Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A Systematic Review

Purpose The aim of this systematic review was to summarize and evaluate the evidence available for oral supplementation with coenzyme Q10 (CoQ10) to improve the tolerability of cancer treatments. Materials and Methods Searches for all published and unpublished controlled trials were carried out on seven databases. Manufacturers of CoQ10 were identified and contacted. Controlled clinical trials of monopreparations of CoQ10 administered orally to cancer patients were included. No language restrictions were imposed. Data were extracted independently by two authors according to predefined criteria. Results Six studies were included in the review, including three randomized clinical trials and three nonrandomized clinical trials. Patients in five of six studies received anthracyclines. The results suggested that CoQ10 provides some protection against cardiotoxicity or liver toxicity during cancer treatment. However, because of inadequate reporting and analysis, as well as questionable validity of outcome measures, the results are not conclusive. Conclusion Suggestions that CoQ10 might reduce the toxicity of cancer treatments have not been tested by rigorous trials. Further investigations are necessary to determine whether CoQ10 can improve the tolerability of cancer treatments.

Download Full-text

Effect of Orthodontic Treatment on Tooth Autotransplantation: Systematic Review of Controlled Clinical Trials

European Journal of Dentistry ◽

10.1055/s-0040-1708329 ◽

2020 ◽

Vol 14 (03) ◽

pp. 467-482

Author(s):

Rogério Lacerda-Santos ◽

Rhaíssa Ferreira Canutto ◽

José Lucas dos Santos Araújo ◽

Fabiola Galbiatti de Carvalho ◽

Eliseu Aldrighi Münchow ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Randomized Clinical Trials ◽

Risk Of Bias ◽

Significant Heterogeneity ◽

Controlled Clinical Trials ◽

Periodontal Tissues ◽

Orthodontic Movement ◽

Anterior Teeth

AbstractThis systematic review was focused on evaluating tooth autotransplantation, considering its impacts on the teeth, bone, soft tissues, and aesthetics in orthodontic patients. A bibliographic search was conducted without limitations on year of publication or language in the databases of PubMed, Web of Science, Scopus, Medline Complete, Cochrane, Clinical Trials, and Trials Central. For triage of articles, indications, surgical planning, orthodontic movement, risk factors for treatment, and long-term follow-ups were considered. For outcomes, the results with reference to teeth, alveolar bone, periodontal tissues, and esthetic satisfaction were considered. Risk of bias was evaluated using the methodological index for nonrandomized studies-MINORS. The results showed 10 controlled clinical trials, and no randomized clinical trials were found. The selected studies included 715 patients and 934 autotransplanted teeth among which there were premolars, molars, and anterior teeth evaluated in the long term, indicating that orthodontics associated with autotransplantation indicated a result that was generally clinically acceptable. The quality of the set of evidence was considered medium due to the presence of different methodological problems, risk of bias, and significant heterogeneity in the evaluated studies. There was a sufficient body of evidence that justified autotransplantation in patients who needed orthodontic movement. In teeth, there was an increase in root resorption influenced by orthodontics, but without impacting on the general clinical result in the long term. Bone and periodontal tissue do not appear to be affected by orthodontics. The patient’s aesthetic satisfaction was not considered in the studies.

Download Full-text

Early Palliative Care in Cancer Patients. Systematic Review of Literature, with Meta-Analysis of Randomized Clinical Trials

Annals of Oncology ◽

10.1093/annonc/mdu350.6 ◽

2014 ◽

Vol 25 ◽

pp. iv472

Author(s):

A. Affatato ◽

L. Stocchi ◽

F. Drudi ◽

S. Nicoletti ◽

M.C. Monterubbianesi ◽

...

Keyword(s):

Systematic Review ◽

Palliative Care ◽

Clinical Trials ◽

Cancer Patients ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Review Of Literature ◽

Early Palliative Care

Download Full-text

Non-pharmacological therapies for depressive symptoms in breast cancer patients: Systematic review and meta-analysis of randomized clinical trials

The Breast ◽

10.1016/j.breast.2019.01.006 ◽

2019 ◽

Vol 44 ◽

pp. 135-143 ◽

Cited By ~ 4

Author(s):

