Geographic distribution of cervical cancer-associated human leucocyte antigens and cervical cancer incidence in Finland

Cervical cancer (CxCa) is a long-term sequelae caused by persistent human papillomavirus (HPV) infection. Genetic susceptibility to the persistent infection and CxCa is associated with certain human leucocyte antigen (HLA) types. The same susceptibility genes may also determine whether a woman will be protected against the persistent infection and against CxCa by HPV vaccination or not. A systematic review of literature identified following HLAs to be associated with CxCa: A11 (odds ratio [OR] = 1.4, 95% confidence interval [CI] 1.1–2.0); B7 (1.5, 1.1–2.0); B15 (0.6, 0.4–0.8); DR2 (1.2, 1.1–1.4) and DR6 (0.6, 0.5–0.8). In the Caucasian population, HLA-B7 and DR6, and DR2 and B15 antigens showed at least borderline associations. In view of a bone marrow donor registry at the Finnish Red Cross and the Finnish Cancer Registry, we created geographic distribution maps of index HLA frequencies and CxCa incidence in the fertile-aged Finnish population. Increased incidence of CxCa was found in a region of western coastal Finland, where frequency of two CxCa susceptibility genes (HLA-DR2 and B7) was increased, and frequency of one CxCa resistance gene (HLA-B15) was decreased. Whether or not HLA type determines also regional susceptibility to persistent HPV infection, and the success of HPV vaccination in preventing both the persistent infection and CxCa warrants further investigation.

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Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China: a systematic review and meta-analysis

Sexually Transmitted Infections ◽

10.1136/sextrans-2017-053412 ◽

2018 ◽

Vol 94 (6) ◽

pp. 434-442 ◽

Cited By ~ 13

Author(s):

Xiaomeng Ma ◽

Qian Wang ◽

Jason J Ong ◽

Christopher K Fairley ◽

Shu Su ◽

...

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Human Papillomavirus ◽

Meta Analysis ◽

Hpv Vaccination ◽

Hpv Infection ◽

Central China ◽

Hiv Positive ◽

Heterosexual Men ◽

Hpv Prevalence

ObjectiveHuman papillomavirus (HPV) infection causes multiple cancers in both women and men. In China, both HPV vaccination and cervical cancer screening coverages are low. We aim to investigate the temporal and geographical trends of HPV DNA prevalence in heterosexual men, women, men who have sex with men (MSM) and people living with HIV (PLHIV) in China.MethodsWe conducted a systematic review, collecting publications in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Data from January 2000 to May 2017. A total of 247 studies were selected for this meta-analysis to estimate pooled HPV prevalence, incidence of cervical cancer and risk of infection for subgroups. Meta-regression was applied to identify contributing factors to prevalence heterogeneities.ResultsThe national HPV prevalence was 15.6% (95% CI (14.4% to 16.9%)) in women with normal cervical cytology, and Central China had the highest prevalence (20.5% (15.2% to 25.8%)). HPV prevalence in heterosexual men (14.5% (11.3% to 17.7%)) was comparable with that of women (OR=1.09 (0.98 to 1.17)), but HPV prevalence in MSM (59.9% (52.2% to 67.6%)) was significantly higher than that in heterosexual men (OR=8.81 (8.01 to 9.69)). HIV-positive women (45.0% (38.4% to 51.6%)) and HIV-positive MSM (87.5% (82.3% to 90.9%)) had 4.67 (3.61 to 6.03) and 6.46 (5.20 to 8.02) times higher risk of HPV infection than their HIV negative counterparts.ConclusionHPV infection is prevalent in China, particularly in Central China, in comparison with the global level and neighbouring countries. Targeted HPV vaccination for women, MSM and PLHIV and scale-up of cervical screening for women are priorities in curbing the HPV epidemic in China.

