scholarly journals Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats

2017 ◽  
Vol 23 ◽  
pp. 3961-3970 ◽  
Author(s):  
Xia Zhao ◽  
Qian Liu ◽  
Haixiang Sun ◽  
Yali Hu ◽  
Zhaoxu Wang
Keyword(s):  
Wistar Rats ◽  
Systemic Toxicity ◽  
Toxicity Study ◽  
Intrauterine Devices ◽  
Female Wistar Rats

scholarly journals Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
C. P. Ekanayake ◽  
M. G. Thammitiyagodage ◽  
S. Padumadasa ◽  
B. Seneviratne ◽  
C. Padumadasa ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Ethyl Acetate ◽  
Wistar Rats ◽  
Cocos Nucifera ◽  
Toxicity Study ◽  
Immature Inflorescence ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Female Wistar Rats

Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.

The effects of hexachloronaphthalene on selected parameters of heme biosynthesis and systemic toxicity in female wistar rats after 90-day oral exposure

2018 ◽  
Vol 33 (6) ◽  
pp. 695-705 ◽  
Author(s):  
Michal Klimczak ◽  
Adam Darago ◽  
Elzbieta Bruchajzer ◽  
Katarzyna Domeradzka-Gajda ◽  
Maciej Stepnik ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Systemic Toxicity ◽  
Heme Biosynthesis ◽  
Oral Exposure ◽  
Female Wistar Rats

scholarly journals Assessment of haematological, serum biochemical and histopathological effects of subchronic dietary fumonisin b1 in rats

1970 ◽  
Vol 18 ◽  
pp. 74-83
Author(s):  
FA Gbore ◽  
A Ologundudu ◽  
AO Arowosegbe ◽  
TM Ologun ◽  
FA Jolade ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Fusarium Verticillioides ◽  
Fumonisin B1 ◽  
Live Weight ◽  
Toxicity Study ◽  
Feed Consumption ◽  
Short Term ◽  
Female Wistar Rats ◽  
Serum Biochemical ◽  
Histopathological Effects

Context: Fumonisin B1 (FB1), a mycotoxin produced by Fusarium verticillioides and other Fusarium species that grow on maize worldwide, has been documented to cause various physiological responses in animals. Consumption of lesser amounts of fumonisins at levels below those that cause overt toxicity may exert haematological, serum biochemical and/or histopathological effects in animals.   Objective: The effects of dietary FB1 on haematology, serum biochemistry and histopathology were assessed in female Wistar rats in a short-term toxicity study.   Materials and Methods: Thirty-nine mature female Wistar rats (Rattus norvegicus) weighing between 167.5 – 170.5 g were used in the study. The rats were assigned to diets containing 0.2, 10.0 and 20.0 mg FB1/kg constituting diets 1, 2 and 3, respectively. After 14 days of feeding, blood samples were obtained from four rats per treatment. The rats were sacrificed by cervical dislocation, eviscerated for organ collections and subsequently processed for histology.   Results: Significant differences in feed consumption and body weight gains were not observed. The final live weight of the rats, however, seemed to decline with an increase in dietary FB1 levels. Significant (P<0.05) alterations were observed in the haematological and serum biochemical parameters with increasing levels of dietary FB1. Diets containing different FB1 concentrations, the decreased values of PCV, Hb, erythrocyte and monocyte counts could be attributed to the FB1 effects on the blood-forming tissues in animals placed on diets 2 and 3 as compared to those fed diet 1. Also, histopathological changes were observed in the livers, kidneys, spleens and hearts of rats fed diets 2 and 3.   Conclusion: This study revealed that the No-observable adverse effect level (NOAEL) of dietary FB1 above which may cause significant physiological changes without overt toxicity for short-term toxicity study in female Wistar rats is <0.74 mg/kg bw per day.   Keywords: Blood; Rat; Mycotoxin; Fusarium verticillioides; Fumonisin B1; Histopathology. DOI: http://dx.doi.org/10.3329/jbs.v18i0.8779 JBS 2010; 18(0): 74-83

scholarly journals Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
E. N. Sholikhah ◽  
M. Mustofa ◽  
D. A. A. Nugrahaningsih ◽  
F. S. Yuliani ◽  
S. Purwono ◽  
...  
Keyword(s):  
Microscopic Examination ◽  
Wistar Rats ◽  
Allium Sativum ◽  
Toxicity Study ◽  
Toxic Effects ◽  
Oral Toxicity ◽  
Polyherbal Formulation ◽  
Female Wistar Rats ◽  
Terminalia Bellirica ◽  
Amomum Compactum

The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its blood pressure-lowering effect on a rat model of hypertension. However, toxicity data were not available for this polyherbal formulation. This study is aimed at evaluating the acute and subchronic oral toxicity of the polyherbal formulation in rats. The acute toxicity study was conducted on 6 female Wistar rats using the fixed-dose method for the treatment group and 5 female Wistar rats for the control. The single dose of 2,000 mg/kg of the polyherbal formulation was given orally. There were no significant toxic effects and no death observed until the end of the study, and it was showed that the lethal dose 50% (LD50) of the polyherbal formulation was estimated to be more than 2,000 mg/kg. The macroscopic and microscopic examination of vital organs showed no symptoms of toxicity. At the subchronic toxicity study, the polyherbal formulation with 3 dose variations of 252 mg/kg, 1,008 mg/kg, and 4,032 mg/kg was administered for 91 days orally. The lowest dose of 252 mg/kg is equivalent to the daily recommended dose for a human. There were no significant toxic effects observed at all doses on physical sign and symptoms, weight gain, food intake, hematological parameters, biochemical parameters, and macroscopic and microscopic examination of organs. These findings showed that the short- and long-term oral administration of the polyherbal formulation is safe to use within its dose recommendation.

NEW DATA CONCERNING THE ROLE PLAYED BY PROGESTERONE IN THE CONTROL OF FOLLICULAR GROWTH IN THE RAT

1974 ◽  
Vol 75 (3) ◽  
pp. 569-578 ◽  
Author(s):  
G. Buffler ◽  
S. Roser
Keyword(s):  
Wistar Rats ◽  
Venous Blood ◽  
Oestrous Cycle ◽  
Female Rats ◽  
Cycle Duration ◽  
Follicular Growth ◽  
The Third ◽  
Female Wistar Rats

ABSTRACT The mechanisms involved in the prolongation of the oestrous cycle following LH administration were studied in 4-day cyclic female Wistar rats. In females injected with LH on the morning of dioestrus I there was an increase in ovarian venous blood progesterone as compared with non-injected animals. In both LH-treated females, and those injected with progesterone on the morning of dioestrus I, a slowing up in follicular growth was observed from the afternoon of dioestrus I. The size of follicles greater than 400 urn present in LH or progesterone injected animals on the third day of cycle was similar to the size reached by the same range of follicles in non-injected animals on the second day of the cycle. Hence, the increase in endogenous ovarian progesterone elicited by LH was considered as the cause of the slowing up of follicular growth and therefore of the lengthening of the oestrous cycle duration in female rats injected with LH at the beginning of 4-day cycle.

Oral in vivo Bactofection in Dextran Sulfate Sodium Treated Female Wistar Rats

2010 ◽  
Vol 58 (3) ◽  
pp. 171-176 ◽  
Author(s):  
Roland Pálffy ◽  
Michal Behuliak ◽  
Roman Gardlík ◽  
Peter Jáni ◽  
L'udevít Kádaši ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Female Wistar Rats
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