scholarly journals The role of ferroptosis in lung cancer

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Sikai Wu ◽  
Chengchu Zhu ◽  
Daolin Tang ◽  
Q. Ping Dou ◽  
Jianfei Shen ◽  
...  

AbstractLung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.

2021 ◽  
Vol 11 (2) ◽  
pp. 97
Author(s):  
Rakhmetkazhy Bersimbaev ◽  
Olga Bulgakova ◽  
Akmaral Aripova ◽  
Assiya Kussainova ◽  
Oralbek Ilderbayev

MicroRNAs are a class of small noncoding endogenous RNAs 19–25 nucleotides long, which play an important role in the post-transcriptional regulation of gene expression by targeting mRNA targets with subsequent repression of translation. MicroRNAs are involved in the pathogenesis of numerous diseases, including cancer. Lung cancer is the leading cause of cancer death in the world. Lung cancer is usually associated with tobacco smoking. However, about 25% of lung cancer cases occur in people who have never smoked. According to the International Agency for Research on Cancer, asbestos has been classified as one of the cancerogenic factors for lung cancer. The mechanism of malignant transformation under the influence of asbestos is associated with the genotoxic effect of reactive oxygen species, which initiate the processes of DNA damage in the cell. However, epigenetic mechanisms such as changes in the microRNA expression profile may also be implicated in the pathogenesis of asbestos-induced lung cancer. Numerous studies have shown that microRNAs can serve as a biomarker of the effects of various adverse environmental factors on the human body. This review examines the role of microRNAs, the expression profile of which changes upon exposure to asbestos, in key processes of carcinogenesis, such as proliferation, cell survival, metastasis, neo-angiogenesis, and immune response avoidance.


1999 ◽  
Vol 14 (10) ◽  
pp. 967-972 ◽  
Author(s):  
Fumihiro Iwata ◽  
Takashi Joh ◽  
Toyohiro Tada ◽  
Noriko Okada ◽  
B Paul Morgan ◽  
...  

2020 ◽  
Vol 22 (1) ◽  
pp. 72-79
Author(s):  
Alexandra Lee ◽  
◽  
Warwick Butt ◽  
◽  
◽  
...  

Inhaled nitric oxide has been used for 30 years to improve oxygenation and decrease pulmonary vascular resistance. In the past 15 years, there has been increased understanding of the role of endogenous nitric oxide on cell surface receptors, mitochondria, and intracellular processes involving calcium and superoxide radicals. This has led to several animal and human experiments revealing a potential role for administered nitric oxide or nitric oxide donors in patients with systemic inflammatory response syndrome or ischaemia–reperfusion injury, and in patients for whom exposure of blood to artificial surfaces has occurred.


2021 ◽  
Vol 10 (4) ◽  
pp. 75
Author(s):  
A.A. Izmailov ◽  
A.F. Nasretdinov ◽  
A.V. Sultanbaev ◽  
D.D. Sakaeva ◽  
K.V. Menshikov ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Lihui Chen ◽  
Jie Li ◽  
Wu Zhu ◽  
Yehong Kuang ◽  
Tao Liu ◽  
...  

Psoriasis affects the health of myriad populations around the world. The pathogenesis is multifactorial, and the exact driving factor remains unclear. This condition arises from the interaction between hyperproliferative keratinocytes and infiltrating immune cells, with poor prognosis and high recurrence. Better clinical treatments remain to be explored. There is much evidence that alterations in the skin and intestinal microbiome play an important role in the pathogenesis of psoriasis, and restoration of the microbiome is a promising preventive and therapeutic strategy for psoriasis. Herein, we have reviewed recent studies on the psoriasis-related microbiome in an attempt to confidently identify the “core” microbiome of psoriasis patients, understand the role of microbiome in the pathogenesis of psoriasis, and explore new therapeutic strategies for psoriasis through microbial intervention.


