scholarly journals Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load

Neurology ◽  
2017 ◽  
Vol 88 (6) ◽  
pp. 569-576 ◽  
Author(s):  
Michel J. Grothe ◽  
Sylvia Villeneuve ◽  
Martin Dyrba ◽  
David Bartrés-Faz ◽  
Miranka Wirth ◽  
...  
Keyword(s):  
Sex Education ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Older Individuals ◽  
Multimodal Neuroimaging ◽  
Matter Volume ◽  
Amyloid Pathology ◽  
Aged Brain ◽  
Age Related ◽  
Amyloid Load

Objective:To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.Methods:Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging markers.Results:In region-of-interest–based analyses, APOE2 carriers had significantly less precuneal amyloid pathology and did not show the typical age-related increase in amyloid load, although the age × genotype interaction was only trend-level significant. In contrast, parietal metabolism and hippocampal volume did not differ between APOE2 and APOE3 genotypes, and both groups showed comparable negative effects of age on these markers. The amyloid specificity of APOE2-related brain changes was corroborated in 2 complementary analyses: spatially unbiased voxel-wise analyses showing widespread reductions in amyloid deposition but no differences in gray matter volume or metabolism and an analysis of CSF-based biomarkers showing a significant effect on amyloid but not on tau pathology.Conclusions:Regarding the range of Alzheimer disease biomarkers considered in the present study, the APOE2 allele appears to have a relatively selective effect on reduced accumulation of amyloid pathology in the aged brain.

Sleep Duration, Sleep Apnea, and Gray Matter Volume

2021 ◽  
pp. 089198872098891
Author(s):  
Regina Eun Young Kim ◽  
Robert Douglas Abbott ◽  
Soriul Kim ◽  
Robert Joseph Thomas ◽  
Chang-Ho Yun ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Sleep Duration ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Structures ◽  
Brain Regions ◽  
Population Based ◽  
Older Individuals ◽  
Bootstrap Sampling ◽  
Matter Volume

This study aimed to evaluate the effect of sleep duration on brain structures in the presence versus absence of sleep apnea in middle-aged and older individuals. The study investigated a population-based sample of 2,560 individuals, aged 49-80 years. The presence of sleep apnea and self-reported sleep duration were examined in relation to gray matter volume (GMV) in total and lobar brain regions. We identified ranges of sleep duration associated with maximal GMV using quadratic regression and bootstrap sampling. A significant quadratic association between sleep duration and GMV was observed in total and lobar brain regions of men with sleep apnea. In the fully adjusted model, optimal sleep durations associated with peak GMV between brain regions ranged from 6.7 to 7.0 hours. Shorter and longer sleep durations were associated with lower GMV in total and 4 sub-regions of the brain in men with sleep apnea.

scholarly journals Age-related changes in baroreflex sensitivity and cardiac autonomic tone in children mirrored by regional brain gray matter volume trajectories

2017 ◽  
Vol 83 (2) ◽  
pp. 498-505 ◽  
Author(s):  
Mark W DiFrancesco ◽  
Abu Shamsuzzaman ◽  
Keith B McConnell ◽  
Stacey L Ishman ◽  
Nanhua Zhang ◽  
...  
Keyword(s):  
Gray Matter ◽  
Baroreflex Sensitivity ◽  
Gray Matter Volume ◽  
Autonomic Tone ◽  
Matter Volume ◽  
Regional Brain ◽  
Age Related ◽  
Age Related Changes

scholarly journals Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment

2015 ◽  
Vol 221 (4) ◽  
pp. 2135-2146 ◽  
Author(s):  
Zoe Arvanitakis ◽  
Debra A. Fleischman ◽  
Konstantinos Arfanakis ◽  
Sue E. Leurgans ◽  
Lisa L. Barnes ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Older Individuals ◽  
Matter Volume

scholarly journals Cerebrospinal fluid levels of synaptic and neuronal integrity correlate with gray matter volume and amyloid load in the precuneus of cognitively intact older adults

2019 ◽  
Vol 149 (1) ◽  
pp. 139-157 ◽  
Author(s):  
Jolien Schaeverbeke ◽  
Benjamin Gille ◽  
Katarzyna Adamczuk ◽  
Hugo Vanderstichele ◽  
Emeric Chassaing ◽  
...  
Keyword(s):  
Older Adults ◽  
Cerebrospinal Fluid ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cerebrospinal Fluid Levels ◽  
Matter Volume ◽  
Amyloid Load ◽  
Fluid Levels ◽  
Cognitively Intact

scholarly journals Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?

2012 ◽  
Vol 33 (3) ◽  
pp. 617.e1-617.e9 ◽  
Author(s):  
Herve Lemaitre ◽  
Aaron L. Goldman ◽  
Fabio Sambataro ◽  
Beth A. Verchinski ◽  
Andreas Meyer-Lindenberg ◽  
...  
Keyword(s):  
Surface Area ◽  
Cortical Thickness ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Age Related

scholarly journals Emerging beta‐amyloid pathology is associated with tau, synaptic, neurodegeneration and gray matter volume differences

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Jose Luis Molinuevo ◽  
Marta Milà‐Alomà ◽  
Gemma Salvadó ◽  
Juan Domingo Gispert ◽  
Oriol Grau‐Rivera ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Beta Amyloid ◽  
Matter Volume ◽  
Amyloid Pathology

scholarly journals Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults

2019 ◽  
Vol 75 (8) ◽  
pp. 1558-1565 ◽  
Author(s):  
Cutter A Lindbergh ◽  
Kaitlin B Casaletto ◽  
Adam M Staffaroni ◽  
Fanny Elahi ◽  
Samantha M Walters ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Health ◽  
Necrosis Factor Alpha ◽  
Matter Volume ◽  
Age Related ◽  
Tnf Α ◽  
Factor Alpha ◽  
State Examination ◽  
Necrosis Factor

Abstract Background Central nervous system levels of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, regulate the neuroinflammatory response and may play a role in age-related neurodegenerative diseases. The longitudinal relation between peripheral levels of TNF-α and typical brain aging is understudied. We hypothesized that within-person increases in systemic TNF-α would track with poorer brain health outcomes in functionally normal adults. Methods Plasma-based TNF-α concentrations (pg/mL; fasting morning draws) and magnetic resonance imaging were acquired in 424 functionally intact adults (mean age = 71) followed annually for up to 8.4 years (mean follow-up = 2.2 years). Brain outcomes included total gray matter volume and white matter hyperintensities. Cognitive outcomes included composites of memory, executive functioning, and processing speed, as well as Mini-Mental State Examination total scores. Longitudinal mixed-effects models were used, controlling for age, sex, education, and total intracranial volume, as appropriate. Results TNF-α concentrations significantly increased over time (p < .001). Linear increases in within-person TNF-α were longitudinally associated with declines in gray matter volume (p < .001) and increases in white matter hyperintensities (p = .003). Exploratory analyses suggested that the relation between TNF-α and gray matter volume was curvilinear (TNF-α 2p = .002), such that initial increases in inflammation were associated with more precipitous atrophy. There was a negative linear relationship of within-person changes in TNF-α to Mini-Mental State Examination scores over time (p = .036) but not the cognitive composites (all ps >.05). Conclusion Systemic inflammation, as indexed by plasma TNF-α, holds potential as a biomarker for age-related declines in brain health.

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