SAT-004 Prevalence of Abnormalities of Glucose Metabolism in Teenage Indian Girls with PCOS

Abstract Background:Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders affecting young women and has been associated with an increased risk of impaired glucose tolerance and type 2 diabetes mellitus. However, there are very few studies on glucose abnormalities in Indian adolescent girls with PCOS. This study was conducted to determine the prevalence of abnormal glucose metabolism in this patient population. Method: Study group comprised of 106 young females aged 13–18 years. None of them were on metformin at the time of initial visit. Clinical examination along with Anthropometric evaluation was done and along with routine hormonal assessment they underwent a standard 75-g oral glucose tolerance test (OGTT). American Diabetes Association (ADA) criteria were used for diagnosis of diabetes (2 hr value>200mg/dl), Impaired glucose tolerance (2 hour value > 140 -199 mg/dl) and Impaired fasting glucose (blood glucose level of 100–125 mg/dl) Results:Out of 106 girls with PCOS diagnosis;1 girl met criteria for diagnosis of type 2 diabetes mellitus (0.9%).15 had impaired glucose tolerance (14.1%). In addition, 2 girls with impaired glucose tolerance were also noted to have impaired fasting glucose (1.9%).Abnormalities of glucose metabolism had significant correlation with BMI(p-0.02),Waist circumference (p-0.01) and testosterone levels (p-0.02). Conclusions:In our series of adolescent PCOS subjects, we report the prevalence of abnormal glucose metabolism to be 14.1% which is quite significant. Based on our results, we recommend that all adolescent girls with a diagnosis of PCOS should undergo formal oral glucose tolerance testing. Further studies are necessary in this field, so as to make guidelines regarding the timing and frequency of this testing, as well as its utility in the clinical management of these girls.

Download Full-text

Using Ice Cream for Diagnosis of Diabetes Mellitus and Impaired Glucose Tolerance: An Alternative to the Oral Glucose Tolerance Test

The American Journal of the Medical Sciences ◽

10.1016/j.amjms.2017.08.007 ◽

2017 ◽

Vol 354 (6) ◽

pp. 581-585 ◽

Cited By ~ 1

Author(s):

Wandee Chanprasertpinyo ◽

Nattapimon Bhirommuang ◽

Titiporn Surawattanawiset ◽

Thanwarin Tangsermwong ◽

Pariya Phanachet ◽

...

Keyword(s):

Diabetes Mellitus ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Impaired Glucose Tolerance ◽

Glucose Tolerance Test ◽

Ice Cream ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Diagnosis Of Diabetes Mellitus

Download Full-text

Prevalence of newly diagnosed prediabetes, diabetes mellitus among the officers from Phuoc Long district of Binh Phuoc province

Vietnam Journal of Diabetes and Endocrinology ◽

10.47122/vjde.2020.40.4 ◽

2021 ◽

pp. 24-28

Author(s):

Thanh Long Le ◽

Trung Vinh Hoang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Newly Diagnosed ◽

Personal Communications

Objective: To evaluate the prevalence of newly diagnosed prediabetes, diabetes mellitus among the officers from Phuoc Long district of Binh Phuoc province. Subjects and methods: 268 personals communications service was examined the impaired fasting glucose (G0); impaired glucose tolerance (G2) anh HbA1c. Results: Prevalence of prediabetes, type 2 diabetes mellitus by G0, G2, HbA1c as follows 16,0%; 13,1%; 17,9% and 3,8%; 6,7%; 2,2%. Common prevalence of prediabetes in 26,9%; type 2 diabetes mellitus in 7,1%. Conclusion: Personal communications service from Phuoc Long district have percentage of prediabetes higher compared to type 2 diabetes mellitus which of prediabetes was diagnosed by HbA1c which takes up the highest percentage; diabetes mellitus was diagnosed by G2which takes up the highest percentage.

Download Full-text

Insulin supersensitivity and normoinsulinaemic hypoglycaemia in uncontrolled type 2 diabetes mellitus: clinical usefulness of 3 h assessment in the 75 g oral glucose tolerance test

BMJ Case Reports ◽

10.1136/bcr-2013-201908 ◽

2014 ◽

Vol 2014 (apr08 1) ◽

pp. bcr2013201908-bcr2013201908 ◽

Cited By ~ 2

Author(s):

S. Sugiyama ◽

H. Jinnouchi ◽

K. Hieshima ◽

T. Jinnouchi

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance

Download Full-text

Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione

Diabetes Obesity and Metabolism ◽

10.1111/j.1463-1326.2005.00568.x ◽

2006 ◽

Vol 8 (5) ◽

pp. 561-567 ◽

Cited By ~ 13

Author(s):

A. Kautzky-Willer ◽

A. Tura ◽

C. Winzer ◽

O. F. Wagner ◽

B. Ludvik ◽

...

