scholarly journals A meta-analysis of the therapeutic effect of intranasal salmon calcitonin on osteoporosis

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Ning Li ◽  
Yi Chen Gong ◽  
Jianer Chen
Keyword(s):  
Alkaline Phosphatase ◽  
Salmon Calcitonin ◽  
Meta Analysis ◽  
Lumbar Vertebrae ◽  
Total Sample ◽  
Mineral Density ◽  
Blood Calcium ◽  
Treatment Of Osteoporosis ◽  
Chinese And English ◽  
Better Than

Abstract Objective To evaluate the efficacy and safety of intranasal salmon calcitonin in the treatment of osteoporosis. Methods Eight Chinese and English databases were searched by electronic search (from the establishment of the database to October 2019). The literature was screened according to the inclusion criteria and exclusion criteria, the quality was evaluated according to Cochrane software, and the Review Manager 5.2 software was used for statistical analysis. Results A total of 374 documents were retrieved and 12 (12 original studies) were included after the screening, with a total sample capacity of 1068 cases. Meta-analysis showed that the intranasal salmon calcitonin had obvious advantages in reducing blood calcium, improving the ratio of serum creatinine and alkaline phosphatase. In addition, the intranasal salmon calcitonin had no obvious advantages in other indicators. It cannot be illustrated that the combination of intranasal salmon calcitonin and other conventional drugs is more effective than the simple use of conventional drugs. Conclusion The intranasal salmon calcitonin is superior to conventional drugs in reducing blood calcium, increasing creatinine ratio, and alkaline phosphatase, but its advantages in other indicators such as improving the bone mineral density (BMD) of lumbar vertebrae and hip have not been confirmed, and it is not clear that the combination of intranasal salmon calcitonin and other conventional drugs is better than the simple conventional drugs.

scholarly journals A Meta-analysis of the Therapeutic Effect of Intranasal Salmon Calcitonin on Osteoporosis

2021 ◽  
Author(s):  
Ning Li ◽  
Yi Chen Gong
Keyword(s):  
Alkaline Phosphatase ◽  
Salmon Calcitonin ◽  
Meta Analysis ◽  
Lumbar Vertebrae ◽  
Total Sample ◽  
Blood Calcium ◽  
Treatment Of Osteoporosis ◽  
Chinese And English ◽  
Review Manager ◽  
Better Than

Abstract Objective: To evaluate the efficacy and safety of intranasal salmon calcitonin in the treatment of osteoporosis.Methods: eight Chinese and English databases were searched by electronic search (from the establishment of the database to October 2019). The literature was screened according to the inclusion criteria and exclusion criteria, the quality was evaluated according to Cochrane software, and the Review Manager 5.2 software was used for statistical analysis. Results: a total of 374 documents were retrieved and 12 (12 original studies) were included after the screening, with a total sample capacity of 1068 cases. Meta-analysis showed that the intranasal salmon calcitonin had obvious advantages in reducing blood calcium, improving the ratio of serum creatinine and alkaline phosphatase. In addition, The intranasal, salmon calcitonin had no obvious advantages in other indicators, It can't be illustrated that the combination of BCS and other conventional drugs is more effective than the simple use of conventional drugs. Conclusion: The intranasal salmon calcitonin is superior to conventional drugs in reducing blood calcium, increasing creatinine ratio, and alkaline phosphatase, but its advantages in other indicators such as improving the bone density of lumbar vertebrae and hip have not been confirmed, and it is not clear that the combination of intranasal salmon calcitonin and other conventional drugs is better than the simple conventional drugs.

scholarly journals Association between calcium supplementation and bone mineral density in children: a systematic review and meta-analysis

2021 ◽  
Vol 8 (2) ◽  
pp. 169-176
Author(s):  
Jin-Ping Gao ◽  
Hong-Xia Ren ◽  
Yan-Fei Wang ◽  
Shi-Fan Han ◽  
Chang-Tai Zhu
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Randomized Clinical Trials ◽  
Calcium Supplementation ◽  
Meta Analysis ◽  
Lumbar Vertebrae ◽  
Whole Body ◽  
Cochrane Library ◽  
Mineral Density ◽  
Standard Mean Difference

