Metal Nanoparticles as a Surrogate Carrier in Drug Delivery and Diagnostics

2021 ◽  
pp. 139-161
Author(s):  
Sushama Talegaonkar ◽  
Debopriya Dutta ◽  
Namita Chaudhary ◽  
Surya Goel ◽  
Ruchi Singh
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles

scholarly journals Bacterial Exopolysaccharides as Reducing and/or Stabilizing Agents during Synthesis of Metal Nanoparticles with Biomedical Applications

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Carlos Enrique Escárcega-González ◽  
Javier A. Garza-Cervantes ◽  
Augusto Vázquez-Rodríguez ◽  
José Rubén Morones-Ramírez
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Metal Nanoparticles ◽  
Chemical Sensors ◽  
Extracellular Space ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Cellular Interactions ◽  
Stabilizing Agents ◽  
Bacterial Exopolysaccharides

Bacterial exopolysaccharides (EPSs) are biomolecules secreted in the extracellular space and have diverse biological functionalities, such as environmental protection, surface adherence, and cellular interactions. EPSs have been found to be biocompatible and eco-friendly, therefore making them suitable for applications in many areas of study and various industrial products. Recently, synthesis and stabilization of metal nanoparticles have been of interest because their usefulness for many biomedical applications, such as antimicrobials, anticancer drugs, antioxidants, drug delivery systems, chemical sensors, contrast agents, and as catalysts. In this context, bacterial EPSs have been explored as agents to aid in a greener production of a myriad of metal nanoparticles, since they have the ability to reduce metal ions to form nanoparticles and stabilize them acting as capping agents. In addition, by incorporating EPS to the metal nanoparticles, the EPS confers them biocompatibility. Thus, the present review describes the main bacterial EPS utilized in the synthesis and stabilization of metal nanoparticles, the mechanisms involved in this process, and the different applications of these nanoparticles, emphasizing in their biomedical applications.

Bioactivity of noble metal nanoparticles decorated with biopolymers and their application in drug delivery

2015 ◽  
Vol 496 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Mahendra Rai ◽  
Avinash P. Ingle ◽  
Indarchand Gupta ◽  
Adriano Brandelli
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Noble Metal Nanoparticles

scholarly journals Silver and gold nanoparticles as an integral part of nanooncology: current state of the problem

2021 ◽  
pp. 89-100 ◽  
Author(s):  
M.A. Osadchuk ◽  
N.V. Kireeva ◽  
N.P. Korzhenkov ◽  
M.V. Trushi
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Metal Nanoparticles ◽  
Targeted Drug Delivery ◽  
Colloidal Stability ◽  
Multiple Use ◽  
High Permeability ◽  
Gold And Silver Nanoparticles ◽  
Current State ◽  
Potential Tool

Gold and silver nanoparticles are easily synthesized and the most effective nanostructures in clinical practice. Their optical properties, ease of synthesis, colloidal stability and the ability to form any surface for easier conjugation with biological particles, the ability to individual multiple use, make them especially important in oncology. Gold and silver nanoparticles are capable of providing targeted drug delivery, which depends on the photothermal, photodynamic, and antiangiogenic properties of the metal. Due to their exceptional properties, these nanoparticles are considered as a potential tool for the diagnosis of various types of cancer and drug delivery. The non-toxic and non-immunogenic nature of gold and silver nanoparticles, as well as their high permeability and retention effect, provide additional advantages, allowing drugs to easily penetrate and accumulate at tumor sites. The effectiveness of precious metal nanoparticles as radiosensitizers, dose enhancers and contrast agents is gaining increasing recognition. An important problem associated with the use of biogenic metal nanoparticles is the study of their genotoxicity, since they play an important role in the initiation and progression of abnormalities, including genetic ones.

Green methods for the synthesis of metal nanoparticles using biogenic reducing agents: a review

2018 ◽  
Vol 34 (4) ◽  
pp. 529-559 ◽  
Author(s):  
Zahra Vaseghi ◽  
Ali Nematollahzadeh ◽  
Omid Tavakoli
Keyword(s):  
Drug Delivery ◽  
Wastewater Treatment ◽  
Green Chemistry ◽  
Metal Nanoparticles ◽  
Plant Extracts ◽  
Antibacterial Agents ◽  
Dna Analysis ◽  
Nanoparticle Synthesis ◽  
Microbial Synthesis ◽  
Stabilizing Agents

Abstract Metal nanoparticles are being extensively used in a variety of sectors, including drug delivery, cancer treatment, wastewater treatment, DNA analysis, antibacterial agents, biosensors and catalysts. Unlike chemically produced nanoparticles, biosynthesized metal nanoparticles based on green chemistry perspectives impose limited hazards to the environment and are relatively biocompatible. This review is therefore focused on green methods for nanoparticle synthesis by emphasizing on microbial synthesis using bacteria, fungi, algae, and yeasts, as well as phytosynthesis using plant extracts. Furthermore, a detailed description of bioreducing and capping/stabilizing agents involved in the biosynthesis mechanism using these green sources is presented.

scholarly journals Shape-transformable liquid metal nanoparticles in aqueous solution

2017 ◽  
Vol 8 (5) ◽  
pp. 3832-3837 ◽  
Author(s):  
Yiliang Lin ◽  
Yang Liu ◽  
Jan Genzer ◽  
Michael D. Dickey
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Liquid Metal ◽  
Metal Nanoparticles ◽  
Metal Particles ◽  
Potential Applications

This paper reports the formation of shape-changing and phase-transforming liquid metal particles that have potential applications in drug delivery, catalysis, colloidal jamming, and optics.

scholarly journals Genotoxicity Assessment of Metal-Based Nanocomposites Applied in Drug Delivery

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6551
Author(s):  
Sara Cardoso ◽  
Classius F. da Silva ◽  
Patrícia Severino ◽  
Amélia M. Silva ◽  
Selma B. Souto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Comet Assay ◽  
Metal Nanoparticles ◽  
Size Range ◽  
Genetic Material ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
Reliable Source ◽  
Nanometer Size Range ◽  
Dna Strand

Nanocomposites as drug delivery systems (e.g., metal nanoparticles) are being exploited for several applications in the biomedical field, from therapeutics to diagnostics. Green nanocomposites stand for nanoparticles of biocompatible, biodegradable and non-toxic profiles. When using metal nanoparticles for drug delivery, the question of how hazardous these “virus-sized particles” can be is posed, due to their nanometer size range with enhanced reactivity compared to their respective bulk counterparts. These structures exhibit a high risk of being internalized by cells and interacting with the genetic material, with the possibility of inducing DNA damage. The Comet Assay, or Single-Cell Gel Electrophoresis (SCGE), stands out for its capacity to detect DNA strand breaks in eukaryotic cells. It has huge potential in the genotoxicity assessment of nanoparticles and respective cells’ interactions. In this review, the Comet assay is described, discussing several examples of its application in the genotoxicity evaluation of nanoparticles commonly administered in a set of routes (oral, skin, inhaled, ocular and parenteral administration). In the nanoparticles boom era, where guidelines for their evaluation are still very limited, it is urgent to ensure their safety, alongside their quality and efficacy. Comet assay or SCGE can be considered an essential tool and a reliable source to achieve a better nanotoxicology assessment of metal nanoparticles used in drug delivery.

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