scholarly journals Antidepressant therapy and C-reactive protein levels

2006 ◽  
Vol 188 (5) ◽  
pp. 449-452 ◽  
Author(s):  
Sinead M. O'Brien ◽  
Lucinda V. Scott ◽  
Timothy G. Dinan
Keyword(s):  
Major Depression ◽  
Inflammatory Response ◽  
Antidepressant Medication ◽  
C Reactive Protein ◽  
Significant Drop ◽  
Protein Levels ◽  
Reactive Protein ◽  
Before And After ◽  
The Impact ◽  
Ssri Treatment

BackgroundMajor depression is associated with activation of the inflammatory response.AimsTo examine C-reactive protein levels in depression and to determine the impact of selective serotonin reuptake inhibitor (SSRI) therapy.MethodAtwo-part study. In study 1, which used a between-subjects design, C-reactive protein was measured in 32 patients (20 currently depressed, 12 euthymic) with a history of DSM–IV major depression, all of whom were treated with an SSRI, and in a healthy comparison group (n=20). Study 2 employed a within-subject design: C-reactive protein was measured in 20 patients with major depression both before and after SSRI treatment.ResultsIn study 1, C-reactive protein levels did not differ between the group with depressive disorder (either currently depressed or euthymic) treated with SSRIs and the healthy group. In study 2 the protein levels dropped significantly following treatment with antidepressant medication.ConclusionsFollowing SSRI treatment for major depression there is a significant drop in C-reactive protein concentrations whether or not the depression resolves. These findings indicate that antidepressants induce an anti-inflammatory response independent of antidepressant action.

scholarly journals Proteasome Activity and C-Reactive Protein Concentration in the Course of Inflammatory Reaction in Relation to the Type of Abdominal Operation and the Surgical Technique Used

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Marzena Tylicka ◽  
Ewa Matuszczak ◽  
Maria Karpińska ◽  
Adam Hermanowicz ◽  
Wojciech Dębek ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Abdominal Surgery ◽  
Tissue Damage ◽  
Protein Concentration ◽  
Rate Of Change ◽  
Proteasome Activity ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Before And After

Surgical tissue damage and the accompanying inflammatory response lead to proteasome activation, initiation of damaged protein degradation, and induction of acute-phase inflammatory response. The aim of this study was to investigate the rate of change in proteasome chymotrypsin-like (ChT-L) activity and C-reactive protein concentration depending on the degree of tissue damage and their correlation with prealbumin concentrations in children before and after abdominal surgery. This experimental study included children who underwent abdominal surgery between 2015 and 2017. Plasma prealbumin concentrations and C-reactive protein levels (CRP) were determined by standard biochemical laboratory procedures. Proteasome activity was assessed using a Suc-Leu-Leu-Val-Tyr-AMC peptide substrate. Elevation of plasma proteasome activity was noted in children after laparoscopic and open abdominal surgeries. However, 20S proteasome activity in children undergoing conventional open surgery was significantly higher (P<0.05) than in patients subjected to laparoscopy. At the same time, an increase in the CRP level was observed. However, there was no correlation between C-reactive protein concentrations and the type of abdominal surgery while there was a correlation observed in the case of proteasomes. Proteasome activity correlates with the degree of surgical tissue damage and prealbumin concentrations. More invasive surgery leads to a stronger activation of the proteasome involved in removing proteins that were damaged due to the surgical procedure. Proteasomes are more specific markers because there is a correlation between proteasome activity and the type of abdominal surgery in contrast to C-reactive protein concentrations which are not different in response to surgery performed in regard to ovarian cysts or cholelithiasis.

