Acute and Sub Acute Toxicity Study of Ethanolic Extract of Plakobranchus Ocellatus on Female Wistar Rats

2016 ◽  
Vol 4 (6) ◽  
pp. 143-152
Author(s):  
Priyanka Devi ◽  
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Female Wistar Rats

scholarly journals Acute toxicity study of the ethanolic extract of Eleutherine bulbosa Urb in Wistar rats

2021 ◽  
pp. 143-147
Author(s):  
Helmina Wati ◽  
Rahmi Muthia ◽  
Kartini ◽  
Finna Setiawan
Keyword(s):  
Acute Toxicity ◽  
Toxicity Test ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Test Study ◽  
Limit Test ◽  
Low Toxicity ◽  
Medicinal Properties

Introduction: Eleutherine bulbosa Urb is a plant species with medicinal properties, including anti-inflammatory, widely relied upon in traditional practices. For this reason, the present research was intended to assess and, thus, ensure the safety of this plant for conventional medicinal purposes using a toxicity test study. Methods: The acute toxicity test of the ethanolic extract of E. bulbosa Urb (EEEB) used the method adopted from the Organization Economic Cooperation and Development (OECD) guidelines 425 for testing Wistar rats. Results: During 14 days of the acute toxicity study, there were no significant changes in rat weight, no mortality, and no signs of toxicity after the oral EEEB administration at 2000 mg/kg body weight (bw). The limit test showed that the LD50 of EEEB was higher than 2000 mg/kg bw. Conclusion: EEEB has low toxicity because its LD50 is higher than the limit test results.

scholarly journals Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
C. P. Ekanayake ◽  
M. G. Thammitiyagodage ◽  
S. Padumadasa ◽  
B. Seneviratne ◽  
C. Padumadasa ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Ethyl Acetate ◽  
Wistar Rats ◽  
Cocos Nucifera ◽  
Toxicity Study ◽  
Immature Inflorescence ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Female Wistar Rats

Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg body weight has been reported. Acute and subacute toxicity studies of EASPA of the IC carried out using female Wistar rats according to Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively, are reported herein. In the acute toxicity study, a single dose of EASPA (2000 mg/kg body weight) was orally administered to rats, which were monitored for 14 days. In the subacute toxicity study, rats were orally administered with EASPA daily for 28 days at doses of 1.75, 3.5, 7, and 14 mg/kg body weight. No rat in either the acute or subacute toxicity study exhibited mortality or clinical signs of toxicity. Further, these rats did not show any significant change in their mean body weight, food, and water intake, haematological and biochemical parameters as well as in the results of their histopathological examinations compared to those of control group rats. According to results of the acute toxicity, the LD50 of EASPA is estimated to be greater than 2000 mg/kg body weight. Considering the results of the subacute toxicity study, the oral administration of EASPA daily for 28 days was well tolerated up to the dose, 14 mg/kg by rats. These results will be useful in the development of a novel therapeutic agent from EASPA of the IC for the treatment of menorrhagia, which incapacitates a considerable proportion of women worldwide.

Acute Toxicity Study of Herbal Ovulation Inducer Product ‘Estrofarm’ in Wistar Rats

2011 ◽  
Vol 4 (5) ◽  
pp. 528-529
Author(s):  
M. M. Gatne M. M. Gatne ◽  
◽  
M.J Saxena M.J Saxena ◽  
K. Ravikanth K. Ravikanth ◽  
A. Thakur A. Thakur
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Toxicity Study ◽  
Acute Toxicity Study

scholarly journals ANTIHYPERLIPIDEMIC AND HEPATOPROTECTIVE STUDIES ON LEAVES OF MACARANGA TANARIUS

2016 ◽  
Vol 10 (1) ◽  
pp. 239
Author(s):  
Phebe Hendra ◽  
Fenty Fenty ◽  
Jeffry Julianus ◽  
Oktariani Aurelia Jamil ◽  
Dian Ayu Maharani ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Toxicity Study ◽  
Lipoprotein Cholesterol ◽  
Acute Toxicity Study ◽  
Macaranga Tanarius ◽  
Serum Glutamate ◽  
Ethanol Fraction

ABSTRACTObjective: This study investigated the antihyperlipidemic and hepatoprotective effects of the hexane-ethanol fraction of methanol extract ofMacaranga tanarius (HEM) in rats.Methods: The hexane-ethanol fraction was screened for toxicity by oral acute toxicity study. The antihyperlipidemic effect of the hexane-ethanolfraction and the unsolved of the hexane-ethanol fraction is measured against Wistar rats induced by glucose-fructose diets for 42 days throughmeasuring serum cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and fastingblood glucose. The hepatoprotective effect of the hexane-ethanol fraction is determined against Wistar rats with liver damage induced by carbontetrachloride through measuring serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkalinephosphatase (ALP), albumin, lactate dehydrogenase (LDH), and total bilirubin.Results: There is no toxic effect that was observed on acute toxicity study. The TG, LDL-c, and fasting blood glucose levels were significantly (p<0.05)reduced after both of treatment the hexane-ethanol fraction and the unsolved HEM. Administration of the hexane-ethanol fraction 68.6 mg/kgBWsignificantly (p<0.05) prevented elevation of SGPT, SGOT, LDH, ALP, and decreasing of albumin level.Conclusion: The study showed antihyperlipidemic and hepatoprotective activities of the HEM in animal models.Keywords: Macaranga tanarius, Antihyperlipidemic, Hepatoprotective.

