scholarly journals Cyclical endometrial repair and regeneration

Development ◽  
2021 ◽  
Vol 148 (17) ◽  
Author(s):  
Lois A. Salamonsen ◽  
Jennifer C. Hutchison ◽  
Caroline E. Gargett
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Extracellular Vesicles ◽  
Stem Cell Niche ◽  
Wound Repair ◽  
Human Endometrium ◽  
Adult Tissues ◽  
Reproductive Life ◽  
Cell Niche ◽  
Menstrual Fluid

ABSTRACT Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review examines what is known of endometrial repair and regeneration following menstruation and parturition, including comparisons with wound repair and the influence of menstrual fluid components. We also discuss the contribution of endometrial stem/progenitor cells to endometrial regeneration, including the importance of the stem cell niche and stem cell-derived extracellular vesicles. Finally, we comment on the value of endometrial epithelial organoids to extend our understanding of endometrial development and regeneration, as well as therapeutic applications.

Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region

Spine ◽  
2009 ◽  
Vol 34 (21) ◽  
pp. 2278-2287 ◽  
Author(s):  
Helena B. Henriksson ◽  
Maria Thornemo ◽  
Camilla Karlsson ◽  
Olle Hägg ◽  
Katarina Junevik ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Intervertebral Disc ◽  
Progenitor Cells ◽  
Stem Cell Niche ◽  
Disc Region ◽  
Cell Niche

Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity

2006 ◽  
Vol 290 (2) ◽  
pp. G189-G193 ◽  
Author(s):  
Neil D. Theise
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Cell Biology ◽  
Stem Cell Niche ◽  
Progenitor Cell ◽  
Stem Cell Biology ◽  
Cell Plasticity ◽  
Self Renewal ◽  
Cell Niche

This essay will address areas of liver stem/progenitor cell studies in which consensus has emerged and in which controversy still prevails over consensus, but it will also highlight important themes that inevitably should be a focus of liver stem/progenitor cell investigations in coming years. Thus concepts regarding cell plasticity, the existence of a physiological/anatomic stem cell niche, and whether intrahepatic liver stem/progenitor cells comprise true stem cells or progenitor cells (or both) will be approached in some detail.

scholarly journals A Stem Cell Niche for Intermediate Progenitor Cells of the Embryonic Cortex

2009 ◽  
Vol 19 (suppl_1) ◽  
pp. i70-i77 ◽  
Author(s):  
Ashkan Javaherian ◽  
Arnold Kriegstein
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Stem Cell Niche ◽  
Cell Niche

scholarly journals The Wnt Antagonist Dickkopf-1 Mobilizes Vasculogenic Progenitor Cells via Activation of the Bone Marrow Endosteal Stem Cell Niche

2008 ◽  
Vol 103 (8) ◽  
pp. 796-803 ◽  
Author(s):  
Alexandra Aicher ◽  
Orit Kollet ◽  
Christopher Heeschen ◽  
Stefan Liebner ◽  
Carmen Urbich ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Stem Cell Niche ◽  
Cell Niche ◽  
Dickkopf 1

scholarly journals Stem cell niche signals Wnt, Hedgehog, and Notch distinctively regulate Drosophila follicle precursor cell differentiation

2017 ◽  
Author(s):  
Wei Dai ◽  
Amy Peterson ◽  
Thomas Kenney ◽  
Denise J. Montell
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Cell Fate ◽  
Stem Cell Niche ◽  
Adult Stem Cells ◽  
Cell Types ◽  
Wnt Signalling ◽  
Main Body ◽  
Cell Niche

AbstractAdult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. Signals within the stem cell niche maintain the undifferentiated state. However it is unclear whether or how niche signals might also coordinate fate decisions within the progenitor pool. Here we use quantitative microscopy to elucidate distinct roles for Wnt, Hedgehog (Hh), and Notch signalling in progenitor development in the Drosophila ovary. Follicle stem cells (FSCs) self-renew and produce precursors whose progeny adopt distinct polar, stalk, and main body cell fates. We show that a steep gradient of Wnt signalling maintains a multipotent state in proximally located progenitor cells by inhibiting expression of the cell fate determinant Eyes Absent (Eya). A shallower gradient of Hh signalling controls the proliferation to differentiation transition. The combination of Notch and Wnt signalling specifies polar cells. These findings reveal a mechanism by which multiple niche signals coordinate cell fate diversification of progenitor cells.

scholarly journals Macrophages provide a transient muscle stem cell niche via NAMPT secretion

2020 ◽  
Author(s):  
Dhanushika Ratnayake ◽  
Phong D. Nguyen ◽  
Fernando J. Rossello ◽  
Verena C. Wimmer ◽  
Abdulsalam I. Isiaku ◽  
...  
Keyword(s):  
Stem Cell ◽  
Satellite Cell ◽  
Stem Cell Niche ◽  
Wound Repair ◽  
Repair Process ◽  
Cellular Interactions ◽  
Muscle Stem Cell ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Specific Subset ◽  
Cell Niche

AbstractSkeletal muscle is paradigmatic of a regenerative tissue that repairs itself via the activation of a resident stem cell1. Termed the satellite cell, these normally quiescent cells are induced to proliferate by ill-defined wound-derived signals2. Identifying the source and nature of these pro-regenerative cues has been hampered by an inability to visualise the complex cellular interactions that occur within the wound environment. We therefore developed a zebrafish muscle injury model to systematically capture satellite cell interactions within the injury site, in real time, throughout the repair process. This analysis identified that a specific subset of macrophages ‘dwells’ within the injury, establishing a transient but obligate stem cell niche required for stem cell proliferation. Single cell profiling identified specific signals secreted from dwelling macrophages that include the cytokine, Nicotinamide phosphoribosyltransferase (NAMPT/Visfatin/PBEF). Here we show that NAMPT secretion from the macrophage niche is required for muscle regeneration, acting through the C-C motif chemokine receptor type 5 (CCR5) expressed on muscle stem cells. This analysis reveals that along with their well-described ability to modulate the pro-inflammatory and anti-inflammatory phases of wound repair, specific macrophage populations also provide a transient stem cell-activating niche, directly supplying pro-proliferative cues that govern the timing and rate of muscle stem cell-mediated repair processes.

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