Role of MRI in diagnosing the primary site of origin in indeterminate cases of uterocervical carcinomas: a systematic review and meta-analysis

Objective: To perform a literature review assessing role of MRI in predicting origin of indeterminate uterocervical carcinomas with emphasis on sequences and imaging parameters. Methods: Electronic literature search of PubMed was performed from its inception until May 2020 and PICO model used for study selection; population was female patients with known/clinical suspicion of uterocervical cancer, intervention was MRI, comparison was by histopathology and outcome was differentiation between primary endometrial and cervical cancers. Results: Eight out of 9 reviewed articles reinforced role of MRI in uterocervical primary determination. T2 and Dynamic contrast were the most popular sequences determining tumor location, morphology, enhancement, and invasion patterns. Role of DWI and MR spectroscopy has been evaluated by even fewer studies with significant differences found in both apparent diffusion coefficient values and metabolite spectra. The four studies eligible for meta-analysis showed a pooled sensitivity of 88.4% (95% confidence interval 70.6 to 96.1%) and a pooled specificity of 39.5% (95% confidence interval 4.2 to 90.6%). Conclusions: MRI plays a pivotal role in uterocervical primary determination with both conventional and newer sequences assessing important morphometric and functional parameters. Socioeconomic impact of both primaries, different management guidelines and paucity of existing studies warrants further research. Prospective multicenter trials will help bridge this gap. Meanwhile, individual patient database meta-analysis can help corroborate existing data. Advances in knowledge: MRI with its classical and functional sequences helps in differentiation of the uterine ‘cancer gray zone’ which is imperative as both primary endometrial and cervical tumors have different management protocols.

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Depression and risk of disability pension: A systematic review and meta-analysis

The International Journal of Psychiatry in Medicine ◽

10.1177/0091217419837412 ◽

2019 ◽

pp. 009121741983741 ◽

Cited By ~ 4

Author(s):

Sohrab Amiri ◽

Sepideh Behnezhad

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Publication Bias ◽

Risk Ratio ◽

Disability Pension ◽

Common Mental Disorder ◽

Meta Analysis ◽

Psychological Consequences ◽

Treatment Of Depression

Background and objective Depression is a common mental disorder that leads to undesirable consequences. The study of the role of depression in disability pension can provide valuable insights. This study was conducted with the goal of systematic review and meta-analysis of the relationship between depression and disability pension. Methods PubMed, Scopus, PsycInfo, and Google Scholar databases were systematically searched until March 2018. Fifteen prospective cohort studies were selected and included in the meta-analysis. The random-effects method was used to combine the studies. Subgroup analysis was performed, and publication bias was also examined. Results Depression was a risk factor for disability pension (pooled risk ratio =1.68 and 95% confidence interval = 1.50–1.88). In men, pooled risk ratio was 1.82 for the effect of depression on the risk of disability pension (95% confidence interval = 1.45–2.28). In women, pooled risk ratio was 1.62 (95% confidence interval = 1.31–2.02). The results showed that there is publication bias. Conclusions Depression is a factor for retirement due to disability. Therefore, the prevention and treatment of depression can reduce socioeconomic and psychological consequences imposed on society.

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Role of apparent diffusion coefficient values for the differentiation of viable and necrotic areas of breast cancer and its potential utility to guide voxel positioning for MRS in the absence of dynamic contrast-enhanced MRI data

Magnetic Resonance Imaging ◽

10.1016/j.mri.2012.02.009 ◽

2012 ◽

Vol 30 (5) ◽

pp. 649-655 ◽

Cited By ~ 21

Author(s):

Uma Sharma ◽

Rani G. Sah ◽

Rajinder Parshad ◽

Raju Sharma ◽

Vurthaluru Seenu ◽

...

Keyword(s):

Breast Cancer ◽

Diffusion Coefficient ◽

Apparent Diffusion Coefficient ◽

Potential Utility ◽

Dynamic Contrast Enhanced ◽

Apparent Diffusion Coefficient Values ◽

Contrast Enhanced ◽

Apparent Diffusion ◽

Contrast Enhanced Mri

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Hormonal Predictors of Prostate Cancer: A Meta-Analysis

Journal of Clinical Oncology ◽

10.1200/jco.2000.18.4.847 ◽

2000 ◽

Vol 18 (4) ◽

pp. 847-847 ◽

Cited By ~ 199

Author(s):