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Human papillomavirus vaccination coverage among working women

Asian Journal of Medical and Biological Research ◽

10.3329/ajmbr.v6i4.51238 ◽

2021 ◽

Vol 6 (4) ◽

pp. 714-722

Author(s):

Sajeda Khatun ◽

Ashees Kumar Saha ◽

Irtiza Ahmed Chowdhury ◽

Arifa Sultana ◽

Mst Wazeda Begum ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Vaccination Coverage ◽

Hpv Vaccination ◽

Working Women ◽

Hpv Infection ◽

Cross Sectional Study ◽

P Value ◽

Human Papillomavirus Vaccination ◽

Cross Sectional

Human papillomavirus (HPV) infection is one of the causes of cervical cancer which is preventable. The study was a cross-sectional study with the objective was to determine the Human papillomavirus (HPV) vaccination coverage among working women. A total 236 educated working women were selected purposively from different working places in Dhaka city. A pretested semi- structured questionnaire was used for data collection. The knowledge was assessed by using modified Blooms cut off points which was developed with cervical cancer and vaccine knowledge related questions. The study result revealed that among 236 working women 71.2% knew about the risk factor of cervical cancer. It was found that 92.8% knew about the way of prevention of cervical cancer respectively. The overall knowledge on cervical cancer and vaccine was found to be having good knowledge 21.2%, satisfactory knowledge 41.9% and poor knowledge 36.9%. Out of the total working women only 5.1% had HPV vaccination coverage. Reason behind non vaccinations, 50% mentioned had no knowledge about vaccine, 35.3% mentioned can’t decide and 8.9% mentioned high cost of vaccine. Significant association has been observed in between vaccination coverage with over all knowledge of cervical cancer (p value .04). It may be concluded that HPV vaccination coverage is very low which needs awareness program on this issues through mass media, educational session, counseling and so on to reduce human papillomavirus associated cancers as well as economic burden. Asian J. Med. Biol. Res. December 2020, 6(4): 714-722

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Human papillomavirus vaccination: evidence base for efficacy and safety

GYNECOLOGY ◽

10.26442/20795696.2021.2.200742 ◽

2021 ◽

Vol 23 (2) ◽

pp. 125-130

Author(s):

Yuliya E. Dobrokhotova ◽

Ekaterina I. Borovkova

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Hpv Vaccination ◽

Intraepithelial Neoplasia ◽

Evidence Base ◽

Hpv Infection ◽

Efficacy And Safety ◽

Human Papillomavirus Vaccination ◽

Hpv Types ◽

Further Development

The article provides a literature review on the prevention of cervical cancer by human papillomavirus (HPV) vaccination. Currently, 3 vaccines are available: the 4-valent vaccine against HPV types 6, 11, 16 and 18, the 9-valent vaccine against HPV types 6, 11, 16, 18, 31, 33, 45, 52, 58 and the bivalent vaccine against HPV types 16 and 18. Vaccination provides protection for women and men against infection with HPV and further development of HPV-associated diseases. Following immunization, seroconversion develops in 93-100% of women and in 99-100% of men and is effective in preventing incident and persistent HPV infection as well as cervical intraepithelial neoplasia. HPV immunization is ineffective in treating an existing HPV infection, genital warts, or anogenital intraepithelial neoplasia. HPV vaccination status does not affect recommendations for cervical cancer screening.

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Prevention of human papillomavirus (HPV) infection and cervical cancer in China: How does HPV vaccination bring about benefits to Chinese women?

BioScience Trends ◽

10.5582/bst.2013.v7.4.159 ◽

2013 ◽

Cited By ~ 2

Author(s):

Liu

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Chinese Women ◽

Hpv Vaccination ◽

Hpv Infection

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HPV infection: in need of timely intervention

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20190254 ◽

2019 ◽

Vol 5 (2) ◽

pp. 66

Author(s):

Ankit Chaudhary ◽

Vijay K. Barwal ◽

Shaina Chamotra ◽

Anjali Mahajan

Keyword(s):

