Obesity as a prognostic factor for incidence and survival in female patients diagnosed with breast cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12567-e12567
Author(s):  
Islam Elsayed Ramadan
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Normal Weight ◽  
Obese Patients ◽  
Age Group ◽  
Female Patients ◽  
Younger Age ◽  
The Impact

e12567 Background: The incidence of obesity in females ≥15 years of age in Egypt is one of the highest all over the world (33%)we investigated the impact of increased BMI on breast cancer incidence and survival. Methods: we reviewed files for 1873 female patients with breast cancer, presented at ACOD, from Jan. 1996 to Dec. 2005. , only 907 were eligible BMI of every patient was calculated and four groups were formed.The duration of follow-up was calculated from the date of registration to the date of death or last follow-up. The locoregional control period was between the end of treatment and failure of local control at 5 years or death or last follow-up OS was measured as the interval between the beginning of treatment and death or last follow-up evaluation. Results: patients were classified into 4 groups, the first group included 100 patients of BMI less than 18.5, the second group including 299 patients of BMI more than or equal to 18.5 and less than 25, the third group including 336 patients of BMI more than or equal to 25 and less than 30, and the fourth group including 172 patients of BMI more than 30. the highest peak of breast cancer incidence was in the age group 55-65 years (32.4%), while the lowest incidence was in the age group more than 65 (8.6%). Obese patients had the tendency to have breast cancer in younger age than normal weight patients with a mean of 38.6 years vs. 58.6 years. results showed that over weight patients constituted more than 37% while obese patients only constituted 19 %, normal weight 33% and underweight 11%. In our study, the majority of cases were staged as stage II and III (42.6 and 45.9 % respectively). Only 10.2% of patients in our series were recorded with stage IV; most of them were obese.Patients with increased BMI, in our study, had a significantly lower DFS ( p < 0.013).there was a statistically significant correlation between overall survival and BMI of patients (p=0.0015); there was an increase in mortality with increasing BMI. Conclusions: Our results report an increase in the incidence of breast cancer in overweight and obese patients in our population. Patients with high BMI were diagnosed at younger age, had more advanced stage and a statistically significant lower DFS & OS as compared to normal weight patients.

scholarly journals Risk-Reducing Salpingo-Oophorectomy and Breast Cancer Risk Reduction in the Gynecologic Oncology Group Protocol-0199 (GOG-0199)

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Phuong L Mai ◽  
Austin Miller ◽  
Mitchell H Gail ◽  
Steven Skates ◽  
Karen Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Incidence Rates ◽  
Pathogenic Variant ◽  
Risk Reducing ◽  
Cancer Risk Reduction

Abstract Background Risk-reducing salpingo-oophorectomy (RRSO) has been associated with approximately 50% breast cancer risk reduction among women with a pathogenic variant in BRCA1 or BRCA2 (BRCA1/2), a finding that has recently been questioned. Methods We estimated incidence rates of breast cancer and all cancers combined during 5 years of follow-up among participants selecting RRSO or ovarian cancer screening (OCS) among women with a BRCA1/2 pathogenic variant or strong breast and/or ovarian cancer family history. Ovarian or fallopian tube or peritoneal cancer incidence rates were estimated for the OCS group. Breast cancer hazard ratios (HRs) for time-dependent RRSO were estimated using Cox regression with age time-scale (4943 and 4990 women-years in RRSO and OCS cohorts, respectively). All statistical tests were two-sided. Results The RRSO cohort included 925 participants, and 1453 participants were in the OCS cohort (381 underwent RRSO during follow-up), with 88 incident breast cancers diagnosed. Among BRCA1/2 pathogenic variant carriers, a non-statistically significant lower breast cancer incidence was observed in the RRSO compared with the OCS cohort (HR = 0.86, 95% confidence interval  = 0.45 to 1.67; P = .67). No difference was observed in the overall population or among subgroups stratified by prior breast cancer history or menopausal status. Seven fallopian tube and four ovarian cancers were prospectively diagnosed in the OCS cohort, and one primary peritoneal carcinoma occurred in the RRSO cohort. Conclusions These data suggest that RRSO might be associated with reduced breast cancer incidence among women with a BRCA1/2 pathogenic variant, although the effect, if present, is small. This evolving evidence warrants a thorough discussion regarding the impact of RRSO on breast cancer risk with women considering this intervention.

Light at night and breast cancer incidence in Connecticut: An ecological study of age group effects

2016 ◽  
Vol 572 ◽  
pp. 1020-1024 ◽  
Author(s):  
Boris A. Portnov ◽  
Richard G. Stevens ◽  
Holly Samociuk ◽  
Daniel Wakefield ◽  
David I. Gregorio
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Ecological Study ◽  
Breast Cancer Incidence ◽  
Age Group ◽  
Light At Night ◽  
Group Effects

Absence of sustained breast cancer incidence inflation in a national mammography screening programme

2018 ◽  
Vol 26 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Stephen Morrell ◽  
Marli Gregory ◽  
Kerry Sexton ◽  
Jessica Wharton ◽  
Nisha Sharma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
New Zealand ◽  
Cancer Incidence ◽  
Invasive Breast Cancer ◽  
Mammography Screening ◽  
Screening Programme ◽  
Breast Cancer Incidence ◽  
Age Groups ◽  
Incidence Trends ◽  
The Impact

Objective To investigate the impact of population mammography screening on breast cancer incidence trends in New Zealand. Methods Trends in age-specific rates of invasive breast cancer incidence (1994–2014) were assessed in relation to screening in women aged 50–64 from 1999 and 45–69 following the programme age extension in mid-2004. Results Breast cancer incidence increased significantly by 18% in women aged 50–64 compared with 1994–98 (p<0.0001), coinciding with the 1999 introduction of mammography screening, and remained elevated for four years, before declining to pre-screening levels. Increases over 1994–99 incidence occurred in the 45–49 (21%) and 65–69 (19%) age groups following the 2004 age extension (p<0.0001). Following establishment of screening (2006–10), elevated incidence in the screening target age groups was compensated for by lower incidence in the post-screening ⩾70 age groups than in 1994–98. Incidence in women aged ⩾45 was not significantly higher (+5%) after 2006 than in 1994–98. The cumulated risk of breast cancer in women aged 45–84 for 1994–98 was 10.7% compared with 10.8% in 2006–10. Conclusions Increases in breast cancer incidence following introduction of mammography screening in women aged 50–64 did not persist. Incidence inflation also occurred after introduction of screening for age groups 45–49 and 65–69. The cumulated incidence for women aged 45–84 over 2006–10 after screening was well established, compared with 1994–98 prior to screening, shows no increase in diagnosis. Over-diagnosis is not inevitable in population mammography screening programmes.

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