Abstract Objective To evaluate the effects of calcium supplementation on bone mineral density in children. Methods The PubMed, Embase, and Cochrane library were systematically searched. The retrieve inception date was between October 2001 and October 2019. Two reviewers independently performed the data extraction and assessed methodology quality. Studies were limited to randomized clinical trials comparing calcium supplement with a placebo for bone mineral density in children. A meta-analysis was performed to calculate standard mean difference (SMD) and 95% confidence interval (CI). Results A total of 6 randomized controlled trials involving 408 participants (calcium supplementation group: 198; placebo group: 210) were finally included in this study. The meta-analysis revealed that, compared with placebos, calcium supplementation had no effect on the bone mineral densities [the whole-body: SMD with CI = 0.43 (−0.05–0.91), P=0.08, I 2 = 75%; the 2nd–4th lumbar vertebrae: SMD with 95% CI = 0.27 (−0.17 to 0.70), P = 0.07, I 2 = 0%)]. Sensitivity analysis revealed that the results of the whole-body bone mineral density were unstable and that the bone density of the 2nd–4th lumbar spine was robust. Conclusions The results of this meta-analysis suggested that calcium supplementation did not improve bone mineral density in children. However, there continues to be a need for more high-quality studies to verify this fact in the future.

scholarly journals A Meta-analysis of the Effect of the Sandwich Teaching Model on the Learning Outcomes of Nursing Students

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Yanqiu Hao ◽  
Xiangshu Cui
Keyword(s):  
Nursing Students ◽  
Learning Outcomes ◽  
Quality Evaluation ◽  
Teaching Method ◽  
Meta Analysis ◽  
Operational Performance ◽  
Teaching Model ◽  
Traditional Teaching ◽  
Chinese And English ◽  
Better Than

Objective: To evaluate the effect of the sandwich teaching model on the learning effect of nursing students. Methods: The Chinese and English databases of CNKI, WanFang, Vip, superstar, and PubMed were searched by computer, and the data were analyzed by Rev Man 5.3 software after literature quality evaluation. Results: Meta-analysis showed that the theoretical and operational performance of the nursing students in the sandwich teaching method was better than that of the traditional teaching group. Conclusion: The sandwich approach was superior to the traditional teaching method in the learning outcomes of nursing students.

scholarly journals Promotion of Bone Formation by Red Yeast Rice in Experimental Animals: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Bin Wu ◽  
Jie-Feng Huang ◽  
Bang-Jian He ◽  
Chen-Wei Huang ◽  
Jian-Hua Lu
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Red Yeast Rice ◽  
Osteoblast Proliferation ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Experimental Animals ◽  
Red Yeast

Objective. To systematically evaluate the effects of red yeast rice (RYR) and its extract on bone formation in experimental animals and to provide reference data for clinical research on the treatment of osteoporosis. Methods. Chinese and English language databases, including Web of Science, PubMed, the Cochrane Library, Elsevier, Google Scholar, SpringerLink, Embase, China National Knowledge Infrastructure (CNKI), Weipu Chinese Sci-tech periodical full-text database (VIP), and Wanfang Data Knowledge Service Platform (Wanfang), were searched from their establishment to February 2020 using the following terms: “hongqu,” “red yeast rice,” “Monascus purpureus-fermented rice,” “bone mineral density,” “osteoblast,” “osteoporosis,” and “animal models.” After excluding nonrelevant articles, Review Manager 5.2 was used to evaluate article quality and to analyze the data. Outcome indicators included bone mineral density (BMD), osteoblast proliferation, and the expression of alkaline phosphatase (ALP). Results. A total of 11 randomized controlled trials were included in the meta-analysis, all of which were animal studies. Six studies included data on BMD, five on osteoblast proliferation, and six on the expression of ALP. The results of the meta-analysis showed that RYR can significantly improve BMD (standardized mean difference SMD=3.12, 95% confidence interval (CI) 1.41 to 4.83, P=0.0003), promote osteoblast proliferation (SMD=1.64, 95% CI 1.04 to 2.23, P<0.00001), and increase ALP expression in rats (SMD=1.25, 95% CI 0.69 to 1.80, P<0.00001). Conclusions. RYR can promote bone formation in experimental animals and may be useful for the treatment of osteoporosis.

