Influence of prognostic factors in pediatric high-grade osteosarcoma survival.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 9572-9572
Author(s):  
A. Castellanos-Toledo ◽  
R. Rivera-Luna ◽  
R. Cardenas-Cardos ◽  
J. d. J. Figueroa Carbajal ◽  
C. A. Leal-Cavazos
Keyword(s):  
Prognostic Factors ◽  
High Grade ◽  
High Grade Osteosarcoma

scholarly journals Survival Analysis of 3 Different Age Groups and Prognostic Factors among 402 Patients with Skeletal High-Grade Osteosarcoma. Real World Data from a Single Tertiary Sarcoma Center

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 486
Author(s):  
Richard E. Evenhuis ◽  
Ibtissam Acem ◽  
Anja J. Rueten-Budde ◽  
Diederik S. A. Karis ◽  
Marta Fiocco ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Medical Center ◽  
Age Groups ◽  
High Grade ◽  
Real World Data ◽  
Poor Overall Survival ◽  
Histopathological Response ◽  
Curative Intent ◽  
Entire Cohort ◽  
High Grade Osteosarcoma

Age is a known prognostic factor for many sarcoma subtypes, however in the literature there are limited data on the different risk profiles of different age groups for osteosarcoma survival. This study aims to provide an overview of survival in patients with high-grade osteosarcoma in different age groups and prognostic variables for survival and local control among the entire cohort. In this single center retrospective cohort study, 402 patients with skeletal high-grade osteosarcoma were diagnosed and treated with curative intent between 1978 and 2017 at the Leiden University Medical Center (LUMC). Prognostic factors for survival were analyzed using a Cox proportional hazard model. In this study poor overall survival (OS) and event-free survival (EFS) were associated with increasing age. Age groups, tumor size, poor histopathological response, distant metastasis (DM) at presentation and local recurrence (LR) were important independent prognostic factors influencing OS and EFS. Differences in outcome among different age groups can be partially explained by patient and treatment characteristics.

scholarly journals Analysis of Prognostic Factors in High-Grade Osteosarcoma of the Extremities in Children: A 15-Year Single-Institution Experience

2016 ◽  
Vol 6 ◽  
Author(s):  
Liliana Vasquez ◽  
Fanny Tarrillo ◽  
Monica Oscanoa ◽  
Ivan Maza ◽  
Jenny Geronimo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
High Grade ◽  
Single Institution ◽  
High Grade Osteosarcoma

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

2002 ◽  
Vol 20 (3) ◽  
pp. 776-790 ◽  
Author(s):  
Stefan S. Bielack ◽  
Beate Kempf-Bielack ◽  
Günter Delling ◽  
G. Ulrich Exner ◽  
Silke Flege ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Wide Spectrum ◽  
Survival Rates ◽  
Study Group ◽  
High Grade ◽  
Tumor Site ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Response To Chemotherapy ◽  
High Grade Osteosarcoma

PURPOSE: To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease. PATIENTS AND METHODS: A total of 1,702 consecutive newly diagnosed patients with high-grade osteosarcoma of the trunk or limbs registered into the neoadjuvant studies of the Cooperative Osteosarcoma Study Group before July 1998 were entered into an analysis of demographic, tumor-related, and treatment-related variables, response, and survival. The intended therapeutic strategy included preoperative and postoperative chemotherapy with multiple agents as well as surgery of all operable lesions. RESULTS: Axial tumor site, male sex, and a long history of symptoms were associated with poor response to chemotherapy in univariate and multivariate analysis. Actuarial 10-year overall and event-free survival rates were 59.8% and 48.9%. Among the variables assessable at diagnosis, patient age (actuarial 10-year survival ≥ 40, 41.6%; < 40, 60.2%; P = .012), tumor site (axial, 29.2%; limb, 61.7%; P < .0001), and primary metastases (yes, 26.7%; no, 64.4%; P < .0001), and for extremity osteosarcomas, also size (≥ one third, 52.5%; < one third, 66.7%; P < .0001) and location within the limb (proximal, 49.3%; other, 63.9%; P < .0001), had significant influence on outcome. Two additional important prognostic factors were treatment related: response to chemotherapy (poor, 47.2%; good, 73.4%; P < .0001) and the extent of surgery (incomplete, 14.6%; macroscopically complete, 64.8%; P < .0001). All factors except age maintained their significance in multivariate testing, with surgical remission and histologic response emerging as the key prognostic factors. CONCLUSION: Tumor site and size, primary metastases, response to chemotherapy, and surgical remission are of independent prognostic value in osteosarcoma.

