Effect of Tango on Motor Symptoms in Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis

Objective: In this study, we systematically reviewed the efficacy of tango in alleviating the motor symptoms of patients with Parkinson's disease (PD).Methods: We searched internet databases, such as PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science Core collection, and CNKI, for studies examining the effects of tango on the motor symptoms of patients with Parkinson's disease, published from September 2021 to date. All types of tango intervention, including traditional tango, Argentinian tango, and adapted tango, were examined in our review. The Cochrane bias risk assessment tool was used to evaluate the quality of methodologies used in the included studies. RevMan 5.4 software was used for meta-analysis.Result: Eleven studies that included 390 Parkinson's patients met our inclusion criteria. Meta-analysis indicated that after tango, PD patients showed a considerable decrease in the overall severity of motor symptoms and improvement in balance, functional mobility, fast gait velocity, preferred gait velocity, stride length, and gait cadence. Compared with exercise, tango showed stronger effects on balance and functional mobility; however, no significant differences in the severity of motor symptoms, fast gait velocity, or preferred gait velocity were observed between the group treated using tango and that treated using exercise.Conclusion: Interventions using tango may help alleviate the severity of motor symptoms, and specifically promote balance and functional mobility, in patients with Parkinson's disease. However, except for improving balance and functional mobility, tango showed no significant advantages over exercise in alleviation of motor symptoms in patients with Parkinson's disease.

State-of-Art in the Age Determination of Venous Thromboembolism: A Systematic Review

Venous thromboembolism (VTE), consisting of deep vein thrombosis (DVT) and pulmonary embolism (PE), requires a forensic age determination to ascertain their causal relationship with recent events, such as trauma or medical treatment. The main objective of this systematic review is to identify the current state-of-the-art immunohistochemical methods for age determination of fatal VTE. A literature search was performed through different databases, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Within the study, we have selected only cases represented by deceased patients for DVT and/or PTE in which thromboembolic material was collected during an autoptic examination and then subjected to a histological and an immunohistochemical investigation. Studies based on animal models were not included. We assessed bias risk. A database-based search produced a total of 19 articles. After excluding duplicate items from the selection, 14 articles were reviewed. Ten articles were excluded because they did not meet the inclusion criteria. The results have pointed out 4 studies that were included in the present analysis for a total of 157 samples of DVT and 171 PTE samples. These were analyzed using traditional histological and immunohistochemical techniques. The results must be interpreted with a critical eye because of their heterogeneity in terms of time, geography, and study design. The present review highlights the importance of associating specific immunohistochemical markers with a histological analysis for the timing of DVT/PTE fatal events. Further future experiences will hopefully endorse actual knowledge on the subject to increase the accuracy in the assessment of thrombus-embolus age.

Meta-analysis of the Effect of Shenfu Injection on Immune Function in Patients with Sepsis

Objective: To systematically evaluate the effects of Shenfu Injection on immune function of sepsis patients by meta-analysis. Methods: The randomized controlled trials of Shenfu Injection in the treatment of sepsis published from 2000 to February 2021 were searched in CNKI, WanFang database and VIP database. The control group was treated with routine treatment; The experimental group was treated with Shenfu Injection on the basis of routine treatment. The included literature was evaluated by Cochrane bias risk evaluation table, and Shenfu Injection was used to treat patients with sepsis with RevMan 5.3 software. The results of meta-analysis were as reported. Conclusion: However, due to the limitation of the quality and quantity of the included research, multi center, large sample volume and high-quality RCT are still needed to verify the research results.

Earthquake risk over time windows: Do people bias risk to the end of an interval?

<p>Located on the edge of two tectonic plates, New Zealand has numerous fault lines and seismic risk across the whole country. The way this risk is communicated affects whether people prepare effectively or at all. Research has shown that perceptions of risk are affected by slight changes in wording, and that probabilities commonly reported by experts and media are often interpreted subjectively based on context. In the context of volcanoes, research has found that given a certain probability of a volcano in a specific time window, people perceive risk as higher in later time intervals within that window. The present study examines this pattern with regard to earthquakes and aftershocks in the New Zealand context. Participants in both Wellington (N = 102) and Christchurch (N = 98) were presented an expert statement of earthquake risk within a given time window in Wellington and aftershock risk in Christchurch, and asked to rate their perception of risk in specific intervals across the time window. For a Wellington earthquake, participants perceived risk as incrementally higher toward the end of the 50 year time window whereas for a Christchurch aftershock, risk perception increased slightly for the first three intervals of the 12 month time window. Likelihood of preparing was constant over the time windows, with Wellington citizens rating themselves more likely than Christchurch citizens to prepare for either an earthquake or aftershock, irrespective of current level of preparedness. These findings suggest that people view earthquakes as more likely later toward the end of a given time window and that they view aftershocks very differently to scientific predictions.</p>

Earthquake risk over time windows: Do people bias risk to the end of an interval?

