scholarly journals Proteomic Analysis in Cyclosporin A-Induced Overgrowth of Human Gingival Fibroblasts

2009 ◽  
Vol 32 (8) ◽  
pp. 1480-1485 ◽  
Author(s):  
Ji Yeon Jung ◽  
Gi Chang Kang ◽  
Yeon Jin Jeong ◽  
Sun Hun Kim ◽  
Yong Geun Kwak ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Proteomic Analysis ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts

The Upregulation of Transglutaminase-2 by Cyclosporin A in Human Gingival Fibroblasts Is Augmented by Oxidative Stress

2013 ◽  
Vol 84 (10) ◽  
pp. 1469-1475 ◽  
Author(s):  
Shiuan-Shinn Lee ◽  
Chung-Hung Tsai ◽  
Yu-Hsiang Kuan ◽  
Fu-Mei Huang ◽  
Yu-Chao Chang
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Transglutaminase 2 ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts

Effects of Cyclosporin A on the Cell Cycle Regulation of Human Gingival Fibroblasts

2001 ◽  
Vol 31 (3) ◽  
pp. 611
Author(s):  
Sung-Hee Pi ◽  
Dae-Kyum Kim ◽  
Tak Kim ◽  
Yong-Ouk You ◽  
Hyung-Keun You ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cyclosporin A ◽  
Cell Cycle Regulation ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Cycle Regulation

The Effects of Culture Environment on the Response of Human Gingival Fibroblasts to Cyclosporin A

1995 ◽  
Vol 66 (5) ◽  
pp. 339-344 ◽  
Author(s):  
Jacqueline A. James ◽  
Christopher R. Irwin ◽  
Gerard J. Linden
Keyword(s):  
Cyclosporin A ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Culture Environment

scholarly journals Cyclosporin A and Phenytoin Modulate Inflammatory Responses

2009 ◽  
Vol 88 (12) ◽  
pp. 1131-1136 ◽  
Author(s):  
A.M.M. Suzuki ◽  
A. Yoshimura ◽  
Y. Ozaki ◽  
T. Kaneko ◽  
Y. Hara
Keyword(s):  
Cyclosporin A ◽  
Inflammatory Responses ◽  
Chinese Hamster ◽  
Human Gingival Fibroblasts ◽  
Common Side Effect ◽  
Gingival Fibroblasts ◽  
Toll Like Receptor ◽  
Gingival Overgrowth ◽  
Anti Epileptic Drug ◽  
Tlr4 Ligand

Gingival overgrowth is a common side-effect of administration of the immunosuppressant cyclosporin A and the anti-epileptic drug phenytoin. While cyclosporin-induced gingival overgrowth is often accompanied by gingival inflammation, phenytoin-induced gingival overgrowth usually forms fibrotic lesions. To determine whether these drugs alter the inflammatory responses of gingival fibroblasts, we investigated the effects of cyclosporin and phenytoin on Toll-like receptor (TLR)-mediated responses to microbial components. In Chinese hamster ovary reporter cell lines, cyclosporin alone triggered signaling, whereas phenytoin down-regulated signaling induced by the TLR2 or TLR4 ligand. In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses. Cyclosporin also augmented CD54 expression in gingiva of mice injected with lipopolysaccharide. These results indicated that cyclosporin positively and phenytoin negatively modulated inflammatory responses of human gingival fibroblasts.

Inhibition of apoptotic signals in overgrowth of human gingival fibroblasts by cyclosporin A treatment

2008 ◽  
Vol 53 (11) ◽  
pp. 1042-1049 ◽  
Author(s):  
Ji-Yeon Jung ◽  
Yeon-Jin Jeong ◽  
Tea-Sul Jeong ◽  
Hyun-Ju Chung ◽  
Won-Jae Kim
Keyword(s):  
Cyclosporin A ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts

Cyclosporin A and hydroxycyclosporine (M-17) affect the secretory phenotype of human gingival fibroblasts

2007 ◽  
Vol 27 (6) ◽  
pp. 260-266 ◽  
Author(s):  
Angelo Mariotti ◽  
Thomas Hassell ◽  
David Jacobs ◽  
C. Jo Manning ◽  
Arthur F. Hefti
Keyword(s):  
Cyclosporin A ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Secretory Phenotype
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