scholarly journals Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qiangqiang Li ◽  
Guangpu Yang ◽  
Hongtao Xu ◽  
Shaowen Tang ◽  
Wayne Yuk-wai Lee
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Randomized Controlled Trials ◽  
Bone Mineral ◽  
Bone Markers ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Bone Biomarkers ◽  
Mineral Density ◽  
Randomized Controlled

Abstract Background The results from clinical trials have revealed that the effects of resveratrol supplementation on bone mineral density (BMD) and bone biomarkers are inconsistent. Our objective was to determine the effects of resveratrol supplementation on BMD and serum bone biomarkers. Methods PubMed, Cochrane library, EMBASE, Web of science and Scopus were searched up to August 24, 2020. Two reviewers independently performed the articles search and screen according to defined selection criteria. The study quality of the randomized controlled trials (RCTs) was evaluated with the Cochrane scoring system. Heterogeneity among studies was examined by Cochrane Q test. Retrieved data were pooled after mean differences (MD) were computed between two groups for BMD and serum biomarkers. Subgroup analyses were performed to evaluate a potential difference in terms of dose of resveratrol and intervention duration. Sensitivity analysis was executed by omitting studies with imputed values in order to evaluate the influence of these studies on the overall results. Results Ten eligible studies involving 698 subjects were included in this meta-analysis with 401 participants receiving resveratrol and 297 receiving placebo. Supplementation of resveratrol had no statistically significant effects on areal bone mineral density (aBMD) at lumbar spine (MD: -0.02, 95% CI: − 0.05, 0.01, p = 0.26, I2 = 6%), total hip BMD (MD: -0.01, 95% CI: − 0.04, 0.02, p = 0.65, I2 = 0%), and whole body BMD (MD: 0.00, 95% CI: − 0.02, 0.02, p = 0.74, I2 = 0%). Supplementation of resveratrol also did not result in significant change in bone serum markers, including serum alkaline phosphatase (ALP), bone alkaline phosphatase (BAP), osteocalcin (OCN), procollagen I N-terminal propeptide (PINP), C-terminal telopeptide of type I collagen (CTX) and parathyroid hormone (PTH). Subgroup analysis showed the effect of resveratrol supplementation on BMD and serum bone markers were similar in trails of different doses, intervention duration, and pathological conditions of the participants. Conclusion Resveratrol supplementation did not show any significant effect on BMD or serum bone markers with the current evidence. Further investigation with more well-organized multicentre randomized trial is warranted.

The Effectiveness of Acupuncture for Osteoporosis: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 46 (03) ◽  
pp. 489-513 ◽  
Author(s):  
Hong Pan ◽  
Rongjiang Jin ◽  
Mengxiao Li ◽  
Zhihong Liu ◽  
Qing Xie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alkaline Phosphatase ◽  
Serum Calcium ◽  
Western Medicine ◽  
Serum Alkaline Phosphatase ◽  
Meta Analysis ◽  
Mineral Density ◽  
Bias Risk ◽  
Relieve Pain

