Future Leader to Watch – Olayemi Joseph Olajide

ABSTRACTFuture Leader to Watch is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Olayemi Joseph Olajide is first author on ‘Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease’, published in BiO. He is a Research Fellow in the Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada, investigating the mechanisms of molecular neurodegeneration during the pathogenesis of Alzheimer's disease.

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First person – Komal Panchal

Biology Open ◽

10.1242/bio.055632 ◽

2020 ◽

Vol 9 (9) ◽

pp. bio055632

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Drosophila Melanogaster ◽

Molecular Basis ◽

Rho Gtpase ◽

Early Career ◽

First Person ◽

Early Career Researchers ◽

Disease Associated Genes ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Komal Panchal is first author on ‘Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster’, published in BiO. Komal is a PhD student in the lab of Dr Anand K. Tiwari at the Institute of Advanced Research (IAR), Koba Institutional Area, Gujarat, India, investigating the possible molecular basis of Alzheimer's disease.

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Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease

Biology Open ◽

10.1242/bio.056796 ◽

2021 ◽

Vol 10 (1) ◽

pp. bio056796

Author(s):

Olayemi Joseph Olajide ◽

Marcus E. Suvanto ◽

Clifton Andrew Chapman

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Entorhinal Cortex ◽

Medial Temporal Lobe ◽

Molecular Mechanisms ◽

Hippocampal Formation ◽

Selective Vulnerability ◽

Primary Role ◽

Cellular Mechanisms ◽

Molecular Neurodegeneration

ABSTRACTThe entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its contributions to cognitive processes and memory formation are supported through its extensive interconnections with the hippocampal formation. During the pathogenesis of Alzheimer's disease (AD), many of the earliest degenerative changes are seen within the EC. Neurodegeneration in the EC and hippocampus during AD has been clearly linked to impairments in memory and cognitive function, and a growing body of evidence indicates that molecular and functional neurodegeneration within the EC may play a primary role in cognitive decline in the early phases of AD. Defining the mechanisms underlying molecular neurodegeneration in the EC is crucial to determining its contributions to the pathogenesis of AD. Surprisingly few studies have focused on understanding the mechanisms of molecular neurodegeneration and selective vulnerability within the EC. However, there have been advancements indicating that early dysregulation of cellular and molecular signaling pathways in the EC involve neurodegenerative cascades including oxidative stress, neuroinflammation, glia activation, stress kinases activation, and neuronal loss. Dysfunction within the EC can impact the function of the hippocampus, which relies on entorhinal inputs, and further degeneration within the hippocampus can compound this effect, leading to severe cognitive disruption. This review assesses the molecular and cellular mechanisms underlying early degeneration in the EC during AD. These mechanisms may underlie the selective vulnerability of neuronal subpopulations in this brain region to the disease development and contribute both directly and indirectly to cognitive loss.This paper has an associated Future Leader to Watch interview with the first author of the article.

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First person – Fanny Jaudon and Martina Albini

Journal of Cell Science ◽

10.1242/jcs.259251 ◽

2021 ◽

Vol 134 (16) ◽

Keyword(s):

Neurotrophic Factor ◽

Neurological Disorders ◽

Molecular Mechanisms ◽

Neurological Diseases ◽

Early Career ◽

First Person ◽

Early Career Researchers ◽

And Function ◽

The University ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Fanny Jaudon and Martina Albini are co-first authors on ‘ A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor’, published in JCS. Fanny is a postdoc at the University of Trieste in the lab of Lorenzo A. Cingolani at Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy, investigating the molecular mechanisms controlling development and function of neuronal circuits and implementing genome-editing approaches for the treatment of neurological disorders. Martina is a PhD student at the Istituto Italiano di Tecnologia in the lab of Fabio Benfenati and Fabrizia Cesca investigating neurotrophin biology and its involvement in neurological diseases.

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First person – Laura Tamberg

Disease Models & Mechanisms ◽

10.1242/dmm.046532 ◽

2020 ◽

Vol 13 (7) ◽

pp. dmm046532

Keyword(s):

Transcription Factor ◽

Drosophila Melanogaster ◽

Molecular Mechanisms ◽

Model System ◽

Early Career ◽

Disease Models ◽

First Person ◽

Early Career Researchers ◽

University Of Technology ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Laura Tamberg is first author on ‘Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome’, published in DMM. Laura is a PhD student in the lab of Tõnis Timmusk at the Tallinn University of Technology, Tallinn, Estonia. Her research involves investigating the use of Drosophila melanogaster as a model system to understand the molecular mechanisms underlying transcription factor TCF4-related neuronal diseases.