Acute Toxicity Study and Faecal Dropping Capability of Ethanolic Extract of Tecoma stans in Albino Rats

Pharmacologia ◽  
2013 ◽  
Vol 4 (7) ◽  
pp. 464-468 ◽  
Author(s):  
S. Kameshwara ◽  
C. Jothimaniv ◽  
R. Senthilkum ◽  
S. Thenmozhi ◽  
R. Sundaragan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Toxicity Study ◽  
Albino Rats ◽  
Acute Toxicity Study

scholarly journals Acute and Subacute Toxic Aqueous Extract of the Leaves of Petroselinum Crispum Mill. in Male and Female Wistar Rats

2021 ◽  
Vol 17 (40) ◽  
pp. 178
Author(s):  
Kablan Kassi Jean Jacques ◽  
Blahi Adelaïde Nadia, ◽  
Kouakou Koffi Roger ◽  
Diby Yao Seraphin ◽  
Siapo Yao Martin ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Toxicity Study ◽  
Female Rats ◽  
Petroselinum Crispum ◽  
Male And Female ◽  
Acute Toxicity Study ◽  
Male And Female Rats ◽  
Female Wistar Rats

The present study is part of a vast program of the valorization of the medicinal flora and to help the populations to make a real profit from the use of plants in order to avoid any problem of poisoning. Petroselinum crispum Mill. (Apiaceae) is a plant, whose therapeutic virtues are diverse. The toxicological aspect of the aqueous extract of Petroselinum crispum leaves in male and female rats was investigated. The acute toxicity study with the single dose of 5000 mg/Kg body weight shows that the aqueous extract from the leaves of Petroselinum crispum is not toxic orally. According to Organisation for Economic Cooperation and Development (OECD) Guideline 423, the oral LD50 for this extract is greater than 5000 mg/kg body weight. In addition, the sub-acute toxicity study (OECD 407) showed that the aqueous extract from the leaves of Petroselinum crispum did not show any toxic effects at doses 50,100 and 200 mg/kg body weight and would have an orexigenic effect after 28 days of treatment. The different histological sections showed that the aqueous extract of Petroselinum crispum is not toxic on the vital organs and appears to be hepatoprotective.

scholarly journals Study the Acute & Sub Acute Toxicity of Ricinus cummunis Lnn. Ethanol Extract of Seed in Albino Mice

2018 ◽  
Vol 6 (02) ◽  
Author(s):  
Manal H. AL-Jborrey ◽  
Muastafa A. K. Altaie ◽  
Ayyad W. Al-Shahwany
Keyword(s):  
Acute Toxicity ◽  
Morphological Changes ◽  
Ricinus Communis ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Chronic Administration ◽  
Industrial Applications ◽  
Toxicity Study ◽  
Herbal Extract ◽  
Acute Toxicity Study

Background: Toxicity still a global problem for the environment, agriculture and ultimately human health. Objective: In this study attempt to investigate the toxicological profile of the ethanol, extract of Ricinus cummunis after acute and sub-chronic administration to mice. Methods: In the acute toxicity study, a single administration of the extract at doses of 1000,2000,3000,4000 and 5000 mg/kg, respectively, was gave orally. Mice were observed for general behavioral changes, adverse effects and mortality up to 10 days post-treatment. In sub-acute toxicity studies, herbal extract was gave orally to mice at doses of 50 mg/kg, 100 mg/kg and 150 mg/kg for 10 days. Results: In the acute toxicity study, the mortality appeared in 2000 mg/kg and LD50 were calculated at 1100 mg/kg. In the sub-chronic toxicity the study show significant differences in body weight between the control and treated groups (p < 0.05). Histopathology of vital organ (liver & kidney) show morphological changes. Conclusions: These results demonstrate the real toxic effect of the ethanolic extract after single dose. The LD50 value is 1100 mg/kg and research indicates that successive use of the seed at the dose above (2 g/kg in human) daily for long period may cause toxic signs. Highlights: The Ricinus communis oil's has wide variety of industrial applications: as a drying oil for paints, varnishes, plastics and resins is an ingredient in numerous cosmetics. But it need to toxicity study as acute and sub-acute with observation of hematological and histopathological to be more safety  for used.

scholarly journals Phytochemical and acute toxicity study of aqueous extract of Bambusa vulgaris leaves on Wistar rats

2020 ◽  
Vol 02 (04) ◽  
pp. 107
Author(s):  
Appy Simone Abe ◽  
Kouao Augustin Amonkan ◽  
Kacou Marius Jules Djetouan ◽  
Kesse Philippe N’Da
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Bambusa Vulgaris
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