Factorial analysis of the influence of dissolution medium on drug release from carrageenan-diltiazem complexes

Karaya gum (KG) is one of the least soluble of the gums. It does not dissolve in water to give a clear solution but instead absorbs water rapidly to form viscous colloidal sols. Carboxymethylation of Karaya gum is expected to improve its aqueous solubility and gelling behavior. Another objective of the research is to evaluate the potential of carboxymethylated Karaya gum (CMKG) as drug release modulator (in acidic dissolution medium) when combined with HPMC K15M based polymeric matrices bearing Propranolol HCl. In the present study, KG was carboxymethylated using Williamson Ether synthesis. FTIR spectroscopy confirmed the formation of CMKG. The prepared CMKG was used in conjunction with HPMC K15M as a polymer matrix in the formulation capsule dosage form, using Propranolol HCl as model drug. The filled capsules were then coated with Gelucire 43/01 to convert them into hydrodynamically balanced (HBS) capsule dosage form. Dextrose & fructose were also added to the drug-polymer mix as osmogen to facilitate the drug release. The degree of substitution of CMKG was found to be 0.87. HBS capsule dosage forms remained buoyant on 0.1 HCl for up to 6 hr, the buoyancy was attributed to the Gelucire 43/01 coating around the capsule shell. From the experimentation it was observed that CMKG, when mixed with HPMC K15M at 1:3 ratios, extended the release of model drug from HBS capsule dosage forms in 0.1 HCl. At CMKG: HPMC K15M ratio 2:1, release of Propranolol Hydrochloride from hydrodynamically balanced (HBS) capsules revealed fast drug release in 0.1 HCl. From the observations it is evident that KG is amenable to carboxymethylation to form CMKG. It is also evident that it is advantageous to combine CMKG with HPMC K15M as release modulator to retard the release of Propranolol HCl in acidic dissolution medium.

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Dissolution Medium Responsive Simvastatin Release from Biodegradable Apatite Cements Drug Delivery System - The Therapeutically Effect and their Histology in Osteoporosis Rats -

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.493-494.684 ◽

2011 ◽

Vol 493-494 ◽

pp. 684-688 ◽

Cited By ~ 1

Author(s):

Makoto Otsuka ◽

Hideyuki Hamada ◽

Kuniko Otsuka ◽

Hiroyuki Ohshima

Keyword(s):

Bone Mineral Density ◽

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Bone Mineral ◽

Delivery System ◽

Dissolution Medium ◽

Mineral Density ◽

Apatite Cement

A biodegradable drug delivery system was established using an apatite cement containing simvastatin. The in-vitro drug release from apatite with lower-crystallinity was investigated under simulated osteoblast and osteoclast conditions (SOB and SOC). Apatite cement containing 6% simvastatin had lower crystallinity as the same as natural bone. In-vitro drug release tests were performed under SOB in simulated body fluid (pH 7.8), and then under SOC in acetate buffer (pH4.5) at 37.0｡C, and the process repeated twice. The device had lower drug release rates under SOB, but significantly higher rates under SOC. The simvastatin release rate was 15 times higher under SOC than SOB. The device showed dissolution medium responsive drug release. After implantation of the APC containing simvastatin in osteoporosis rats, the bone mineral density was evaluated by the X-ray computed tomography. The result indicated that the bone mineral density of APC implanted rat was significantly higher than that of control diseased.

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Evaluation of the Effect of Dissolution Conditions on the Release Profiles of Felodipine from the Extended Release Push-Pull Osmotic Tablets

VNU Journal of Science Medical and Pharmaceutical Sciences ◽

10.25073/2588-1132/vnumps.4218 ◽

2020 ◽

Vol 36 (1) ◽

Author(s):

Vũ Thị Thanh Huyền ◽

Nguyen Thanh Hai ◽

Pham Thi Minh Hue

Keyword(s):

