scholarly journals Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women

2021 ◽  
Author(s):  
Adam Mitchell ◽  
Tove Fall ◽  
Håkan Melhus ◽  
Lars Lind ◽  
Karl Michaëlsson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Bone Area ◽  
Mineral Density ◽  
Cross Sectional ◽  
Total Hip

Abstract Context In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with a greater bone mineral density (BMD) at the total hip. Objective To investigate these associations longitudinally, by studying T2DM status (no T2DM n=1521, incident T2DM n=119 or prevalent T2DM n=106) in relation to changes in total hip bone area and BMD. Methods In three cohorts, the Swedish Mammography Cohort Clinical (SMCC; n=1060, Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n=483) and Uppsala Longitudinal Study of Adult Men (ULSAM; n=203), with repeat assessment of T2DM status and dual energy x-ray absorptiometry (DXA) measurements of total hip bone area and BMD on average 8 years apart, a linear regression model was used to assess the effect of T2DM status on change in bone area and BMD at the total hip. Results After meta-analysis, the change in bone area at the total hip was 0.5% lower among those with incident T2DM compared to those without T2DM (-0.18 cm 2 [95% CI -0.30, -0.06]). The change in bone area was similar among those with prevalent T2DM compared to those without (0.00 cm 2 [95% CI -0.13, 0.13]). For BMD, the combined estimate was 0.004 g/cm 2 (95% CI -0.006, 0.014) among those with incident T2DM and 0.010 g/cm 2 (95% CI -0.000, 0.020) among those with prevalent T2DM, compared to those without T2DM. Conclusion Those with incident T2DM have a lower expansion in bone area at the total hip compared to those without T2DM.

Circulating Leptin and Bone Mineral Density in Rheumatoid Arthritis

2009 ◽  
Vol 36 (3) ◽  
pp. 512-516 ◽  
Author(s):  
ERIKA A. AGUILAR-CHAVEZ ◽  
JORGE I. GAMEZ-NAVA ◽  
MARIA A. LOPEZ-OLIVO ◽  
SILVIA GALVAN-MELENDRES ◽  
ESTHER G. CORONA-SANCHEZ ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Leptin ◽  
Total Hip

Objective.To evaluate the association between circulating leptin and bone mineral density (BMD) in patients with rheumatoid arthritis (RA).Methods.One-hundred thirty postmenopausal women with RA were assessed for body mass index (BMI), disease characteristics, history of drug use, rheumatoid factor, and erythrocyte sedimentation rate (ESR). BMD (g/cm2) was determined in the hip and spine by DEXA. Serum leptin concentrations were measured by ELISA. Spearman’s correlation coefficients (rho) were determined between BMD and leptin and other variables. A multiple regression analysis was used to adjust for confounders.Results.Patients’ serum leptin levels varied widely (range 2–128 ng/ml). Thirty-three patients (25%) had osteoporosis. Higher levels of leptin correlated significantly with BMD in the lumbar spine (rho = 0.17, p = 0.04) and total hip (rho = 0.21, p = 0.01). The variables that were negatively correlated with BMD were age, duration of menopause, and ESR. After adjustment for confounders, leptin was no longer associated with BMD. In the multivariate model, factors that remained associated with BMD in the total hip were age (p = 0.021) and BMI (p = 0.003); and the factors that remained associated with BMD in the lumbar spine were BMI (p = 0.03) and ESR (p = 0.01).Conclusion.No relevant association was found between circulating leptin levels and BMD in patients with RA in this cross-sectional study. Followup studies are needed to evaluate whether abnormal leptin levels confer a risk for fractures due to osteoporosis.

scholarly journals Prevalence and Associated Factors of Low Bone Mineral Density in the Femoral Neck and Total Hip in Axial Spondyloarthritis: Data from the CASTRO Cohort

2021 ◽  
Vol 10 (12) ◽  
pp. 2664
Author(s):  
Laura Bautista-Aguilar ◽  
Clementina López-Medina ◽  
Lourdes Ladehesa-Pineda ◽  
María del Carmen Ábalos-Aguilera ◽  
Desirée Ruiz-Vilchez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Axial Spondyloarthritis ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Factors Associated ◽  
Total Hip ◽  
Asas Criteria

