplexy in the literature. Case presentation: To elucidate further such a rare complication of temporal lobe epilepsy, we describe here the rare clinical manifestations of a 55-year-old previously healthy male with pituitary apoplexy harboring headache, combined palsies involving cranial nerves III to VI, endocrinologic disturbances, and temporal lobe epilepsy. In addition, we discuss the temporal lobe epilepsy of pituitary adenoma based on the literature. Conclusion: Although further accumulation of clinical data is needed, we would like to emphasize the importance of recognition of temporal lobe epilepsy due to pituitary apoplexy, and suggest that early surgery should be considered as an option in patients with such a rare complication.

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

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