Keyword(s):

Insulin Sensitivity ◽

Glucose Metabolism ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Type 2 Diabetic

Download Full-text

439: Can the oral glucose tolerance test and the glycemic control during pregnancy with gestational diabetes mellitus predict future development of diabetes mellitus type 2?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2015.10.481 ◽

2016 ◽

Vol 214 (1) ◽

pp. S241-S242

Author(s):

Enav Yefet ◽

Naama Schwartz ◽

Zohar Nachum

Keyword(s):

Diabetes Mellitus ◽

Glycemic Control ◽

Gestational Diabetes ◽

Glucose Tolerance ◽

Diabetes Mellitus Type 2 ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance

Download Full-text

Status of Glucose Metabolism and the Factors Affecting It, in Children with Thalassemia Major.

Blood ◽

10.1182/blood.v106.11.3848.3848 ◽

2005 ◽

Vol 106 (11) ◽

pp. 3848-3848

Author(s):

Anupam Sachdeva ◽

Satya Prakash Yadav ◽

Subash C. Arya ◽

Virender K. Khanna ◽

Archana D. Arya

Keyword(s):

Diabetes Mellitus ◽

Glucose Metabolism ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Glucose Tolerance Test ◽

Age Of Onset ◽

Thalassemia Major ◽

Tolerance Test ◽

Oral Glucose ◽

Normal Glucose

Abstract Abnormalities of the glucose metabolism are well documented in patients with Thalassemia Major who are frequently transfused and receiving therapy for chelation, due to excess iron deposition in the pancreas. The incidence of abnormalities in the glucose metabolism increase with age, with peak incidence between 16–20 years. The Indian (Asian) population is genetically predisposed to developing type 2 diabetes mellitus which is an additional risk factor for our Thalassemic population. Chelation is suboptimal in most of the patients due to economic reasons and ignorance. Impaired glucose tolerance (IGT) usually precedes the development of frank diabetes mellitus and intensive chelation in those with impaired glucose tolerance test may delay/prevent the onset of diabetes mellitus. Hence it is important to know the glyco-metabolic status of these children. At our Thalassemia endocrinology clinic, glucose tolerance test (GTT) is performed routinely in all subjects with Thalassemia major who have not already developed diabetes to identify the “at risk” population.GTT is performed by drawing a baseline fasting sample for blood glucose, oral glucose was given in a dose of 1.75mg/kg upto a maximum of 75 gms. Blood glucose level is measured 2 hours after oral glucose. According to the WHO criteria, Fasting plasma glucose between 110–126mg/dl is classified as impaired fasting and above 126mg/dl as diabetes. 2-hour plasma glucose value between 140–200mg/dl is classified as impaired glucose tolerance and above 200 mg/dl as diabetes. The purpose of this study was to analyze the status of the glucose metabolism of children and young adults with Thalassemia major who were attending our Thalassemia endocrinology clinic and to compare the factors affecting subjects with an abnormal glucose metabolism with those who have a normal glucose metabolism. The parameters compared were: effect of mean S. ferritin levels, age of onset of chelation and genetic predisposition. Retrospective analysis of our case records was done to determine the prevalence of diabetes and impaired glucose tolerance in children and young adults between 13 and 25 years of age. Of the 33 subjects evaluated, 16 out of 33 (48.5%) subjects had an abnormality of the glucose metabolism. 14/33 subjects (42.4%) had developed diabetes mellitus and 2 had an impaired GTT. Of the 16 affected subjects 9 were males and 7 were females (M:F = 1.28:1). The mean serum ferritin for this group was 5464ng/ml, 5503ng/ml for the diabetic group and 5425 for those with impaired GTT. (Range 2523–10904ng/ml). History of diabetes in a first or second degree relative was positive in 9 subjects(56.25%), negative in 2 and unknown in 5 subjects. Average age of onset of chelation was 8 years in this group. Oral glucose tolerance test was normal in 17/33(51.5%) subjects of which 10 were males and 7 were females (1.42:1). Average serum ferritin was 4747.4ng/ml in the group with a normal glucose tolerance. (1600–8294ng/ml). Family history of diabetes in a first or second degree relative was positive in 8 subjects(47%), negative in 4 and unknown in 5 subjects. Average age of onset of chelation was 6.5 years in the group with normal glucose metabolism. In conclusion of the 33 subjects evaluated, 48.5% had an abnormal glucose metabolism.

Download Full-text

Conformance of the diagnostic criteria for diabetes mellitus estimated from the results of the oral glucose tolerance testsand glycated hemoglobin (HbA1c) level

Problems of Endocrinology ◽

10.14341/probl201460136-38 ◽

2014 ◽

Vol 60 (1) ◽

pp. 36-38

Author(s):

E A Shestakova

Keyword(s):

Diabetes Mellitus ◽

Glucose Tolerance ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Oral Glucose ◽

Diabetic Patients ◽

Oral Glucose Tolerance ◽

Study Population ◽

Hba1c Measurement

The study population of 127 patients with type 2 diabetes mellitus (T2DM) risk factors underwent oral glucose tolerance test (OGTT) and HbA1c measurement for diagnostic reasons. HbA1c revealed less diabetic patients than OGTT (31% vs 43%). HbA1c >7% and OGTT were similar in confirming diabetes, but HbA1c <7% suggests the need for OGTT performance to validate the diagnosis.

Download Full-text