Using Kitchen Appliance Analogies to Improve Students' Reasoning about Neurological Results

2005 ◽  
Vol 32 (2) ◽  
pp. 107-109 ◽  
Author(s):  
Peter M. Vishton

This article describes and evaluates a new technique for teaching students to interpret studies of patients with brain injuries. This technique asks students to consider how knives and blenders lose specific functionality when they are damaged. This approach better prepares students to make proper inferences from behavioral deficits observed after brain injury, specifically with reference to single and double dissociation. Significantly improved performance on multiple-choice and identification questions included in midterm examinations suggests that the impact of these thought experiments was substantive and long lasting.

Author(s):  
O. Knotek ◽  
B. Bosserhoff ◽  
A. Schrey ◽  
T. Leyendecker ◽  
O. Lemmer ◽  
...  

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Riccardo Cesari ◽  
Leandro D’Aurizio

Abstract Following the increasing necessity of quantitative measures for the impact of natural catastrophes, this paper proposes a new technique for a probabilistic assessment of seismic risk by using publicly available data on the earthquakes that have occurred in Italy. We implement an insurance-oriented methodology to produce a new map of the seismic risk and to evaluate, under various hypotheses, the costs of insuring all the Italian housing units against it. The model is compared with two main privately developed models, well known in the reinsurance industry, providing fairly similar results.


2020 ◽  
Vol 9 (3) ◽  
pp. 150 ◽  
Author(s):  
Peng Chen ◽  
Justin Kurland

“Strike Hard” is an enhanced law-enforcement strategy in China that aims to suppress crime, but measurement of the crime-reducing effect and potential changes in the spatiotemporal concentration of crime associated with “Strike Hard” remain unknown. This paper seeks to examine the impact, if any, of “Strike Hard” on the spatiotemporal clustering of burglary incidents. Two and half years of residential burglary incidents from Chaoyang, Beijing are used to examine repeat and near-repeat burglary incidents before, during, and after the “Strike Hard” intervention and a new technique that enables the comparison of repeat and near repeat patterns across different temporal periods is introduced to achieve this. The results demonstrate the intervention disrupted the repeat pattern during the “Strike Hard” period reducing the observed ratio of single-day repeat burglaries by 155%; however, these same single-day repeat burglary events increased by 41% after the cessation of the intervention. Findings with respect to near repeats are less remarkable with nominal evidence to support that the intervention produced a significant decrease, but coupled with other results, suggest that spatiotemporal displacement may have been an undesired by-product of “Strike Hard”. This study from a non-Western setting provides further evidence of the generalizability of findings related to repeat and near repeat patterns of burglary and further highlights the limited preventative effect that the “Strike Hard” enhanced law enforcement campaign had on burglary.


2001 ◽  
Vol 31 (6) ◽  
pp. 965-968 ◽  
Author(s):  
Ken Vallens ◽  
Eric Bescher ◽  
J.D Mackenzie ◽  
Ed Rice

Author(s):  
Bruno Fran??ois ◽  
Philippe Vacher ◽  
J??rome Roustan ◽  
Jean-Yves Salle ◽  
Jackie Vidal ◽  
...  

2020 ◽  
Vol 21 (4) ◽  
pp. 1395 ◽  
Author(s):  
Ilias Thomas ◽  
Alex M. Dickens ◽  
Jussi P. Posti ◽  
Mehrbod Mohammadian ◽  
Christian Ledig ◽  
...  

Recent evidence suggests that patients with traumatic brain injuries (TBIs) have a distinct circulating metabolic profile. However, it is unclear if this metabolomic profile corresponds to changes in brain morphology as observed by magnetic resonance imaging (MRI). The aim of this study was to explore how circulating serum metabolites, following TBI, relate to structural MRI (sMRI) findings. Serum samples were collected upon admission to the emergency department from patients suffering from acute TBI and metabolites were measured using mass spectrometry-based metabolomics. Most of these patients sustained a mild TBI. In the same patients, sMRIs were taken and volumetric data were extracted (138 metrics). From a pool of 203 eligible screened patients, 96 met the inclusion criteria for this study. Metabolites were summarized as eight clusters and sMRI data were reduced to 15 independent components (ICs). Partial correlation analysis showed that four metabolite clusters had significant associations with specific ICs, reflecting both the grey and white matter brain injury. Multiple machine learning approaches were then applied in order to investigate if circulating metabolites could distinguish between positive and negative sMRI findings. A logistic regression model was developed, comprised of two metabolic predictors (erythronic acid and myo-inositol), which, together with neurofilament light polypeptide (NF-L), discriminated positive and negative sMRI findings with an area under the curve of the receiver-operating characteristic of 0.85 (specificity = 0.89, sensitivity = 0.65). The results of this study show that metabolomic analysis of blood samples upon admission, either alone or in combination with protein biomarkers, can provide valuable information about the impact of TBI on brain structural changes.


2020 ◽  
Author(s):  
Mathieu Laflamme ◽  
Hourmazd Haghbayan ◽  
Manoj M Lalu ◽  
Ryan Zarychanski ◽  
Francois Lauzier ◽  
...  

Abstract Background: Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models.Methods: We will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE and Web of Science databases for eligible studies. Two independent reviewers will perform study selection and data extraction. We will report our results in a descriptive synthesis focusing on characteristics of included studies, reported outcomes, risk of bias and construct validity. If appropriate, we will also perform a quantitative synthesis and pool results using random-effect models. Heterogeneity will be expressed with I2 statistics. Subgroup analyses are planned according to animal model characteristics, co-interventions and risks of bias.Discussion: Our study is aligned with the efforts to better understand the level of evidence on the impact of red blood cell transfusion strategies from preclinical studies in animal models of acute brain injury and the potential translation of information from the preclinical to the clinical research field.Systematic review registration: PROSPERO CRD42018086662


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