scholarly journals The role of estrone in feminizing hormone treatment

2021 ◽  
Author(s):  
Marieke Tebbens ◽  
Annemieke C Heijboer ◽  
Guy T’Sjoen ◽  
Peter H Bisschop ◽  
Martin den Heijer
Keyword(s):  
Hormone Treatment ◽  
Breast Development ◽  
Administration Route ◽  
Breast Volume ◽  
Fat Percentage ◽  
In Trans ◽  
Trans Women ◽  
One Year

Abstract Context In trans women, hormone treatment induces feminization, however the degree of feminization varies from person to person. A possible contributing factor could be estrone, a weak estrogen that interferes with the estrogen receptor. Objective To assess whether estrone is involved in feminization induced by hormone treatment. Design Prospective cohort study, with one year follow-up. Setting Gender identity clinic. Participants 212 adult trans women, starting hormone treatment between July 2017 and December 2019, median age 25 years. Intervention Gender affirming hormone treatment. Main outcome measures Change in fat percentage and breast development. Results After 12 months of hormone treatment, estrone concentration was 187pmol/L (95%CI 153 – 220) in transdermal and 1516pmol/L (95%CI 1284 – 1748) in oral estradiol users. Fat percentage increased by 1.2% (IQR 0.3 – 4.8) in transdermal and 4.6% (IQR 2.5 – 5.9) in oral estradiol users. This was not associated with estrone concentrations in transdermal(+4.4% (95%CI -4.0 – 13) per 100pmol/L increase in estrone concentration) nor in oral estradiol users (-0.7% (95%CI -1.7 – 0.3)). Breast volume increased by 69ml (IQR 58 – 134) in transdermal and 62ml (IQR 32 – 95) in oral estradiol users. This was not associated with estrone concentrations in transdermal (+ 14% (95%CI -49 – 156) per 100pmol/L increase in estrone concentration) nor oral estradiol users (+ 11% (95%CI -14 – 43)). Conclusions Change in fat percentage and breast development in trans women were not associated with estrone concentrations nor with administration route. Therefore measurement of estrone concentrations does not have a place in the monitoring of feminization in trans women.

scholarly journals Prostate Cancer Incidence under Androgen Deprivation: Nationwide Cohort Study in Trans Women Receiving Hormone Treatment

2020 ◽  
Vol 105 (9) ◽  
pp. e3293-e3299 ◽  
Author(s):  
Iris de Nie ◽  
Christel J M de Blok ◽  
Tim M van der Sluis ◽  
Ellis Barbé ◽  
Garry L S Pigot ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Gender Identity ◽  
Prostate Cancer Risk ◽  
Hormone Treatment ◽  
Androgen Deprivation ◽  
Male Population ◽  
In Trans ◽  
Trans Women

Abstract Context Trans women (male sex assigned at birth, female gender identity) mostly use antiandrogens combined with estrogens and can subsequently undergo vaginoplasty including orchiectomy. Because the prostate remains in situ after this procedure, trans women are still at risk for prostate cancer. Objective To assess the incidence of prostate cancer in trans women using hormone treatment. Design In this nationwide retrospective cohort study, data of participants were linked to the Dutch national pathology database and to Statistics Netherlands to obtain data on prostate cancer diagnosis and mortality. Setting Gender identity clinic. Participants Trans women who visited our clinic between 1972 and 2016 and received hormone treatment were included. Main Outcome Measures Standardized incidence ratios (SIRs) were calculated using the number of observed prostate cancer cases in our cohort and the number of expected cases based on age-specific incidence numbers from the Netherlands Comprehensive Cancer Organization. Results The study population consisted of 2281 trans women with a median follow-up time of 14 years (interquartile range 7-24), and a total follow-up time of 37 117 years. Six prostate cancer cases were identified after a median 17 years of hormone treatment. This resulted in a lower prostate cancer risk in trans women than in Dutch reference males (SIR 0.20, 95% confidence interval 0.08-0.42). Conclusions Trans women receiving androgen deprivation therapy and estrogens have a substantially lower risk for prostate cancer than the general male population. Our results support the hypothesis that androgen deprivation has a preventive effect on the initiation and development of prostate cancer.

