Racial/ethnic variation in a common genetic alteration in prostate cancer.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 14-14
Author(s):  
Isabell Sesterhenn ◽  
Denise Young ◽  
Yongmei Chen ◽  
Gyorgy Petrovics ◽  
Jennifer Cullen ◽  
...  

14 Background: The molecular basis of racial/ethnic differences in the detection and outcomes of the carcinoma of the prostate (CaP) needs to be better defined to improve biomarkers and identify appropriate therapeutic targets. ETS-related gene fusions in proto-oncogenes (ERG, ETV1) are among the most common early oncogenic alterations described in CaP. Studies have highlighted the racial/ethnic variation in ERG fusion and ERG oncoprotein expression frequencies showing: the highest frequencies in Caucasian (CA) men, the lowest frequencies in Asian men, and intermediate frequencies in African American (AA) men. These differences persisted when patients were carefully matched for age and clinico-pathologic features. Building on previous work, the current study was conducted to evaluate ERG expression frequencies in a large cohort of AA and CA CaP patients. Methods: Patients enrolled at the Walter Reed National Military Medical Center who consented to provide radical prostatectomy (RP) specimens to the CPDR Tissue Bank and Clinical Database were evaluated. The current study included 443 AA and 696 CA patients. ERG oncoprotein expression was detected by immunohistochemistry using the 9FY mouse monoclonal anti-ERG antibody and was correlated with clinico-pathologic features and CaP outcomes. Results: Lower frequencies of ERG in the index tumors of AA men as compared to CA men (28.4% vs. 51.5%, p < 0.0001) were observed. Furthermore, AA men with higher grade CaP (Gleason 8-10) had even lower ERG frequency (16%), suggesting distinct molecular biologic features in aggressive CaP for AA men. A trend with age was observed for both racial groups, with younger CA showing higher ERG frequencies. At least one focus of ERG positive PIN was present in prostates with ERG positive tumors. In both CA and AA patients, a very low frequency (8%) of ERG expression was noted in anterior index tumors compared to posterior tumors. Conclusions: This study lends increasing support to differences of the most common early genomic alteration (ERG) between AA and CA CaP patients. The study also underscores the importance of identifying new or improving existing biomarkers with consideration of patient race/ethnicity.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e13531-e13531
Author(s):  
John Chan ◽  
Michelle Ann P. Caesar ◽  
Chloe Chan ◽  
Michael Richardson ◽  
Daniel Stuart Kapp ◽  
...  

e13531 Background: To examine trends in modifiable behaviorally related cancers among racial groups in the United States. Methods: Data were obtained from the United States Cancer Statistics (USCS) database for all cancers diagnosed between 2001 and 2017. Alcohol-associated cancers, HPV-associated, obesity-associated, physical inactivity-associated, and tobacco-associated were defined using ICD-O-3 site codes. SEER*Stat 8.3.8 and Joinpoint regression program 4.8.0.1 were used to calculate the trends of associated cancers expressed per 100,000. Results: In women, the incidence of all cancers has decreased significantly or remain unchanged for all racial groups in 2017, with the exception of an increase of HPV related cancers in white women (APC = 0.77%, p < 0.001), obesity related cancers in Hispanic women (APC = 0.46%, p < 0.001), and postmenopausal breast cancer in Black and Asian women (APC 0.78%, 1.06%, p < 0.001). The incidence of alcohol, tobacco, obesity, and physical inactivity associated cancer decreased significantly in men for all racial groups in 2017. HPV related cancers increased annually by 3.13% (p < 0.001) in White men and 0.90% in Asian men (p = 0.022). The highest decrease in modifiable factors associated with cancers was in physical inactivity related cancers in black men from the west (APC = -3.79, p < 0.001). The intersection of black race and U.S. region had the highest decreases in all cancers except obesity-related cancers where the intersection of Asian race and Midwest region had the highest decrease. Conclusions: In women, most modifiable factors associated with cancer are decreasing except in obesity related cancers and physical inactivity/obesity related postmenopausal breast cancer. In men, these rates of cancer are decreasing for all racial groups except HPV related cancers in White and Asian men.


2012 ◽  
Vol 34 (3) ◽  
pp. 394-427 ◽  
Author(s):  
Vanessa R. Wight ◽  
Suzanne M. Bianchi ◽  
Bijou R. Hunt

Using a national sample of 12,424 partnered women and 10,721 partnered men from the 2003-2006 American Time Use Survey, this article examines racial/ethnic variation in women’s and men’s housework time and its covariates. The ratio of women’s to men’s housework hours is greatest for Hispanics and Asians and smallest for Whites and Blacks. White and Hispanic women’s housework hours are associated with household composition and employment suggesting that the time availability perspective is a good predictor for these women, but may have less explanatory power for other race/ethnic groups of women. Relative resources also have explanatory power for White women’s housework time but are weak predictors for women of Other race/ethnicities. Time availability and relative resource measures show some association with White men’s housework time but are generally poor predictors among other race/ethnic groups of men, suggesting that traditional models of housework allocation do not “fit” all groups equally.


Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Julian N Acosta ◽  
Yasheng Chen ◽  
Cameron Both ◽  
Audrey C Leasure ◽  
Fernando Testai ◽  
...  

Introduction: Perihematomal Edema (PHE) is a neuroimaging biomarker of secondary brain injury in patients with spontaneous, non-traumatic intracerebral hemorrhage (ICH). There are limited data on racial/ethnic differences in the development of PHE. This dearth of data is partially driven by the time-consuming process of manually segmenting PHE. Leveraging a validated automated pipeline for PHE segmentation, we evaluated whether race and ethnicity influence baseline PHE volume in patients with ICH. Methods: The Ethnic/Racial Variations in Intracerebral Hemorrhage (ERICH) study is a prospective, multicenter study of ICH that recruited 1,000 adult participants from each of three racial/ethnic groups (non-Hispanic White, non-Hispanic Black, and Hispanic). We applied a previously validated deep learning algorithm to automatically determine PHE volumes on baseline CTs in these study participants. Quality control procedures were used to include only sufficiently accurate PHE measurements. Linear regression was used to identify factors associated with log-transformed PHE volume and to identify differences across Ethnic/Racial groups. Results: Our imaging pipeline provided good quality baseline PHE measurements on 2,008 out of 3,000 ERICH study participants. After excluding infratentorial hemorrhages (273) and those with missing or null baseline ICH volume (49), 1,686 remained for analysis (median age 59 [IQR 51-71], 687 [41%] female sex). Median PHE volume was 12.0 (IQR 4.8-27.1) for whites, 11.9 (IQR 4.5-26.1) for Hispanics and 8.3 (IQR 3.0-19.2) for blacks. Compared to Blacks, Hispanics (beta 0.22; 95%CI 0.11-0.32; p<0.001) and Whites (beta 0.20; 95%CI 0.07-0.33; p=0.003) had higher baseline PHE volumes, in multivariable analysis adjusting for age, sex, ICH location, log-baseline ICH volume, log-baseline intraventricular volume, and systolic blood pressure on admission. Conclusion: Race and ethnicity influence the volume of baseline PHE. Further studies are needed to validate our results and investigate the biological underpinnings of this difference.


2019 ◽  
pp. 1-24 ◽  
Author(s):  
Pamela Joshi ◽  
Maura Baldiga ◽  
Alison Earle ◽  
Rebecca Huber ◽  
Theresa Osypuk ◽  
...  

2010 ◽  
Vol 15 (8) ◽  
pp. 1160-1165 ◽  
Author(s):  
Allison S. Bryant ◽  
Yvonne W. Cheng ◽  
Aaron B. Caughey

2005 ◽  
Vol 95 (4) ◽  
pp. 710-716 ◽  
Author(s):  
Zheng Wu ◽  
Christoph M. Schimmele

2019 ◽  
Vol 34 (1) ◽  
pp. 131-152 ◽  
Author(s):  
Candace Miller ◽  
Josipa Roksa

Our study highlights specific ways in which race and gender create inequality in the workplace. Using in-depth interviews with 67 biology PhD students, we show how engagement with research and service varies by both gender and race. By considering the intersection between gender and race, we find not only that women biology graduate students do more service than men, but also that racial and ethnic minority men do more service than white men. White men benefit from a combination of racial and gender privilege, which places them in the most advantaged position with respect to protected research time and opportunities to build collaborations and networks beyond their labs. Racial/ethnic minority women emerge as uniquely disadvantaged in terms of their experiences relative to other groups. These findings illuminate how gendered organizations are also racialized, producing distinct experiences for women and men from different racial groups, and thus contribute to theorizing the intersectional nature of inequality in the workplace.


2020 ◽  
Vol 6 ◽  
pp. 237802312094404
Author(s):  
Paul Hemez ◽  
Karen Benjamin Guzzo ◽  
Wendy D. Manning ◽  
Susan L. Brown ◽  
Krista K. Payne

This data visualization uses several cycles of the National Survey of Family Growth to compare trends in median ages at first sex, birth, cohabitation, and marriage between 1995 and 2015 across non-Hispanic white, non-Hispanic black, native-born Hispanic, and foreign-born Hispanic women aged 40 to 44 years. Generally, women’s ages at first sex declined, ages at first cohabitation remained stable, and ages at marriage and birth increased. However, there were substantial race-ethnicity-nativity differences in the timing and sequencing of women’s reproductive and family experiences, and these differences grew over time. These descriptive findings point to the importance of identifying the larger social forces that contribute to differential experiences while underscoring the fundamental problems inherent with defining whites’ reproductive and family behaviors as “normal.”


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