Comparison of the Neutrophil/Lymphocyte Ratio and C-Reactive Protein Levels in Patients With Amputation for Diabetic Foot Ulcers

2017 ◽  
Vol 16 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Hasan Metineren ◽  
Turan Cihan Dülgeroğlu
Keyword(s):  
Diabetic Foot ◽  
Inflammatory Marker ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
C Reactive Protein ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Protein Levels ◽  
Reactive Protein ◽  
Before And After

This study compared the effectiveness of the neutrophil/lymphocyte ratio (NLR) versus C-reactive protein (CRP) for evaluating the prognosis and degree of inflammation in patients with amputation for a diabetic foot ulcer (DFU). This study enrolled 56 patients with amputations for DFU with gangrene and compared the CRP levels and NLR measured before and after surgery. Overall, 24 patients (42%) died within 2 weeks postoperatively. Mortality increased with a preoperative/postoperative CRP difference ≤1.5 ( P < .001) and age 73 years or older ( P < .001). The postoperative NLR was lower than the preoperative value but was not significant as a prognostic or inflammatory marker ( P = .945). An increasing serum CRP level is a significant predictor of mortality. CRP and old age are reliable prognostic factors in patients with DFU.

scholarly journals SERUM ZINC AND C-REACTIVE PROTEIN LEVELS AS RISK FACTORS FOR MORTALITY IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME

2018 ◽  
Vol 24 (1) ◽  
pp. 1
Author(s):  
Dwi Retnoningrum ◽  
Banundari Rachmawati ◽  
Dian Widyaningrum
Keyword(s):  
Risk Factors ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Serum Zinc ◽  
Latex Agglutination ◽  
Systemic Inflammatory Response ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

Kondisi Systemic Inflammatory Response Syndrome (SIRS) berkebahyaan terjadinya sepsis dan kegagalan multi organ. Inflamasidapat menyebabkan terjadinya redistribusi zinc ke jaringan sehingga terjadi penurunan kadar zinc plasma. Kadar CRP pada SIRSmeningkat sebagai respons peningkatan protein tahap akut. Tujuan penelitian ini untuk mengetahui apakah kadar zinc dan CRP serummerupakan faktor kebahayaan kematian di pasien SIRS. Penelitian observasional analitik dengan pendekatan kohort prospektif di 30pasien SIRS berusia 27–64 tahun. Kadar zinc serum diperiksa dengan metode atomic absorbance spectrophotometer (AAS) dan CRPserum dengan metode latex agglutination immunoassay menggunakan alat autoanaliser. Kejadian kematian subjek dinilai setelah 28hari perawatan. Data dilakukan uji statistik Chi-Kwadrat, bila tidak memenuhi maka dilakukan uji alternatif Fisher. Besarnya nilaifaktor kebahyaan dilakukan perhitungan kebahayaan relatif. Rerata kadar zinc dan CRP berturut-turut 81,24 ± 8,72 μg/dL, dan 8,13± 8,12 mg/dL. Kematian dalam 28 hari adalah 33,3%. Penelitian ini menunjukkan bahwa kadar zinc plasma < 80 μg/dL bukanmerupakan faktor kebahayaan terjadinya kematian (p=0,114), sedangkan kadar CRP ≥ 10 mg/dL merupakan faktor kebahayaanterjadinya kematian di pasien SIRS (RR=3,28, 95% CI 1,33-8,13, p=0,015). Kadar zinc plasma bukan merupakan faktor kebahayaanterjadinya kematian pada SIRS, sedangkan kadar CRP merupakan faktor kebahayaan terjadinya kematian di pasien SIRS.

scholarly journals Algoritm for diagnostics of appendicitis in childhood and SIRS

2018 ◽  
Vol 16 (3) ◽  
pp. 218-223
Author(s):  
Y. Dimcheva ◽  
Kr. Kalinova ◽  
K. Georgiev
Keyword(s):  
Inflammatory Response ◽  
Outcome Measure ◽  
Clinical Symptoms ◽  
Primary Outcome Measure ◽  
Systemic Inflammatory Response ◽  
Secondary Outcome ◽  
Secondary Outcome Measure ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

