scholarly journals Breastfeeding Is Associated With Lower Prevalence of Metabolic Syndrome in Women With Recent Gestational Diabetes in the Early Postpartum Period

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A432-A432
Author(s):  
João Sergio Neves ◽  
Rachel Blair ◽  
Jacinda M Nicklas ◽  
Christine Horn ◽  
Geraldine Skurnik ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gestational Diabetes ◽  
Postpartum Period ◽  
Lower Prevalence ◽  
Weight Retention ◽  
Early Postpartum Period ◽  
Early Postpartum ◽  
Lipid Panel ◽  
Increased Risk ◽  
Significant Difference

Abstract Introduction: Women with gestational diabetes (GD) are at increased risk of future cardiovascular disease. The identification of factors that reduce metabolic syndrome (MetS) is important to improve cardiovascular outcomes. MetS has been shown to be associated with breastfeeding in women remote from pregnancy. We examined the association of breastfeeding with MetS in women with recent GD in the very early postpartum (pp) period. Methods: We performed a secondary analysis of the Balance After Baby (BAB) program which enrolled women with recent GD. GD was defined by Carpenter-Coustan criteria, a 50 gram glucose load test >200 mg/dL or by clinician diagnosis. Data collected during an early (~6 weeks) pp visit was used in this analysis. At this visit, weight, height, waist circumference (WC), blood pressure (BP), fasting plasma glucose (FPG) and lipid panel were obtained. MetS was classified per NCEP III. We defined breastfeeding as currently breastfeeding or not currently breastfeeding. We performed Student’s t-tests and Wilcoxon rank-sum tests as appropriate, and fit logistic and linear regression models. Models were adjusted for age, race/ethnicity, low household income, pre-pregnancy BMI, and weeks since delivery. An exploratory model further adjusted for postpartum weight retention. Results: Of 181 women enrolled in BAB, 178 were included in this analysis (3 excluded for missing lipid panels). The mean (± SD) age of participants was 33 ± 5 years and were 8.0 ± 1.8 weeks since delivery. Thirty-four % were Hispanic. Of non-Hispanics, 31.5% were White, 18.5% Asian and 12.9% Black/African American. The prevalence of MetS was 42.9% in women not breastfeeding versus 17.1% in women breastfeeding (P < 0.001; adjusted odds ratio [aOR] 0.16 [95% CI 0.06–0.41]). Breastfeeding women had significantly lower odds of FPG ≥100 mg/dL (aOR 0.36 [95% CI 0.14–0.95], p=0.039), HDL <50 mg/dL (aOR 0.19 [95% CI 0.08–0.46], p<0.001), and triglycerides (TG) ≥150 mg/dL (aOR 0.26 [95% CI 0.10–0.66], p=0.005). There was no significant difference in WC or BP between groups. All ORs remained significant after adjusting for weight retention. When evaluated as continuous variables, WC, FPG, and TG were significantly lower and HDL significantly higher in women breastfeeding in the early pp period (vs not breastfeeding). Conclusion: In a diverse population of women with recent GD, there was a lower prevalence of MetS in women breastfeeding compared to those not breastfeeding in the early postpartum period. This study extends the findings of an association of breastfeeding with MetS previously reported at times remote from pregnancy. Further studies are needed to determine if there is a protective role of breastfeeding on the risk of MetS.

scholarly journals OR08-03 Association of Hemoglobin A1c with Early Postpartum Metabolic Syndrome in Women with Gestational Diabetes

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Rachel A Blair ◽  
João Sérgio Neves ◽  
Jacinda M Nicklas ◽  
Geraldine Skurnik ◽  
Ellen Wells Seely
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Gestational Diabetes ◽  
Postpartum Period ◽  
Hemoglobin A1c ◽  
Study Visit ◽  
Baseline Study ◽  
Early Postpartum Period ◽  
Early Postpartum

