Voltage-gated Na+channel ligands and ATP: relative molecular similarity and implications for channel function

2006 ◽  
Vol 58 (9) ◽  
pp. 1235-1241
Author(s):  
W. R. Williams
Keyword(s):  
Molecular Similarity ◽  
Na Channel ◽  
Voltage Gated ◽  
Channel Function

Aging-associated changes in motor axon voltage-gated Na + channel function in mice

2016 ◽  
Vol 39 ◽  
pp. 128-139 ◽  
Author(s):  
Mihai Moldovan ◽  
Mette Romer Rosberg ◽  
Susana Alvarez ◽  
Dennis Klein ◽  
Rudolf Martini ◽  
...  
Keyword(s):  
Motor Axon ◽  
Na Channel ◽  
Voltage Gated ◽  
Channel Function

scholarly journals Statistical Approach to Incorporating Experimental Variability into a Mathematical Model of the Voltage-Gated Na+ Channel and Human Atrial Action Potential

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1516
Author(s):  
Daniel Gratz ◽  
Alexander J Winkle ◽  
Seth H Weinberg ◽  
Thomas J Hund
Keyword(s):  
Action Potential ◽  
Mathematical Models ◽  
Cardiac Myocyte ◽  
Population Level ◽  
Na Channel ◽  
Model Parameters ◽  
Healthy Population ◽  
Experimental Measurements ◽  
Voltage Gated ◽  
Experimental Variability

The voltage-gated Na+ channel Nav1.5 is critical for normal cardiac myocyte excitability. Mathematical models have been widely used to study Nav1.5 function and link to a range of cardiac arrhythmias. There is growing appreciation for the importance of incorporating physiological heterogeneity observed even in a healthy population into mathematical models of the cardiac action potential. Here, we apply methods from Bayesian statistics to capture the variability in experimental measurements on human atrial Nav1.5 across experimental protocols and labs. This variability was used to define a physiological distribution for model parameters in a novel model formulation of Nav1.5, which was then incorporated into an existing human atrial action potential model. Model validation was performed by comparing the simulated distribution of action potential upstroke velocity measurements to experimental measurements from several different sources. Going forward, we hope to apply this approach to other major atrial ion channels to create a comprehensive model of the human atrial AP. We anticipate that such a model will be useful for understanding excitability at the population level, including variable drug response and penetrance of variants linked to inherited cardiac arrhythmia syndromes.

Homozygous SCN1B variants causing early infantile epileptic encephalopathy 52 affect voltage‐gated sodium channel function

Epilepsia ◽  
2021 ◽  
Author(s):  
Marcello Scala ◽  
Stephanie Efthymiou ◽  
Tipu Sultan ◽  
Jolien De Waele ◽  
Marta Panciroli ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Epileptic Encephalopathy ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Channel Function

scholarly journals Double mutant gating perturbation analysis predicts a high conformational stability of the domain IV S6 segment of the voltage-gated Na+ channel

2009 ◽  
Vol 9 (Suppl 2) ◽  
pp. A25
Author(s):  
René Cervenka ◽  
Touran Zarrabi ◽  
Péter Lukács ◽  
Xaver König ◽  
Karlheinz Hilber ◽  
...  
Keyword(s):  
Perturbation Analysis ◽  
Double Mutant ◽  
Conformational Stability ◽  
Na Channel ◽  
Voltage Gated

scholarly journals Ca 2+ /Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na + Channel in Cardiac Disease

Circulation ◽  
2012 ◽  
Vol 126 (17) ◽  
pp. 2084-2094 ◽  
Author(s):  
Olha M. Koval ◽  
Jedidiah S. Snyder ◽  
Roseanne M. Wolf ◽  
Ryan E. Pavlovicz ◽  
Patric Glynn ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cardiac Disease ◽  
Na Channel ◽  
Dependent Protein Kinase ◽  
Voltage Gated ◽  
Protein Kinase Ii ◽  
Dependent Protein

Simulation on the Physical Process of Neural Electromagnetic Signal Generation Based on a Simple but Functional Bionic Na+ Channel

2021 ◽  
Author(s):  
Fan Wang ◽  
Jingjing Xu ◽  
Yanbin Ge ◽  
Shengyong Xu ◽  
Yanjun Fu ◽  
...  
Keyword(s):  
Dynamic Equilibrium ◽  
Electromagnetic Signal ◽  
Na Channel ◽  
Physical Processes ◽  
Flux Transport ◽  
Ionic Flux ◽  
Concentration Difference ◽  
Voltage Gated ◽  
Electromagnetic Signals ◽  
The Impact

Abstract The physical processes occurring at open Na+ channels in neural fibers are essential for understanding the nature of neural signals and the mechanism by which the signals are generated and transmitted along nerves. However, there is less generally accepted description of these physical processes. We studied changes in the transmembrane ionic flux and the resulting two types of electromagnetic signals by simulating the Na+ transport across a bionic nanochannel model simplified from voltage-gated Na+ channels. Results show that the Na+ flux can reach a steady state in approximately 10 ns owing to the dynamic equilibrium of Na+ ions concentration difference between the both sides of membrane. After characterizing the spectrum and transmission of these two electromagnetic signals, the low-frequency transmembrane electric field is regarded as the physical quantity transmitting in waveguide-like lipid dielectric layer and triggering the neighboring voltage-gated channels. Factors influencing the Na+ flux transport are also studied. The impact of the Na+ concentration gradient is found higher than that of the initial transmembrane potential on the Na+ transport rate, and introducing the surface-negative charge in the upper third channel could increase the transmembrane Na+ current. This work can be further studied by improving the simulation model; however, the current work helps to better understand the electrical functions of voltage-gated ion channels in neural systems.

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