The Prognostic Significance of an R1 Resection in Gastric Cancer Patients Treated with Adjuvant Chemoradiotherapy

To explore exosomal miR-375 expression in gastric cancer patients and its relationship with patient prognosis. A total of 53 patients diagnosed with gastric cancer in our hospital from May 2014 to May 2016 were included as the gastric cancer group, and 46 healthy women who came to our hospital for physical examination during the same period were enrolled as the healthy group. Exosomal miR-375 expression level was detected using qRT-PCR, and the diagnostic performance and prognostic significance of exosomal miR-375 in gastric cancer were explored. The gastric cancer group showed increased exosomal miR-375 expression than the healthy group (P< 0.05); Kaplan-Meier survival analysis exhibited that serum exosomal miR-375 has an AUC of 0.778, sensitivity of 69.57%, and specificity of 75.47%, whereas Cox regression analysis showed that the miR-375 expression in exosomes was an independent risk factor affecting the prognosis of gastric cancer patients (P< 0.05). Patient with gastric cancer showed upregulated miR-375 expression in serum exosomes. Serum exosomal miR-375 was found to has positive sensitivity and specificity in the diagnosis of gastric cancer, which may be associated with poor prognosis of gastric cancer patients.

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Prognostic Significance of the Metastatic Lymph Node Ratio in Gastric Cancer Patients

World Journal of Surgery ◽

10.1007/s00268-009-0205-1 ◽

2009 ◽

Vol 33 (11) ◽

pp. 2378-2382 ◽

Cited By ~ 25

Author(s):

Naoto Fukuda ◽

Yasuyuki Sugiyama ◽

Akira Midorikawa ◽

Hiroyuki Mushiake

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Cancer Patients ◽

Lymph Node Ratio ◽

Metastatic Lymph Node ◽

Prognostic Significance ◽

Metastatic Lymph ◽

Node Ratio ◽

Gastric Cancer Patients

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Prognostic significance of combined Lymphocyte-monocyte Ratio and Tumor-associated Macrophages in Gastric Cancer Patients after Radical Resection

Journal of Cancer ◽

10.7150/jca.44440 ◽

2020 ◽

Vol 11 (17) ◽

pp. 5078-5087

Author(s):

Bin-bin Xu ◽

Yu Xu ◽

Jun Lu ◽

Yuan Wu ◽

Jia-bin Wang ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Prognostic Significance ◽

Radical Resection ◽

Tumor Associated Macrophages ◽

Gastric Cancer Patients

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Prognostic Significance of Serum Uric Acid and Gamma-Glutamyltransferase in Patients with Advanced Gastric Cancer

Disease Markers ◽

10.1155/2019/1415421 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Shanshan Yang ◽

Xinjia He ◽

Ying Liu ◽

Xiao Ding ◽

Haiping Jiang ◽

...

Keyword(s):

Gastric Cancer ◽

Uric Acid ◽

Prognostic Factors ◽

Advanced Gastric Cancer ◽

Cancer Patients ◽

Serum Uric Acid ◽

Univariate Analysis ◽

Prognostic Significance ◽

Gamma Glutamyltransferase ◽

Gastric Cancer Patients

Purpose. In this study, we aim to evaluate the prognostic role of serum uric acid and gamma-glutamyltransferase in advanced gastric cancer patients. Methods. A total of 180 patients pathologically diagnosed with advanced gastric cancer were included in this retrospective study. We used time-dependent receiver operating characteristic (ROC) curves to identify the optimal cut-off value of serum uric acid (UA) and gamma-glutamyltransferase (GGT). Survival analysis was performed using the Kaplan–Meier method and log-rank test, and multivariate Cox regression analyses were applied. A nomogram was formulated, and the calibration and discrimination of the nomogram were determined by calibration curve and concordance index (C-index). We validated the results using bootstrap resampling and a separate study on 60 patients collected from 2015 to 2017 using the same criteria in other medical center. Results. Both higher serum uric acid (>228 μmol/L) and higher gamma-glutamyltransferase (>14 U/L) had worse OS and PFS. Univariate analysis indicated that serum uric acid (UA) (p<0.001 and p<0.001) and gamma-glutamyltransferase (GGT) (p<0.001 and p=0.044) were significantly related to overall survival (OS) and progression-free survival (PFS), respectively. Multivariate analysis revealed serum uric acid (UA) and gamma-glutamyltransferase (GGT) were independent prognostic factors for OS (p=0.012, p=0.001). The optimal agreement between actual observation and nomogram prediction was shown by calibration curves. The C-indexes of the nomogram for predicting OS and PFS were 0.748 (95% CI: 0.70-0.79) and 0.728 (95% CI: 0.6741-0.7819), respectively. The results were confirmed in the validation cohort. Conclusion. We observed that both serum UA and GGT were poor prognostic factors in patients with advanced gastric cancer. And we also formulated and validated a nomogram which can predict individual survival for advanced gastric cancer patients.

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Tumour-stroma ratio and 5-year mortality in gastric adenocarcinoma: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-019-52606-7 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Niko Kemi ◽

Maarit Eskuri ◽

Joonas H. Kauppila

Keyword(s):

Gastric Cancer ◽

Prognostic Factor ◽

Neoadjuvant Therapy ◽

Cancer Patients ◽

Gastric Adenocarcinoma ◽

Meta Analysis ◽

Prognostic Significance ◽

Tumour Stroma ◽

Potential Prognostic Factor ◽

Gastric Cancer Patients

Abstract Tumour-stroma ratio (TSR) is a novel potential prognostic factor in cancers and based on the proportions of stroma and tumour area. The prognostic value of TSR in gastric cancer is incompletely known. The aim of this study was to estimate prognostic significance of TSR in gastric adenocarcinoma. A search of PubMed (MEDLINE), Web of Science, EMBASE, Cochrane and Scopus databases was performed. A meta-analysis was conducted on five-year survival in gastric cancer patients using inverse variance random-effects methods. The literature search yielded 5329 potential titles, of which a total of seven studies were eligible. Results of six studies including a total of 1779 patients were pooled in the meta-analysis. Only 23 (1.3%) of the patients received neoadjuvant therapy. All six studies had a cut-off of 50% for the proportion of stroma when dividing the patients into low- and high stroma groups. Low TSR (high amount of stroma) was strongly associated with increased five-year mortality (hazard ratio 2.19, 95% CI 1.69–2.85). In conclusion, TSR is a strong prognostic factor in gastric cancer. It could be used to estimate prognosis of gastric cancer patients not receiving neoadjuvant chemotherapy. Further studies including patients receiving neoadjuvant therapy are recommended.

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