Effects of X-rays and cigarette smoking on leukocyte, lymphocyte and mitotic index values and SCE rates: the relationship between mitotic index and lymphocyte count

2003 ◽  
Vol 19 (2-6) ◽  
pp. 81-91 ◽  
Author(s):  
E Akbaş ◽  
F Söylemez ◽  
E Derici ◽  
G Börekci ◽  
A Kanik
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Minjae Yoon ◽  
Jaewon Oh ◽  
Kyeong-Hyeon Chun ◽  
Chan Joo Lee ◽  
Seok-Min Kang

AbstractImmunosuppressive therapy can decrease rejection episodes and increase the risk of severe and fatal infections in heart transplantation (HT) recipients. Immunosuppressive therapy can also decrease the absolute lymphocyte count (ALC), but the relationship between early post-transplant ALC and early cytomegalovirus (CMV) infection is largely unknown, especially in HT. We retrospectively analyzed 58 HT recipients who tested positive for CMV IgG antibody and received basiliximab induction therapy. We collected preoperative and 2-month postoperative data on ALC and CMV load. The CMV load > 1200 IU/mL was used as the cutoff value to define early CMV infection. Post-transplant lymphopenia was defined as an ALC of < 500 cells/μL at postoperative day (POD) #7. On POD #7, 29 (50.0%) patients had post-transplant lymphopenia and 29 (50.0%) patients did not. The incidence of CMV infection within 1 or 2 months of HT was higher in the post-transplant lymphopenia group than in the non-lymphopenia group (82.8% vs. 48.3%, P = 0.013; 89.7% vs. 65.5%, P = 0.028, respectively). ALC < 500 cells/μL on POD #7 was an independent risk factor for early CMV infection within 1 month of HT (odds ratio, 4.14; 95% confidence interval, 1.16–14.77; P = 0.029). A low ALC after HT was associated with a high risk of early CMV infection. Post-transplant ALC monitoring is simple and inexpensive and can help identify patients at high risk of early CMV infection.


2021 ◽  
Vol 366 (6) ◽  
Author(s):  
Hidetoshi Sano ◽  
Yasuo Fukui

AbstractWe review recent progress in elucidating the relationship between high-energy radiation and the interstellar medium (ISM) in young supernova remnants (SNRs) with ages of ∼2000 yr, focusing in particular on RX J1713.7−3946 and RCW 86. Both SNRs emit strong nonthermal X-rays and TeV $\gamma $ γ -rays, and they contain clumpy distributions of interstellar gas that includes both atomic and molecular hydrogen. We find that shock–cloud interactions provide a viable explanation for the spatial correlation between the X-rays and ISM. In these interactions, the supernova shocks hit the typically pc-scale dense cores, generating a highly turbulent velocity field that amplifies the magnetic field up to 0.1–1 mG. This amplification leads to enhanced nonthermal synchrotron emission around the clumps, whereas the cosmic-ray electrons do not penetrate the clumps. Accordingly, the nonthermal X-rays exhibit a spatial distribution similar to that of the ISM on the pc scale, while they are anticorrelated at sub-pc scales. These results predict that hadronic $\gamma $ γ -rays can be emitted from the dense cores, resulting in a spatial correspondence between the $\gamma $ γ -rays and the ISM. The current pc-scale resolution of $\gamma $ γ -ray observations is too low to resolve this correspondence. Future $\gamma $ γ -ray observations with the Cherenkov Telescope Array will be able to resolve the sub-pc-scale $\gamma $ γ -ray distribution and provide clues to the origin of these cosmic $\gamma $ γ -rays.


2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1740.1-1740
Author(s):  
J. H. Kang ◽  
S. E. Choi ◽  
H. Xu ◽  
D. J. Park ◽  
S. S. Lee

Background:Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA), with mixed results.Objectives:The aim of this study was to investigate the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA.Methods:A total of 2,402 subjects were recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored by a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear regression analysis.Results:Subjects with higher tertiles of serum adiponectin were older and had a lower body mass index than those with lower tertiles. In the knee joint scores, serum adiponectin levels were positively associated with the total score (P<0.001), osteophyte score (P=0.003), and joint space narrowing (JSN) score (P<0.001) among the three tertiles after adjustment for age, sex, body mass index, smoking, alcohol consumption, education, and physical activity. In the hand joint scores, no association was found between serum adiponectin levels and the total score, osteophyte score, JSN score, subchondral cyst score, sclerosis score, erosion score, and malalignment score among the three tertiles after adjustment.Conclusion:In this study, we found that increased adiponectin levels were associated with higher radiographic scores in the knee joint, but not in the hand joint, suggesting different pathophysiologic mechanisms in the development of OA.Disclosure of Interests:None declared


2013 ◽  
Vol 49 (6) ◽  
pp. 708-714 ◽  
Author(s):  
Jennifer Dahne ◽  
Kelcey J. Stratton ◽  
Ruth Brown ◽  
Ananda B. Amstadter ◽  
Carl W. Lejuez ◽  
...  

1991 ◽  
Vol 16 (3-4) ◽  
pp. 103-110 ◽  
Author(s):  
Robert N. Jamison ◽  
Barbara A. Stetson ◽  
Winston C.V. Parris

The study of β-ray spectra has now advanced to that stage at which, for the majority of radioactive substances, the velocities of the homogeneous electrons forming the “lines” have been measured with a fair accuracy. The relative intensities of the “lines” have in the past been obtained by visual estimation of the photographic blackening of the plates on which they have been recorded, and it has become important to obtain more precise information on this subject. The most direct method of determining the relative intensities would be to count the number of, or measure the total charge carried by, the particles forming the lines. This is not practicable, to any high degree of accuracy, because of the small effects which are obtainable, and it is obvious that the photographic plate, in giving quite intense and sharp lines, in addition to a permanent record, presents many advantages. The use of this method, however, necessitates the calibration of the plate both for the variation of the blackening with exposure and also with velocity of the rays. The corresponding calibrations for ordinary light have now become a matter of routine, but since there has, as yet, been little systematic work on the behaviour of the photographic plate to β-rays, we have thought it best to record in this paper such experiments as we have found necessary before undertaking the main intensity problem. It is the dependence of blackening on exposure which is mainly treated in this paper, although we have in addition obtained some interesting results on the effect of β-particles of different velocities. In an investigation on the relationship between blackening and exposure i. e ., the characteristic curve of a type of plate, it is first necessary to find the dependence of the blackening D on the time of exposure t , when the product of intensity I and time of exposure t is kept constant. If D is independent of t , when I. t is constant, then the Reciprocity Law of Bunsen and Roscoe is said to be valid for the plate. This law, although it has to be slightly modified for luminous radiation, has been shown to be true in the case of X-rays and also for heterogeneous β-rays. In all previous work on the photographic action of β-rays the particles were of heterogeneous velocities, but in view of the ultimate object of this investigation it was thought unsatisfactory to employ heterogeneous particles, and although the procedure was thereby made rather more laborious, beams of practically homogeneous particles, taken from the continuous β-ray spectrum, were used. It is in general important, when dealing with an unknown type of plate, after investigating the validity of the Reciprocity Law, to determine the variation of the characteristic curve with time of development, and thereby find the optimum value. Our general experience in photographing β-ray spectra had led us to employ a particular type of plate and method of development, and the main value of our experiments on the variation of the characteristic curve with time of development was that it indicated the error introduced into the value of the density for a given uncertainty in the time of development.


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