Molecular Weight ◽

Drug Release ◽

Osmotic Pressure ◽

Extended Release ◽

Primary Component ◽

Dissolution Medium ◽

Drug Release Profile ◽

Permeable Membrane ◽

Release Profiles

The bilayered push–pull osmotic tablets of 5 mg felodipine were prepared by the double compression method, then the core tablets were coated with cellulose acetate as a semipermeable membrane. One releasing orifice was drilled by laser on the drug side of tablets. The osmotic tablets of felodipine containing low molecular weight PEO (200.000) as the primary component in the drug layer, high molecular weight PEO (5.000.000) as a swelling agent in the push layer and natri chloride as osmotic agent in both drug and push layers which were semi-permeable membrane coated with a weight gain of 8.5 % and the drilled release oriﬁce of 0.8 mm. The influence of dissolution conditions on the release profiles of felodipine from the extended release push-pull osmotic tablets was studied. Dissolution studies of the osmotic tablets of felodipine were carried out in dissolution media with different media pH, stirring speeds or osmotic pressures. The results of the study showed that the drug release profile was similar in dissolution media containing surfactant mimics the in vivo state with varying pH and stirring speeds. However, felodipine released from the osmotic tablets was inversely proportional to the osmotic pressure of the dissolution medium. Therefore, the drug release rate from the osmotic tablets was independent of media pH and stirring speeds, but dependent on the osmotic pressure of the dissolution medium. Keywords Felodipine, push - pull osmotic pump, pH, stirring speeds, osmotic pressure. References

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Investigation on Effect of Stress on Dissolution Stability of Drug Product by Applying Thermal and NonThermal Methods of Analysis

Asian Journal of Applied Chemistry Research ◽

10.9734/ajacr/2019/v4i1-230103 ◽

2019 ◽

pp. 1-20

Author(s):

Krishna R. Gupta ◽

Rahul P. Chaudhari ◽

Anita R. Pounikar ◽

Anvesha V. Ganorkar

Keyword(s):

Drug Release ◽

Research Work ◽

Stress Conditions ◽

Test Method ◽

Pharmaceutical Chemistry ◽

Solution Stability ◽

Dissolution Medium ◽

Thermal Methods ◽

Drug Content ◽

Bonferroni Test

Aim: The aim of the research work has to development and validation of dissolution test method for Tapentadol using HPLC method, investigate the effects of stress on dissolution stability by thermal and non-thermal methods. The present research work mainly focused on the evaluation and compares the influence of accelerated-aging conditions on the drug content and in vitro dissolution stability. Place and duration of Study: Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (MS). Methodology and Results: Saturated solubility study of tapentadol were carried out using different dissolution media and different conditions such as type of dissolution medium, volume of dissolution medium and rotation speed of paddle were evaluated. Basis of it, dissolution testing were carried out on a suitably calibrated USP Apparatus II (TDT-06L) at 50 ± 1 rpm, under sink conditions in 900 mL of deaerated distilled water at 37±0.5ºC for each test and selected most optimized dissolution parameter which given maximum % release of drug. The drug release was evaluated by high-performance liquid chromatographic method. Also proposed method were validated as per ICH guidelines with respect to system suitability, linearity, precision, accuracy, range, robustness, ruggedness and solution stability parameters were evaluated and the obtained results were within the acceptable range. The stress on dissolution stability of standard powdered drug, tablet formulation and packed strip formulation were investigated by using thermal and non thermal methods. The results obtained in all stress conditions such as thermal, humidity, UV light and visible light were evaluated for drug content and drug release. The results were statistically evaluated by applying two-way ANOVA followed by post-hoc Bonferroni test and their results represented as a graphical plot. Conclusion: In our investigation of stress dissolution of drug it was found that Tapentadol HCl std. drug was susceptible to degradation. The tablet and packaged formulation were susceptible to photolytic degradation indicated by difference in drug content while the release was more affected under UV exposed to tablet and strip packaged formulation as compared to other stress conditions.

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Drug release from calcium and zinc pectinate beads: Impact of dissolution medium composition

Carbohydrate Polymers ◽

10.1016/j.carbpol.2011.02.037 ◽

2011 ◽

Vol 85 (2) ◽

pp. 388-393 ◽

Cited By ~ 33

Author(s):

Ali Assifaoui ◽

Odile Chambin ◽

Philippe Cayot

Keyword(s):

Drug Release ◽

Medium Composition ◽

Dissolution Medium

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Bone cell activity responsive drug release from biodegradable apatite/collagen nano-composite cements—In vitro dissolution medium responsive vitamin K2 release

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2011.03.006 ◽

2011 ◽

Vol 85 (2) ◽

pp. 338-342 ◽

Cited By ~ 14

Author(s):

