scholarly journals Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Men

2005 ◽  
Vol 90 (12) ◽  
pp. 6403-6409 ◽  
Author(s):  
Annewieke W. van den Beld ◽  
Theo J. Visser ◽  
Richard A. Feelders ◽  
Diederick E. Grobbee ◽  
Steven W. J. Lamberts
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Physical Function ◽  
Grip Strength ◽  
High Serum ◽  
Healthy Adults ◽  
Elderly Men ◽  
Normal Range ◽  
Free T4 ◽  
Low T3

Context: Physiological changes in thyroid hormone concentrations might be related to changes in the overall physical function in the elderly. Objective: We determined to what extent thyroid hormone concentrations are related to physical function and mortality in elderly men. Design: A longitudinal population study (the Zoetermeer study) was conducted. Mortality was registered in the subsequent 4 yr. Participants: Four hundred three independently and ambulatory living men (aged 73–94 yr) participated. Main Outcome Measures: The study examined the association between serum thyroid hormones and parameters of physical function as well as the association with mortality. Methods: TSH, free T4 (FT4) total T4, T3, rT3, and T4-binding globulin were measured. Physical function was estimated by the number of problems in activities of daily living, a measure of physical performance score (PPS), leg extensor strength and grip strength, bone density, and body composition. Results: Serum rT3 increased significantly with age and the presence of disease. Sixty-three men met the biochemical criteria for the low T3 syndrome (decreased serum T3 and increased serum rT3). This was associated with a lower PPS, independent of disease. Furthermore, higher serum FT4 (within the normal range of healthy adults) and rT3 (above the normal range of healthy adults) were related with a lower grip strength and PPS, independent of age and disease. Isolated low T3 was associated with a better PPS and a higher lean body mass. Low FT4 was related to a decreased risk of 4-yr mortality. Conclusions: In a population of independently living elderly men, higher FT4 and rT3 concentrations are associated with a lower physical function. High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state. Low serum FT4 is associated with a better 4-yr survival; this may reflect an adaptive mechanism to prevent excessive catabolism.

scholarly journals Thyroid hormone profile and PELOD score in children with sepsis

2014 ◽  
Vol 54 (4) ◽  
pp. 245
Author(s):  
Agung G. Tanurahardja ◽  
Antonius H. Pudjiadi ◽  
Pramita G. Dwipoerwantoro ◽  
Aman Pulungan
Keyword(s):  
Thyroid Hormone ◽  
Pediatric Intensive Care ◽  
Cross Sectional Study ◽  
Free T4 ◽  
Cross Sectional ◽  
Risk Of Death ◽  
Hormone Profile ◽  
Low T3 ◽  
Hormonal Dysfunction ◽  
Pelod Score

Background Thyroid hormonal dysfunction, also known aseuthyroid sick syndrome or nonthyroidal illness, can be seenin sepsis. There have been few studies on thyroid hormonedysfunction in septic children, as well as on a relationshipbetween their thyroid hormone profiles and pediatric logisticorgan dysfunction (PELOD) scores. Procakitonin (PCT) is oneof the sepsis biomarker.Objective To evaluate the thyroid hormone profile in childrenwith sepsis as well as to assess for a correlation between the thyroidlevels and PELOD scores, PCT levels, and patient outcomes.Methods This cross-sectional study included children aged 1- 18years admitted to the pediatric intensive care unit (PICU) with aprimary diagnosis of sepsis. PELOD scores and thyroid hormonallevels were assessed once during the first 24 hours after PICUadmission.Results Thirty subjects were included in the study. The medianvalues ofT3, free T4, and TSH were 45 (range 17 -133) ng/dL,0.81 (range 0.3-1.57) ng/dL, and 1.36 (range 0.05-7.78) μIU/L,respectively. The T3, free T4, and TSH levels were decreased in97%, 50% and 40% of the subjects. There were no significantdifferences between low and normal to high TSH with regards tothe PELOD score (P=0.218), PCT level (P=0.694), or patientoutcomes (P=0.55). The risk of death increased by 15 timesamong the subjects with PELOD score ~20 compared to thosewith PELOD score <20 (OR 15; 95%CI: 1.535 to 146.545;P=0.012).Conclusion Thyroid hormones are decreased in septic childrenwith the majority having low T3. A high PELOD score is stronglycorrelated with mortality and can be used as a prognostic parameterfor septic children in the PICU, but there is no correlation withdecreased TSH.

