scholarly journals Phytochemical Studies of Seeds of Medicinal Plants. III. Ursolic Acid and Oleanolic Acid Glycosides from Seeds of Patrinia scabiosaefolia Fischer.

1993 ◽  
Vol 41 (1) ◽  
pp. 183-186 ◽  
Author(s):  
Tsutomu NAKANISHI ◽  
Keishi TANAKA ◽  
Hiroko MURATA ◽  
Midori SOMEKAWA ◽  
Akira INADA
Keyword(s):  
Medicinal Plants ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Oleanolic Acid Glycosides ◽  
Patrinia Scabiosaefolia ◽  
Phytochemical Studies

Antileukemic Activity of Selected Natural Products in Taiwan

2003 ◽  
Vol 31 (01) ◽  
pp. 37-46 ◽  
Author(s):  
Lien-Chai Chiang ◽  
Win Chiang ◽  
Mei-Yin Chang ◽  
Lean-Teik Ng ◽  
Chun-Ching Lin
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Lymphoma Cell ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Antileukemic Activity ◽  
Lymphoma Cells ◽  
Strong Activity

The aim of the present study was to evaluate the antileukemic activity of six chemical classes of pure compounds present in commonly used medicinal plants in Taiwan – such as the genus Plantago. Studies were conducted on a series of human leukemia and lymphoma cell lines. Results showed that water soluble compounds (aucubin, caffeic acid, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid) exhibited a weak antileukemic activity (IC50: 26–56 μg/ml, SI: 2–11). On the other hand, water insoluble compounds such as triterpenoids (oleanolic acid and ursolic acid), monoterpene (linalool) and flavonoid (luteolin) possessed strong activity against human leukemia and lymphoma cell lines. Among them, linalool showed the strongest activity against histiocytic lymphoma cells U937 (IC50: 3.51 μg/ml, SI: 592.6) and Burkitt lymphoma cells P3HR1 (IC50: 4.21 μg/ml, SI: 494.1). Ursolic acid was effective against P3HR1 cells (IC50: 2.5 μg/ml, SI: 262.6) and chronic myelogenous leukemia cells K562 (IC50: 17.79 μg/ml, SI: 36.91), whereas oleanolic acid inhibited the growth of P3HR1 cells (IC50: 26.74 μg/ml, SI: 11.37). Luteolin exhibited effective activity against K562 cells (IC50: 18.96 μg/ml, SI: 5.14) and P3HR1 cells (IC50: 18.99 μg/ml, SI: 5.13). We conclude that terpenes and flavonoid in commonly used medicinal plants possess strong activity against lymphoma and leukemia cells, especially human lymphoma cells, suggesting the potential use of these compounds for treatment of lymphoma.

scholarly journals Phytochemical studies of seeds of medicinal plants. I. Two sulfated triterpenoid glycosides, sulfapatrinosides I and II, from seeds of Patrinia scabiosaefolia FISCHER.

1988 ◽  
Vol 36 (11) ◽  
pp. 4269-4274 ◽  
Author(s):  
AKIRA INADA ◽  
MASAAKI YAMADA ◽  
HIROKO MURATA ◽  
MARI KOBAYASHI ◽  
HARUMASA TOYA ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Patrinia Scabiosaefolia ◽  
Triterpenoid Glycosides ◽  
Phytochemical Studies

scholarly journals Determination of oleanolic acid and ursolic acid in Chinese medicinal plants using HPLC with PAH polymeric C18

2013 ◽  
Vol 9 (36) ◽  
pp. 19 ◽  
Author(s):  
Yong Zhang ◽  
Kunpeng Xue ◽  
EugeneYuexing Zhao ◽  
Yin Li ◽  
Lixin Yao ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Chinese Medicinal Plants

Fernandoa adenophylla: A review of its phytochemistry, traditional and pharmacology use and future aspects

2020 ◽  
Vol 06 ◽  
Author(s):  
Anushma Chorsiya ◽  
Manju Vyas Singh ◽  
Shaik Khasimbi
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Crude Extract ◽  
Skin Disorder ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
The Future

Abstract: Fernandoa adenophylla (Heterophragma adenophyllum), commonly known as Dhopa-phali, Ziron, Mostanphul, Lotum-poh and Karen wood of family Bignoniaceae, has been used traditionally for snakebite (Morigaon district of Assam, India), hemorrhoids and constipation (Chakma tribe, Bangladesh) and skin disorder (Thai traditional medicine). This review covers pharmacognostic, phytochemical, and pharmacological as well as the traditional aspect of the plant and enlightens possible pharmacological activities Received: that can be assessed in the future. Fernandoa adenophylla has been reported to constitute potent phytochemicals like novel napthaquinones, their derivatives (dilapachone, adenophyllone, peshwaraquinone, lapachol, and indadone) and triterpenoids (β-sitosterol, β-amyrin, ursolic acid, and oleanolic acid) which have potential pharmacological activities assessed and reported. The Crude extract of Fernandoa adenophylla has already been tested for pharmacological properties like antimicrobial, antifungal, anti-TB, and antihypertensive and leishmanicidal activities. Since not many researches have been carried out on Fernandoa adenophylla, it paves way for researchers to explore its potential in the field of medicinal plants