Abstract Background: Women with gestational diabetes (GDM) are at increased risk of metabolic syndrome (MetS), an important risk factor for development of type 2 diabetes (T2DM) and cardiovascular disease. Elevated hemoglobin A1c (HbA1c) is associated with MetS outside of pregnancy and may enhance detection of MetS. It is not known whether HbA1c is associated with MetS in the early postpartum period in women with recent GDM. Objective: We aimed to characterize the prevalence of MetS 4-12 weeks postpartum in women with recent GDM and to determine whether there was an association between HbA1c and MetS. Methods: Women with GDM as defined by Carpenter-Coustan criteria or clinician diagnosis were enrolled into the Balance After Baby Intervention trial of a web-based intervention to prevent T2DM. They underwent a baseline study visit at 4-12 weeks postpartum. Waist circumference and blood pressure were obtained and a fasting lipid panel, HbA1c and a 75-g, 2 hr OGTT was performed. We defined MetS by NCEP ATP III criteria. We fit a logistic regression model adjusted for age, race/ethnicity, and number of weeks postpartum. Results: 181 women with GDM were enrolled in the study. Three women were excluded because they did not have fasting lipid measurements. Women were a mean of 8.0 ± 1.8 weeks postpartum at their baseline study visit. 24.2% (n=43) of women had MetS (at least 3 of 5 NCEP ATP III criteria). Of these, 77% met the waist circumference criterion, 37.6% met the HDL criterion, 23.6% met the triglycerides criterion, 16.9% met the fasting glucose criterion and 14.6% met the blood pressure criterion. HbA1c as a continuous variable was not significantly associated with MS (OR for each 0.5% increase: 1.60, 95% CI 0.88-2.91). Elevated HbA1c (prediabetes range ≥5.7 to <6.5%) was also not associated with MetS (OR 0.98, 95% CI 0.46-2.12). A 2 hr blood glucose value of ≥140 mg/dL on OGTT testing was significantly associated with MetS (OR 5.28, 95% CI 2.11-13.22). Conclusion: Nearly 1 in 4 women with recent GDM had MetS in the early postpartum period. There was no significant association between HbA1c and presence of MetS. However, an elevated 2 hr value on OGTT was significantly associated with MetS, suggesting that women with elevated 2 hr values may require additional monitoring for MetS and may have elevated cardiometabolic risk beyond the risk of development of T2DM.

scholarly journals Risk factors during the early postpartum period for type 2 diabetes mellitus in women with gestational diabetes

2020 ◽  
Vol 67 (4) ◽  
pp. 427-437
Author(s):  
Maki Kawasaki ◽  
Naoko Arata ◽  
Naoko Sakamoto ◽  
Anna Osamura ◽  
Siori Sato ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Postpartum Period ◽  
Early Postpartum Period ◽  
Early Postpartum

scholarly journals Type 1 Diabetes Mellitus Diagnosed during Follow-up of Gestational Diabetes Mellitus in the Early Postpartum Period

2018 ◽  
Vol 57 (23) ◽  
pp. 3413-3418
Author(s):  
Toshiyuki Ikeoka ◽  
Ayaka Sako ◽  
Genpei Kuriya ◽  
Hiroshi Yamashita ◽  
Ichiro Yasuhi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Type 1 Diabetes Mellitus ◽  
Postpartum Period ◽  
Early Postpartum Period ◽  
Early Postpartum

scholarly journals Predictors of Abnormal Glucose Tolerance in the Early Postpartum Period in Patients with Gestational Diabetes

2016 ◽  
Vol 62 (3.4) ◽  
pp. 47-51 ◽  
Author(s):  
SHIGERU INOUE ◽  
TAKAAKI SHINAGAWA ◽  
TAKASHI HORINOUCHI ◽  
YUTAKA KOZUMA ◽  
KOJI YONEMOTO ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Postpartum Period ◽  
Abnormal Glucose Tolerance ◽  
Early Postpartum Period ◽  
Early Postpartum

scholarly journals Exclusive Breastfeeding Is Not Associated with Maternal–Infant Bonding in Early Postpartum, Considering Depression, Anxiety, and Parity

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1184
Author(s):  
Naoki Fukui ◽  
Takaharu Motegi ◽  
Yuichiro Watanabe ◽  
Koyo Hashijiri ◽  
Ryusuke Tsuboya ◽  
...  
Keyword(s):  
Mental Health ◽  
Path Analysis ◽  
Exclusive Breastfeeding ◽  
Postpartum Period ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Women’S Mental Health ◽  
Women's Mental Health ◽  
Early Postpartum Period ◽  
Early Postpartum