To summarize the existing evidence and evaluate the efficacy of acupuncture as a clinical treatment for osteoporosis. Six English and four Chinese databases were searched from their inception to April 2017. Randomized controlled trials were included, in which warm acupuncture, needling or electroacupuncture were compared with sole Western medicine with osteoporosis. All the data were assessed and extracted by two authors independently. The bias risk assessment recommended by the Cochrane Collaboration’s tool was used to assess the quality of the selected studies. This meta-analysis was conducted by using RevMan 5.3. Pooled analyses were calculated by standardized mean difference (SMD) and 95% confidence interval (CI). Heterogeneity was assessed by I2 test. Thirty-five studies involving 3014 patients were located. Meta-analysis showed that warm acupuncture could increase the bone mineral density of lumar (SMD [Formula: see text] 0.93, 95% CI [Formula: see text] 0.65, 1.21, [Formula: see text][Formula: see text]0.00001) and femur (MD[Formula: see text][Formula: see text][Formula: see text]0.11, 95% CI[Formula: see text][Formula: see text][Formula: see text]0.05, 0.16, P[Formula: see text][Formula: see text][Formula: see text]0.0002), the level of serum calcium (MD[Formula: see text][Formula: see text][Formula: see text]0.18, 95% CI[Formula: see text][Formula: see text][Formula: see text]0.13, 0.24, [Formula: see text][Formula: see text]0.00001) and estradiol (SMD[Formula: see text][Formula: see text][Formula: see text]0.65, 95% CI[Formula: see text][Formula: see text][Formula: see text]0.32, 0.98, P[Formula: see text][Formula: see text][Formula: see text]0.0001), relieve pain (MD[Formula: see text][Formula: see text][Formula: see text]–1.64, 95% CI[Formula: see text][Formula: see text][Formula: see text]–2.69, –0.59, P[Formula: see text][Formula: see text][Formula: see text]0.002), decrease the level of serum alkaline phosphatase (MD[Formula: see text][Formula: see text][Formula: see text]–7.8, 95% CI[Formula: see text][Formula: see text][Formula: see text]–14.17, –0.84, P [Formula: see text] 0.03) compared with sole Western medicine. Electroacupuncture could relieve pain (MD[Formula: see text][Formula: see text] –1.32, 95% CI[Formula: see text][Formula: see text][Formula: see text]–2.15, –0.48, P[Formula: see text][Formula: see text][Formula: see text]0.002), increase the level of serum calcium (MD[Formula: see text][Formula: see text][Formula: see text]–0.12, 95% CI [Formula: see text] –0.16,-0.09, [Formula: see text][Formula: see text]0.00001) and decrease the level of serum alkaline phosphatase (MD [Formula: see text] –3.63, 95% CI [Formula: see text] –6.60, –0.66, P [Formula: see text] 0.02) compared with sole Western medicine. Needling could relieve pain (MD [Formula: see text] –2.27, 95% CI [Formula: see text] –3.11, –1.43, [Formula: see text][Formula: see text]0.00001) compared with sole Western medicine. This present systematic review indicated that acupuncture could be an effective therapy for treating osteoporosis. Warm acupuncture seemed to more effective than electroacupuncture and needling for osteoporosis in comparison to sole Western medicine.

Is Romosozumab better than Teriparatide for the treatment of osteoporosis? A meta-analysis through a grade analysis of evidence

2019 ◽  
Author(s):  
Zhao-hui Liu ◽  
Jian-xiong Ma ◽  
Xiao-lei Sun ◽  
Shun Zhang ◽  
Ming-jie Kuang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Injection Site Reaction ◽  
Treatment Method ◽  
Cochrane Library ◽  
Ageing Population ◽  
Serious Adverse Events ◽  
Treatment Of Osteoporosis ◽  
Skeletal Disease ◽  
Socioeconomic Effect ◽  
Better Than

Abstract Background Osteoporosis is a common systemic skeletal disease. With an ageing population, the socioeconomic effect of osteoporosis will remarkably improve. Romosozumab (EVENITYTM) is a new osteoanabolic drug, which is a humanised monoclonal antibody against sclerostin, and received its first global approval for the treatment of osteoporosis in patients at high risk of fracture in Japan on January 8, 2019. Teriparatide is the first osteoanabolic drug. However, there is no comprehensive analysis and systematic review about the efficacy and safety of the two treatment. Method Randomized controlled trials (RCTs) about our analysis were searched from electronic database, including Pubmed (1996 to June 2019), Embase (1980 to June 2019), Cochrane Library (CENTRAL, June 2019), Web of Science (1998 to June 2019) and others. Four studies were included in our meta-analysis. Results Four studies containing 1304 patients meet our selection criteria. Our result of analysis indicated that Romosozumab showed better effects in improving BMD of lumbar spine (month 6: MD=3.54, 95% CI [3.13, 3.94], P<0.00001; month 12: MD=4.93, 95% CI [4.21, 5.64], P<0.00001), total hip (month 6: MD=2.27, 95% CI [0.62, 3.91], P=0.007; month 12: MD=3.17, 95% CI [2.68, 3.65], P<0.00001) and femoral neck (month 6: MD=2.30, 95% CI [0.51, 4.08], P=0.01; month 12: MD=3.04, 95% CI [2.29, 3.78], P<0.00001). And the injection-site reaction was fewer (month 12: RR=2.84, 95% CI [1.22, 6.59], P=0.02).But there were no significant differences in the incidence of serious adverse events (month 12: RR=0.78, 95% CI [0.46, 1.33], P=0.37), and death (month 12: RR=0.61, 95% CI [0.08, 4.62], P=0.63). Conclusion Based on the available studies, our current results demonstrated that Romosozumab was better than Teriparatide both in terms of efficacy and side effects.