Thyroid hormone concentrations in the plasma of fed and fasted Brahman and Hereford steers

1994 ◽  
Vol 34 (4) ◽  
pp. 439
Author(s):  
JC O'Kelly ◽  
WG Spiers
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Plasma Concentrations ◽  
Free T4 ◽  
Rumen Metabolism ◽  
Body Tissues ◽  
Breed Differences ◽  
Feeding Regimes ◽  
Ad Libitum ◽  
Brahman Steers

Plasma concentration patterns of thyroxine (TJ, free T4 (FT4), triiodothyronine (T3), and free T3 (FT3) were determined in Brahman steers fed lucerne hay ad libitum and in Brahman and Hereford steers fed restricted intakes of lucerne hay at the rate of either 208 g/h before fasting for 72 h or 250 g/h before fasting for 96 h. In Brahmans fed ad libitum, the plasma concentrations of all thyroid hormone fractions were significantly (P<0.01) correlated with one another and with feed intake. Within breeds, the concentrations of thyroid hormones were higher (P<0.001) when animals were fed at 250 g k than at 208 g/h. During both hourly feeding regimes T4, FT4, T3, and FT3 concentrations were higher (P<0.001) in Brahmans than in Herefords. Fasting after both hourly feeding regimes lowered (P<0.001) the concentrations of T4 about 53% in Brahmans and 30% in Herefords, while FT4, T3, and FT3 were lowered about 68% in Brahmans and 50% in Herefords. Consequently, thyroid hormone concentrations were significantly lower in Brahmans than in Herefords after 72 h fasting but did not differ significantly between breeds after 96 h fasting. The present results, together with those of our previous work showing breed differences in rumen metabolism, support the concept that, in Hereford and Brahman steers fed the same amount of hay in a thermoneutral environment, breed differences in plasma concentrations of thyroid hormones originate from quantitative differences in the supply of nutrients from the rumen to body tissues.

Specific measurement of cyclosporine concentrations in whole blood: radioimmunoassay and fluorescence polarization immunoassay compared

1991 ◽  
Vol 37 (12) ◽  
pp. 2150-2152 ◽  
Author(s):  
Kathleen A Fuller ◽  
Wayne S Brown ◽  
John W Koenig ◽  
Barbara J Eveland ◽  
Mitchell G Scott
Keyword(s):  
Thyroid Hormone ◽  
Whole Blood ◽  
Fluorescence Polarization ◽  
Hashimoto Thyroiditis ◽  
High Serum ◽  
Fluorescence Polarization Immunoassay ◽  
Normal Range ◽  
Normal Value ◽  
Serum T3 ◽  
History Of

Letters A 39-year-old woman with a 20-year history of hypothyroidism caused by Hashimoto thyroiditis had been managed adequately with oral thyroxun (T4), 200 mg/day, until a few months before referral, at which time she developed symptoms of hyperthyroidism. Her thyroid hormone proffle at the time of referral is shown in Table 1 (Sample 1). Her normal value for serum thyrotropin (TSH) concentration indicates that she was euthyreid but, because of the high serum triiodothyronune (T3) value, the daily oral doseof T4 was decreased to 100 mg. The serum thyroid tests were repeated four weeks later (Table 1, Sample 2): The decreased T4 and increased TSH show that the patient had become hypothyroid at this dosagé of T4 but the serum T3 concentration was still in the high normal range.

scholarly journals Association between thyroid hormones and diabetic complications in patients with newly diagnosed type 2 diabetes: A cross-sectional study

2021 ◽  
Author(s):  
Yanli Li ◽  
Min Yi ◽  
Xiaoyi Deng ◽  
Wangen Li ◽  
Yimei Chen ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Diabetic Complications ◽  
Demographic Factors ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Free T4 ◽  
Cross Sectional ◽  
Low T3