Sustained Breast Development and Breast Anthropometric Changes in 3 Years of Gender-Affirming Hormone Treatment

2020 ◽  
Author(s):  
Christel J M de Blok ◽  
Benthe A M Dijkman ◽  
Chantal M Wiepjes ◽  
Annemieke S Staphorsius ◽  
Floyd W Timmermans ◽  
...  
Keyword(s):  
3D Imaging ◽  
Hormone Treatment ◽  
Measurement Methods ◽  
Breast Development ◽  
Breast Size ◽  
Breast Volume ◽  
Trans Women ◽  
3D Volume ◽  
Observation Period ◽  
Sustained Increase

Abstract Context Breast development is important for most trans women. An important limitation of current breast development measurement methods is that these do not allow for 3D volume analyses. Objectives To examine breast development and change in anthropometry during the first 3 years of gender-affirming hormone treatment using 3D imaging. Associations with clinical or laboratory parameters and satisfaction with the gained breast development were also studied. Design Prospective cohort study. Setting Specialized tertiary gender identity clinic in Amsterdam, the Netherlands. Participants Participants were 69 adult trans women with a median age of 26 years (interquartile range, 21-38). Interventions Gender-affirming hormone treatment. Main Outcome Measures Volumetric and anthropometric breast development and satisfaction. Results Breast volume increased by 72 cc (95% confidence interval [CI], 48-97) to 100 cc (standard deviation 48). This resulted in a cup-size <A-cup in 71% of the participants. Although the change in breast-chest difference plateaued after approximately 9 months, sustained increase in breast volume was observed during the 3-year observation period. Sternal notch to nipple distance increased by 1.3 cm (95% CI, 0.9-1.7) and internipple distance increased by 1.0 cm (95% CI, 0.4-1.5). At least 58% of trans women were satisfied with the gained breast size. Conclusions Sustained breast growth and development during hormone treatment was observed during the full 3-year observation period. The breasts of trans women are positioned more laterally and caudally on the chest compared with cis women. Although modest breast volumes were observed, breast development was satisfactory to most trans women.

Individualized Behavioural Treatment of Severe Stuttering

1991 ◽  
Vol 19 (4) ◽  
pp. 347-357 ◽  
Author(s):  
Willi Ecker ◽  
Victor Meyer
Keyword(s):  
Oral Reading ◽  
Reading Improvement ◽  
Behavioural Treatment ◽  
Communication Situations ◽  
Cognitive Techniques ◽  
One Year

This case study illustrates the reduction of severe stuttering by an individually tailored treatment programme. Interventions are derived from a tripartite analysis (Lang, 1971) and include EMG biofeedback, regulated breathing, exposure in vivo to stressful communication situations and cognitive techniques to reduce relapse risk. The role of dysfunctional response system interactions in stuttering is emphasized. Treatment resulted in a marked reduction of stuttering and associated facial contortions during videotaped conversations with strangers and oral reading. Improvement was maintained at one-year follow-up.

scholarly journals Role of methyleprednisolone succinate in the management of acute spinal cord injury

1970 ◽  
Vol 9 (3) ◽  
pp. 168-172
Author(s):  
NK Karn ◽  
BP Shrestha ◽  
GP Khanal ◽  
R Rijal ◽  
P Chaudhary ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Status ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
And Gender ◽  
One Year

Objective: To see the role of methyleprednisolone succinate in the management of acute spinal cord injury. Methods: A randomized control trial was done including the patients with acute spinal cord injury. They were divided into age and gender matched two groups. Patients with presence of active infection, associated open fracture, those on long term steroid and those who did not give consent to participate in the trial were excluded. One group received methyleprednisolone succinate within 8 hours of injury and another group did not receive the drug. Both the groups were managed nonoperatively. The neurological status of the patients was assessed at presentation, once spinal shock was over, at 6th week and 6th month and after one year according to ASIA scoring. Frankel grading was also assessed in every follow up. Conclusion: Methylprednisolone succinct prevents secondary cord injury to a great extent and hence its administration within 8 hours of injury results in a better functional (motor and sensory) outcome. Keywords: acute spinal cord injury; methyleprednisolone succinate DOI: http://dx.doi.org/10.3126/hren.v9i3.5585   HR 2011; 9(3): 168-172

Different Therapeutic Approaches and Outcome in the Treatment of Pterygium

1998 ◽  
Vol 8 (3) ◽  
pp. 148-152 ◽  
Author(s):  
C. H. Karabatsas ◽  
G. W. Marsh ◽  
A. M. Cook ◽  
S. D. Cook
Keyword(s):  
Surgical Treatment ◽  
Surgical Techniques ◽  
Surgical Excision ◽  
Lamellar Keratoplasty ◽  
Therapeutic Approaches ◽  
Therapeutic Modalities ◽  
Results Of Treatment ◽  
One Year