17p-estradiol (1 mg daily) in continuous combination with dydrogesterone (5.10 or 20 mg daily) increases bone mineral density in postmenopausal women

2021 ◽  
Vol 50 (4) ◽  
pp. 67-71
Author(s):  
J. С. Stevenson ◽  
P. Teter ◽  
В. Lees
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Randomized Study ◽  
Lumbar Vertebrae ◽  
Mineral Density ◽  
Double Blind ◽  
Treatment Of Osteoporosis ◽  
Hip Bmd

Although the minimal dose of 17/3-estradiol in hormone replacement regimens was originally considered to be 2 mg a day, it is now increasingly accepted that a lower dose of 1 mg a day is effective in protecting women from the detrimental effects of the menopause. A 1-year, multicentre, double-blind, randomized study was conducted in 214 healthy postmenopausal women in order to assess the effect of 17(3-estradiol (1 mg a day) continuously combined with dydrogesterone (5,10 or 20 mg/day) in preventing bone loss. Bone mineral density (BMD) was evaluable in 177 women who completed the study. In all women, a statistically significant increase from baseline in lumbar vertebrae (L.2~L4) BMD was seen after 6 months (+ 2,4%; p0,01); this increase was somewhat greater after 12 months (+ 3,6%;p 0,01). Similar effects were seen in the hip. After 6 months, BMD in the femoral neck, Wards triangle and trochanter had increased by 0,20% (not significant [n.s.]), 0,32% (n.s.)and 1,08% (p0,01), respectively, compared with baseline. Greater increases were again seen after 12 months (+1,16%, + 1,62% and +2,83%, respectively), all of which were statistically significant (p0,01) compared with baseline. The change in BMD from baseline did not diff er significantly between the three dydrogesterone dosages for either L.2~L4 or hip. All dosages were well tolerated and amenorrhoea was achieved in over 70%. In conclusion, 17(3-estradiol (1 mg/day) continuously combined with dydrogesterone (5, 10 or 20 mg/day) results in a significant increase in lumbar vertebrae and hip BMD in postmenopausal women. The lower dose of oestrogen and the avoidance of cyclical bleeding make this a particularly suitable regimen for the prevention and treatment of osteoporosis in older women.

The Validity of Specific Cognitive Abilities for the Prediction of Training Success in Germany

2014 ◽  
Vol 13 (3) ◽  
pp. 123-133 ◽  
Author(s):  
Wiebke Goertz ◽  
Ute R. Hülsheger ◽  
Günter W. Maier
Keyword(s):  
Cognitive Abilities ◽  
Personnel Selection ◽  
Meta Analysis ◽  
Mental Ability ◽  
Occupational Category ◽  
General Mental Ability ◽  
Training Success ◽  
Specific Cognitive Abilities ◽  
Better Than

General mental ability (GMA) has long been considered one of the best predictors of training success and considerably better than specific cognitive abilities (SCAs). Recently, however, researchers have provided evidence that SCAs may be of similar importance for training success, a finding supporting personnel selection based on job-related requirements. The present meta-analysis therefore seeks to assess validities of SCAs for training success in various occupations in a sample of German primary studies. Our meta-analysis (k = 72) revealed operational validities between ρ = .18 and ρ = .26 for different SCAs. Furthermore, results varied by occupational category, supporting a job-specific benefit of SCAs.

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