Ethnobotanical and phytochemical studies of medicinal plants of minority groups in southern china

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
C Long ◽  
Y Wang ◽  
F Zhao ◽  
G Tang ◽  
X Sui
Keyword(s):  
Medicinal Plants ◽  
Minority Groups ◽  
Southern China ◽  
Phytochemical Studies

Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities

2016 ◽  
Vol 10 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Dharambir Kashyap ◽  
Ajay Sharma ◽  
Hardeep S. Tuli ◽  
Sandeep Punia ◽  
Anil K. Sharma
Keyword(s):  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Anti Inflammatory

Antiproliferative Effects of Ocimum basilicum Methanolic Extract and Fractions, Oleanolic Acid and 3-epi-Ursolic Acid

2020 ◽  
Vol 6 (2) ◽  
pp. 134-146 ◽  
Author(s):  
Kehkashan Arshad Qamar ◽  
Ahsana Dar Farooq ◽  
Bina S. Siddiqui ◽  
Nurul Kabir ◽  
Sabira Begum
Keyword(s):  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Mitotic Spindle ◽  
Immunofluorescence Microscopy ◽  
Methanolic Extract ◽  
Folk Medicine ◽  
Ocimum Basilicum ◽  
Antiproliferative Effects ◽  
Ancient Times ◽  
Mcf 7

Aims: The aim of the current study was to identify active compound(s) responsible for the antiproliferative effects of O. basilicum and explore their underlying mechanism/s. Background: Plants have been the source of medicines for the treatment of various diseases since ancient times. Ocimum basilicum (Sweet Basil, Bobai Tulsi) has been used in the folk medicine for the treatment of human liver, spleen and stomach cancers. Background: Plants have been the source of medicines for the treatment of various diseases since ancient times. Ocimum basilicum (Sweet Basil, Bobai Tulsi) has been used in the folk medicine for the treatment of human liver, spleen and stomach cancers. Objective: To emphasize the importance of O. basilicum as a potential novel non-toxic alternative to the conventional anticancer therapy. Method: O. basilicum (aerial parts) methanolic extract and fractions were screened against HT-144, MCF-7, NCI-H460 and SF-268 human cancer cell lines using sulforhodamine B assay. The more active Petroleum Ether Insoluble (PEI) fraction was fractionated into six sub-fractions (OB-1 to OB-6). Four pure compounds (3-O-methyl ursolic acid, oleanolic acid, 3-epi-ursolic acid and ursolic acid) were isolated from the more potent sub-fraction OB- 6. Triple channel immunofluorescence microscopy was employed to observe the effects of methanolic extract, PEI fraction, sub-fractions OB-5 and OB-6, 3-epi-ursolic acid and oleanolic acid on the cytoskeleton and nuclei of MCF-7 cells. Result: The methanolic extract and the PEI fraction exhibited selectively greater growth inhibition against MCF-7 cell line (TGI: 56 and 36.2 µg/ml, respectively). By using triple channel immunofluorescence microscopy, it was observed that the methanolic extract, PEI fraction, sub-fraction OB-5 and 3-epi-ursolic acid induced irregular mitotic spindle formation and slowing of mitotic progression in MCF-7 cells while sub-fraction OB-6 induced mitotic arrest in the prophase stage. F-actin aggregation was also visible in PEI fraction, subfraction OB-5 and 3-epi-ursolic acid treated MCF-7 cells. Conclusion: These results emphasize the importance of O. basilicum as a potential novel non-toxic alternative to the conventional anticancer therapy and suggest that it inhibits the growth of MCF-7 cancer cells via multiple mechanisms such as interaction with the microtubules and mitotic spindle apparatus, and F-actin aggregation.

scholarly journals Synthesis and Anti-Fungal Activity of Seven Oleanolic Acid Glycosides

Molecules ◽  
2011 ◽  
Vol 16 (2) ◽  
pp. 1113-1128 ◽  
Author(s):  
Hanqing Zhao ◽  
Guanghui Zong ◽  
Jianjun Zhang ◽  
Daoquan Wang ◽  
Xiaomei Liang
Keyword(s):  
Oleanolic Acid ◽  
Fungal Activity ◽  
Oleanolic Acid Glycosides ◽  
Anti Fungal
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