Purpose This study was initiated to investigate the role of different therapeutic modalities in the outcome of the surgical treatment of pterygium. Methods The results of treatment of pterygia with a variety of surgical techniques were studied in 56 eyes (49 patients) operated on at Bristol Eye Hospital during a period of five years. The surgical techniques included simple excision; bare sclera; conjunctival autograft; sliding conjunctival flap; lamellar keratoplasty and penetrating keratoplasty. Twelve eyes received additional beta irradiation in a fractionated total dose of 40 Gys. Results The incidence of recurrence was 23.2% for the 43 treated primary pterygia, and 23% for the 13 recurrent pterygia. All recurrences occurred between 2.5 and 11 months postoperatively. None of the 11 cases where additional beta irradiation was used showed any recurrence or other complication within the study period. In the recurrent pterygia group, the cases treated with a combination of surgical excision and beta irradiation, showed significantly lower recurrence rate (p<0.001) compared to those cases treated with surgical excision alone. Conclusions Beta irradiation as a complement to surgical treatment of pterygium, is successful in treating high risk cases such as reoperations, whereas for the majority of primary pterygia surgical excision alone is adequate. Additionally, follow up of one year will reveal any recurrences.

scholarly journals Role of a follow-up in puberty children with diffuse euthyroid goiter

2003 ◽  
Vol 49 (6) ◽  
pp. 32-36
Author(s):  
A. V. Kiyaev ◽  
I. O. Zaikova ◽  
V. V. Fadeev
Keyword(s):  
Random Sample ◽  
Clinical Examination ◽  
Autoimmune Thyroiditis ◽  
Therapeutic Intervention ◽  
Presumptive Diagnosis ◽  
One Year ◽  
Toxic Goiter

То identify patients with autoimmune thyroiditis (AIT) in a random sample of children, a stepwise clinical examination was conducted among 427 ninth-form pupils (aged 14-15 years) from 4 Yekaterinburg districts. Among 58 children with goiter as shown by ultrasonography, 18 were initially diagnosed as having hypertrophic AIT; 38patients had diffuse euthyroid goiter; one patient had diffuse toxic goiter; and mixed euthyroid goiter was detected in one case. At one-year follow-up, re-examination rejected the diagnosis of AIT in 13 of the 18 patients. It was concluded that: (1) the follow-up of children with a presumptive diagnosis of AIT suggests that the latter plays a much less role in the etiological pattern of diffuse euthyroid goiter as compared with the data of the primary examination; (2) most changes originally interpreted as manifestations of AIT are reversible, which suggests that it is preferable to follow-up children with a presumptive diagnosis of AIT in the phase of euthyrosis under active therapeutic intervention.

scholarly journals Physical and Sociodemographic Features Associated With Quality of Life Among Transgender Women and Men Using Gender-Affirming Hormone Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Eliane D. Silva ◽  
Tayane M. Fighera ◽  
Roberta M. Allgayer ◽  
Maria Inês R. Lobato ◽  
Poli Mara Spritzer
Keyword(s):  
Quality Of Life ◽  
Hormone Therapy ◽  
Gender Dysphoria ◽  
Transgender Women ◽  
Breast Development ◽  
Body Hair ◽  
Trans Men ◽  
In Trans ◽  
Trans Women

Background: Gender dysphoria is defined as a feeling of distress resulting from the incongruence between the sex assigned at birth and the gender identity, lasting longer than 6 months. In individuals with gender dysphoria, gender-affirming hormone therapy (GAHT) may improve quality of life (QoL).Objectives: We aimed to assess perceived QoL, to compare QoL scores between trans women and men and to identify possible contributing factors related to GAHT in a sample of transgender women and transgender men.Methods: In this cross-sectional study, transgender women and men were recruited by availability sampling from a national transgender health service. Individuals over 18 years old with a confirmed diagnosis of gender dysphoria receiving medically prescribed GAHT for at least 6 months were consecutively included. Also included were trans men who had undergone mastectomy and trans women who had received breast augmentation surgery. Individuals who had undergone gender affirmation surgery (specifically genital surgery) or with uncontrolled clinical/psychiatric conditions at the time of the initial assessment were excluded. Sociodemographic, physical, and hormone data were collected from all participants. The WHOQOL-BREF questionnaire was used to evaluate QoL. A total of 135 transgender individuals were invited. Seventeen individuals with previous genital surgery (12.6%) and five who refused to participate (3.7%) were excluded. Therefore, 113 patients were enrolled and completed the study (60 trans women and 53 trans men).Results: QoL scores did not differ between trans women and trans men. In trans women, greater breast development and stable relationships, and higher body mass index were associated with higher QoL domain scores. In trans men, higher domain scores were found in individuals in a stable relationship, with increased body hair, engaging in physical activity, and being employed.Conclusion: Data from this study suggest that GAHT-related physical characteristics, such as breast development in trans women and increased body hair in trans men, are similar between groups, are associated with higher QoL scores, and that sociodemographic parameters may impact these associations. Healthcare providers might consider these factors when planning interventions to improve QoL in transgender individuals.