Author(s):  
Vadzim S. Mikhailouski

Neo-Marxism world-system analysis was an effective means of the understanding of the postcolonial global order. The concepts of «core», «periphery» and «semi-periphery» reflected the dependent development of states in the global capitalist system. Capitalism structured the global order in the classical Marxist dichotomy of exploiters and exploited which can be represented with various subjects (states, groups of states, territories) and which according to neo-Marxism can’t disappear, because it reflects the essence of global antagonism. However, the realities of global development at the end of the 20th century demanded that neo-Marxism should reconsider the rigid link between the core-peripheral approach and the horizontal vision of the world: globalisation caused massive flows of migrants to highly developed countries and the gradual blurring of the boundaries between the core and periphery. There was the question in neo-Marxism which was about the ability of capitalism to preserve the core-peripheral organisation of the global division of labour. There was the idea that capitalism was able to reproduce core-periphery relations within the core states by including immigrants in the super-exploitation of labour through a covert policy of neo-racism. Such a vertical organisation of the core-peripheral model around the world, which was called dual society in neo-Marxism, would mean the formation of the global semi-periphery. The purpose of the article is to verify the neo-Marxist concept of the global semi-periphery using the example of the role of the migration factor in its formation. The study is based on UN data, as well as studies with a pronounced statistical component. According to the results of the study, it was concluded that the neo-Marxist concept of the global semi-periphery had not been verified by actual empirical material (on the example of the role of the migration factor). The available statistical and analytical data do not allow to totally confirm the neo-Marxist position that the global order under the influence of migration has been transformed and that it works in the conceptual model of a dual society. Globally, migration is not a determining factor in the widespread formation and unification of the dual method of labour exploitation within states. The quantitative data on the flow of migrants, comparative data on salaries in the countries of the core and the degree of concentration of income among certain groups of the population in the countries of the capitalist system state that the world is still largely reproduced in the horizontal core-peripheral model. Thus, there are no empirical grounds for stating the presence of a global dual society under the influence of the migration factor and consequently the presence of a global semi-periphery within the neo-Marxist approach of E. Balibar, I. Wallerstein, M. Hardt and A. Negri.


2020 ◽  
pp. 1-20
Author(s):  
Abdullah A. Abdullah

Abstract This article examines challenges and proposes legal solutions for the enforcement of contracts especially after the transformation of the economy following Covid-19 and related governmental measures that have swept throughout the world since December 2019. Maximising the role of the judge and increasing the contractual parties’ involvement in phases of contractual disputes constitute the core of this research. This article argues for strengthening the contractual guarantees by advocating for the use of the two contract doctrines of force majeure that normally lead to termination of contractual obligations, and changed circumstances that may trigger intervention of the judge to lift the economic burden of the debtor and reach a fair solution. This article also argues for adopting a more flexible approach to the application of the doctrine of change of circumstances during the performance of the contract that not necessarily relies on this traditional distinction between force majeure and hardship.


Author(s):  
Joana Costa

Entrepreneurship is a worldwide reality. Since the beginning of times and all around the world people have created businesses. Entrepreneurial orientation, from a macroeconomic perspective, allows income and employment generation, thus boosting growth. At the microeconomic level, it is a competition booster playing a central role in a globalized market. In this entrepreneurial ecosystem in which knowledge-based activity is the core booster of employment, economic growth, and competitiveness, universities and, in particular, entrepreneurial universities play either the role of knowledge production and dissemination. The present work aims to understand the role of education (formal and entrepreneurship) on entrepreneurial activity combined with heterogeneous individual characteristics and different cultures and geographies. Specifically, the study identifies substitution and complementary effects among both types of education according to individual taxonomies.


Author(s):  
F. Cuccurullo ◽  
A. Mezzetti ◽  
A. Arduini ◽  
E. Porreca ◽  
D. Lapenna ◽  
...  

2020 ◽  
Vol 17 (10) ◽  
pp. 1459-1472 ◽  
Author(s):  
Manish Kumar ◽  
Abhishek Jha ◽  
Madhu Dr ◽  
Brahmeshwar Mishra

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