Liliana Coutiño-Escamilla ◽

Maricela Piña-Pozas ◽

Aurelio Tobías Garces ◽

Brenda Gamboa-Loira ◽

Lizbeth López-Carrillo

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Clinical Trials ◽

Depressive Symptoms ◽

Cancer Patients ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Breast Cancer Patients

Download Full-text

Effects of oral supplementation in the management of oral mucositis in cancer patients: A meta‐analysis of randomized clinical trials

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12901 ◽

2019 ◽

Vol 49 (2) ◽

pp. 117-125 ◽

Cited By ~ 1

Author(s):

Amanda Gomes Menêses ◽

Ana Gabriela Costa Normando ◽

Isabela Porto de Toledo ◽

Paula Elaine Diniz Reis ◽

Eliete Neves Silva Guerra

Keyword(s):

Clinical Trials ◽

Cancer Patients ◽

Oral Mucositis ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Oral Supplementation

Download Full-text

Systematic Review of Randomized Clinical Trials of Acupressure Therapy for Primary Dysmenorrhea

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/169692 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Hui-ru Jiang ◽

Shuang Ni ◽

Jin-long Li ◽

Miao-miao Liu ◽

Ji Li ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Statistical Analysis ◽

Adverse Events ◽

Randomized Clinical Trials ◽

Controlled Trials ◽

Cochrane Central Register ◽

Primary Dysmenorrhea ◽

Randomized Controlled ◽

Central Register

The evidence of acupressure is limited in the management of dysmenorrhea. To evaluate the efficacy of acupressure in the treatment of primary dysmenorrhea based on randomized controlled trials (RCTs), we searched MEDLINE, the Chinese Biomedical Database (CBM), and the Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception until March 2012. Two reviewers independently selected articles and extracted data. Statistical analysis was performed with RevMan 5.1 software. Eight RCTs were identified from the retrieved 224 relevant records. Acupressure improved pain measured with VAS (−1.41 cm 95% CI [−1.61, −1.21]), SF-MPQ at the 3-month followup (WMD −2.33, 95% CI [−4.11, −0.54]) and 6-month followup (WMD −4.67, 95% CI [−7.30, −2.04]), and MDQ at the 3-month followup (WMD −2.31, 95% CI [−3.74, −0.87]) and 6-month followup (WMD −4.67, 95% CI [−7.30, −2.04]). All trials did not report adverse events. These results were limited by the methodological flaws of trials.

Download Full-text

Randomized Controlled Trials of Early Ambulatory Hydroxychloroquine in the Prevention of COVID-19 Infection, Hospitalization, and Death: Meta-Analysis

10.1101/2020.09.30.20204693 ◽

2020 ◽

Author(s):

Joseph A. Ladapo ◽

John E. McKinnon ◽

Peter A. McCullough ◽

Harvey Risch

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Side Effects ◽

Fixed Effects ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Controlled Trials ◽

Cochrane Central Register ◽

Randomized Controlled ◽

Exposure Prophylaxis

Objective--To determine if hydroxychloroquine (HCQ) reduces the incidence of new illness, hospitalization or death among outpatients at risk for or infected with SARS-CoV-2 (COVID-19). Design--Systematic review and meta-analysis of randomized clinical trials. Data sources--Search of MEDLINE, EMBASE, PubMed, medRxiv, PROSPERO, and the Cochrane Central Register of Controlled Trials. Also review of reference lists from recent meta-analyses. Study selection--Randomized clinical trials in which participants were treated with HCQ or placebo/standard-of-care for pre-exposure prophylaxis, post-exposure prophylaxis, or outpatient therapy for COVID-19. Methods--Two investigators independently extracted data on trial design and outcomes. Medication side effects and adverse reactions were also assessed. The primary outcome was COVID-19 hospitalization or death. When unavailable, new COVID-19 infection was used. We calculated random effects meta-analysis according to the method of DerSimonian and Laird. Heterogeneity between the studies was evaluated by calculation of Cochran Q and I2 parameters. An Egger funnel plot was drawn to investigate publication bias. We also calculated the fixed effects meta-analysis summary of the five studies. All calculations were done in Excel, and results were considered to be statistically significant at a two-sided threshold of P=.05. Results--Five randomized controlled clinical trials enrolling 5,577 patients were included. HCQ was associated with a 24% reduction in COVID-19 infection, hospitalization or death, P=.025 (RR, 0.76 [95% CI, 0.59 to 0.97]). No serious adverse cardiac events were reported. The most common side effects were gastrointestinal. Conclusion--Hydroxychloroquine use in outpatients reduces the incidence of the composite outcome of COVID-19 infection, hospitalization, and death. Serious adverse events were not reported and cardiac arrhythmia was rare. Systematic review registration--This review was not registered.

