Outcomes for stage IVA squamous cell carcinoma of the oral cavity according to staging subtypes.

6076 Background: Patients with locoregionally advanced squamous cell carcinoma of the oral cavity (SCCOC), defined as stages III to IVB without T4b, are treated similarly and combined for enrollment into most clinical trials. There are several combinations of tumor (T) and lymph node (N) categories for stage IVA. We evaluated the differences in outcomes according to subtypes of patients with stage IVA SCCOC. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for patients with stage IVA SCCOC diagnosed between 1988 and 2007. Patients were subdivided according to tumor (T) and lymph node (N) status. Overall survival (OS) was estimated by the Kaplan-Meier method and compared by using log-rank test. Cox proportional hazard regression models were used for multivariate analyses. Results: Among the 3,904 patients meeting inclusion criteria, most patients underwent surgery, either alone (24%) or with radiation (59%). There was a significant difference in outcomes according to AJCC subsets (T4aN0, T4aN1, T1N2, T2N2, T3N2 and T4N2), with 5-year OS ranging from 15.8% in T4aN2 to 41.3% in T4aN0 (HR 2.3; 95% CI 2.03-2.62, p < 0.001). Since the 5-year OS was similar for patients with T1N2-T2N2 and T3N2-T4aN2, these groups were further subdivided according to the T (T1-2 or T3-4a) and N2 subsets. The 5-year OS was significantly different according to the subgroups, ranging from 11.8% in T3-4aN2c to 37.5% in T1-2N2a (Table). The stage subgroups remained independent predictors for survival after adjusting for age, gender, race and treatment. Conclusions: Stage IVA SCCOC is a heterogeneous disease with significant differences in outcomes according to its subsets. If these findings are confirmed in additional studies, further subdivision of stage IVA may be warranted. [Table: see text]

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Influence of marginal and segmental bony resection on the local control of oral Squamous cell carcinoma involving the mandible

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v18i4.42908 ◽

2019 ◽

Vol 18 (4) ◽

pp. 801-807

Author(s):

Mohammad Deedarul Alam

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Local Control ◽

Squamous Cell ◽

Segmental Resection ◽

Marginal Group ◽

Significant Difference

Background and objective: Marginal or segmental resection of bone are often required for tumor removal in oral squamous cell carcinoma patients to secure adequate margin. The present study aims to evaluate the surgical outcome and post-operative complication of both group of patients and also assesses the local control of the disease in the oral cavity. Methods: In this prospective study, 32 patients who were treated with marginal or segmental jaw resection for oral squamous cell carcinoma of the lower part of oral cavity was undertaken within September 2008 to August 2013.There were 9 males and 23 females with a median age of 40.5 years. Twenty patients underwent marginal and 12 patients had segmental resection of the mandible. Distribution of the subject by age, sex, primary site of lesion, pathologic tumor stage, presence of mandibular invasion, pathologic cervical lymph node stage and feature of post- operative complications were analyzed prospectively. Results: According to this study, the mandible was involved in 83.3% of patient with segmental resection and 15% of patients with marginal resection. Buccal mucosa was mostly involved site in marginal group (60%) and retro molar trigon was highly involved site with segmental group (41.7%). In marginal group 30% cases was involved with stage1 and 70% was stage2; in segmental group 25% cases were stage2 and 67.7% were stage3. Statistically significant difference was exist in pathological cervical node stage(p<0.05). Mandibular invasion was significantly more in segmental group (p<0.05). Soft tissue surgical margins were positive in 4 patients (20%) in the marginal group and in 3 patients (25%) in the segmental group. Negative neck lymph node was found in 20 (63%) cases and positive neck node was found in 12 (37%) cases, of which four patients, including 2(15%) cases in the marginal group and 2(8.3%) cases in the segmental group was died. Trismus and mastication problems were found higher in segmental than marginal resection group. Conclusion: Marginal resection of mandible is effective for patient with oral squamous cell carcinoma in the early stage. Post-operative outcome and local control of disease in segmental group were slightly higher than marginal group. Positive surgical margin status and bone invasion was found as the most important predictor of local control of the diseases in patient with oral squamous cell carcinoma. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.801-807

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Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol22no2.26873 ◽

2010 ◽

Vol 22 (2) ◽

Author(s):