It is important to clarify how the breastfeeding method affects women’s mental health, and how women’s mental health affects the breastfeeding method in the early postpartum period when major depression and other psychiatric problems are most likely to occur. This study aimed to examine this bidirectional relationship in the early postpartum period. Participants were 2020 postpartum women who completed the Hospital Anxiety and Depression Scale (HADS) and Mother-to-Infant Bonding Scale (MIBS). We obtained data for participants’ breastfeeding method for four weeks after childbirth. We performed a path analysis with factors including breastfeeding method (exclusive breastfeeding or non-exclusive breastfeeding), parity (primipara or multipara), the two HADS subscales (anxiety and depression), and the two MIBS subscales (lack of affection and anger and rejection). The path analysis showed that breastfeeding method did not significantly affect depression, anxiety, and maternal–infant bonding in the early postpartum period. Women with higher anxiety tended to use both formula-feeding and breastfeeding. Our study suggests that exclusive breastfeeding is not associated with maternal-fetal bonding in early postpartum, considering depression, anxiety, and parity.

scholarly journals Increased Levels of Adipocyte and Epidermal Fatty Acid-Binding Proteins in Acute Lymphoblastic Leukemia Survivors

2021 ◽  
Vol 10 (8) ◽  
pp. 1567
Author(s):  
Katarzyna Konończuk ◽  
Eryk Latoch ◽  
Beata Żelazowska-Rutkowska ◽  
Maryna Krawczuk-Rybak ◽  
Katarzyna Muszyńska-Rosłan
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Acute Lymphoblastic Leukemia ◽  
Binding Proteins ◽  
Lymphoblastic Leukemia ◽  
Fatty Acid Binding Proteins ◽  
Fatty Acid Binding ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Significant Difference

Childhood cancer survivors are highly exposed to the development of side effects after many years of cessation of anticancer treatment, including altered lipid metabolism that may result in an increased risk of overweight and metabolic syndrome. Adipocyte (A-FABP) and epidermal (E-FABP) fatty acid-binding proteins are expressed in adipocytes and are assumed to play an important role in the development of lipid disturbances leading to the onset of metabolic syndrome. The aim of this study was to investigate the association between serum A-FABP and E-FABP levels, overweight, and components of the metabolic syndrome in acute lymphoblastic leukemia survivors. Sixty-two acute lymphoblastic leukemia (ALL) survivors (34 females) were included in the study. The mean age at the time of the study was 12.41 ± 4.98 years (range 4.71–23.43). Serum levels of A-FABP and E-FABP were analyzed using a commercially available ELISA kit. The ALL survivors presented statistically higher A-FABP levels in comparison with the healthy controls (25.57 ± 14.46 vs. 15.13 ± 7.61 ng/mL, p < 0.001). The subjects with body mass index (BMI) above the normal range (18 overweight, 10 obese) had a greater level of A-FABP compared to the ALL group with normal BMI (32.02 ± 17.10 vs. 20.33 ± 9.24 ng/mL, p = 0.006). Of all participants, 53.23% had at least one risk factor of metabolic syndrome; in this group, only the A-FABP level showed a statistically significant difference compared to the healthy control group (30.63 ± 15.91 vs. 15.13 ± 7.61 ng/mL, p < 0.001). The subjects with two or more metabolic risk factors (16.13%) presented higher levels of both A-FABP (33.62 ± 17.16 vs. 15.13 ± 7.61 ng/mL, p = 0.001) and E-FABP (13.37 ± 3.62 vs. 10.12 ± 3.21 ng/mL, p = 0.021) compared to the controls. Univariable regression models showed significant associations between BMI and systolic blood pressure with the A-FABP level (coeff. 1.02 and 13.74, respectively; p < 0.05). In contrast, the E-FABP level was only affected by BMI (coeff. 0.48; p < 0.01). The findings reported herein suggest that the increased levels of A-FABP and E-FABP may be involved in the pathogenesis of overweight and the onset of metabolic syndrome in acute lymphoblastic leukemia. However, further longitudinal, prospective studies of fatty acid-binding proteins and their potential role in the pathogenesis of obesity and metabolic syndrome in ALL survivors remain to be performed.

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