scholarly journals Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

2016 ◽  
pp. 483 ◽  
Author(s):  
Tarek Ahmed ◽  
Bader Aljaeid
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Potential Application ◽  
Chitosan Derivatives ◽  
Pharmaceutical Drug

Modular Synthesis of Amphiphilic Chitosan Derivatives Based on Copper-Free Click Reaction for Drug Delivery

2021 ◽  
pp. 120798
Author(s):  
Yu Tao ◽  
Ding Qu ◽  
Chunli Tian ◽  
Yingshuang Huang ◽  
Lingjing Xue ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Reaction ◽  
Chitosan Derivatives ◽  
Modular Synthesis

Synthesis of PMMA-b-PS Block Copolymer by Emulsion ATRP and its Self-Assembly Property

2013 ◽  
Vol 705 ◽  
pp. 115-119
Author(s):  
Bao Yong Tian ◽  
Er Jun Tang ◽  
Miao Yuan ◽  
Rui Xia Hao ◽  
Cun Man Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Self Assembly ◽  
Potential Application ◽  
Morphological Characteristic ◽  
Living Polymerization ◽  
The Self ◽  
Emulsion System ◽  
Copolymer Concentration ◽  
Ft Ir

The well-defined block copolymer PMMA-b-PS was prepared by two-step ATRP in emulsion system. GPC results indicate that Mn increased linearly with conversion and polydispersity remained relatively narrow. It presents the characteristics of living polymerization in emulsion system. FT-IR demonstrated that block copolymer PMMA-b-PS could be successfully synthesized by ATRP with macroinitiator PMMA-Cl in emulsion system. The morphological characteristic of the self-assembly depends on the block copolymer concentration and transforms between spheres and rodlike micelles. The property indicates a perfect potential application in drug delivery materials.

Synthesis of calcium carbonate nanocrystals and their potential application as vessels for drug delivery

2015 ◽  
Author(s):  
Viviana Vergaro ◽  
Elisabetta Carata ◽  
Elisa Panzarini ◽  
Francesca Baldassare ◽  
Luciana Dini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Potential Application

scholarly journals Using Chitosan or Chitosan Derivatives in Cancer Therapy

2021 ◽  
Vol 2 (4) ◽  
pp. 795-816
Author(s):  
Md Salman Shakil ◽  
Kazi Mustafa Mahmud ◽  
Mohammad Sayem ◽  
Mahruba Sultana Niloy ◽  
Sajal Kumar Halder ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Agents ◽  
Chitosan Nanoparticles ◽  
Chemotherapeutic Drugs ◽  
Chitosan Derivatives ◽  
Drug Delivery Vehicles ◽  
Modified Chitosan ◽  
Therapeutic Benefits ◽  
Delivery Vehicles

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

scholarly journals Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery

2014 ◽  
Vol 5 (22) ◽  
pp. 6461-6471 ◽  
Author(s):  
Sarah Decato ◽  
Troy Bemis ◽  
Eric Madsen ◽  
Sandro Mecozzi
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Amphiphilic Polymers ◽  
Synthesis And Characterization ◽  
Hydrophobic Drug ◽  
Tert Butyl ◽  
Theranostic Applications ◽  
Polymer Surfactants

Semifluorinated polymer surfactants containing one, two, or three perfluoro-tert-butyl groups were synthesized and fully characterized. Theranostic applications are discussed.

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

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