Karyomegaly of tubular kidney cells in human chronic interstitial nephropathy in Tunisia: respective role of Ochratoxin a and possible genetic predisposition

2004 ◽  
Vol 23 (7) ◽  
pp. 339-346 ◽  
Author(s):  
Wafa Hassen ◽  
Salwa Abid-Essafi ◽  
Abdellatif Achour ◽  
Noureddine Guezzah ◽  
Abdelfettah Zakhama ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Food Samples ◽  
Balkan Endemic Nephropathy ◽  
Unknown Aetiology ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Endemic Nephropathy ◽  
Interstitial Nephropathy ◽  
Renal Tubular

Karyomegalic nephropathy associated to bizarre enlargement of nuclei in renal tubular epithelial cells was first described by Mihatch in 1979. We present herein additional cases occurring in three siblings suffering from chronic interstitial nephropathy (CIN) of unknown aetiology where the renal biopsies showed numerous enlarged and hyperchromatic nuclei. CIN of unknown aetiology has been previously characterized and showed striking similarities with Balkan Endemic Nephropathy (BEN). Ochratoxin A (OTA) is a nephrotoxic mycotoxin suspected to be the causal agent of the BEN as well as the Tunisian CIN of unknown aetiology. OTA is incriminated in the onset of these disclosed cases of karyomegalic nephropathy since high OTA concentrations were found in blood (505.83 ng/ml, 102.63 ng/ml and 1023 ng/ml) and in urine (94.40 ng/ml and 10.18 ng/ml) of two of them. Moreover, we have investigated OTA in blood and urine as well as in food samples of the entire household (21 people). Our findings suggest (i) a link between OTA and the outcome of this karyomegalic nephropathy, and (ii) the possible involvement of a genetic factor since the three cases have the same haplotype B27/35.

Ochratoxin A in human blood in relation to nephropathy in Tunisia

1995 ◽  
Vol 14 (7) ◽  
pp. 609-614 ◽  
Author(s):  
K. Maaroufi ◽  
A. Achour ◽  
M. Hammami ◽  
M. El May ◽  
AM Betbeder ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Human Blood ◽  
Western Europe ◽  
The Other ◽  
Balkan Endemic Nephropathy ◽  
Mean Values ◽  
The Balkans ◽  
Endemic Nephropathy ◽  
Interstitial Nephropathy

The determination of ochratoxin A (OTA) in human blood in Tunisian populations is underway. The range of conta mination is between 0.7 to 7.8 ng ml-1 for the general popu lation and 12 to 55 ng ml-1 for people suffering from chron ic renal failure. It appears that 21 to 64% of people suffer ing from nephropathy are OTA positive with a detection limit of 1ng ml-1. This situation prompted us to search for possible association of OTA contamination and nephropa thy resembling Balkan endemic nephropathy. The classifi cation of the ill population into chronic interstitial nephropathy (CIN), chronic glomerular nephropathy (CGN), chronic vascular nephropathy (CVN) and others, indicated that the largest is the CIN group which is signifi cantly different from the other groups, and from the con trol (P < 0.005). Furthermore, it presented the highest OTA mean values (25 to 59 ng ml-1) compared with the control, CGN, CVN and other groups (6 to 18 ng ml-1) according to the designated region in Tunisia. The rural population seems to be more exposed to ochratoxins in Tunisia, as has been previously reported in the Balkans and Western Europe. Altogether, these results emphasise that in Tunisia an endemic ochratoxin-related nephropathy is probably occurring.

The role of autophagy during cadmium induced apoptosis in rat renal tubular epithelial cells

2016 ◽  
Vol 259 ◽  
pp. S174 ◽  
Author(s):  
G. Liu ◽  
J.C. Bian ◽  
X.Z. Liu ◽  
Y. Yuan ◽  
J.H. Gu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis
Sign in / Sign up

Export Citation Format

Share Document