According to the connotation of Scientific Outlook on Development, this paper constructs an enterprises scientific development performance evaluation model based on factor analysis and combination weighting. The innovation points and contributions are in three aspects. First, by evaluating performance from the manpower criterion, the basic idea of Scientific Outlook on Development of people-oriented is reflected. Second, by applying the factor analysis to screen evaluation indicators, fourteen indicators are selected to reflect more than 85% of original information and avoids information duplication and redundancy. Third, by determining the combination weight through multiplicative synthesis method based on G1 and TOPSIS, it fully utilizes experts’ subjective experiences and objective information.