Deece Patuti ◽

Harmas Yazid Yusuf ◽

Bethy Suryawathy Hernowo

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Regional Lymph Node ◽

Rank Test ◽

Regional Lymph Nodes ◽

Stromal Tissue ◽

Correlation Strength

Introduction: CD10 can also facilitate the ability of tumour metastasis by its ability to invade blood vessel walls.Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity. Methods: This study was preceded by collecting data on squamous cell carcinoma of the oral cavity in the medical record and paraffin blocks in the Anatomy Pathology section of 15 samples with enlarged regional lymph nodes and 15 samples without enlargement of regional lymph nodes. Then two preparations were made, the first preparation was stained with Hematoxylin Eosin (HE) to establish the diagnosis and determine the histopathological gradation, then count the number of eosinophils, and the other development was smeared with CD10. Outward immunohistochemistry uses the Labelled streptavidin biotin immunoperoxidase complex (LSAB) method using the Starr Trek Universal HRP Detection system. (Biocare Medical, USA). The primary antibody used was CD10 (Novocastra Laboratories Ltd, Newcastle upon Tyne, UK) with a dilution of 1:25 - 1: 50. Results: There was no statistically significant correlation between CD10 and enlargement of the lymph node regionally tested statistically using the Spearman rank test rs = -0.236, meaning that the increase in CD10 immunoexpression is inversely proportional to the enlargement of regional lymph node, but the correlation is not statistically significant The results of the analysis using the Spearman rank test found significance of p = 0.043 (significant) with a correlation strength of 37.2% Conclusion: There was no correlation between CD10 and enlargement of the lymph node regionally and correlation strength eosinophil distribution in squamous cell carcinoma of the oral cavity without regional lymph node enlargement.

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Effects of postoperative chemotherapy and radiotherapy on patients with squamous cell carcinoma of the oral cavity and multiple regional lymph node metastases

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.ijom.2013.11.013 ◽

2014 ◽

Vol 43 (6) ◽

pp. 680-685 ◽

Cited By ~ 7

Author(s):

H. Takahashi ◽

S. Yanamoto ◽

S. Yamada ◽

M. Umeda ◽

T. Shigeta ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Metastases ◽

Regional Lymph Node ◽

Postoperative Chemotherapy ◽

Node Metastases

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Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0901-5027(99)80098-8 ◽

1999 ◽

Vol 28 (5) ◽

pp. 403

Author(s):

H. Tideman

Keyword(s):

Squamous Cell Carcinoma ◽

Multivariate Analysis ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Prognostic Indicator ◽

Node Metastasis ◽

Occult Lymph Node Metastasis

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The Role of Sentinel Lymph Node Biopsy in Oral Cavity Squamous Cell Carcinoma

The American Surgeon ◽

10.1177/000313481908501114 ◽

2019 ◽

Vol 85 (11) ◽

pp. 549-552

Author(s):

Anna Lazutkin ◽

Ron Eliashar ◽

Jawad Abu-Tair ◽

Jeffrey M. Weinberger ◽

Nir Hirshoren

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymph Node Biopsy ◽

Node Biopsy

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AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck

Cancers ◽

10.3390/cancers11030347 ◽

2019 ◽

Vol 11 (3) ◽

pp. 347 ◽

Cited By ~ 4

Author(s):

Xiaolian Gu ◽

Lixiao Wang ◽

Linda Boldrup ◽

Philip Coates ◽

Robin Fahraeus ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Positive Impact ◽

The Cancer Genome Atlas ◽

Rank Test ◽

Enhancer Rna ◽

Kaplan Meier ◽

Significant Survival

A growing number of long non-coding RNAs (lncRNAs) have been linked to squamous cell carcinoma of the head and neck (SCCHN). A subclass of lncRNAs, termed enhancer RNAs (eRNAs), are derived from enhancer regions and could contribute to enhancer function. In this study, we developed an integrated data analysis approach to identify key eRNAs in SCCHN. Tissue-specific enhancer-derived RNAs and their regulated genes previously predicted using the computational pipeline PreSTIGE, were considered as putative eRNA-target pairs. The interactive web servers, TANRIC (the Atlas of Noncoding RNAs in Cancer) and cBioPortal, were used to explore the RNA levels and clinical data from the Cancer Genome Atlas (TCGA) project. Requiring that key eRNAs should show significant associations with overall survival (Kaplan–Meier log-rank test, p < 0.05) and the predicted target (correlation coefficient r > 0.4, p < 0.001), we identified five key eRNA candidates. The most significant survival-associated eRNA was AP001056.1 with ICOSLG encoding an immune checkpoint protein as its regulated target. Another 1640 genes also showed significant correlation with AP001056.1 (r > 0.4, p < 0.001), with the “immune system process” being the most significantly enriched biological process (adjusted p < 0.001). Our results suggest that AP001056.1 is a key immune-related eRNA in SCCHN with a positive impact on clinical outcome.

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