scholarly journals Changes in extra-striatal functional connectivity in patients with schizophrenia in a psychotic episode

2017 ◽  
Vol 210 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Henning Peters ◽  
Valentin Riedl ◽  
Andrei Manoliu ◽  
Martin Scherr ◽  
Dirk Schwerthöffer ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Resting State ◽  
Ventral Striatum ◽  
Magnetic Resonance Images ◽  
Anterior Insula ◽  
Psychotic Episode ◽  
Functional Magnetic Resonance ◽  
Intrinsic Connectivity

BackgroundIn patients with schizophrenia in a psychotic episode, intra-striatal intrinsic connectivity is increased in the putamen but not ventral striatum. Furthermore, multimodal changes have been observed in the anterior insula that interact extensively with the putamen.AimsWe hypothesised that during psychosis, putamen extra-striatal functional connectivity is altered with both the anterior insula and areas normally connected with the ventral striatum (i.e. altered functional connectivity distinctiveness of putamen and ventral striatum).MethodWe acquired resting-state functional magnetic resonance images from 21 patients with schizophrenia in a psychotic episode and 42 controls.ResultsPatients had decreased functional connectivity: the putamen with right anterior insula and dorsal prefrontal cortex, the ventral striatum with left anterior insula. Decreased functional connectivity between putamen and right anterior insula was specifically associated with patients' hallucinations. Functional connectivity distinctiveness was impaired only for the putamen.ConclusionsResults indicate aberrant extra-striatal connectivity during psychosis and a relationship between reduced putamen–right anterior insula connectivity and hallucinations. Data suggest that altered intrinsic connectivity links striatal and insular pathophysiology in psychosis.

scholarly journals Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

2012 ◽  
Vol 43 (9) ◽  
pp. 1921-1927 ◽  
Author(s):  
Y. Tang ◽  
L. Kong ◽  
F. Wu ◽  
F. Womer ◽  
W. Jiang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Resting State ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Major Depressive ◽  
Treatment Naïve

BackgroundConvergent studies provide support for abnormalities in the structure and functioning of the prefrontal cortex (PFC) and the amygdala, the key components of the neural system that subserves emotional processing in major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala–PFC functional connectivity abnormalities in treatment-naive subjects with MDD.MethodsResting-state fMRI data were acquired from 28 individuals with MDD and 30 healthy control (HC) subjects. Amygdala–PFC functional connectivity was compared between the MDD and HC groups.ResultsDecreased functional connectivity to the left ventral PFC (VPFC) from the left and right amygdala was observed in the MDD group, compared with the HC group (p < 0.05, corrected).ConclusionsThe treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the left VPFC. This suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.

scholarly journals Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI

2021 ◽  
Vol 12 ◽  
Author(s):  
Ting Yang ◽  
Bangli Shen ◽  
Aiqin Wu ◽  
Xinglu Tang ◽  
Wei Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Resting State ◽  
Depression Symptoms ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Convergent evidence indicates that individuals with symptoms of depression exhibit altered functional connectivity (FC) of the amygdala, which is a key brain region in processing emotions. At present, the characteristics of amygdala functional circuits in patients with mild cognitive impairment (MCI) with and without depression are not clear. The current study examined the features of amygdala FC in patients with MCI with depression symptoms (D-MCI) using resting-state functional magnetic resonance imaging. We acquired resting-state functional magnetic resonance imaging data from 16 patients with D-MCI, 18 patients with MCI with no depression (nD-MCI), and 20 healthy controls (HCs) using a 3T scanner and compared the strength of amygdala FC between the three groups. Patients with D-MCI exhibited significant FC differences in the amygdala–medial prefrontal cortex and amygdala–sensorimotor networks. These results suggest that the dysfunction of the amygdala–medial prefrontal cortex network and the amygdala–sensorimotor network might be involved in the neural mechanism underlying depression in MCI.

scholarly journals Structural-functional connectivity mapping of the insular cortex system: A combined data-driven and meta-analytic topic mapping approach

2021 ◽  
Author(s):  
Benjamin Klugah-Brown ◽  
Pan Wang ◽  
Yuan Jiang ◽  
Benjamin Becker ◽  
Peng Hu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Resting State ◽  
Insular Cortex ◽  
Anterior Insula ◽  
Data Driven ◽  
Functional Magnetic Resonance ◽  
Functional Relationships ◽  
The Core ◽  
Cortex System

