scholarly journals Phytochemical studies for quantitative estimation of iridoid glycosides in Picrorhiza kurroa Royle

2016 ◽  
Vol 57 (1) ◽  
Author(s):  
Phalisteen Sultan ◽  
Arif Jan ◽  
Qazi Pervaiz
Keyword(s):  
Quantitative Estimation ◽  
Iridoid Glycosides ◽  
Picrorhiza Kurroa ◽  
Phytochemical Studies

Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth

2020 ◽  
Vol 169 ◽  
pp. 112185 ◽  
Author(s):  
Toshio Morikawa ◽  
Yusuke Nakanishi ◽  
Naoki Inoue ◽  
Yoshiaki Manse ◽  
Hideyuki Matsuura ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Iridoid Glycosides ◽  
Picrorhiza Kurroa

Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar

Fitoterapia ◽  
2019 ◽  
Vol 134 ◽  
pp. 101-107 ◽  
Author(s):  
Nwet Nwet Win ◽  
Takeshi Kodama ◽  
Khine Zar Wynn Lae ◽  
Yi Yi Win ◽  
Hla Ngwe ◽  
...  
Keyword(s):  
Viral Protein ◽  
Iridoid Glycosides ◽  
Picrorhiza Kurroa ◽  
Viral Protein R

Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of Endangered Herb Picrorhiza kurroa (Kutki): A comprehensive review (2010-2020)

2021 ◽  
Vol 21 ◽  
Author(s):  
Sharuti Mehta ◽  
Anil Kumar Sharma ◽  
Rajesh K. Singh
Keyword(s):  
Iridoid Glycosides ◽  
Review Article ◽  
Bioactive Metabolites ◽  
Future Research ◽  
Picrorhiza Kurroa ◽  
Bioactive Constituents ◽  
Active Metabolites ◽  
Natural Habitats ◽  
Picroside Ii ◽  
Endangered Status

: Picrorhiza kurroa Royle ex Benth. (Family: Plantaginaceae) is a well-recognized an Ayurvedic herb. It is commonly called “Kutki” or “Kurro” and ‘Indian gentian’. Iridoid glycosides are the plant’s bioactive constituents and accountable for the bitter taste and medicinal properties of the plant. The iridoid glycosides such as picrosides and other active metabolites of the plant exhibited many pharmacological activities like hepatoprotective, antioxidant, anti-inflammatory, anticancer, immunomodulator, anti-ulcerative colitis, antimicrobial etc. This review aims to provide updated information on the ethnobotany, synthetic phytochemistry, pharmacological potential, safety and toxicology of P. kurroa and its active metabolites. Indiscriminate exploitation, ecological destruction of natural habitats, slower plant growth and unawareness regarding cultivation and uprooting of plants has brought kutki as an endangered status. So, various techniques used for the conservation and production of bioactive metabolites from P. kurroa have also been reported. Information on the plant has been collected from Science Direct, Google Scholar, PubMed, Scopus by using ‘Picrorhiza kurroa’, ‘Picroside-‘, ‘Picroside-II’, ‘Picroliv’, ‘Immunomodulator’ keywords. All studies on ethnobotany, phytochemistry and pharmacology of plant from 2010- 2020 were comprised in this review article. The possible directions for the future research have also been outlined in brief in review article.

scholarly journals Quality Evaluation of Ayurvedic Crude DrugDaruharidra, Its Allied Species, and Commercial Samples from Herbal Drug Markets of India

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Sharad Srivastava ◽  
A. K. S. Rawat
Keyword(s):  
Quality Evaluation ◽  
Quantitative Estimation ◽  
Powdered Material ◽  
Drug Markets ◽  
Total Alkaloids ◽  
Ich Guidelines ◽  
Oriental Sore ◽  
Pharmaceutical Industries ◽  
Phytochemical Studies ◽  
Important Drug

Berberis aristataknown as “Daruharidra” in Ayurveda is a versatile medicinal plant used singly or in combination with other medicinal plants for treating a variety of ailments like jaundice, enlargement of spleen, leprosy, rheumatism, fever, morning/evening sickness, snakebite, and so forth. A major bioactive marker of this genus is an alkaloid berberine, which is known for its activity against cholera, acute diarrhea, amoebiasis, and latent malaria and for the treatment of oriental sore caused byLeishmania tropica. Although the roots ofB. aristataare considered as the official drug (Ayurvedic Pharmacopoeia of India), the study revealed that different species ofBerberis,namely.B. asiatica,B. chitria,andB. lyciumare also used under the name ofDaruharidrain different parts of the country. Detailed physicochemical and phytochemical studies of subjects like total ash, acid insoluble ash, tannins, and total alkaloids were calculated from the shade dried powdered material according to the recommended procedures. Further, heavy metal studies and quantitative estimation of berberine through HPTLC have also been performed as per ICH guidelines. A detailed study of fourBerberisspecies, namelyB. aristata,B. asiatica,B. chitria,andB. lycium,which are implicated asDaruharidraand collected from wild and ten commercial samples procured from various important drug markets in India has been carried out, which may be useful to pharmaceutical industries for the authentication of the commercial samples and exploring the possibilities of using other species as a substitute ofB. aristata.