Abstract Background Diabetes mellitus (DM) and thyroid dysfunction (TD) are two closely associated disorders. The coexistence of TD could adversely influence metabolic control and even increase the long-term mortality in patients with DM. The objective of the present study was to investigate the thyroid status and the relationship between thyroid hormones, diabetic complications and metabolic parameters in patients with newly diagnosed type 2 DM (T2DM). Methods This is an observational cross-sectional study, conducting on 340 patients with newly diagnosed T2DM who were admitted to ward of endocrinology department and 120 matched nondiabetic subjects. Clinical characteristics were collected and laboratory measurements were conducted. Results Levels of free T3 (FT3), free T4 (FT4) and TSH were significantly lower in patients with T2DM as compared to nondiabetic subjects. The prevalence of TD was 21.2% in patients with diabetes, higher than that of controls (4.2%). The low T3 syndrome was the most frequent TD, shown in 14.7% of patients. The presence of diabetic complications (diabetic nephropathy (DN), diabetic ketosis), metabolic and demographic factors, including age, glycemic control and insulin resistance were factors associated with levels of thyroid hormones. FT3 level was inversely correlated with the level of urinary total protein (mg/24h) and the presence of DN. Multivariate analysis indicated low FT3 level as a strong independent risk factor (OR = 0.364, P < 0.001) for DN. Conclusions TD is not rarely seen in patients with newly diagnosed T2DM. Diabetic complications and diabetes-related metabolic and demographic factors are related to TD. Decreased FT3 is strongly correlated with the presence of DN.

Three-compartmental analysis of effects of D-propranolol on thyroid hormone kinetics

1988 ◽  
Vol 255 (1) ◽  
pp. E80-E86 ◽  
Author(s):  
J. T. van der Heijden ◽  
E. P. Krenning ◽  
H. van Toor ◽  
G. Hennemann ◽  
R. Docter
Keyword(s):  
Mass Transfer ◽  
Thyroid Hormone ◽  
Mass Transfer Rate ◽  
Kinetic Studies ◽  
Compartmental Analysis ◽  
Metabolic Clearance ◽  
Free T4 ◽  
Transfer Rates ◽  
Plasma Pool ◽  
Low T3

Tracer thyroxine (T4), 3.3',5-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) kinetic studies were performed in normal T4 substituted subjects before and during oral D-propranolol treatment to determine whether changes in thyroid hormone metabolism in a propranolol-induced low-T3 syndrome result from inhibition of 5'-deiodination or inhibition of transport of iodothyronines into tissues. Data were analyzed according to a three-compartmental model of distribution and metabolism. T4 plasma appearance rate decreased by 16% (P less than 0.01), reflecting a decreased intestinal absorption of orally administered T4 during propranolol. Serum T4 and free T4 levels increased significantly by 14%, whereas T4 metabolic clearance rate (MCR) was lowered by 26% (P less than 0.001). No changes were observed in size of the three T4 compartments or in fractional and mass transfer rates of T4 from plasma to the rapidly (REP) and slowly (SEP) equilibrating pools. Serum T3, free T3, T3 plasma pool, T3 mass transfer rate to REP and SEP, and the T3 pool masses were all significantly decreased during propranolol to a similar extent as the T3 plasma production rate (PR). T3 MCR decreased by 14% (P less than 0.05). Serum total and free rT3 increased, whereas the rT3 MCR was substantially lowered during propranolol (P less than 0.001). The rT3 plasma pool, rT3 REP and SEP, and the mass transfer rates to REP and SEP increased, whereas no alterations were observed in rT3 PR and fractional transfer rates of rT3 to REP and SEP.(ABSTRACT TRUNCATED AT 250 WORDS)

THYROID PROFILE IN CHILDREN WITH NEPHROTIC SYNDROME

2021 ◽  
pp. 75-77
Author(s):  
Meiyappan Kavitha ◽  
Mallaiyan Manonmani
Keyword(s):  
Nephrotic Syndrome ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Thyroid Stimulating Hormone ◽  
The Body ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Free Triiodothyronine ◽  
Free T4 ◽  
Renal Disorder