Makoto Otsuka ◽

Ryuhei Hirano

Keyword(s):

Drug Release ◽

Cell Activity ◽

Bone Cell ◽

Vitamin K2 ◽

In Vitro Dissolution ◽

Dissolution Medium ◽

Nano Composite ◽

Composite Cements

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Effect of Viscosity Imparting Agents on In vitro Drug Release from PEG Based Suppositories

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v4i1.190 ◽

1970 ◽

Vol 4 (1) ◽

Author(s):

Md. Kamruzzaman Akanda ◽

SM Ashraful Islam ◽

Jakir Ahmed Chowdhury ◽

Md. Selim Reza

Keyword(s):

Drug Release ◽

Release Rate ◽

Phosphate Buffer ◽

Xanthan Gum ◽

Methyl Cellulose ◽

Lag Time ◽

Carboxy Methyl Cellulose ◽

Dissolution Medium ◽

Carboxy Methyl

Acetaminophen loaded suppositories were prepared and the effects of viscosity imparting agents on drug release were investigated. Suppositories containing 125 mg of acetaminophen were prepared by fusion method using PEG 4000 and PEG 1500 as hydrophilic base. In vitro dissolution studies were carried out by a thermal shaker with a shaking speed of 90 rpm at a temperature of 37 ± 0.50C in phosphate buffer of pH 6.8. The effect of viscosity imparting agents on the drug release into phosphate buffer were investigated by adding 0.1, 0.2 and 0.3% Xanthan gum, sodium carboxy methyl cellulose, acacia, hydroxyl propyl methyl cellulose 15 cps and 50 cps. The In vitro release data showed that drug release was linear in phosphate buffer. After incorporation of viscosity imparting agents in phosphate buffer a biphasic drug release profile i.e. initial lag phase followed by linear phase was observed. Lag time depends on nature and concentration of viscosity imparting agents. It is evident from the result that lag time increases with the increase in percentage of viscosity imparting agent. There is less or no effect of change of concentration of acacia on the lag time. After lag time drug release from the suppositories showed a linear fashion. It was found that the release rate decreases when dissolution medium contains high percentage of Xanthan gum and also sodium carboxy methyl cellulose. However in case of incorporation of HPMC into the dissolution medium, release rate decreased up to 0.2% HPMC, but with 0.3% HPMC the release rate increased. Inclusion of different percentage of acacia into the dissolution medium has not significantly changed the release of acetaminophen from suppositories. Key words: Suppositories, Acetaminophen, Viscosity imparting agent Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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IDENTIFICATION OF KEY VARIABLES AFFECTIN G DRUG RELEASE FROM LIPID MATRIX IN HYDROALCOHOLIC DISSOLUTION MEDIUM CONTAININ G HYDROXYPROPYL METHYLCELLULOSE

INDIAN DRUGS ◽

10.53879/id.53.11.10666 ◽

2016 ◽

Vol 53 (11) ◽

pp. 72-76

Author(s):

P. R Babariya ◽

◽

M. C Gohel ◽

V. T. Thakkar ◽

L. H. Baldaniya ◽

...

Keyword(s):

Drug Release ◽

Alcohol Intake ◽

Hydroxypropyl Methylcellulose ◽

Research Work ◽

Direct Compression ◽

Dissolution Medium ◽

Experimental Conditions ◽

Dissolution Study ◽

Key Variables ◽

Compritol 888 Ato

The present research work was undertaken to formulate modified release tablets of lornoxicam using Compritol 888 ATO as a lipid matrixing agent and to evaluate the tablets for dissolution in hydro-alcoholic dissolution media to meet the requirement of regulators. The dissolution study was also conducted in aqueous medium containing alcohol and hydroxylpropyl methylcellulose to mimic the viscosity and pH after food and alcohol intake. The tablets were prepared by direct compression by adopting the concept of design of experiments and evaluated mainly for dissolution studies in aqueous dissolution media containing 10, 25 and 40% ethyl alcohol. The formulated tablets satisfied the USP requirements of drug release at 2, 6 and 10 hr. The drug release was insignificantly altered when the dissolution study was conducted in media containing increasing amount of alcohol probably due to higher solubility of the drug in alcohol. The drug release was suppressed when HPMC was used in the dissolution media. This may be due to rise in viscosity of the dissolution media. Dose dumping was not noticed under the experimental conditions.

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