Cervical Cancer ◽

Positive Impact ◽

Hpv Vaccination ◽

Age Groups ◽

Good Health ◽

Hpv Infection ◽

Women Empowerment ◽

Immunization Program ◽

Papilloma Virus ◽

Universal Immunization Program

<p class="abstract">Persistent infection with human papilloma virus (HPV) has been proved beyond doubt to be associated with the development of cervical cancer. One woman dies of cervical cancer every 8 minutes in India. As per estimations for the year 2018, about 96922 new cervical cancer cases are diagnosed annually in India and it ranks as the second most common female cancer in all age groups. But being an infectious cause it is possible to contain its development and transmission. Coupled with this, we have a potent vaccine to fight this infection. A well documented account of positive impact of HPV vaccination has been published in numerous studies around the globe. By 2013, its vaccination had been introduced in about fifty countries around the globe. In India also, recently, two HPV vaccination projects for operational feasibility were launched in Andhra Pradesh and Gujarat. In November 2016, Punjab became the first state in the country to include the vaccine in its universal immunization program. This era belongs to women empowerment and we cannot deny them the opportunity of good health. Hence it’s high time India introduces an effective HPV vaccination program.</p>

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HPV-Related Cancers: A Growing Threat to U.S. Military Health and Readiness

Military Medicine ◽

10.1093/milmed/usab443 ◽

2021 ◽

Author(s):

Julia Seay ◽

Rayna Matsuno ◽

Jennifer Buechel ◽

Karen Tannenbaum ◽

Natalie Wells

Keyword(s):

Cervical Cancer ◽

Hpv Vaccination ◽

The United States ◽

Hpv Infection ◽

Active Duty ◽

Future Research ◽

Policy Recommendations ◽

Military Health ◽

Cancer Screenings ◽

Uptake Rates

ABSTRACT The incidence of human papillomavirus (HPV) related cancers is growing in the United States. Active duty service members (ADSM) have higher rates of HPV infection than civilians and are therefore at greater risk of developing HPV-related cancers. The purpose of this commentary is to examine the burden of HPV-related cancers in ADSM. The current HPV vaccination and cervical cancer screening uptake rates of U.S. ADSM are presented, including a literature review of military-focused studies on HPV vaccination and cervical cancer screenings. We provide directions for future research, interventions, and policy recommendations to improve HPV-related cancer prevention among ADSM.

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Improvement of Parent’s Awareness, Knowledge, Perception, and Acceptability of HPV Vaccination After a Structured-educational Intervention

10.21203/rs.3.rs-30161/v2 ◽

2020 ◽

Author(s):

Mei Neni Sitaresmi ◽

Nisrina Maulida Rozanti ◽

Lamria Besty ◽

Abdul Wahab

Keyword(s):

Cervical Cancer ◽

Primary School ◽

Educational Intervention ◽

Hpv Vaccination ◽

Hpv Infection ◽

Primary School Students ◽

School Students ◽

Demonstration Program ◽

Vaccine Acceptability ◽

Parental Awareness

Abstract Background: Regardless of the disease burden of HumanPapilloma Virus (HPV), the vaccine has not been included in the Indonesia National Immunization Program. Since 2017 there was a demonstration program of the HPV vaccination in Yogyakarta Province. This vaccine was given free to female primary school students in the 5 th and 6 th grades (11-13 years old). This study aimed to assess whether a structured-educational intervention focus on HPV increases the parental awareness, knowledge, and perceptions toward HPV and the vaccine acceptability. Methods: We conducted a pre-post structured-educational intervention study from July to August 2017 before the implementation of the HPV vaccination demonstration program, in Kulon Progo District, Yogyakarta Province, Indonesia. Parents of female primary school students grades 5 th and 6 th were selected using a school-based proportional random sampling. A pediatric resident provided a structured-educational intervention, which consists of the burden and risk of HPV disease, as well as the benefit and safety of the vaccine. Parents were required to complete validated self-administered questionnaires before and after the structured-educational intervention. Results: A total of 506 parents participated. Before receiving the structured-educational intervention, parents' awareness of HPV infection and the vaccines were low. Only 49.2% of parents had heard HPV infection, and 48.8% had heard about the vaccine. After the structured-educational intervention, there were significant improvements in parent’s awareness, knowledge, and perceptions of HPV infection, cervical cancer, and HPV vaccination (all p <0.001). HPV vaccine's acceptability increased from 74.3% to 87.4% ( p <0.001). There was a significant correlation between increasing HPV vaccine acceptability with the improvement of awareness, knowledge, and perception toward HPV infection, cervical cancer and HPV vaccination (r=0.32 to 0.53, p <0.001). After the structured-educational intervention, better knowledge and positive perceptions of HPV vaccination were predictive of HPV vaccine's acceptability with OR 1.90 (95%CI:1.40-2.57) and OR 1.31(95%CI:1.05-1.63), respectively. Conclusions: A structured-educational intervention is effective in improving parental awareness, knowledge, and perceptions toward HPV as well as the acceptability of the vaccine. The structured-educational intervention designed for parents have important implications for improving vaccine acceptability.