Download Full-text

Dental Composite Restorations Repair: A Systematic Review and Meta-analysis

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i59a34322 ◽

2021 ◽

pp. 707-738

Author(s):

Abdulmohsen Al Rabiah ◽

Alamri Zahrah ◽

Tuwaym Malath ◽

Al Daghri Ebtihal ◽

Al Suhaibani Daniyah ◽

...

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Prospective Cohort ◽

Randomized Clinical Trials ◽

Assessment Tool ◽

Risk Of Bias ◽

Dental Composite ◽

Controlled Trials ◽

Cochrane Central Register ◽

Bias Assessment

Background: Controversy exists in the literature regarding the most optimal repair procedure for improving the adhesion between the repair resin and the existing resin composite materials. Hence the aim of the present study was to do a systematic review and to analyze the adhesion potential of resin-based composites to similar and dissimilar composites and aimed to determine the possible dominant factors affecting the bond strength results. Materials & Methods: Randomized clinical trials (RCTs) and prospective cohort design were searched through electronic databases including MEDLINE, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials for randomized clinical trials (RCTs) until July 2020 that compared different methods of composite restoration repair and a minimum mean follow-up time of 1 year. There were no restrictions on a particular treatment indication or outcome measures. Two authors independently conducted screening, risk of bias assessment, and data extraction of eligible trials in duplicate. We applied the Cochrane risk of bias assessment tool to consider the risk of bias. Results: We identified 10 articles; two of them were RCTs, and eight prospective cohort studies. There were 530 participants, with 990 teeth, dealing with resin-based composite (RBC) restorations. The intervention of defective restorations ranged from minimal intervention to total restoration replacement. The evaluation criteria were also varied with different evaluation protocols. The low number and heterogeneity of RCTs did not allow for meta-analyses. Conclusions: Although different repair protocols are mentioned in the literature according to the included studies, an appropriate and definitive conclusion can't be drawn. However, it seems repairs versus replacements should be considered as the first line of treatment when all factors lead to repair rather than replacement. Further randomized controlled trials with high methodological quality need to be conducted in order to establish evidence-based recommendations, particularly for RBC repair.

Download Full-text

Endpoints for Perianal Crohn’s Disease Trials: Past, Present and Future

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjab026 ◽

2021 ◽

Author(s):

Bénédicte Caron ◽

Ferdinando D’Amico ◽

Silvio Danese ◽

Laurent Peyrin-Biroulet

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Clinical Response ◽

Primary Endpoint ◽

Randomized Clinical Trials ◽

Controlled Trials ◽

Perianal Crohn’S Disease ◽

Perianal Crohn's Disease

Abstract Background and Aims Since the 1980s, many studies have evaluated the efficacy of therapies to improve the outcomes of patients with perianal Crohn’s disease. We performed a systematic review to describe the evolution of endpoints in perianal fistulizing Crohn’s disease. Efficacy outcomes, definitions and measurement tools were assessed. Methods Electronic databases were searched up to November 1, 2020. All published randomized placebo-controlled trials enrolling patients with perianal fistula and Crohn’s disease were eligible for inclusion. Ongoing randomized clinical trials were also described. Results Nineteen randomized controlled trials were included. Clinical efficacy endpoints were reported in all trials. Clinical response was the most frequent primary endpoint [6/19 studies, 31.6%], followed by clinical remission in four studies [21%]. Clinical response was defined as closure of at least 50% of fistulas, while remission was defined as closure of all fistulas. A combined clinical and radiological primary endpoint was used to assess fistula healing in four studies [21%]. The Perianal Disease Activity Index was a primary endpoint in only one study [5.5%]. In addition, eight ongoing controlled trials were identified. Combined clinical and radiological remission was the most frequent primary endpoint in these studies [4/8, 50%]. Conclusion In this systematic review, significant changes in outcomes used in randomized clinical trials of perianal Crohn’s disease were observed. Radiological endpoints are increasingly used in perianal fistulizing Crohn’s disease trials.

Download Full-text