The insular cortex is an important anatomical integration hub and can serve as a suitable model for exploring structural-functional relationships. In this study, we examined structural and functional magnetic resonance correspondence via the diffusion tensor imaging (DTI) and resting-state functional connectivity (RSFC) profiles of the insular cortex and its mapping with functional networks (FNs) across the brain. We explored these associations primarily by using a data-driven method to independently estimate the structural-functional connectivity in the human insular cortex system. Data were obtained from the Human Connectome Project comprising 108 resting-state functional magnetic resonance neuroimaging (fMRI) and DTI. Brain networks were acquired and defined according to the seven Yeo FNs. In general, we observed moderate to high association between the structural and functional mapping results of three distinct insular subregions: the posterior insula (sensorimotor: RSFC, DTI = 50%, 72%, respectively), dorsal anterior insula (ventral attention: RSFC, DTI = 83%, 83%, respectively), and ventral anterior insula (frontoparietal: RSFC, DTI = 42%, 89%, respectively). We also examined the cognitive and behavioral domains associated with these three insular subregions using meta-analytic topic mapping and found cognitive and behavioral relations to affective processes, reflecting the core properties of the cytoarchitecture. In sum, given the core role of the insula in the human brain, our findings on the correspondence of the insular cortex system between DTI and RSFC mappings provide a novel approach and insight for clinical researchers to detect dysfunctional brain organization in various neurological disorders.

scholarly journals Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis

2021 ◽  
Vol 15 ◽  
Author(s):  
Ke Song ◽  
Yong Wang ◽  
Mei-Xia Ren ◽  
Jiao Li ◽  
Ting Su ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Functional Magnetic Resonance Imaging ◽  
Optic Neuritis ◽  
Resting State ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Functional Connectivity Density ◽  
The Right

Background: Using resting-state functional connectivity (rsFC), we investigated alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with optic neuritis (ON).Methods: We enrolled 28 patients with ON (18 males, 10 females) and 24 healthy controls (HCs; 16 males, 8 females). All subjects underwent functional magnetic resonance imaging (fMRI) in a quiet state to determine the values of rsFC, long-range FCD (longFCD), and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were generated to distinguish patients from HCs.Results: The ON group exhibited obviously lower longFCD values in the left inferior frontal gyrus triangle, the right precuneus and the right anterior cingulate, and paracingulate gyri/median cingulate and paracingulate gyri. The left median cingulate and paracingulate gyri and supplementary motor area (SMA) were also significantly lower. Obviously reduced IFCD values were observed in the left middle temporal gyrus/angular gyrus/SMA and right cuneus/SMA compared with HCs.Conclusion: Abnormal neural activities were found in specific brain regions in patients with ON. Specifically, they showed significant changes in rsFC, longFCD, and IFCD values. These may be useful to identify the specific mechanism of change in brain function in ON.

Altered Functional Connectivity within Default Mode Network in Patients with Transient Ischemic Attack: A Resting-State Functional Magnetic Resonance Imaging Study

2019 ◽  
Vol 48 (1-2) ◽  
pp. 61-69 ◽  
Author(s):  
Tingting Zhu ◽  
Lingyu Li ◽  
Yulin Song ◽  
Yu Han ◽  
Chengshu Zhou ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Functional Magnetic Resonance Imaging ◽  
Transient Ischemic Attack ◽  
Default Mode Network ◽  
Resting State ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Ischemic Attack

Default mode network (DMN) is an important functional brain network that supports aspects of cognition. Stroke has been reported to be associated with functional connectivity (FC) impairments within DMN. However, whether FC within DMN changes in transient ischemic attack (TIA), an important risk factor for stroke, remains unclear. Forty-eight TIA patients and 41 age- and sex-matched healthy controls (HCs) were recruited in this study. Using resting-state functional magnetic resonance imaging seed-based FC methods, we examined FC alterations within DMN in TIA patients, tested its associations with clinical information, and further explored the ability of FC abnormalities to predict follow-up ischemic attacks. We found significantly decreased FC of left middle temporal gyrus/angular gyrus both with medial prefrontal cortex (mPFC) and posterior cingulate cortex/precuneus (PCC/Pcu) and significantly decreased FC among each pair of mPFC, left PCC, and right Pcu in patients with TIA as compared with HCs. Moreover, the connectivity between mPFC and left PCC could predict future ischemic attacks of the patients. Collectively, these findings may provide insights into further understanding of the underlying pathological mechanism in TIA, and aberrant FC between the hubs within DMN may provide a reference for the imaging diagnosis and early intervention of TIA.

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