<p>Located on the edge of two tectonic plates, New Zealand has numerous fault lines and seismic risk across the whole country. The way this risk is communicated affects whether people prepare effectively or at all. Research has shown that perceptions of risk are affected by slight changes in wording, and that probabilities commonly reported by experts and media are often interpreted subjectively based on context. In the context of volcanoes, research has found that given a certain probability of a volcano in a specific time window, people perceive risk as higher in later time intervals within that window. The present study examines this pattern with regard to earthquakes and aftershocks in the New Zealand context. Participants in both Wellington (N = 102) and Christchurch (N = 98) were presented an expert statement of earthquake risk within a given time window in Wellington and aftershock risk in Christchurch, and asked to rate their perception of risk in specific intervals across the time window. For a Wellington earthquake, participants perceived risk as incrementally higher toward the end of the 50 year time window whereas for a Christchurch aftershock, risk perception increased slightly for the first three intervals of the 12 month time window. Likelihood of preparing was constant over the time windows, with Wellington citizens rating themselves more likely than Christchurch citizens to prepare for either an earthquake or aftershock, irrespective of current level of preparedness. These findings suggest that people view earthquakes as more likely later toward the end of a given time window and that they view aftershocks very differently to scientific predictions.</p>

Are Mechanical Vibrations an Effective Alternative to Accelerate Orthodontic Tooth Movement in Humans? A Systematic Review

The objective of this article was to conduct a systematic review of the literature to contrast the existing evidence on the effect of mechanical vibrations, either high or low frequency, as an alternative to accelerate orthodontic tooth movement in humans. A literature search from 2010 to June 2021 was conducted in the electronic databases: PubMed, NCBI, Google Scholar, EBSCO, Cochrane, and Ovid, using the eligibility criteria to identify the studies. Only randomized clinical trials (RCT) were included. The certainty of the evidence was assessed using the GRADE tool and the risk of bias (RoB) in individual studies was evaluated according to the Cochrane bias risk tool. Fifteen RTCs were included for final review. Overall, the RoB was classified as low (3), moderate (5), and high (7). Three articles with low RoB, four with moderate RoB, and four with high RoB found no significant effect in the use of vibrations on orthodontic movement. Only four articles, three of them with high RoB and one with moderate RoB, found that mechanical vibrations are effective at accelerating orthodontic tooth movement. The results seemed to indicate that there is no evidence that vibratory stimuli can increase the rate of dental movement or reduce neither the time of dental alignment nor canine retraction during orthodontic treatment. It is important to note that a greater number of high-quality randomized controlled trials are urgently needed.

Effects of Different Recovery Positions on the Postpercutaneous Liver Biopsy Complications: A Metaanalysis

Objective: We aim to evaluate the effects of different recovery positions on the adverse events and the patient acceptability in those who underwent percutaneous liver biopsy (PLB).Methods: A literature search was conducted in the Cochrane Library, Embase, Scopus, PubMed, CNKI, Sinomed, and Wanfang databases. The time for the article extraction was until July 2020. The articles were screened by two independent researchers, together with the bias risk evaluation and data extraction. The RevMan 5.4 software was utilized for the metaanalysis.Results: Finally, two articles involving 180 subjects were eligible for this study. Metaanalysis showed that at T0, the alternation between right-side and combined position (CRP) would induce an elevation of post-PLB pain compared with the dorsal/supine position (SRP) [WMD = −2.00, 95% CI (−3.54, −0.47), p = 0.01]. There were no statistical differences in the postoperative pain among the CRP, SRP, and right-side position (RRP). The patient acceptability of SRP and RRP was higher than that of the CRP. Finally, two eligible studies were included, which showed no incidence of pneumothorax and abdominal bleeding.Conclusions: CRP would induce post-PLB pain at T0. SRP was the most acceptable position for the cases that underwent PLB. There were no statistical differences in the incidence of pneumothorax and abdominal bleeding.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO, identifier: CRD42020196633.

