Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice

Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which possesses antitumor, antioxidant, anti-virus, hypoglycemic, and hypolipidemic activities. In this review, the current advancements on extraction, purification, structural characteristics, and biological activities of IOPS were summarized. This review can provide significant insight into the IOPS bioactivities as their in vitro and in vivo data were summarized, and some possible mechanisms were listed. Furthermore, applications of IOPS were reviewed and discussed; IOPS might be a potential candidate for the treatment of cancers and type 2 diabetes. Besides, new perspectives for the future work of IOPS were also proposed.

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Gut microbiota in chronic pancreatitis patients are characterized by significant dysbiosis and overgrowth by opportunistic pathogens

Pancreatology ◽

10.1016/j.pan.2020.07.148 ◽

2020 ◽

Vol 20 ◽

pp. S90-S91

Author(s):

F. Frost ◽

F. Weiss ◽

M. Sendler ◽

T. Kacprowski ◽

M. Rühlemann ◽

...

Keyword(s):

Chronic Pancreatitis ◽

Gut Microbiota ◽

Opportunistic Pathogens

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Disordered Gut Microbiota in Children Who Have Chronic Pancreatitis and Different Functional Gene Mutations

Clinical and Translational Gastroenterology ◽

10.14309/ctg.0000000000000150 ◽

2020 ◽

Vol 11 (3) ◽

pp. e00150

Author(s):

Wei Wang ◽

Yuan Xiao ◽

Xinqiong Wang ◽

Yiran Zhou ◽

Ting Wang ◽

...

Keyword(s):

Chronic Pancreatitis ◽

Gut Microbiota ◽

Gene Mutations ◽

Functional Gene

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Altered Gut Microbiota in Patients With Chronic Pancreatitis is Associated With Gut Barrier Dysfunction and Metabolic Abnormalities

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2016.09.023 ◽

2017 ◽

Vol 15 (1) ◽

pp. 153

Author(s):

Rupjyoti Talukdar ◽

S.M. Jandhyala ◽

R. Reddy ◽

M. Arutla ◽

D.N. Reddy

Keyword(s):

Chronic Pancreatitis ◽

Gut Microbiota ◽

Metabolic Abnormalities ◽

Barrier Dysfunction ◽

Gut Barrier

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Effects of selenizing modification on characteristics and antioxidant activities of Inonotus obliquus polysaccharide

Macromolecular Research ◽

10.1007/s13233-017-5030-z ◽

2017 ◽

Vol 25 (3) ◽

pp. 222-230 ◽

Cited By ~ 4

Author(s):

Yang Hu ◽

Shanyi Shi ◽

Lu Lu ◽

Chunying Teng ◽

Sumei Yu ◽

...

Keyword(s):

Antioxidant Activities ◽

Inonotus Obliquus ◽

Inonotus Obliquus Polysaccharide

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Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis

PLoS ONE ◽

10.1371/journal.pone.0259570 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0259570

Author(s):

Binhong Hu ◽

Yuqing Dong ◽

Wenjing Zhou ◽

Yichuan Ma ◽

Luyao Li ◽

...

Keyword(s):

16S Rrna ◽

High Throughput Sequencing ◽

Biological Activities ◽

Intestinal Flora ◽

Inonotus Obliquus ◽

Medicinal Fungus ◽

Tnf Α ◽

Wide Range ◽

Inonotus Obliquus Polysaccharide ◽

Factor Α

Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation. The purpose of this study is to investigate whether IOP can help to reduce acute endometritis by regulating intestinal flora. We observed pathological changes in mice with endometritis following treatment with IOP and evaluated changes in the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), and further studied the effects of IOP on the intestinal flora of endometritis mice using 16S rRNA high-throughput sequencing. The results showed that IOP improved the condition of uterine tissues and reduced the release of pro-inflammatory cytokines. Meanwhile, the 16S rRNA sequencing results showed that IOP could regulate the changes in intestinal microflora at the level of genera, possibly by changing the relative abundance of some genera.

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Lipid-Lowering Effects of Inonotus obliquus Polysaccharide In Vivo and In Vitro

Foods ◽

10.3390/foods10123085 ◽

2021 ◽

Vol 10 (12) ◽

pp. 3085

Author(s):

Mo Yang ◽

Dong Hu ◽

Zhengying Cui ◽

Hongxuan Li ◽

Chaoxin Man ◽

...

Keyword(s):

Oleic Acid ◽

High Fat Diet ◽

Cell Model ◽

Lipid Lowering ◽

Mice Model ◽

High Fat ◽

Inonotus Obliquus ◽

Inonotus Obliquus Polysaccharide

Excessive lipid intake will cause hyperlipidemia, fatty liver metabolism disease, and endanger people’s health. Edible fungus polysaccharide is a natural active substance for lipid lowering. In this study, the HepG2 cell model induced by oleic acid and mice model induced by a high-fat diet was established. The lipid-lowering effects of Inonotus obliquus polysaccharide (IOP) was investigated in vivo and in vitro. Glucose (251.33 mg/g), rhamnose (11.53 mg/g), ribose (5.10 mg/g), glucuronic acid (6.30 mg/g), and galacturonic acid (2.95 mg/g) are present in IOP, at a ratio of 85.2:3.91:1.73:2.14:1. The molecular weight of IOP is 42.28 kDa. Treatment with 60 mg/L of IOP showed a significant lipid-lowering effect in HepG2 cells compared with the oleic acid-treated group. In the oil red O-stained images, the red fat droplets in the IOP-treated groups were significantly reduced. TC and TG levels of IOP-treated groups decreased. IOP can alleviate the lipid deposition in the mice liver due to high-fat diet, and significantly reduce their serum TC, TG, and LDL-C contents. IOP could activate AMPK but decrease the SREBP-1C, FAS, and ACC protein expression related to adipose synthesis in mice. IOP has a certain potential for lipid-lowering effects both in vivo and in vitro.

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