scholarly journals Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma

Sarcoma ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sheila Thampi ◽  
Katherine K. Matthay ◽  
W. John Boscardin ◽  
Robert Goldsby ◽  
Steven G. DuBois
Keyword(s):  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Clinical Features ◽  
Older Patients ◽  
High Grade ◽  
Tumor Site ◽  
Extraskeletal Osteosarcoma ◽  
Tissue Of Origin ◽  
High Grade Osteosarcoma

Background. Extraskeletal osteosarcoma (ESOS) is a rare subtype of osteosarcoma. We investigated patient characteristics, overall survival, and prognostic factors in ESOS.Methods. We identified cases of high-grade osteosarcoma with known tissue of origin in the Surveillance, Epidemiology, and End Results database from 1973 to 2009. Demographics were compared using univariate tests. Overall survival was compared with log-rank tests and multivariate analysis using Cox proportional hazards methods.Results. 256/4,173 (6%) patients with high-grade osteosarcoma had ESOS. Patients with ESOS were older, were more likely to have an axial tumor and regional lymph node involvement, and were female. Multivariate analysis showed ESOS to be favorable after controlling for stage, age, tumor site, gender, and year of diagnosis [hazard ratio 0.75 (95% CI 0.62 to 0.90);p=0.002]. There was an interaction between age and tissue of origin such that older patients with ESOS had superior outcomes compared to older patients with skeletal osteosarcoma. Adverse prognostic factors in ESOS included metastatic disease, larger tumor size, older age, and axial tumor site.Conclusion. Patients with ESOS have distinct clinical features but similar prognostic factors compared to skeletal osteosarcoma. Older patients with ESOS have superior outcomes compared to older patients with skeletal osteosarcoma.

Prognostic factors for teenage and adult patients with high-grade osteosarcoma: an analysis of 240 patients

2013 ◽  
Vol 30 (3) ◽  
Author(s):  
Ayse Durnali ◽  
Necati Alkis ◽  
Sengul Cangur ◽  
Fisun Ardic Yukruk ◽  
Ali Inal ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Adult Patients ◽  
High Grade ◽  
High Grade Osteosarcoma

scholarly journals Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient

Sarcoma ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Kjetil Berner ◽  
Kirsten Sundby Hall ◽  
Odd R. Monge ◽  
Harald Weedon-Fekjær ◽  
Olga Zaikova ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Metastatic Disease ◽  
Tumour Size ◽  
Local Relapse ◽  
High Grade ◽  
Treatment Results ◽  
Dramatic Difference ◽  
Adequate Surgery ◽  
High Grade Osteosarcoma ◽  
Clinical Records

Purpose. A retrospective study of prognostic factors and treatment outcome of osteosarcoma (OS) during modern chemotherapy era with focus on patients with primary metastatic disease, nonextremity localisation, or age >40 years (nonclassical OS).Methods. A nationwide cohort, comprising 424 high-grade Norwegian bone OS patients, was based on registry sources supplemented with clinical records from hospitals involved in sarcoma management between 1975 and 2009.Results. Only 48% were younger patients with tumour in the extremities and without metastasis at diagnosis (classical OS). A considerable discrepancy in survival between classical and nonclassical OS was observed: 61% versus 26% 10-year sarcoma specific survival. Twice as many of the former received both adequate surgery and chemotherapy compared to the latter. This could only partly explain the differences in survival due to inherent chemoresistance in primary metastatic disease and a higher rate of local relapse among patients with axial tumours. Metastasis at diagnosis, increased lactate dehydrogenase, age > 40 years, and tumour size above median value were all adverse prognostic factors for overall survival.Conclusion. We confirm a dramatic difference in outcome between classical and nonclassical high-grade OS patients, but treatment variables could only partly explain the dismal outcome of the latter.

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