Objectives: Nephrotic syndrome is a common renal disorder seen in children, with proteinuria as the hallmark. Growth retardation is a known feature of nephrotic syndrome, either due to the disease or treatment with steroids. Thyroid hormone strongly inuences growth of the body. So, the present study was undertaken with the objective to assess the thyroid prole in children with nephrotic syndrome Methods: The study involved 41 cases of nephrotic syndrome and 41 age and sex matched controls. Serum total triiodothyronine (T3), total thyroxine (T4), free triiodothyronine (T3), free thyroxine (T4) and thyroid stimulating hormone (TSH) were assessed in these subjects. The thyroid hormones were correlated with urinary protein creatinine ratio. The cases were followed up after one month and the levels of thyroid hormones were reassessed. Results: Total T3, total T4, free T3 and free T4 are signicantly decreased and TSH signicantly increased among cases when compared to controls. TSH is positively correlating with urinary protein creatinine ratio in cases. After one month of treatment, total T3 and total T4 are signicantly increased in cases. Conclusions: The thyroid hormone levels are altered in children with nephrotic syndrome during the episode. A state of subclinical hypothyroidism exists during the nephrotic stage. The alteration is normalized with remission and does not require treatment.

scholarly journals Thyroid Function in Rubinstein-Taybi Syndrome*

1997 ◽  
Vol 82 (10) ◽  
pp. 3264-3266
Author(s):  
David P. Olson ◽  
Ronald J. Koenig
Keyword(s):  
Mental Retardation ◽  
Thyroid Hormone ◽  
Binding Protein ◽  
Hormone Deficiency ◽  
Hormone Resistance ◽  
Creb Binding Protein ◽  
Normal Range ◽  
Free T4 ◽  
Genetic Syndrome ◽  
Thyroid Hormone Resistance

Abstract Rubinstein-Taybi syndrome (RTS) is a genetic syndrome characterized by broad thumbs and halluces, growth retardation, mental retardation, and craniofacial abnormalities. This condition recently was found to be caused by mutations in the gene encoding cAMP response element-binding protein (CREB)-binding protein. As CREB-binding protein has been shown to be a critical coactivator for thyroid hormone receptors, it is plausible that RTS would be characterized by thyroid hormone resistance. In fact, features of RTS, such as mental retardation and short stature, are consistent with thyroid hormone deficiency or resistance. To assess the function of the thyroid axis in RTS, free T4 and TSH were measured in 12 subjects with this syndrome. The free T4 level was normal in all 12 (mean ± sd, 0.97 ± 0.20 ng/dL; normal range, 0.73–1.79), as was the TSH level (2.24 ± 0.87 μU/mL; normal range, 0.3–6.5). Thus, overt thyroid hormone resistance does not appear to be a typical feature of RTS.

scholarly journals Modern concepts of primary thyroid gland failure

1996 ◽  
Vol 42 (1) ◽  
pp. 179-182 ◽  
Author(s):  
E C Ridgway
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Hormone Deficiency ◽  
Clinical Effects ◽  
Normal Range ◽  
Medical Disorder ◽  
Clinical Detection ◽  
Key Genes ◽  
Serum Tsh

Abstract Primary thyroid gland failure is a common medical disorder occurring in mild or severe forms in 10% to 15% of our population. Symptoms may be classical and easy to recognize or very subtle, escaping clinical detection. This disorder is more common in females and increases with advancing age. The most important diagnostic test is measurement of the serum thyrotropin (TSH) concentration, which will increase above the normal range in both mild and severe cases. Most clinical effects of thyroid hormone deficiency can be explained by the "nuclear thyroid hormone hypothesis," which states that thyroid hormones act predominantly by effecting the transcription of key genes in affected tissues. Therapy of hypothyroidism is easy, inexpensive, and precise, involving pure L-thyroxine and measuring dose requirements and efficacy by monitoring serum TSH concentrations.

scholarly journals Consequences of Monocarboxylate Transporter 8 Deficiency for Renal Transport and Metabolism of Thyroid Hormones in Mice

Endocrinology ◽  
2010 ◽  
Vol 151 (2) ◽  
pp. 802-809 ◽  
Author(s):  
Marija Trajkovic-Arsic ◽  
Theo J. Visser ◽  
Veerle M. Darras ◽  
Edith C. H. Friesema ◽  
Bernhard Schlott ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Psychomotor Retardation ◽  
High Serum ◽  
Monocarboxylate Transporter ◽  
Iodothyronine Deiodinase ◽  
Serum T4 ◽  
Mct8 Deficiency ◽  
Low Serum