Effects of Exercise Therapy on Anxiety and Depression in Patients With Coronary Heart Disease: A Meta-Analysis of a Randomized Controlled Study

Objective: The purpose of this review was to evaluate the effect of exercise therapy on anxiety and depression symptoms in patients with coronary heart disease (CHD).Methods: A systematic review of papers published between January 2000 and February 2021 was conducted. MEDLINE, Embase, the Cochrane Library and Web of Science were searched. Meta-analysis was used to compare the results of the included studies. Bias risk assessment was performed using the Cochrane Collaboration bias risk tool. If half or more of the seven items in Randomized controlled trials (RCTs) were low-risk, then the RCT was considered low-risk research; otherwise, it was high-risk. Statistical analyses were performed using RevMan version 5.3 and STATA version 12.0.Results: We performed a meta-analysis of 11 randomized clinical studies including 771 subjects. Eight studies (73%) were of high quality. Compared with the control group, the exercise group showed a significant improvement in anxiety [standard mean difference (SMD) = −0.61; 95% confidence interval (CI): −0.86, −0.35]. The depression level in the exercise group was also significantly reduced (SMD = −0.48; 95% CI: −0.92, −0.04). Aerobic fitness and athletic endurance also improved [mean difference (MD) = 0.77; 95% CI: 0.58, 0.95; and MD = 20.69; 95% CI: 6.91, 34.46; respectively].Conclusions: This meta-analysis suggests that exercise therapy may be effective in alleviating anxiety and depression symptoms in patients with coronary heart disease. Due to methodological weaknesses, rigorous research needs to be designed to further confirm the effectiveness of exercise therapy in improving the mental health of patients with coronary heart disease.Systematic Review Registration:https://inplasy.com/projects/, identifier: INPLASY202160017.

The Efficacy of Antioxidative Stress Therapy on Oxidative Stress Levels in Rheumatoid Arthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Objective. To explore the efficacy of antioxidative stress therapy on oxidative stress levels in rheumatoid arthritis (RA) by a systematic review and meta-analysis of randomized controlled trials. Methods. Chinese and English databases such as PubMed, Embase, China National Knowledge Infrastructure (CNKI), and China Biomedical Literature were searched, mainly searching for clinical randomized controlled trials of antioxidant therapy for rheumatoid arthritis. The search time is from the establishment of the database to July 2021. Two researchers independently carried out literature search, screening, and data extraction. The bias risk tool provided by the Cochrane Collaboration was used to evaluate the bias risk of all the included literature, and the RevMan 5.3 software was used for meta-analysis. Results. A total of 24 RCTs (28 records) and 1277 participants were included. The time span of randomized controlled trials (RCTs) is from 1986 to 2020. These RCTs involve 14 types of antioxidants or antioxidant therapies, and these therapies have varying degrees of improvement on oxidative stress in RA patients. The summary results showed that the MDA in the experiment group is lower (SMD -0.82, 95% CI -1.35 to -0.28, P = 0.003 ). The difference of TAC, SOD, NO, GPx, CAT, and GSH between two groups was of no statistical significance (TAC (SMD 0.27, 95% CI -0.21 to 0.75, P = 0.27 ), SOD (SMD 0.12, 95% CI -0.16 to 0.40, P = 0.41 ), NO (SMD -2.03, 95% CI -4.22 to 0.16, P = 0.07 ), GPx (SMD 0.24, 95% CI -0.07 to 0.54, P = 0.13 ), CAT (SMD 2.95, 95% CI -2.6 to 8.51, P = 0.30 ), and GSH (SMD 2.46, 95% CI -0.06 to 4.98, P = 0.06 )). For adverse events, the summary results showed that the difference was of no statistical significance (RR 1.16, 95% CI 0.79 to 1.71, P = 0.45 ). In addition, antioxidant therapy has also shown improvement in clinical efficacy indexes (number of tender joints, number of swollen joints, DAS28, VAS, and HAQ) and inflammation indexes (ESR, CRP, TNF-α, and IL6) for RA patients. Conclusion. The existing evidence shows potential benefits, mainly in reducing MDA and increasing TAC and GSH in some subgroups. However, more large samples and higher quality RCTs are needed to provide high-quality evidence, so as to provide more clinical reference information for the antioxidant treatment of RA.