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Awareness and knowledge of human papilloma virus (HPV) vaccine in prevention of cervical cancer among medical students

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20184960 ◽

2018 ◽

Vol 7 (12) ◽

pp. 5026

Author(s):

Radhika M. ◽

Sadiqunissa Sadiqunissa ◽

Mehfooza Ahmed

Keyword(s):

Cervical Cancer ◽

Medical Students ◽

Hpv Vaccine ◽

Positive Attitude ◽

Hpv Vaccination ◽

Hpv Infection ◽

Screening Methods ◽

Cancer Cervix ◽

Cross Sectional ◽

Infection Risk Factors

Background: Cervical cancer is the most common malignancy amongst women in India. Identification and prevention of the pre-cancerous lesions helps to reduce the incidence of Carcinoma of cervix. The main aim of the study is to know the awareness and knowledge of HPV vaccine in prevention of cervical cancer among medical students.Methods: The study included 97 medical students (final year) studying in Yenepoya Medical College, Mangalore. It is a cross-sectional questionnaire-based study.Results: The results of awareness and knowledge about the HPV vaccine are interpreted in percentage. In this study, 76% of study subjects were aware that cancer cervix is preventable, 80% of the study subjects were aware about the association between the causation of cancer cervix by HPV. Majority of the study subjects about 72% ware about the vaccines for HPV but, awareness about the cost and efficacy of the vaccine was low only about 30% and 10% respectively. However, importantly students had a positive attitude to educate people regarding HPV vaccination and also to clear myths and misconceptions.Conclusions: Medical students should be educated regarding HPV infection, risk factors for causation of cervical cancer, screening methods which are available, HPV vaccines available in India and also about the efficacy and to motivate the society to have a positive attitude towards HPV vaccination by clearing the misconceptions regarding its information.

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Human papilloma virus vaccination: knowledge, awareness and acceptability among medical and paramedical students

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20196071 ◽

2020 ◽

Vol 9 (2) ◽

pp. 474

Author(s):

Suchith Hoblidar ◽

Suma S. Moni ◽

Rathnamala M. Desai ◽

Asha Neravi

Keyword(s):

Cervical Cancer ◽

Nursing Students ◽

Human Papilloma Virus ◽

Health Care Professionals ◽

Hpv Vaccine ◽

Hpv Vaccination ◽

Target Population ◽

Hpv Infection ◽

Papilloma Virus ◽

Sexually Transmitted

Background: Cervical cancer is the second leading cause of death in india. it is also one of the few malignancies where an infectious etiological agent human papilloma virus (HPV) has been identified. With the advent of HPV vaccination, it is possible to reduce the morbidity and mortality associated with carcinoma cervix. But biggest hurdle to achieve this is the lack of awareness about the availability and use of HPV vaccine. This study was conducted to know knowledge and awareness of HPV infection and vaccination among medical and paramedical students. We also evaluated the acceptability and coverage of HPV vaccine among these students.Methods: This study was conducted among a total of 520 female students of the Sri Dharmasthala Manjunatheshwara University with the help of a questionnaire. The study group included 207 MBBS students, 167 BDS students, 89 nursing students and 57 physiotherapy students.Results: Most of the students were in 18-20 years’ age group. Nearly 40.57% of the students knew that HPV is sexually transmitted and 29.80% were aware that this infection can be prevented. Availability of HPV vaccine was known to 75% of the students and the main source of their information was through their college teachings. Nearly 43.75% of the students knew HPV vaccine protects against cervical cancer and 26.73% of the students were vaccinated. Overall knowledge and awareness were better among medical students.Conclusions: A lot of work needs to be done so as to make the target population accept HPV vaccine. There is a great difference between awareness of availability of the vaccine and its use. This emphasizes the need for health care professionals to take special interest in promoting this vaccine in the general population.

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