Studies on osteoporosis in axial spondyloarthritis (axSpA) have focused on the lumbar segment, and few studies have assessed bone mineral density (BMD) in the hip and femoral neck in these patients. The aim of this study was to evaluate the prevalence of low BMD and osteopenia in the total hip or femoral neck and the factors associated with these conditions in axSpA patients. This was a single-centre, observational, cross-sectional study among consecutive patients with axSpA according to the ASAS criteria from the CASTRO registry. All patients underwent total hip and femoral neck DXA BMD measurements. Low BMD was defined as a Z-score less than −1, and osteopenia was defined as a T-score less than −1. Multivariate logistic and generalised linear regressions were used to evaluate factors independently associated with low BMD and osteopenia in the hip or femoral neck and those associated with variability in BMD, respectively. A total of 117 patients were included, among which 30.8% were female and the mean age was 45 years. A total of 36.0% of patients had low BMD (28.1% in the total hip and 27.4% in the femoral neck), and 56.0% of patients had osteopenia (44.7% in the total hip and 53.8% in the femoral neck). A multivariate logistic regression showed that age, radiographic sacroiliitis and ASAS-HI were independently associated with low BMD in the total hip or femoral neck. Factors that were independently associated with osteopenia were Body Mass Index, disease duration, radiographic sacroiliitis and ASAS-HI. In conclusion, 36% of the patients with axSpA had low BMD in the total hip or femoral neck. A younger age and radiographic sacroiliitis were the most important factors associated with decreased BMD.

Comparative assessment of bone mineral density levels in type 2 diabetic subjects with or without chronic periodontitis: A cross-sectional study

2021 ◽  
Vol 13 (1) ◽  
pp. 28-34
Author(s):  
Hira Ateeq ◽  
Afaf Zia ◽  
Qayyum Husain ◽  
Afshan Bey
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Chronic Periodontitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Positive Correlation

Background. This cross-sectional study investigated the bone mineral density (BMD) in type 2 diabetes mellitus (T2DM) subjects with or without chronic periodontitis (CP). Methods. A total of 120 subjects aged 35‒55, divided equally into four groups: i) T2DM with CP, ii) T2DM without CP, iii) CP alone, and iv) healthy patients, were included in this study. Clinical parameters like plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were recorded. All the participants were evaluated for blood sugar levels using glycated hemoglobin (HbA1c) and BMD by Hologic dual-energy x-ray absorptiometry (DEXA) scan. The association of BMD with clinical periodontal parameters and HbA1c in all groups was investigated using linear correlation analysis (r). Results. The mean value of BMD (0.9020±0.0952 g/cm2) was lower in subjects with both T2DM and CP compared to T2DM and CP alone. BMD was weakly correlated with all the clinical periodontal parameters; a positive correlation was observed between BMD and GI in the T2DM and CP group (r=0.405, P=0.026) and the CP group (r=0.324, P=0.081). A weak positive correlation was observed in BMD and HbA1c in the T2DM group (r=0.261, P=0.13), T2DM and CP group (r=0.007, P=0.970), with a negative correlation to HbA1c in the CP group (r= -0.134, P=0.479). Conclusions: Diabetes mellitus impacts clinical periodontal status and bone mass, and the effect is accentuated when chronic periodontitis is present. Based on the present study, BMD is associated with T2DM and CP, but a weak correlation was observed between BMD and HbA1c and clinical periodontal parameters.

scholarly journals Estimation of bone mineral density among type 2 diabetes mellitus patients in western Odisha

2018 ◽  
Vol 6 (2) ◽  
pp. 459 ◽  
Author(s):  
Atanu Kumar Thakur
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cross Sectional ◽  
Type 2 Diabetics ◽  
Significant Difference

Background: Diabetes Mellitus is one of the most common chronic non-communicable diseases in the world. The relationship between type 2 diabetes mellitus (T2DM) and bone mineral density (BMD) has been controversial. Early identification of reduction in bone mass in a diabetic patient may be helpful in preventing the bone loss and future fracture risks. Objective: The aim is to study the effect of T2DM on BMD among patients in western Odisha.Methods: A cross-sectional study was conducted on 120 patients between 40 and 65 years of age which included 60 diabetic and 60 nondiabetic subjects. BMD was measured using qualitative ultrasound and the data were compared among age-matched subjects of both the groups. Statistical analysis was performed using unpaired Student's t-test and test of equality of proportions.Results: No significant difference was observed in bone density of both the groups. On further analyzing the data, incidence of osteoporosis was higher among diabetic subjects, whereas incidence of osteopenia was higher among nondiabetic subjects.Conclusions: Although significant difference in bone mineral density was not observed in both the groups, the incidence of osteoporosis was higher among type 2 diabetics. Hence, all type 2 diabetics should be evaluated for the risk of osteoporosis and should be offered appropriate preventive measures.

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