scholarly journals Relationship Of Glucose Kinetics With Exercise Capacity, Body Composition, And Mitochondrial Function With Aging

2020 ◽  
Vol 52 (7S) ◽  
pp. 597-597
Author(s):  
Kevin J. Gries ◽  
Hawley E. Kunz ◽  
Corey R. Hart ◽  
Xiaoyan Zhang ◽  
Zachary C. Ryan ◽  
...  
Author(s):  
Dafnis Vidal Pérez ◽  
José Miguel Martínez-Sanz ◽  
Alberto Ferriz-Valero ◽  
Violeta Gómez-Vicente ◽  
Eva Ausó

Weightlifting is a discipline where technique and anthropometric characteristics are essential to achieve the best results in competitions. This study aims to analyse the relationships between body composition, limb length and barbell kinematics in the performance of weightlifters. It consists of an observational and descriptive study of 19 athletes (12 men [28.50 ± 6.37 years old; 84.58 ± 14.11 kg; 176.18 ± 6.85 cm] and 7 women [27.71 ± 6.34 years old; 64.41 ± 7.63 kg; 166.94 ± 4.11 cm]) who met the inclusion criteria. A level I anthropometrist took anthropometric measures according to the methodology of the International Society for the Advancement of Kinanthropometry (ISAK), and the measurement of the barbell velocity was made with the software Kinovea. In terms of body composition, both genders are within the percentage range of fat mass recommended for this sport. In female weightlifters, there is a positive correlation between foot length, maximal velocity in the Snatch (ρ = 0.775, p = 0.041), and performance indicator in the Snatch and the Clean & Jerk (ρ = 0.964, p < 0.001; ρ = 0.883, p = 0.008, respectively). In male weightlifters, a positive correlation between tibial length and average velocity of the barbell in the Snatch is observed (ρ = 0.848, p < 0.001). Muscle mass percentage correlates positively with performance indicator in both techniques (ρ = 0.634, p = 0.027; ρ = 0.720, p = 0.008). Also, the relative length of the upper limb is negatively correlated with the performance indicator (ρ = −0.602, p = 0.038). Anthropometry and body composition may facilitate skill acquisition among this sport population, contributing to increase the limited body of scientific knowledge related to weightlifting.


2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Michael Coronado ◽  
Giovanni Fajardo ◽  
Kim Nguyen ◽  
Mingming Zhao ◽  
Kristina Bezold Kooiker ◽  
...  

Mitochondria play a dual role in the heart, responsible for meeting energetic demands and regulating cell death. Current paradigms hold that mitochondrial fission and fragmentation are the result of pathologic stresses such as ischemia, are an indicator of poor mitochondrial health, and lead to mitophagy and cell death. However, recent studies demonstrate that inhibiting fission also results in cardiac impairment, suggesting that fission is important for maintaining normal mitochondrial function. In this study, we identify a novel role for mitochondrial fragmentation as a normal physiological adaptation to increased energetic demand. Using two models of exercise, we demonstrate that “physiologic” mitochondrial fragmentation occurs, results in enhanced mitochondrial function, and is mediated through beta 1-adrenergic receptor signaling. Similar to pathologic fragmentation, physiologic fragmentation is induced by activation of Drp1; however, unlike pathologic fragmentation, membrane potential is maintained and regulators of mitophagy are downregulated. To confirm the role of fragmentation as a physiological adaptation to exercise, we inhibited the pro-fission mediator Drp1 in mice using the peptide inhibitor P110 and had mice undergo exercise. Mice treated with P110 had significantly decreased exercise capacity, decreased fragmentation and inactive Drp1 vs controls. To further confirm these findings, we generated cardiac-specific Drp1 KO mice and had them undergo exercise. Mice with cardiac specific Drp1 KO had significantly decreased exercise capacity and abnormally large mitochondria compared to controls. These findings indicate the requirement for physiological mitochondrial fragmentation to meet the energetic demands of exercise and support the still evolving conceptual framework, where fragmentation plays a role in the balance between mitochondrial maintenance of normal physiology and response to disease.


1958 ◽  
Vol 12 (3) ◽  
pp. 395-398 ◽  
Author(s):  
B. E. Welch ◽  
R. P. Riendeau ◽  
C. E. Crisp ◽  
R. S. Isenstein

2018 ◽  
Vol 132 (23) ◽  
pp. 2509-2518 ◽  
Author(s):  
Gargi Mahapatra ◽  
S. Carrie Smith ◽  
Timothy M. Hughes ◽  
Benjamin Wagner ◽  
Joseph A. Maldjian ◽  
...  

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.


2020 ◽  
Vol 13 (2) ◽  
pp. 528-530 ◽  
Author(s):  
Shane Nanayakkara ◽  
Fernando Telles ◽  
Anna L. Beale ◽  
Shona Evans ◽  
Donna Vizi ◽  
...  

2002 ◽  
Vol 130 (11-12) ◽  
pp. 361-366
Author(s):  
Zoran Ivanov ◽  
Milena Ivanov

INTRODUCTION Obesity can be defined as an excessive accumulation of health threatening body fat, caused by positive energetic balance. It can be classified according to body mass index as normal body mass, excessive body mass, significant obesity and extreme obesity. According to WHR (waist-hip ratio), it can be classified to android and gynoid type depending on fat tissue distribution. Android type has greater frequency of cardiovascular and metabolic complications, as is occurrence of premature atherosclerosis. As metabolic complications we consider lipid status disorders in obese workers, and these complications are related to body composition. MATERIAL AND METHODS Among 331 workers, we separated 95 persons with BMI > 30 kg/m2. This group was classified according to gender, their body composition has been measured using bioelectri-cal impedance method and, subsequently cholesterol, triglycerides, HDL and LDL levels were determined, searching for relationship of body composition with lipid status fractions p< 0.05. RESULTS High body fatty was found in 33.03% of male and in 37.48% of female subjects. It was found that in male subjects cholesterol levels (6.70 mml/L),triglycerides (2.56 mml/L), limit values of LDL (3.93 mml/Lc and limit values of HDL (1.16 mml/L) were highly risky. Positive insignificant relationship of body fatty mass with cholesterol, triglycerides, LDL, but not with HDL was found. DISCUSSION Results point to highly risky limit values of lipid parameters in male and female subjects. These values can be explained by older age of subjects, their way of life and nutrition regimen, significant comorbidity in this group, and influence on working ability. CONSLUSION It was found that obese male and female subjects have high values of body fatty mass, Male subjects have highly risky levels of lipid status fractions, while in female subjects these are limit values. Insignificant positive correlation of body fatty mass with lipid status fractions in tested population was found. The obtained results are significant regarding morbidity expectation and studies of complications of obese working population, as well as in judgment of working ability.


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