Patients carrying inactivating mutations in the gene encoding the thyroid hormone transporting monocarboxylate transporter (MCT)-8 suffer from a severe form of psychomotor retardation and exhibit abnormal serum thyroid hormone levels. The thyroidal phenotype characterized by high-serum T3 and low-serum T4 levels is also found in mice mutants deficient in MCT8 although the cause of these abnormalities is still unknown. Here we describe the consequences of MCT8 deficiency for renal thyroid hormone transport, metabolism, and function by studying MCT8 null mice and wild-type littermates. Whereas serum and urinary parameters do not indicate a strongly altered renal function, a pronounced induction of iodothyronine deiodinase type 1 expression together with increased renal T3 and T4 content point to a general hyperthyroid state of the kidneys in the absence of MCT8. Surprisingly, accumulation of peripherally injected T4 and T3 into the kidneys was found to be enhanced in the absence of MCT8, indicating that MCT8 deficiency either directly interferes with the renal efflux of thyroid hormones or activates indirectly other renal thyroid hormone transporters that preferentially mediate the renal uptake of thyroid hormones. Our findings indicate that the enhanced uptake and accumulation of T4 in the kidneys of MCT8 null mice together with the increased renal conversion of T4 into T3 by increased renal deiodinase type 1 activities contributes to the generation of the low-serum T4 and the increase in circulating T3 levels, a hallmark of MCT8 deficiency.

scholarly journals Estimation of Tissue Hypothyroidism by a New Clinical Score: Evaluation of Patients with Various Grades of Hypothyroidism and Controls1

1997 ◽  
Vol 82 (3) ◽  
pp. 771-776 ◽  
Author(s):  
Henryk Zulewski ◽  
Beat Müller ◽  
Pascale Exer ◽  
André R. Miserez ◽  
Jean-Jacques Staub
Keyword(s):  
Relaxation Time ◽  
Thyroid Hormones ◽  
Total Cholesterol ◽  
Thyroid Function ◽  
Signs And Symptoms ◽  
Clinical Score ◽  
Overt Hypothyroidism ◽  
Free T4 ◽  
Low T3 ◽  
Hypothyroid Patients

Abstract The classical signs and symptoms of hypothyroidism were reevaluated in the light of the modern laboratory tests for thyroid function. We analyzed 332 female subjects: 50 overt hypothyroid patients, 93 with subclinical hypothyroidism (SCH), 67 hypothyroid patients treated with T4, and 189 euthyroid subjects. The clinical score was defined as the sum of the 2 best discriminating signs and symptoms. Beside TSH and thyroid hormones, we measured parameters known to reflect tissue manifestations of hypothyroidism, such as ankle reflex relaxation time and total cholesterol. Classical signs of hypothyroidism were present only in patients with severe overt hypothyroidism with low T3, but were rare or absent in patients with normal T3 but low free T4 or in patients with SCH (normal thyroid hormones but elevated basal TSH; mean scores, 7.8 ± 2.7 vs. 4.4 ± 2.2 vs. 3.4 ± 2.0; P &lt; 0.001). Assessment of euthyroid subjects and T4-treated patients revealed very similar results (mean score, 1.6 ± 1.6 vs. 2.1 ± 1.5). In overt hypothyroid patients, the new score showed an excellent correlation with ankle reflex relaxation time and total cholesterol (r = 0.76 and r = 0.60; P &lt; 0.0001), but no correlation with TSH (r = 0.01). The correlation with free T4 was r = −0.52 (P &lt; 0.0004), and that with T3 was r = −0.56 (P &lt; 0.0001). In SCH, the best correlation was found between the new score and free T4 (r =− 0.41; P &lt; 0.0001) and TSH (r = 0.35; P &lt; 0.0005). Evaluation of symptoms and signs of hypothyroidism with the new score in addition to thyroid function testing is very useful for the individual assessment of thyroid failure and the monitoring of treatment.

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