scholarly journals Solvent and Steric Effects on the Solvolysis of Polyvinylsulfonic Acid Esters

1966 ◽  
Vol 39 (9) ◽  
pp. 1937-1941
Author(s):  
Sadao Yoshikawa ◽  
Oh-Kil Kim ◽  
Takeshi Hori
Keyword(s):  
Steric Effects ◽  
Polyvinylsulfonic Acid ◽  
Acid Esters

The basic hydrolysis of amino acid esters

1966 ◽  
Vol 19 (7) ◽  
pp. 1197 ◽  
Author(s):  
RW Hay ◽  
LJ Porter ◽  
PJ Morris
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Steric Effects ◽  
Ionization Constants ◽  
Amino Acid Esters ◽  
Kinetic Measurements ◽  
Basic Hydrolysis ◽  
Kinetics Of ◽  
Hydrolysis Of ◽  
Acid Esters

The kinetics of alkaline hydrolyses of nine amino acid esters by the process H,2NCHRCO2R'+OH- + H2NCHRCO2-+R'OH have been studied at 25� and an ionic strength of 0.1M in water over a range of pH. The acid ionization constants of the various amino acid esters have been determined, and these are roughly 2 pK units lower than those of the corresponding amino acids. The kinetic measurements are interpretable on the basis of electrostatic and steric effects.

1832-P: Palmitic Acid Esters of Hydroxy Stearic Acids Reduce Endogenous Glucose Production through GPR43 Activation

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1832-P
Author(s):  
ANNA SANTORO ◽  
PENG ZHOU ◽  
YAN ZHU ◽  
ODILE D. PERONI ◽  
ANDREW T. NELSON ◽  
...  
Keyword(s):  
Palmitic Acid ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose ◽  
Acid Esters

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

2019 ◽  
Author(s):  
Jiang Wang ◽  
Brian P. Cary ◽  
Peyton Beyer ◽  
Samuel H. Gellman ◽  
Daniel Weix
Keyword(s):  
Carboxylic Acid ◽  
Solid Support ◽  
Reaction Conditions ◽  
Decarboxylative Coupling ◽  
New Strategy ◽  
The Cross ◽  
Acyl Donors ◽  
Acid Esters

A new strategy for the synthesis of ketones is presented based upon the decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with S-2-pyridyl thioesters. The reactions are selective for the cross-coupled product because NHP esters act as radical donors and the thioesters act as acyl donors. The reaction conditions are general and mild, with over 40 examples presented, including larger fragments and the 20-mer peptide Exendin(9-39) on solid support.

Electronic or steric effects: Detailed DFT investigations of titanium amino based Kaminsky type olefin catalysts

2018 ◽  
Author(s):  
Jörg Saßmannshausen
Keyword(s):  
Density Functional Theory ◽  
Strong Correlation ◽  
Density Functional ◽  
Steric Effects ◽  
Aryl Group ◽  
Functional Theory

We report detailed Density Functional Theory (DFT) investigations of a series of structurally similar titanium (IV) chelating σ-aryl catalysts. Particular attention was paid to the electronic charges of the Ti, C ipso of the substituted aryl group and the benzylic CH<sub>2</sub> and C<i><sub>ipso</sub></i> atoms. The Bader and NBO derived charges were compared with the recently reported polymerisation results by Chan. We found a strong correlation between the relative energies of one of the computed isomers and the activity of the catalyst. Neither NBO nor Bader charges could be convincingly correlated to the observed activity.

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