Metal Nanoparticles for Drug Delivery and Diagnostic Applications

2020 ◽  
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Diagnostic Applications

68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

2019 ◽  
Vol 107 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Yousef Fazaeli ◽  
Mohammad Amin Hosseini ◽  
Mohammadreza Afrasyabi ◽  
Parviz Ashtari
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Theranostic Agents ◽  
Diagnostic Applications ◽  
G Ratio ◽  
Mcm 41

Abstract Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68Ga]-Py-Butyl@MCM-41, was done in Fibrosarcoma tumor-bearing mice. This labeled nanocomposite with appropriate blood circulation in body, high structural stability, high tumor/blood ID/g% ratio and fast excretion from the body can be proposed as an efficient nano engineered composite for upcoming tumor targeting/imaging nanotechnology-based applications.

scholarly journals Applications of Dendrimers in Drug Delivery Agents, Diagnosis, Therapy, and Detection

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
B. Noriega-Luna ◽  
Luis A. Godínez ◽  
Francisco J. Rodríguez ◽  
A. Rodríguez ◽  
G. Zaldívar-Lelo de Larrea ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Three Dimensional ◽  
Modified Electrodes ◽  
Biologically Active ◽  
Protein Mimics ◽  
Chemically Modified ◽  
Biological Compatibility ◽  
Variable Chemical ◽  
Diagnostic Applications ◽  
Diagnosis Therapy

In recent years, the application of dendrimers in biomedicine attracted much attention from scientists. Dendrimers are interesting for biomedical applications because of their characteristics, including: a hyperbranching, well-defined globular structures, excellent structural uniformity, multivalency, variable chemical composition, and high biological compatibility. In particular, the three-dimensional architecture of dendrimers can incorporate a variety of biologically active agents to form biologically active conjugates. This review of dendrimers focuses on their use as protein mimics, drug delivery agents, anticancer and antiviral therapeutics, and in biomedical diagnostic applications such as chemically modified electrodes.

Metal Nanoparticles as a Surrogate Carrier in Drug Delivery and Diagnostics

2021 ◽  
pp. 139-161
Author(s):  
Sushama Talegaonkar ◽  
Debopriya Dutta ◽  
Namita Chaudhary ◽  
Surya Goel ◽  
Ruchi Singh
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles

scholarly journals Bacterial Exopolysaccharides as Reducing and/or Stabilizing Agents during Synthesis of Metal Nanoparticles with Biomedical Applications

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Carlos Enrique Escárcega-González ◽  
Javier A. Garza-Cervantes ◽  
Augusto Vázquez-Rodríguez ◽  
José Rubén Morones-Ramírez
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Metal Nanoparticles ◽  
Chemical Sensors ◽  
Extracellular Space ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Cellular Interactions ◽  
Stabilizing Agents ◽  
Bacterial Exopolysaccharides

Bacterial exopolysaccharides (EPSs) are biomolecules secreted in the extracellular space and have diverse biological functionalities, such as environmental protection, surface adherence, and cellular interactions. EPSs have been found to be biocompatible and eco-friendly, therefore making them suitable for applications in many areas of study and various industrial products. Recently, synthesis and stabilization of metal nanoparticles have been of interest because their usefulness for many biomedical applications, such as antimicrobials, anticancer drugs, antioxidants, drug delivery systems, chemical sensors, contrast agents, and as catalysts. In this context, bacterial EPSs have been explored as agents to aid in a greener production of a myriad of metal nanoparticles, since they have the ability to reduce metal ions to form nanoparticles and stabilize them acting as capping agents. In addition, by incorporating EPS to the metal nanoparticles, the EPS confers them biocompatibility. Thus, the present review describes the main bacterial EPS utilized in the synthesis and stabilization of metal nanoparticles, the mechanisms involved in this process, and the different applications of these nanoparticles, emphasizing in their biomedical applications.

Bioactivity of noble metal nanoparticles decorated with biopolymers and their application in drug delivery

2015 ◽  
Vol 496 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Mahendra Rai ◽  
Avinash P. Ingle ◽  
Indarchand Gupta ◽  
Adriano Brandelli
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Noble Metal Nanoparticles

scholarly journals Silver and gold nanoparticles as an integral part of nanooncology: current state of the problem

2021 ◽  
pp. 89-100 ◽  
Author(s):  
M.A. Osadchuk ◽  
N.V. Kireeva ◽  
N.P. Korzhenkov ◽  
M.V. Trushi
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Metal Nanoparticles ◽  
Targeted Drug Delivery ◽  
Colloidal Stability ◽  
Multiple Use ◽  
High Permeability ◽  
Gold And Silver Nanoparticles ◽  
Current State ◽  
Potential Tool

Gold and silver nanoparticles are easily synthesized and the most effective nanostructures in clinical practice. Their optical properties, ease of synthesis, colloidal stability and the ability to form any surface for easier conjugation with biological particles, the ability to individual multiple use, make them especially important in oncology. Gold and silver nanoparticles are capable of providing targeted drug delivery, which depends on the photothermal, photodynamic, and antiangiogenic properties of the metal. Due to their exceptional properties, these nanoparticles are considered as a potential tool for the diagnosis of various types of cancer and drug delivery. The non-toxic and non-immunogenic nature of gold and silver nanoparticles, as well as their high permeability and retention effect, provide additional advantages, allowing drugs to easily penetrate and accumulate at tumor sites. The effectiveness of precious metal nanoparticles as radiosensitizers, dose enhancers and contrast agents is gaining increasing recognition. An important problem associated with the use of biogenic metal nanoparticles is the study of their genotoxicity, since they play an important role in the initiation and progression of abnormalities, including genetic ones.

Green methods for the synthesis of metal nanoparticles using biogenic reducing agents: a review

2018 ◽  
Vol 34 (4) ◽  
pp. 529-559 ◽  
Author(s):  
Zahra Vaseghi ◽  
Ali Nematollahzadeh ◽  
Omid Tavakoli
Keyword(s):  
Drug Delivery ◽  
Wastewater Treatment ◽  
Green Chemistry ◽  
Metal Nanoparticles ◽  
Plant Extracts ◽  
Antibacterial Agents ◽  
Dna Analysis ◽  
Nanoparticle Synthesis ◽  
Microbial Synthesis ◽  
Stabilizing Agents

Abstract Metal nanoparticles are being extensively used in a variety of sectors, including drug delivery, cancer treatment, wastewater treatment, DNA analysis, antibacterial agents, biosensors and catalysts. Unlike chemically produced nanoparticles, biosynthesized metal nanoparticles based on green chemistry perspectives impose limited hazards to the environment and are relatively biocompatible. This review is therefore focused on green methods for nanoparticle synthesis by emphasizing on microbial synthesis using bacteria, fungi, algae, and yeasts, as well as phytosynthesis using plant extracts. Furthermore, a detailed description of bioreducing and capping/stabilizing agents involved in the biosynthesis mechanism using these green sources is presented.

scholarly journals Shape-transformable liquid metal nanoparticles in aqueous solution

2017 ◽  
Vol 8 (5) ◽  
pp. 3832-3837 ◽  
Author(s):  
Yiliang Lin ◽  
Yang Liu ◽  
Jan Genzer ◽  
Michael D. Dickey
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Liquid Metal ◽  
Metal Nanoparticles ◽  
Metal Particles ◽  
Potential Applications

This paper reports the formation of shape-changing and phase-transforming liquid metal particles that have potential applications in drug delivery, catalysis, colloidal jamming, and optics.

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