The specific purpose of this study was to describe and characterize the systemic inflammatory response to appendicitis in childhood. The clinical symptoms of SIRS are present in a large proportion of patients . A study of high-risk patients showed that over a given period of time, 44-68% of the patients met the criteria for this condition, while at the same time they had proven infection up to 50%.The incidence of SIRS is even higher in the post-operative period and in trauma regardless of the presence or absence of infection. On the other hand, between 10% and 43% of patients with proven sepsis do not meet the SIRS criteria.The inclusion of a number of biological markers (C-reactive protein, procalcitonin, cytokines) aims to help differentiate SIRS with infectious and noninfectious etiology. Sixty six patients were studied, divided into four groups from onset of symptoms to diagnosis. The primary outcome measure was to determine the systemic inflammatory response to appendicitis according to the established groups of time intervals. The secondary outcome measure was the analysis of C-reactive protein for the same purpose. The variables of the systemic inflammatory response, according to diagnostic intervals, showed non-significant differences in white blood cell count. The temperature rose constantly after 48 h, reaching its peak after 72 h (p = 0.001), and the respiratory rate rose after 72 h (p < 0.0001). After 73 h, most patients had three or four systemic inflammatory response criteria (p < 0.0001). C-reactive protein levels rose progressively, showing higher levels after 48 h (p = 0.005). The inflammatory response to appendicitis is progressive, being more marked along the timeline from onset of symptoms to diagnosis. Key words: appendicitis, diagnostic SIRS, children, algoritm.

scholarly journals The Influence of a Health-Related Fitness Training Program on Motor Performance as Well as Hematological and Biochemical Parameters

2020 ◽  
Vol 17 (2) ◽  
pp. 578
Author(s):  
Dorota Kostrzewa-Nowak ◽  
Anna Nowakowska ◽  
Teresa Zwierko ◽  
Maciej Rybak ◽  
Robert Nowak
Keyword(s):  
Training Program ◽  
General Health ◽  
Motor Performance ◽  
Clinical Chemistry ◽  
Exercise Program ◽  
C Reactive Protein ◽  
Enzymes Activities ◽  
Protein Levels ◽  
Reactive Protein ◽  
Before And After

The study was aimed at designing a health exercise program appealing to inactive young men, and then testing the men’s metabolic responses to the program using common diagnostic markers of general health. Six men, aged 22–29 years, took a part in training program to increase their motor performance and improve general health conditions. Body composition parameters, clinical chemistry variables (metabolites, albumin, total protein, ferritin, C reactive protein, lipid profile, ions, and selected enzymes activities) and blood morphology parameters were determined. Motor performance measured before and after a 4-month-long macrocycle indicated an increase in endurance, pace, and agility of the participants. Significant differences were found in analyzed enzymes activities. There was a significant increase in C-reactive protein levels from pre- to post-training. Additionally, changes in hematological biomarkers were seen that suggest erythropoiesis might significantly increase, specifically during the last 2-month-long mesocycles. The proposed training program induced small improvements in endurance, pace, and agility. It was also confirmed that changes in aspartate (AST) and alanine (ALT) activities emerge before any increase in creatine kinase (CK) activity that is important in monitoring of the training loads. Observed changes in red blood cell-related parameters suggest increase in erythropoiesis in the second half of the training cycle.

scholarly journals The Impact of Educational Attainment on Black Women’s Obesity Rate in the United States

2019 ◽  
Vol 7 (2) ◽  
pp. 345-354 ◽  
Author(s):  
Gwenetta Denise Curry
Keyword(s):  
Black Women ◽  
Educational Attainment ◽  
White Women ◽  
The United States ◽  
C Reactive Protein ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Impact

AbstractOver the last two decades, Black women have been disproportionately impacted by the obesity epidemic in the USA. According to the Centers for Disease Control and Prevention (CDC), 56.6% of Black women are overweight or obese compared with 44.4% Hispanic and 32.8% of white women. Social scientists and public health researchers have argued that increasing educational attainment would lead to overall improvements in health outcomes. Using the National Health and Nutrition Examination Survey (NHANES), a nationally representative cross-sectional survey, Cycles 1999–2010, I examined how educational attainment impacts Black women’s rate of obesity and C-reactive protein levels (N = 2685). Multiple linear regression was used to analyze the association between body mass index (BMI) and educational attainment. C-reactive protein, inflammation response, was used to measure the body’s reaction to being exposed to stress. The results demonstrated that educational attainment among Black women does not decrease their risk of being obese or levels of C-reactive protein. This article provides evidence to support a need to increase awareness of health disparities that disproportionately impact Black women.

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