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First person – Alexander Johnson

Journal of Cell Science ◽

10.1242/jcs.251108 ◽

2020 ◽

Vol 133 (15) ◽

pp. jcs251108

Keyword(s):

Quantitative Evaluation ◽

Molecular Mechanisms ◽

Quantitative Imaging ◽

Science And Technology ◽

Early Career ◽

First Person ◽

Plant Model ◽

Early Career Researchers ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Alexander Johnson is first author on ‘Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis’, published in JCS. Alexander is a postdoc in the lab of Jiri Friml at the Institute of Science and Technology Austria, investigating the characterization of the molecular mechanisms of endocytosis in plants using a range of quantitative imaging and biochemical approaches.

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First person – Fumiya Okawa, Yutaro Hama and Sidi Zhang

Journal of Cell Science ◽

10.1242/jcs.258751 ◽

2021 ◽

Vol 134 (8) ◽

Keyword(s):

Graduate School ◽

Molecular Mechanisms ◽

Structure And Function ◽

Early Career ◽

First Person ◽

Early Career Researchers ◽

School Of Medicine ◽

And Function ◽

The University ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Fumiya Okawa, Yutaro Hama and Sidi Zhang are co-first authors on ‘Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1’, published in JCS. Fumiya and Yutaro are PhD students and Sidi is a postdoc in the lab of Noboru Mizushima at the Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Japan, where they are investigating the molecular mechanisms and origin of autophagy.

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First person – Mohd. Salman

Disease Models & Mechanisms ◽

10.1242/dmm.046169 ◽

2020 ◽

Vol 13 (8) ◽

pp. dmm046169

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Molecular Mechanisms ◽

Drug Repurposing ◽

Early Career ◽

First Person ◽

New Delhi ◽

Neuroprotective Effects ◽

Early Career Researchers ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Mohd. Salman is first author on ‘Nrf2/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats’, published in DMM. Mohd. is a PhD student in the lab of Prof. Suhel Parvez at Jamia Hamdard, New Delhi, India, investigating the cellular and molecular mechanisms involved in traumatic brain injury, ischemic stroke and neurodegenerative diseases, and exploring the avenue of drug repurposing with pre-clinical studies.

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First person – Tatiana Burrinha

Journal of Cell Science ◽

10.1242/jcs.258827 ◽

2021 ◽

Vol 134 (9) ◽

Keyword(s):

Medical School ◽

Chronic Diseases ◽

Molecular Mechanisms ◽

Early Career ◽

Research Center ◽

First Person ◽

Synapse Loss ◽

Early Career Researchers ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Tatiana Burrinha is first author on ‘ Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss’, published in JCS. Tatiana is a PhD student in the lab of Cláudia Guimas Almeida at the Chronic Diseases Research Center (CEDOC), NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal, investigating the cellular and molecular mechanisms underlying neuronal aging.

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First person – Mariana Castro Dias

Journal of Cell Science ◽

10.1242/jcs.258753 ◽

2021 ◽

Vol 134 (8) ◽

Keyword(s):

Neurodegenerative Disorders ◽

Molecular Mechanisms ◽

Early Career ◽

First Person ◽

Early Career Researchers ◽

University Of Bern ◽

Theodor Kocher ◽

Roche Diagnostics ◽

The Brain ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Mariana Castro Dias is first author on ‘Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier’, published in JCS. Mariana conducted the research described in this article while a PhD student in Britta Engelhardt's lab at the Theodor Kocher Institute, University of Bern, Switzerland. She is now an Associate Scientific Communications Manager working for Roche Diagnostics International. She is utterly fascinated by the brain, particularly the molecular mechanisms underlying the pathology of neurodegenerative disorders.

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First person – Yutaka Takeda

Journal of Cell Science ◽

10.1242/jcs.254607 ◽

2020 ◽

Vol 133 (19) ◽

pp. jcs254607

Keyword(s):

Graduate School ◽

Molecular Mechanisms ◽

Early Career ◽

First Person ◽

Mitotic Progression ◽

Pharmaceutical Science ◽

Early Career Researchers ◽

The University ◽

Selection Of ◽

In Cells

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Yutaka Takeda is first author on ‘The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression’, published in JCS. Yutaka is a PhD student in the lab of Daiju Kitagawa at the Graduate School of Pharmaceutical Science, The University of Tokyo, Japan, investigating the molecular mechanisms that ensure proper mitotic progression in cells.

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