scholarly journals Phytochemical Studies onBauhinia racemosaLam.Bauhinia purpureaLinn. andHardwickia binataRoxb

2007 ◽  
Vol 4 (1) ◽  
pp. 21-31 ◽  
Author(s):  
G. K. Sharanabasappa ◽  
M. K. Santosh ◽  
D. Shaila ◽  
Y. N. Seetharam ◽  
I. Sanjeevarao
Keyword(s):  
Secondary Metabolites ◽  
Quantitative Estimation ◽  
Ethanolic Extract ◽  
Phytochemical Study ◽  
Primary And Secondary Metabolites ◽  
Hplc Fingerprint ◽  
Physico Chemical ◽  
Chemical Studies ◽  
Bauhinia Purpurea ◽  
Phytochemical Studies

The present paper deals with the phytochemical studies onBauhinia racemosaLam.,Bauhinia purpureaLinn. andHardwickia binataRoxb. The phytochemical study of three plants involve preliminary phytochemical studies, physico-chemical studies, quantitative estimation of primary and secondary metabolites, TLC study and HPLC fingerprint study of ethanolic extract of leaves of three plants. In HPLC fingerprint study, the three peaks at a retention time of 15 min, 17 min and 19 min were identical inB. racemosaandB. purpureawhich was confirmed by overlaid spectra. The generated data may be useful in suggesting chemotaxonomical interrelation between three plants.

PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDIES ON STAMENS OF MESUA FERREA AS POTENT ANTHELMINTIC AGENT

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (01) ◽  
pp. 40-43
Author(s):  
T Patidar ◽  
◽  
K Daniel ◽  
V. Daniel ◽  
S. Sharma
Keyword(s):  
Quantitative Estimation ◽  
Anthelmintic Activity ◽  
Physical Constant ◽  
Alcoholic Extract ◽  
Diagnostic Features ◽  
Medicinal Value ◽  
Spontaneous Motility ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition ◽  
Phytochemical Studies

Nagkesar (Mesua ferrea Linn.) belonging to the family Guttiferae, has a great medicinal value, so far, proper pharmacognostical and phytochemical studies of stamens have not been reported. Morphological and anatomical aspects as well as differential microchemical response have been worked out to identify the diagnostic features of the stamens. Physical constant values involving moisture content, ash and extractives as well as qualitative and quantitative estimation of various phytochemicals have been studied. The hydro-alcoholic extracts of Mesua ferrea were evaluated for anthelmintic activity using adult earthworms; the extract of Mesua ferrea exhibited a dose dependent inhibition of spontaneous motility (paralysis) and evoked responses to pin-prick. With lower doses the effects were comparable with that of albendazole. However, there was no final recovery in the case of worms treated with hydro-alcoholic extract. The result showed that the hydro-alcoholic extract possessed wormicidal activity and thus, may be useful as an anthelmintic.

scholarly journals In-depth assembly of organ and development dissected Picrorhiza kurroa proteome map using mass spectrometry

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Manglesh Kumari ◽  
Upendra Kumar Pradhan ◽  
Robin Joshi ◽  
Ashwani Punia ◽  
Ravi Shankar ◽  
...  
Keyword(s):  
Large Scale ◽  
Rna Binding ◽  
Developmental Stages ◽  
Rna Binding Proteins ◽  
Iridoid Glycosides ◽  
Specific Protein ◽  
Phytochemical Analysis ◽  
Picrorhiza Kurroa ◽  
Stage Of Development ◽  
Organ Specific

Abstract Background Picrorhiza kurroa Royle ex Benth. being a rich source of phytochemicals, is a promising high altitude medicinal herb of Himalaya. The medicinal potential is attributed to picrosides i.e. iridoid glycosides, which synthesized in organ-specific manner through highly complex pathways. Here, we present a large-scale proteome reference map of P. kurroa, consisting of four morphologically differentiated organs and two developmental stages. Results We were able to identify 5186 protein accessions (FDR < 1%) providing a deep coverage of protein abundance array, spanning around six orders of magnitude. Most of the identified proteins are associated with metabolic processes, response to abiotic stimuli and cellular processes. Organ specific sub-proteomes highlights organ specialized functions that would offer insights to explore tissue profile for specific protein classes. With reference to P. kurroa development, vegetative phase is enriched with growth related processes, however generative phase harvests more energy in secondary metabolic pathways. Furthermore, stress-responsive proteins, RNA binding proteins (RBPs) and post-translational modifications (PTMs), particularly phosphorylation and ADP-ribosylation play an important role in P. kurroa adaptation to alpine environment. The proteins involved in the synthesis of secondary metabolites are well represented in P. kurroa proteome. The phytochemical analysis revealed that marker compounds were highly accumulated in rhizome and overall, during the late stage of development. Conclusions This report represents first extensive proteomic description of organ and developmental dissected P. kurroa, providing a platform for future studies related to stress tolerance and medical applications.

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