Phase II trial with carboplatin/gemcitabine induction chemotherapy followed by radiotherapy concomitantly with paclitaxel/gemcitabine in stage III non-small cell lung cancer (NSCLC)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 7139-7139 ◽  
Author(s):  
V. Hirsh ◽  
M. Duclos ◽  
L. Souhami ◽  
P. Del Vecchio ◽  
L. Ofiara ◽  
...  
Keyword(s):  
Progressive Disease ◽  
Liver Enzymes ◽  
Phase Ii Trial ◽  
Stage Iii ◽  
Stage Iii Nsclc ◽  
Grade 3 ◽  
One Year ◽  
Ecog Ps

7139 Background: The optimal combination of concomitant thoracic radiotherapy (TRT) and CT in stage III unresectable NSCLC remains unclear. The role of induction CT with Cb/G regimen, less toxic than Cisplatin/G, has not been established in stage III NSCLC. Methods: Forty-two patients (pts), 41 evaluable, entered this trial between January 2003 and November 2004, 27 males, 14 females, median age 60 (37–70), 19 pts with ECOG PS 0, 22 pts with PS 1, 22 pts with stage III A (N2), and 19 pts with stage III B (N2, N3). They received Cb AUC 5 i.v. on day 1 and G 1000 mg/m2 i.v. on days 1 + 8 every three weeks x 2 cycles, followed on day 50 by TRT, 60 Gy over 6 weeks, concomitantly with P 50 mg/m2 i.v. and G 100 mg/m2 i.v. on days 1 + 8 every three weeks x 2 cycles. Results: After induction CT, partial response (PR) was 73.1% (30 pts), stable disease (SD) 24.4% (10 pts), and 2.5% (1 pt) had progressive disease. After TRT and P/G, 19.5% (8 pts) had CR, 75.6% (31 pts) PR, and 4.9% (2 pts) PD. Median time-to-disease progression was 11.5 months. Median survival has not been reached yet, but surpassed 16.5 months; one-year survival is 71% (29 pts). Twenty three patients are still alive, after minimal follow-up of 13 months. First site of PD was in lungs in 7 pts, in brain 5 pts, in bones 4 pts; 2 pts died without PD, of cardiovascular disease. Toxicity of induction CT was minimal. During TRT and CT, grade 3 neutropenia, thrombocytopenia, and anemia occurred in 8 pts, 3 pts, and 3 pts respectively, grade 4 neutropenia and thrombocytopenia in one pt each. Nine pts received red cell transfusions, one pt platelet transfusion. One patient developed esophageal fistula with grade 4 toxicity, 3 pts had grade 3 esophagitis, 2 pts grade 3 infections, and one pt grade 3 dermatitis and elevation of liver enzymes. Conclusions: This regimen is effective, well tolerated, and appears to be an excellent choice for stage III NSCLC. Sponsored by Eli Lilly Canada. [Table: see text]

scholarly journals Primary Orbital Myxoid Liposarcoma: A Case Report and Review of Literature

2013 ◽  
Vol 4 (4) ◽  
pp. 28-32
Author(s):  
Chen Niu ◽  
Netra Rana ◽  
Zhi Gang Min ◽  
Ming Zhang
Keyword(s):  
Medical Science ◽  
Myxoid Liposarcoma ◽  
Soft Tissue Tumors ◽  
Lower Limbs ◽  
Mri Findings ◽  
One Year ◽  
The Right ◽  
Ct And Mri

Liposarcomas are common malignant soft-tissue tumors, which come from primitive mesenchymal cells and differentiate into adipose tissue. These tumors are more commonly found in lower limbs and retroperitoneal region but also reported in pharynx, lung, liver, digestive tract, diaphragm, as well as in the spermatic cord. We reported a case of primary orbital myxoid liposarcoma in a 20-year-old female patient presented with a painless proptosis of the right eye. The mass was pathologically diagnosed as a myxoid liposarcoma. The tumor recurred in 9 months after surgical intervention. The second surgery was performed and followed by postoperative local radiotherapy. No recurrence has been reported after one year of follow-up. We highlighted the role of CT and MRI findings in the tumor diagnosis and the importance of local radiotherapy after surgery. Asian Journal of Medical Science, Volume-4 (2013), Pages 28-32 DOI: http://dx.doi.org/10.3126/ajms.v4i4.8311 

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