Abnormal Expression of Genes in Inflammation, Lipid Metabolism, and Wnt Signaling in the Lean Women with Polycystic Ovary Syndrome (PCOS).

2010 ◽  
pp. OR39-3-OR39-3
Author(s):  
G Chazenbalk ◽  
C Wang ◽  
M Pall ◽  
J Xu ◽  
Y-H Chen ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Wnt Signaling ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Abnormal Expression ◽  
Expression Of Genes

scholarly journals Abnormal expression of TLRs may play a role in lower embryo quality of women with polycystic ovary syndrome

2016 ◽  
Vol 62 (5) ◽  
pp. 353-358 ◽  
Author(s):  
Bao-Xia Gu ◽  
Xue Wang ◽  
Bao-Li Yin ◽  
Hai-Bin Guo ◽  
He-Long Zhang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Embryo Quality ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Abnormal Expression

Anti-Müllerian hormone as an indicator of reproductive health in women with obesity and concomitant polycystic ovary syndrome

2016 ◽  
Vol 88 (12) ◽  
pp. 41-44
Author(s):  
A K Durmanova ◽  
N K Otarbaev
Keyword(s):  
Body Mass Index ◽  
Lipid Metabolism ◽  
Reproductive Health ◽  
Polycystic Ovary Syndrome ◽  
Abdominal Obesity ◽  
Polycystic Ovary ◽  
Morphometric Parameters ◽  
Ovary Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
Reproductive Aged Women

Aim. To investigate the ovarian reserve and a relationship between the level of anti-Müllerian hormone (AMH) with that of hormones in reproductive-aged women with abdominal obesity concurrent with and without polycystic ovary syndrome (PCOS). Subjects and methods. A total of 157 women aged 18 to 45 years with a body mass index (BMI) of more than 30 kg/m2 were examined. The 157 women with abdominal obesity were conventionally divided into 2 groups: 1) 20 with PCOS and 2) 137 without this condition. Morphometric parameters, the indicators of carbohydrate and lipid metabolism, and the levels of hormones, including AMH, were studied. Results. The patients with PCOS had statistically significantly elevated AMH levels (11.26±2.63 ng/ml; p

scholarly journals Alternative splicing of the androgen receptor in polycystic ovary syndrome

2015 ◽  
Vol 112 (15) ◽  
pp. 4743-4748 ◽  
Author(s):  
Fangfang Wang ◽  
Jiexue Pan ◽  
Ye Liu ◽  
Qing Meng ◽  
Pingping Lv ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Alternative Splicing ◽  
Polycystic Ovary Syndrome ◽  
Splice Variants ◽  
Polycystic Ovary ◽  
Endocrine Disorders ◽  
Ovary Syndrome ◽  
Insertion And Deletion ◽  
Expression Of Genes ◽  
Genome Wide

Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause of female subfertility. The mechanism underlying the pathophysiology of PCOS remains to be illustrated. Here, we identify two alternative splice variants (ASVs) of the androgen receptor (AR), insertion and deletion isoforms, in granulosa cells (GCs) in ∼62% of patients with PCOS. AR ASVs are strongly associated with remarkable hyperandrogenism and abnormalities in folliculogenesis, and are absent from all control subjects without PCOS. Alternative splicing dramatically alters genome-wide AR recruitment and androgen-induced expression of genes related to androgen metabolism and folliculogenesis in human GCs. These findings establish alternative splicing of AR in GCs as the major pathogenic mechanism for hyperandrogenism and abnormal folliculogenesis in PCOS.

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