scholarly journals First person – Kim Landry-Truchon and Nicolas Houde

2020 ◽  
Vol 13 (12) ◽  
pp. dmm048199
Keyword(s):  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Early Career ◽  
Mouse Lung ◽  
Pleuropulmonary Blastoma ◽  
First Person ◽  
Research Assistant ◽  
Lung Epithelium ◽  
Mouse Development

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Kim Landry-Truchon is first author on ‘Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis’, published in DMM. Kim is a research assistant in the lab of Lucie Jeannotte at Centre de recherche du CHU de Québec-Université Laval, Québec, Canada, investigating organ development and the regulatory networks involved. Nicolas is a research assistant in the same lab, investigating the role of master transcription factors during mouse development.

scholarly journals First person – Alessandra Gallo

2020 ◽  
Vol 133 (18) ◽  
pp. jcs253955
Keyword(s):  
Molecular Mechanisms ◽  
Neurite Growth ◽  
Early Career ◽  
First Person ◽  
Biotech Company ◽  
Early Career Researchers ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Alessandra Gallo is first author on ‘Role of the Sec22b–E-Syt complex in neurite growth and ramification’, published in JCS. Alessandra currently works as a medical affairs manager for the biotech company Alzohis, Paris, France, in the lab of Romain Verpillot, investigating the molecular mechanisms of neurodevelopment and neurodegeneration.

First person – Fanny Jaudon and Martina Albini

2021 ◽  
Vol 134 (16) ◽  
Keyword(s):  
Neurotrophic Factor ◽  
Neurological Disorders ◽  
Molecular Mechanisms ◽  
Neurological Diseases ◽  
Early Career ◽  
First Person ◽  
Early Career Researchers ◽  
And Function ◽  
The University ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Fanny Jaudon and Martina Albini are co-first authors on ‘ A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor’, published in JCS. Fanny is a postdoc at the University of Trieste in the lab of Lorenzo A. Cingolani at Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy, investigating the molecular mechanisms controlling development and function of neuronal circuits and implementing genome-editing approaches for the treatment of neurological disorders. Martina is a PhD student at the Istituto Italiano di Tecnologia in the lab of Fabio Benfenati and Fabrizia Cesca investigating neurotrophin biology and its involvement in neurological diseases.

scholarly journals First person – Magdalena Cardenas-Rodriguez

2021 ◽  
Vol 134 (14) ◽  
Keyword(s):  
Molecular Genetics ◽  
Small Gtpases ◽  
Early Career ◽  
Human Diseases ◽  
First Person ◽  
Research Assistant ◽  
Cellular Processes ◽  
Early Career Researchers ◽  
Genetic Compensation ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Magdalena Cardenas-Rodriguez is first author on ‘ Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases’, published in JCS. Magdalena is a research assistant in the lab of Jose Luis Badano at Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay, investigating the cellular processes that are altered in cilia-related human diseases.

scholarly journals Molecular Events Involved in Influenza A Virus-Induced Cell Death

2022 ◽  
Vol 12 ◽  
Author(s):  
Rui Gui ◽  
Quanjiao Chen
Keyword(s):  
Cell Death ◽  
Influenza A Virus ◽  
Influenza A ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Tissue Destruction ◽  
Inflammatory Reactions ◽  
Molecular Events ◽  
Host Death

Viral infection usually leads to cell death. Moderate cell death is a protective innate immune response. By contrast, excessive, uncontrolled cell death causes tissue destruction, cytokine storm, or even host death. Thus, the struggle between the host and virus determines whether the host survives. Influenza A virus (IAV) infection in humans can lead to unbridled hyper-inflammatory reactions and cause serious illnesses and even death. A full understanding of the molecular mechanisms and regulatory networks through which IAVs induce cell death could facilitate the development of more effective antiviral treatments. In this review, we discuss current progress in research on cell death induced by IAV infection and evaluate the role of cell death in IAV replication and disease prognosis.

scholarly journals The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4576
Author(s):  
Hung-Yu Lin ◽  
Hui-Wen Ho ◽  
Yen-Hsiang Chang ◽  
Chun-Jui Wei ◽  
Pei-Yi Chu
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Drug Resistant ◽  
Therapeutic Targeting ◽  
The Past ◽  
Regulated Cell Death ◽  
Common Malignancy

Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.

scholarly journals First person – Kun Guo

Biology Open ◽  
2021 ◽  
Vol 10 (3) ◽  
Keyword(s):  
Color Change ◽  
Life Sciences ◽  
Early Career ◽  
First Person ◽  
Research Assistant ◽  
Thermal Dependence ◽  
Early Career Researchers ◽  
Takydromus Septentrionalis ◽  
Normal University ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Kun Guo is first author on ‘The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)’, published in BiO. Kun conducted the research described in this article while a PhD student in Xiang Ji's lab at Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Jiangsu, China. They are now research assistant in the lab of Xiang Ji at College of Life and Environmental Sciences, Wenzhou University, Zhejiang, China, and Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.

scholarly journals First person – Elin Schoultz and Ellen Johansson

2021 ◽  
Vol 15 (2) ◽  
Keyword(s):  
Thyroid Gland ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Tumor Development ◽  
Neck Region ◽  
Early Career ◽  
Field Cancerization ◽  
First Person ◽  
Head And Neck Region ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Elin Schoultz and Ellen Johansson are co-first authors on ‘ Tissue architecture delineates field cancerization in BrafV600E-induced tumor development’, published in DMM. Elin is an MD, PhD student in the lab of Mikael Nilsson at Sahlgrenska Centre for Cancer Research, Gothenburg University, Gothenburg. She has a great interest in the thyroid gland in particular, and the mechanisms of tumor development, progression and treatment associated with epithelial carcinomas in general. Ellen is an MD, resident physician in oto-rhino-laryngology and postdoctoral researcher in the lab of Karin Roberg at Department of Biomedical and Clinical Sciences, Division of Cell Biology, Linköping University, Linköping, with broad interest the thyroid gland, tumors of the head and neck region, and the molecular mechanisms that are important for tumor initiation, development, and treatment.

scholarly journals First person – Maayan Barnea-Zohar and Sabina E. Winograd-Katz

2021 ◽  
Vol 134 (9) ◽  
Keyword(s):  
Cell Size ◽  
Cell Fusion ◽  
Cell Biology ◽  
Early Career ◽  
First Person ◽  
Research Assistant ◽  
Weizmann Institute ◽  
Early Career Researchers ◽  
Selection Of ◽  
Dependent Mechanism

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Maayan Barnea-Zohar and Sabina E. Winograd-Katz are co-first authors on ‘ An SNX10-dependent mechanism downregulates fusion between mature osteoclasts’, published in JCS. Maayan is a research assistant in the lab of Ari Elson at the Weizmann Institute of Science, Rehovot, Israel, investigating cell–cell fusion in osteoclasts and how cell size is determined. Sabina is a research assistant and lab manager in the lab of Benjamin Geiger at the Weizmann Institute of Science, investigating cell biology and signaling.

scholarly journals First person – Mohammad Yunus Ansari

2020 ◽  
Vol 133 (22) ◽  
pp. jcs256644
Keyword(s):  
Assistant Professor ◽  
Early Career ◽  
First Person ◽  
Research Assistant ◽  
Cartilage Homeostasis ◽  
Early Career Researchers ◽  
Health And Disease ◽  
Catabolic Response ◽  
Medical University ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Mohammad Yunus Ansari is first author on ‘Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway’, published in JCS. Mohammad Yunus is a Research Assistant Professor in the lab of Tariq M Haqqi, at the Department of Anatomy and Neurobiology, Northeast Ohio Medical University, USA, investigating the mechanism of regulation of mitochondrial function in articular cartilage and its role in cartilage homeostasis in health and disease.

scholarly journals First person – Luv Kishore Srivastava

2021 ◽  
Vol 134 (10) ◽  
Keyword(s):  
Spatial Distribution ◽  
Early Career ◽  
Lamin A ◽  
First Person ◽  
Nuclear Deformation ◽  
Early Career Researchers ◽  
Mcgill University ◽  
Global And Local ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Luv Kishore Srivastava is first author on ‘Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation’, published in JCS. Luv Kishore is a PhD student in the lab of Allen Ehrlicher at McGill University, Montreal, Canada, investigating the role of lamin A/C in global and local nuclear deformation.

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