Terrence Shaneyfelt ◽

Rozita Husein ◽

Glenn Bubley ◽

Christos S. Mantzoros

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Confidence Interval ◽

Population Distribution ◽

Serum Insulin ◽

Meta Analysis ◽

Prostate Cancer Risk ◽

Sex Hormone Binding Globulin ◽

Total Testosterone

PURPOSE: Although there is strong circumstantial evidence that androgens are implicated in the etiology of prostate cancer, epidemiologic investigations have failed to demonstrate consistently that one or more steroid hormones are implicated. In contrast, recent epidemiologic studies unequivocally link serum insulin-like growth factor 1 (IGF-1) levels with risk for prostate cancer. METHODS: We have performed the first meta-analysis of all previously published studies on hormonal predictors of risk for prostate cancer. RESULTS: A meta-analysis restricted to studies that performed mutual adjustment for all measured serum hormones, age, and body mass index indicated that men whose total testosterone is in the highest quartile are 2.34 times more likely to develop prostate cancer (95% confidence interval, 1.30 to 4.20). In contrast, levels of dihydrotestosterone and estradiol do not seem to play a role of equal importance. The only study that provides multivariably adjusted sex hormone–binding globulin data indicates that this binding protein is inversely related to prostate cancer risk (odds ratio, 0.46; 95% confidence interval, 0.24 to 0.89). Finally, all three studies that examined the role of serum IGF-1 have consistently demonstrated a positive and significant association with prostate cancer risk that is similar in magnitude to that of testosterone. CONCLUSION: Men with either serum testosterone or IGF-1 levels in upper quartile of the population distribution have an approximately two-fold higher risk for developing prostate cancer.

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The role of apparent diffusion coefficient values in detecting testicular intraepithelial neoplasia: Preliminary results

European Journal of Radiology ◽

10.1016/j.ejrad.2015.02.013 ◽

2015 ◽

Vol 84 (5) ◽

pp. 828-833 ◽

Cited By ~ 8

Author(s):

Athina C. Tsili ◽

Alexandra Ntorkou ◽

Dimitrios Baltogiannis ◽

Anna Goussia ◽

Loukas G. Astrakas ◽

...

Keyword(s):

Diffusion Coefficient ◽

Apparent Diffusion Coefficient ◽

Intraepithelial Neoplasia ◽

Preliminary Results ◽

Testicular Intraepithelial Neoplasia ◽

Apparent Diffusion Coefficient Values ◽

Apparent Diffusion

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Role of Automatic Tube Compensation as Spontaneous Breathing Trial in Critically Ill Patients: A Systematic Review and Meta-Analysis

10.22514/sv.2020.16.0053 ◽

2020 ◽

Keyword(s):

Confidence Interval ◽

Hospital Mortality ◽

Critically Ill ◽

Critically Ill Patients ◽

Spontaneous Breathing ◽

Meta Analysis ◽

Stay Hospital ◽

Successful Extubation ◽

Tube Compensation

Objectives: The role of automatic tube compensation (ATC) compared to other spontaneous breathing trials (SBTs) in critically ill receiving mechanical ventilation remains uncertain. The aim of this meta-analysis was to determine the role of ATC in critically ill patients compared to alternative SBT techniques. Methods: We searched PubMed, Cochrane Library, and Embase to capture all potential randomized controlled trials (RCTs) investigating the comparative efficacy of ATC related to other SBT techniques including pressure support (PS), T-piece, continuous positive airway pressure (CPAP) from their inception to February 2020. Primary outcomes were successful extubation rate. Duration of weaning, intensive care unit (ICU) stay, hospital stay, and hospital mortality was regarded as secondary outcomes. We used a risk ratio with accompanying 95% confidence interval (CI) to express estimates. Reviewer Manager (RevMan) 5.1.0 was used to complete all statistical analyses. Results: We included 13 studies enrolling 1117 patients in the final analysis. Pooled results indicated no significant difference when ATC plus CPAP (ATC/CAPA) compared to PS (6 RCTs; 572 patients; risk ratio [RR], 1.15; 95% confidence interval [CI], 1.00 to 1.31), ATC versus T-piece (2 RCTs; 157 patients; RR, 1.14; 95% CI, 0.93 to 1.40), ATC plus PS (ATC/PS) versus PS alone (1 RCTs; 100 patients; RR, 1.15; 95% CI, 0.98 to 1.35), ATC/CPAP versus CPAP alone (3 RCTs; 247 patients; RR, 1.12; 95% CI, 0.97 to 1.29) in terms of successful extubation. Additionally, ATC was also not superior to PS, T-piece, or CPAP in improving the rate of reintubation, the duration of weaning, ICU stay, hospital stay, and hospital mortality. Conclusions: Compared to alternative SBT techniques including PSV and T-piece, ATC may have comparable predictive power of successful extubation in critically ill patients. However, a definite conclusion on this topic can not be drawn due to limited data. Therefore, further studies were required to establish our findings due to limited number of eligible studies and small accumulated sample size.

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